NCT02365922

Who might be able to join this trial:

• You have been diagnosed with one of the following conditions: behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), semantic variant PPA, nonfluent variant PPA, frontotemporal dementia with ALS, ALS alone, corticobasal syndrome (CBS), progressive supranuclear palsy (PSP or oPSP), or you have a strong family history of these types of conditions.
• You are between 18 and 85 years old.
• You are able to walk at the time of joining, even if you need some help to do so.
• You have a trusted person (such as a family member or close friend) who knows you well and can give their own assessment of how you are functioning day-to-day.
• You speak English or Spanish.
• You score between 15 and 30 on a standard memory and thinking test called the MMSE (confirm with trial site).

Who may not be able to join:

• You have a known structural problem in the brain, such as a tumor or a stroke, that could explain your symptoms — unless you carry a known gene linked to these conditions.
• You carry a known gene change linked to Alzheimer's disease, or brain tissue testing has shown Alzheimer's disease is causing your symptoms.
• You have a history of a brain condition caused by severe alcohol use (Korsakoff encephalopathy), heavy alcohol or substance use problems within 5 years of your symptoms starting, or another neurological condition such as multiple sclerosis.
• Lab tests or your medical history show problems such as very low vitamin B12, an underactive thyroid, HIV, kidney failure, liver failure, the need for supplemental oxygen, a large brain tumor pressing on brain tissue, a large stroke, significant white matter damage in the brain, or serious heart or other major organ disease.
• You are currently taking certain medications that may affect brain function, including long-acting sedatives like diazepam (Valium), certain antidepressants (other than SSRIs or trazodone), lithium, certain older antipsychotic medications, strong painkillers (narcotics, with some exceptions), seizure medications outside of normal treatment levels, or antihistamines taken more than three times a week — (confirm specific medications with trial site).
• In the opinion of the trial doctor, you are not able to complete enough of the key study activities.
• If MRI scans are part of the study for your group, you cannot have an MRI — for example, because you have a pacemaker or other metal implants in your body.

Important: Always verify eligibility with the trial site directly before applying.