NCT04931342

Who might be able to join this trial:

• You have been diagnosed with a specific type of ovarian, fallopian tube, or peritoneal cancer that has come back or not gone away — including low-grade serous, clear cell, mucinous, carcinosarcoma, and several other types (but NOT high-grade serous or high-grade endometrioid types)
• Your cancer cannot be fully removed by surgery
• At least one area of your cancer can be measured on a scan
• You have already received between one and four previous cancer treatments, and at least one of those included a platinum-based chemotherapy (note: hormone therapy does not count as a treatment line for this purpose)
• Your cancer got worse during or within 6 months after your most recent platinum-based chemotherapy
• You are able to provide a tumour tissue sample suitable for laboratory testing, to help determine which treatment group you would be placed in
• You are also able to provide your local pathology report and, if available, any related tissue slides from your diagnosis
• You are generally well enough to carry out daily activities with little or no limitation (confirm with trial site what this means for you specifically)
• Your blood counts and organ function (such as liver and kidneys) are within acceptable ranges
• If you could become pregnant, you agree to use reliable contraception or remain abstinent during the study, and agree not to donate eggs

Who may not be able to join:

• You are currently pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study
• Your cancer did not respond to your very first platinum-based chemotherapy and got worse during treatment or within 4 weeks of finishing it
• Your cancer has been identified as high-grade serous or high-grade endometrioid ovarian, fallopian tube, or peritoneal cancer
• Your only current diagnosis is a "borderline" ovarian tumour (a low-risk, slow-growing type)
• Your ovarian tumour is a non-epithelial type (confirm with trial site)
• You currently also have endometrial (womb) cancer at the same time
• You have a previous history of endometrial cancer, unless it was caught very early, was a lower-grade type, had no spread into blood or lymph vessels, and was not a high-grade subtype (confirm with trial site)
• You have uncontrolled fluid build-up around your lungs, heart, or abdomen that regularly needs to be drained
• You have brain metastases (cancer that has spread to the brain) that are causing symptoms, have not been treated, or are getting worse
• You had a serious infection within the 4 weeks before starting the study treatment
• You received chemotherapy, radiation, immunotherapy, gene therapy, a vaccine therapy, or another experimental treatment within 28 days before starting the study treatment
• You received hormone therapy within 14 days before starting the study treatment

Important: Always verify eligibility with the trial site directly before applying.