NCT01878617

Who might be able to join this trial:

• You have been diagnosed with medulloblastoma (a type of brain tumor) or a closely related type of brain tumor in the back of the brain, confirmed by a pathologist.
• You are between 3 and 21 years old at the time of diagnosis, OR you are between 22 and 39 years old and have a specific type called SHH medulloblastoma.
• You have not yet received any radiation therapy, chemotherapy, or other brain tumor treatments (steroid medications and surgery are okay).
• You are able to start treatment within 36 days of your main surgery to remove the tumor.
• You are well enough to participate, based on standard medical scoring systems used to measure how well a patient can carry out daily activities.
• If you are a female who could become pregnant (generally over age 10 or after your first period), you must test negative for pregnancy before joining and must not be breastfeeding.
• Biological parents of a child enrolling in this trial may also be able to participate in a separate part of the study (the exclusion criteria listed below do not apply to parents).

Who may not be able to join:

• You have a different type of brain tumor — such as Atypical Teratoid/Rhabdoid Tumor (ATRT), pineoblastoma, or certain other related tumors — rather than medulloblastoma or a posterior fossa PNET.
• You have other serious medical conditions that could make it unsafe to receive the trial treatments or that could interfere with the study results.

For a specific part of the trial involving a medication called vismodegib, you would also need to:

• Have the SHH type of medulloblastoma.
• Have bones that are fully or nearly fully grown (females with a bone age of at least 15 years, males at least 17 years) (confirm with trial site).
• Be able to swallow pills.
• Have a body surface area (a measure based on your height and weight) within a specific range (confirm with trial site).
• Agree to use effective birth control during and after treatment if you are able to have children.
• Have blood counts, kidney function, and liver function results within acceptable ranges as measured by blood tests (confirm with trial site).

For a part of the trial involving an exercise program, you would also need to:

• Be between 5 and 21 years old at the time of joining this part.
• Have no congenital (present from birth) heart disease.
• Be physically able to take part in the exercise program, as decided by your doctor.

For a part of the trial involving a brain training/thinking skills program, you would also need to:

• Have already completed the radiation therapy required by the study.
• Be at least 5 years old, OR between 22 and 39 with SHH medulloblastoma.
• Speak English as your primary language and have a helper who also speaks English available to join sessions.
• Not have a significantly low IQ score (below 70), as measured by study testing or a doctor's assessment.
• Not have major vision, movement, or other difficulties that would prevent valid thinking/memory testing, and no major psychological conditions that would prevent completing the program (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.