NCT00004474

Who might be able to join this trial:

• You have been diagnosed with severe aplastic anemia (a condition where the bone marrow stops making enough blood cells)
• Your bone marrow biopsy shows very low activity, with less than 20% of normal cell production
• You have at least 2 of the following blood count problems: very low infection-fighting white blood cells, very low platelets (cells that help stop bleeding), or very low reticulocytes (young red blood cells)
• You have a brother or sister whose tissue type (HLA) is a close match to yours and who can donate
• Your liver is working reasonably well — blood tests show bilirubin levels below 3 times the normal range
• Your kidneys are working reasonably well — blood tests show creatinine levels below 2 times the normal range
• Your heart is working normally
• You do not have HIV

Who may not be able to join:

• You have certain genetic or chromosomal abnormalities in your blood cells, a condition called paroxysmal nocturnal hemoglobinuria, or a bone marrow condition called myelodysplastic syndrome, diagnosed within 3 months of your aplastic anemia diagnosis
• Your aplastic anemia was present from birth or is related to a genetic condition, including Fanconi anemia (an inherited disorder)
• You have an active infection that is not being controlled
• You have another serious illness alongside your aplastic anemia
• You are able to have children but are not willing or able to use effective contraception during the trial

Important: Always verify eligibility with the trial site directly before applying.