NCT00264433

Who might be able to join this trial:

• You must be willing and able to sign a consent form agreeing to take part in the study
• You must be 18 years of age or older, male or female, and have a solid tumour that has stopped responding to standard treatments or has no known cure
• Your cancer must have been confirmed by a lab test (tissue sample) and must be one of these types: non-small cell lung cancer, cancer of the oesophagus or stomach, kidney cancer, liver cancer, or adrenal gland cancer
• Your cancer must be measurable, meaning it can be detected and tracked using scans or tests
• A test on your tumour tissue (either stored or newly taken) must show the presence of a specific protein called N-cadherin
• You must have an acceptable level of general health and your heart, blood, and organ function must meet certain standards confirmed by blood tests and a heart tracing (ECG)

Who may not be able to join:

• You have previously received a drug called ADH-1 in another study or treatment
• You have had chemotherapy, radiotherapy, or taken part in another drug trial within the last 30 days
• You have a history of spinal cord compression, a brain tumour, or cancer that has spread to the brain, unless it was fully treated with no return for at least 6 months
• Your tumour has shown signs of significant active bleeding (such as coughing up blood, vomiting blood, blood in urine, or bleeding from the tumour surface) within the last 12 weeks
• You have had a stroke, major surgery, or serious tissue injury within the last 30 days
• You have a history of uncontrolled heart failure, coronary artery disease, or dangerous heart rhythm problems
• You have had a heart attack within the last 12 months
• You have significant abnormalities shown on a heart tracing (ECG) (confirm with trial site)
• You have a known condition that causes your blood to clot too easily

Important: Always verify eligibility with the trial site directly before applying.