NCT00002474

Who might be able to join this trial:

• You have been diagnosed with ovarian epithelial cancer that has come back or stopped responding to treatment
• You have previously been treated with a chemotherapy drug called cisplatin or carboplatin, and it did not work
• Your cancer can be measured or tracked — this can include blood test results (CA-125), or fluid build-up in the chest or abdomen that contains cancer cells
• A sample of your bone marrow has been collected (harvested) before joining the study, and a large enough amount was obtained
• Your bone marrow collection sites show no signs of cancer (confirmed by bone marrow samples, X-ray, and bone scan)
• You are under 65 years old
• You are reasonably active and able to care for yourself (confirm with trial site)
• You are expected to live for at least 8 weeks
• Your blood counts are at acceptable levels — including white blood cells, platelets, and haemoglobin
• Your liver is functioning well enough, based on blood tests
• Your kidneys are working well enough, based on a kidney function test
• Your heart is pumping properly, confirmed by a specific heart scan
• You are not currently pregnant, and a pregnancy test is negative
• You do not have HIV
• You are healthy enough to have a general anaesthetic

Who may not be able to join:

• You have had a bone marrow transplant in the past
• You have had previous bleeding or inflammation of the bladder (a condition called haemorrhagic cystitis)
• You have significant hearing loss, particularly with voice-level sounds
• You have an active infection at the time of joining
• There are psychological reasons that would make this treatment unsuitable for you (confirm with trial site)
• You have had chemotherapy, radiotherapy, or other biological treatments less than 4 weeks ago (or less than 6 weeks ago for certain specific chemotherapy drugs), or you have not yet fully recovered from those treatments

Important: Always verify eligibility with the trial site directly before applying.