NCT00004083

Who might be able to join this trial:

• You have been diagnosed with ovarian epithelial cancer that has come back, confirmed by a lab test on a tissue or cell sample
• Your cancer may have spread to other parts of the body (metastatic disease is allowed)
• You have previously been treated with a platinum-based chemotherapy (a common type of chemotherapy for ovarian cancer)
• Your cancer responded to that platinum-based treatment and did not get worse while you were on it
• You had a period of at least 6 months without active disease after finishing your platinum-based treatment
• You have at least one tumour that can be measured in two directions on a scan
• You are 18 years of age or older
• You are in reasonably good general health (able to carry out normal activity with minimal assistance)
• You are expected to live for at least 3 more months
• Your blood counts are at acceptable levels — enough white blood cells, platelets, and haemoglobin (confirm with trial site)
• Your liver is functioning well enough, based on blood test results (confirm with trial site)
• Your kidneys are working well enough, based on a kidney function test (confirm with trial site)
• You have had a hearing test (audiogram) as a baseline before joining
• If you could become pregnant, you must be willing to use effective contraception
• You must be able to understand and give informed consent without significant confusion

Who may not be able to join:

• You have cancer that has spread to the brain or central nervous system
• You have uncontrolled heart disease or significant heart function problems
• You are currently pregnant or breastfeeding
• You have an active infection that requires treatment with systemic (whole-body) medicines
• You have significant confusion, disorientation, or a history of major psychiatric illness that could affect your ability to give informed consent
• You have moderate to severe nerve damage (neuropathy) either from previous cancer treatment or from other causes
• You require a special type of intravenous nutrition that includes fats (total parenteral nutrition with lipids)
• You have previously had an allergic reaction to cisplatin or any platinum-based product
• You have previously received a treatment called SPI-77
• You have had chemotherapy within the last 3 weeks (or 6 weeks for certain specific drugs — confirm with trial site)
• You are currently receiving other cancer-fighting drugs or hormonal cancer treatments
• You have had radiotherapy within the last 2 weeks, or are currently receiving radiotherapy
• You have had major surgery for cancer within the last 2 weeks
• You have taken part in another clinical trial using an experimental treatment within the last 30 days
• You are currently using any other experimental treatments

Important: Always verify eligibility with the trial site directly before applying.