Lung Cancer

You must be at least 18 years old. You must have been diagnosed with a specific advanced form of lung cancer called Stage IV non-small cell lung cancer (NSCLC). Your lung cancer must not have certain specific gene changes (known as EGFR mutation or ALK rearrangement) based on test results. You must not have had any…

People who are in generally good physical condition and able to carry out normal daily activities, with little or no limitation (rated 0 or 1 on a standard oncology performance scale) People who have been diagnosed with a specific type and stage of non-small cell lung cancer (NSCLC), confirmed by tissue or cell…

You have been diagnosed with advanced or spreading non-small cell lung cancer (a type of lung cancer) that has been confirmed by a lab test, and your cancer has a specific gene change (mutation) in a gene called EGFR — either an "Exon 19 deletion" or an "Exon 21 L858R mutation" — detected through an approved blood or…

You have been diagnosed with small cell lung cancer (SCLC) that has spread widely in the body (called "extensive stage") You are able to take care of yourself day-to-day, even if you are unable to do regular work activities You have not yet received any cancer treatments for your small cell lung cancer

You must have a specific type of lung cancer (non-squamous, non-small cell lung cancer) that is at Stage IIIA or Stage IIIB. Your cancer must be measurable using scans, such as a CT scan. You must be able to take care of yourself, move around, and do light activities like housework or office work. You must be 18 years…

You have been diagnosed with a type of lung cancer called non-small cell lung cancer, confirmed by a lab test on a tissue or cell sample. Your cancer tests positive for a specific gene change called the ALK fusion gene (this can be tested at a central or local laboratory). You may have previously taken part in a…

You have been diagnosed with a specific type of non-small cell lung cancer (not the squamous type — for example, adenocarcinoma or large cell) confirmed by a lab test Your cancer is at Stage IV (meaning it has spread) at the time you would enter the study Your cancer can be measured or detected on scans (at least some…

You have been diagnosed with a type of lung cancer (non-squamous cell carcinoma) that has spread or come back and cannot be treated with local treatments like surgery or radiation. Your cancer has tested positive for a specific gene change involving the ALK gene. You have not had any previous systemic treatment (such…

You have been diagnosed with non-small cell lung cancer (NSCLC) that cannot be removed by surgery and has reached Stage III or Stage IV You may currently be receiving maintenance chemotherapy (ongoing treatment to keep cancer from coming back) If you are about to start a new chemotherapy or radiation treatment, it…

You have been diagnosed with advanced lung cancer (stage IIIB or IV) of a specific type called adenocarcinoma, confirmed by a lab test. Your tumour has been tested and found to have a specific gene change (mutation) in the EGFR gene, specifically called Del19 and/or L858R. You have at least one tumour that can be…

You must be at least 18 years old You must have been diagnosed with a specific type of lung cancer called non-small cell lung cancer (NSCLC) that is at an advanced stage (Stage III) and cannot be removed by surgery You must have already received at least 2 cycles of a chemotherapy treatment containing platinum, given…

You have cancer that has spread to the brain (brain metastases) from hormone receptor positive breast cancer, non-small cell lung cancer (NSCLC), or melanoma. If joining Part A, you have HER2-positive breast cancer; if joining Part B, you have HER2-negative breast cancer. If joining Part C, you have hormone receptor…

You have been diagnosed with small cell lung cancer (SCLC), confirmed through a tissue or cell sample test. Your cancer was classified as either "limited stage" (cancer confined to one area) or "extensive stage" (cancer that has spread more widely) when you were first diagnosed. Your cancer has come back or gotten…

You have been diagnosed with advanced (stage IV) non-small cell lung cancer (NSCLC) confirmed by a lab test, and your cancer does not have certain specific genetic changes (called EGFR mutations, ROS1, or ALK translocations). Your cancer can be measured on a scan, following specific medical guidelines (called RECIST…

You must be willing and able to sign a consent form agreeing to take part in the study. You must be 18 years of age or older (any gender). You must have been diagnosed with non-small cell lung cancer (NSCLC) that is either Stage III (and cannot be removed by surgery) or Stage IV, confirmed by a tissue or cell sample.…

You have been diagnosed with a specific type of lung cancer called non-squamous non-small cell lung cancer (NSCLC), confirmed by a lab test on a tissue or cell sample. Your lung cancer is at stage IV (meaning it has spread to other parts of the body). Your doctor has confirmed that certain targeted treatments (aimed…

You have been diagnosed with non-small cell lung cancer (NSCLC) that is locally advanced, has come back, or has spread to other parts of the body (Stage IV), and surgery or radiation as a main treatment is not an option for you. Your cancer has stopped responding to, or you could not tolerate, the standard treatments…

You have been diagnosed with extensive-stage small cell lung cancer (a type of lung cancer that has spread), confirmed through a biopsy or lab test. You have not yet received any treatment for this extensive-stage diagnosis. You are generally able to carry out daily activities with little or no limitation (confirm…

Adults aged 18 or older. People whose general health and ability to function day-to-day falls within an acceptable range for this type of trial (rated on a standard medical scale called ECOG/Zubrod, scores 0, 1, or 2). People whose scan results show signs of non-small cell lung cancer (NSCLC), including tumours that…

Adults aged 18 or older, or teenagers aged 12–17 if a Safety Review Committee has given approval for that age group. People who have a solid tumour (cancer that forms a mass) that has spread locally or to other parts of the body, and whose tumour has a specific genetic change called a TP53 Y220C mutation. People whose…

(Phase 2) You have been diagnosed with non-small cell lung cancer (NSCLC) that cannot be removed by surgery or has spread to other parts of the body, confirmed by a tissue sample, and your cancer has a specific gene change called KRAS G12C. (Phase 3) You have been diagnosed with a specific type of NSCLC (squamous or…

You have been diagnosed with lung cancer (either small-cell or non-small-cell type), confirmed by a tissue sample test You have been referred for radiation treatment with the goal of curing the cancer You are planned to receive a radiation dose of 60–66 Gy in standard-sized sessions, though other dose plans may also…

People who are expected to live for at least 12 weeks. People who have a type of lung cancer called non-small cell lung cancer (NSCLC) that shows high levels of a protein called c-Met, as confirmed by a specific laboratory test approved for this trial. People who are able to provide a stored or fresh tumour tissue…

Adults aged 18 years or older People who are able to understand and agree to participate in the study (give informed consent) People who have been diagnosed with lung cancer and whose treatment plan includes radiation therapy People whose radiation therapy planning involves a type of CT scan that captures movement…

You are 18 years of age or older You are fairly active and able to care for yourself, with little or no limitation on daily activities (this is measured by a standard scale called ECOG, scored 0 or 1) You are willing and able to sign a consent form and follow all study requirements Your cancer has been confirmed by a…

You have been diagnosed with non-small cell lung cancer (NSCLC) confirmed by a tissue sample, and your cancer can be measured on scans (some groups in the trial do not require measurable disease — confirm with trial site) Your cancer is at an advanced stage that cannot be removed by surgery (Stage III or Stage IV)…

Your cancer must be measurable on a CT scan and/or MRI scan using specific medical measurement standards. You may be eligible if you have skin melanoma (cutaneous melanoma) that cannot be surgically removed or has spread to other parts of the body, and your cancer has continued to grow despite previous treatments with…

People who have given written, dated, and signed consent before any study procedures begin. People with a confirmed diagnosis of certain advanced or spread cancers that cannot be removed by surgery, depending on which part of the trial they are entering (see below). For kidney cancer (clear cell type): people who have…

A specific biomarker in the tumour must be confirmed as eligible for this trial. Tumour tissue samples collected before any treatment, along with a pathology report, must be available — ideally as a preserved tissue block, or as at least 10–15 prepared slides. A person must have a performance status score of 0 or 1 on…

People who have been diagnosed with a specific type of lung cancer (non-squamous, non-small cell lung cancer) that is at an advanced or late stage (Stage IIIB, IIIC, or Stage IV), confirmed through a laboratory test on a tissue or cell sample. People whose lung cancer has a specific genetic change called the KRAS G12C…

People aged 18 or older (or the legal adult age in their country, whichever is higher) who have given written consent to participate. People who have been diagnosed with advanced or spreading non-small cell lung cancer (NSCLC) that has been confirmed by a laboratory test. Group A: People whose cancer has a specific…

People who have been diagnosed with non-small cell lung cancer (NSCLC) that is at an advanced stage (Stage IIIB, IIIC, or Stage IV) and is not suitable for surgery or radiation therapy aimed at curing the disease. For certain parts of the trial (Part B and Safety Lead-In Part B): People whose lung cancer is mainly a…

Adults aged 18 years or older. People whose general health and ability to carry out daily activities falls within an acceptable range, as measured by a standard oncology scale called ECOG performance status 0–2 (confirm with trial site). People with a confirmed diagnosis of non-small cell lung cancer, proven through…

People aged 18 years or older People with a general health and activity level rated between 0 and 2 on a standard oncology scale (meaning able to carry out at least some daily activities — confirm with trial site) People who have been diagnosed with Stage II, III, or IV non-small cell lung cancer, confirmed through…

You have been diagnosed with a type of lung cancer called non-small cell lung cancer (NSCLC), confirmed by a lab test on a tissue or cell sample. Your doctor has determined that certain targeted treatments (aimed at specific gene changes called EGFR, ALK, or ROS1) are not the right first treatment for you. A lab test…

People aged 18 or older who are willing and able to sign a consent form before any study procedures begin People with skin (cutaneous) melanoma — including acral (affecting palms or soles) or non-acral types — that has been confirmed by laboratory testing, and whose disease has continued to grow or spread after at…

Adults aged 18 or older who are able to give informed consent People whose general health and blood test results meet the required standards set by the trial People who have a stored tumour tissue sample available, or who are able to have a fresh tumour biopsy taken; people for whom a fresh biopsy is not safely…

People who have been diagnosed with a solid tumour cancer, confirmed through a tissue or cell sample. People who are 18 years of age or older. People who have at least one tumour measuring 1 cm or more visible on a recent PET/CT scan (a type of imaging scan). A small number of participants may be enrolled even if…

You have been diagnosed with a type of lung cancer called non-small cell lung cancer (NSCLC) that has either spread to other parts of the body or cannot be surgically removed, and lab tests have confirmed your cancer has a specific gene change called KRAS G12C. Your cancer can be measured on scans using a standard…

You have been diagnosed with non-small cell lung cancer (a specific type of lung cancer), confirmed by a lab test on a tissue or cell sample. Your lung cancer is either advanced (Stage IIIB or IIIC) and cannot be treated with surgery or chemotherapy/radiation to try to cure it, or it has spread to other parts of the…

People who have been diagnosed with a specific type of lung cancer called non-squamous non-small cell lung cancer (NSCLC), confirmed by a laboratory test on a tissue or cell sample. People whose lung cancer is at an advanced stage (Stage IIIB, IIIC, or Stage IV) and cannot be treated with surgery or a combination of…

People who are 18 years of age or older (or above the legal age of consent in their country) at the time of signing the consent form. People with a confirmed diagnosis of advanced or metastatic non-squamous non-small cell lung cancer (a specific type of lung cancer) that has either spread to other parts of the body or…

People who have one of the following solid tumour cancers, depending on the group (cohort) they would be placed in: urothelial carcinoma, triple negative breast cancer, non-small cell lung cancer, esophageal cancer, pancreatic cancer, ovarian cancer, cervical cancer, head and neck squamous cell carcinoma, or prostate…

People who are able to understand the study and are willing to sign a written consent form People who have been confirmed by lab testing to have advanced or metastatic non-small cell lung cancer, gastroesophageal cancer, colorectal cancer, liver cancer (HCC), pancreatic cancer, or head and neck cancer that cannot be…

People who are able to understand and sign a written consent form agreeing to take part in the trial and all its procedures People aged 18 or older (for the first part of the trial, participants must be between 18 and 75 years old) People whose general physical health and ability to carry out daily activities is rated…

People who previously took part in the MNPR-101-D001 study. Women who could become pregnant must have a negative pregnancy blood test at the screening visit, and a negative pregnancy urine test on the first day of treatment if screening took place more than 7 days earlier. Both men and women must agree to use highly…

People who have been diagnosed with non-small cell lung cancer (a specific type of lung cancer) that has been confirmed by lab testing, has not been treated before, can be surgically removed, and is classified as Stage II, IIIA, or IIIB (N2) using standard cancer staging guidelines. People whose cancer did not…

People diagnosed with one of the following advanced cancers: HER2-positive breast cancer (locally advanced, unable to be surgically removed, or spread to other parts of the body), hormone receptor-positive/HER2-negative breast cancer (advanced), colorectal cancer with a KRAS gene mutation (advanced), or non-small cell…

People who have been diagnosed with squamous non-small cell lung cancer (a specific type of lung cancer), confirmed by a laboratory test on a tissue or cell sample. People whose lung cancer has spread to other parts of the body (Stage IV) and cannot be treated with the aim of a cure. People whose cancer testing has…

You are 18 years of age or older (or considered a legal adult) You have been formally diagnosed with advanced or spreading non-small cell lung cancer (NSCLC) that has specific gene mutations called EGFR or HER2 mutations in certain parts of the gene You have already received standard treatments for your condition You…

People who have been diagnosed with advanced non-small cell lung cancer (a specific type of lung cancer) at Stage IIIB, IIIC, or Stage IV, confirmed by a tissue or cell sample, and who have not yet received any systemic (whole-body) treatment for it — and whose cancer cannot be cured by surgery or radiation. People…

You have been diagnosed with extensive-stage small cell lung cancer (ES-SCLC), confirmed by a lab test on a tissue or cell sample. You have not had any previous systemic (whole-body) treatment for ES-SCLC — though if you were previously treated for an earlier, limited stage of SCLC, you may still be eligible if that…

People who have been diagnosed with lung cancer and are scheduled to have lung removal surgery People who can understand and speak English well enough to follow instructions and complete the assessments involved in the trial People who are 18 years of age or older at the time of the initial screening People who are…

People who have been diagnosed with non-small cell lung cancer (NSCLC) confirmed by a laboratory test, with a specific genetic change in their tumor called a homozygous MTAP deletion, and who are willing to provide a tumor tissue sample at the start of the trial for confirmation of this genetic change. People whose…

You have been diagnosed with non-small cell lung cancer (NSCLC) confirmed by a lab test, of any type. Your lung cancer has spread to other parts of the body (Stage IV) and cannot be cured with current treatments. Your cancer does not have certain specific gene changes (called EGFR mutations, ALK rearrangements, or…

People who have been diagnosed with a specific type of lung cancer (non-squamous non-small cell lung cancer) that has been confirmed by a tissue or cell sample, and whose cancer has a particular genetic change called a KRAS G12C mutation (found in a tumour sample or a blood test). People whose lung cancer has spread…

You are at least 18 years old and have agreed to take part by signing a consent form. You are generally able to carry out daily activities with little to no limitation from your illness (confirm with trial site for exact details). You have been diagnosed with a type of lung cancer called non-small cell lung cancer…

People who are able to give written, documented consent to participate. People aged 18 or older. People who have been diagnosed with non-small cell lung cancer (NSCLC) that has spread locally or to other parts of the body, and where curative treatment is not an option. People who have a confirmed EGFR gene mutation…

Adults aged 18 or older. People with advanced solid tumour cancers that have been confirmed by laboratory testing of tissue or cell samples, where the cancer has continued to grow despite standard treatment, or where no standard treatment exists. People who are largely able to carry out daily activities with little or…

You are generally healthy and active enough to carry out light activities, even if you cannot do heavy physical work (your doctor will assess this using a standard scale). You are willing to provide a tumor tissue sample — either a recent one or one stored from a previous biopsy — so it can be tested for a specific…

People who have given their written agreement to participate before any trial-related activities begin People aged 18 or older (or the legal adult age in their country, if that is older than 18) People who have been diagnosed with an advanced (extensive-stage) form of small cell lung cancer, confirmed through a tissue…

You have been diagnosed with non-small cell lung cancer (NSCLC) that has spread to other parts of the body (Stage IV or returned after treatment), and you have not yet received any systemic treatment (such as chemotherapy) for this advanced stage. Your lung cancer diagnosis has been confirmed through a tissue biopsy…

You must be an adult (18 years or older, or the minimum legal adult age in your country) at the time you sign the consent form. You must have been diagnosed with extensive-stage small cell lung cancer (a type of lung cancer that has spread beyond one lung), confirmed by a lab test on a tissue or cell sample. You must…

You have been diagnosed with a specific type of lung cancer called non-small cell lung cancer (NSCLC) that is either advanced and cannot be surgically removed, or has spread to other parts of the body — and a lab test has confirmed this diagnosis. Your tumor has been tested and shows a certain protein called PD-L1 on…

People who are willing to take part, understand what the study involves, and are able to sign a consent form. People who have been diagnosed with extensive-stage small cell lung cancer (a type of lung cancer that has spread), a cancer type called neuroendocrine carcinoma, or other tumours that test positive for a…

You have been diagnosed with advanced or spreading non-small cell lung cancer (a common type of lung cancer) that cannot be treated with surgery or radiation to cure it, and this has been confirmed through a lab test on a tissue or cell sample. Your lung cancer has been tested (either from a tumor sample or a blood…

People who have been diagnosed with extensive-stage small cell lung cancer (a type of lung cancer that has spread), confirmed through a tissue or cell sample. People who have not yet received chemotherapy, radiation, or combined chemo-radiation treatment for this stage of their lung cancer. People who were previously…

People who have been diagnosed with a specific type of lung cancer called non-small cell lung cancer (NSCLC) of the adenocarcinoma subtype, where the cancer has spread to other parts of the body or cannot be surgically removed or treated with radiation to cure it. People whose cancer has continued to grow or spread…

People who are able to give written consent and understand what the study involves, including its purpose and potential risks Adults aged 18 or older at the time of screening People with a life expectancy of at least 3 months People whose cancer has been confirmed by laboratory testing (tissue or cell sample) and…

You have been diagnosed with a type of lung cancer called non-small cell lung cancer (NSCLC) that cannot be removed by surgery and is at Stage III. You have already received at least 2 rounds of a combined treatment involving chemotherapy and radiation therapy given at the same time, with a total radiation dose of at…

You have been diagnosed with small cell lung cancer that has spread widely in the body (called "extensive-stage"), and this has been confirmed through a tissue test (biopsy). You have not had any previous systemic (whole-body) cancer treatments for this widespread stage of the disease — or, if you were treated at an…

People who have been diagnosed with early-stage (Stage I) non-small cell lung cancer, with a tumour no larger than 4 cm, and at least one higher-risk feature such as a tumour larger than 2 cm, cancer that has grown into the lining around the lung, cancer that has spread into nearby blood or lymph vessels, or a more…

Adults aged 18 or older People with a confirmed diagnosis of certain advanced cancers that have continued to grow or spread after standard treatments, and where no other standard treatment with proven benefit is considered appropriate by the treating doctor People with advanced HER2-positive breast cancer that has…

People who have been diagnosed with stage IV non-small cell lung cancer (a type of lung cancer), or lung cancer that has come back and cannot be removed with surgery. People who have not yet received any systemic (whole-body) treatment, such as chemotherapy, for their advanced or spread lung cancer. People who are…

You must be 18 years old or older (or meet the legal age of consent in your country) at the time of signing the consent form. You must have been diagnosed with a specific type of lung cancer (non-small cell lung cancer, Stage III) that cannot be removed by surgery, confirmed through a tissue or cell sample. You must…

You must be 18 years of age or older (or the legal adult age in your country) at the time of signing the consent form You have been diagnosed with Stage IV non-small cell lung cancer (advanced lung cancer that has spread), confirmed by a tissue or cell sample — this applies to certain groups in the trial You have been…

People diagnosed with a specific type of lung cancer called non-squamous cell non-small cell lung cancer (NSCLC), confirmed by lab testing of tissue or cell samples, that is at an advanced stage (Stage IIIB or IV). A mixed type called adenosquamous is also allowed, but pure squamous cell carcinoma is not. People whose…

You must have tissue samples available that can be used for biomarker testing (biological marker studies).

People who have been diagnosed with certain cancers confirmed by laboratory testing, including non-small cell lung cancer, melanoma, bladder or urinary tract cancer, kidney cancer, triple negative breast cancer, uterine cancer, head and neck cancer (Phase 1), or ovarian cancer, bowel cancer with a specific genetic…

You have been diagnosed with a cancer in or near the chest (such as a lung, breast, or lymphoma cancer), or cancer that has spread to the lungs, and were treated with the goal of curing or fully controlling the disease at Memorial Sloan Kettering (MSK). You completed chest radiation therapy more than 4 weeks ago but…

Your lung cancer tumor has been tested in a certified lab and found to have one of these specific genetic changes: EGFR exon 18 G719X, exon 20 S768I, or exon 21 L861Q (having more than one mutation is allowed, as long as one of these is included). You have been diagnosed with Stage 4 non-small cell lung cancer…

People aged between 45 and 75 years old.

You must already be a participant in both the screening/monitoring program and the treatment program at the World Trade Center (WTC) Health Program at Mount Sinai Medical Center in New York (confirm with trial site)

People who are scheduled to have surgery to remove a lobe or a specific section of the lung to treat a cancerous lung tumour. People who are 18 years of age or older.

Adults aged 18 or older, of any gender. People who have been diagnosed with a specific type of lung cancer called non-small cell lung cancer (NSCLC), confirmed by laboratory testing of tissue, that is mainly of a non-squamous type. People who had a brain scan done before their lung surgery, as part of standard care.…

People who have had planned (non-emergency) lung surgery — specifically a wedge resection, segmentectomy, lobectomy, or bilobectomy — for a suspected type of lung cancer called non-small cell lung cancer. People who have read, understood, and signed the consent form, had the chance to ask questions, and agreed to have…

People aged between 18 and 75 years old, of any gender. People with a good general health and activity level, as measured by a standard performance score (ECOG score of 0–1) (confirm with trial site). People whose lung lesion is suspected to be early-stage non-small cell lung cancer (Stage I, based on a standard…

People aged 20 years or older. People who have been diagnosed with a specific type of lung cancer (non-squamous non-small cell lung cancer, or NSCLC) that has been confirmed by a laboratory test on a tissue sample, and whose cancer is either locally advanced and cannot be removed by surgery or treated with the aim of…

People who are able to understand and are willing to sign a written consent form. People who are aged 18 years or older. People who have been confirmed by laboratory testing to have locally advanced or metastatic non-small cell lung cancer (a type of lung cancer that has spread or cannot be removed, at stage IIIB to…

(AIM II – Screening Data): People aged 50 to 80 years old. (AIM II – Screening Data): People who currently smoke or who quit smoking within the last 15 years. (AIM II – Screening Data): People who have smoked at least 20 pack-years (roughly one pack per day for 20 years, or an equivalent amount over more or fewer…

People who are 18 years of age or older People who have been diagnosed with breast cancer and are planned to receive a specific treatment regimen called Keynote 522, or people who have been diagnosed with non-small-cell lung cancer and are planned to receive a pre-surgery treatment that includes a medicine called…

People who have been newly diagnosed with advanced or metastatic small-cell lung cancer (either stage III that cannot be treated with curative radiation and chemotherapy combined, or stage IV). People who have a tumor tissue sample available — either a recent biopsy taken during routine care or a stored sample taken…

People aged 18 years or older People who have a lung nodule (a small spot on the lung) that has been found or is suspected on a scan or imaging test People who are having surgery to remove part of their lung, whether through open surgery, keyhole (endoscopic), or robotic-assisted surgery People whose doctor has…

You must be 21 years of age or older You must be able to speak English You must be a registered attendee of the advanced 7-day meditation retreat You must be willing to wear a Garmin wearable device for the entire duration of the retreat You must agree to and sign the research consent form to take part in the study…

People diagnosed with Stage I, II, or III non-small cell lung cancer (a common type of lung cancer), confirmed through laboratory testing of tissue or cell samples, based on a specific international staging system (the 8th edition AJCC system). People who have had surgery to remove their lung cancer with the goal of…

A diagnosis of lung adenocarcinoma (a specific type of lung cancer) confirmed through laboratory tissue testing. No other type of cancer or tumour is present alongside the lung adenocarcinoma. A specific genetic change in the EGFR gene has been identified — either a deletion in a region called Exon 19, or a mutation…

People who are willing to give informed consent and agree to follow the requirements set out in the trial protocol. People aged 18 to 75 years old at the time of signing the consent form. People who have a confirmed diagnosis (through cell or tissue testing) of locally advanced, inoperable, or metastatic small cell…

People who are 18 years of age or older. People who have provided written consent to participate. People who have a nodule smaller than 30mm shown on a CT scan. People who do not have any medical reason that would prevent them from safely having a bronchoscopy (a procedure where a thin tube is passed into the airways…

Adults aged 18 or older, of any gender. People who have been confirmed through laboratory testing (biopsy or cell sample) to have locally advanced or metastatic non-small cell lung cancer (NSCLC), including those with cancer that has come back after surgery, or those newly diagnosed with Stage IIIb, IIIc, or IV NSCLC.…

People aged 18 to 75 years, of any gender. People who have been diagnosed with limited-stage small cell lung cancer (a type of lung cancer that has not spread widely), confirmed by a tissue sample, and who have not yet received any systemic cancer treatment. People whose cancer is classified as stage I, II, or III…

People who have been diagnosed with extensive-stage small cell lung cancer (ES-SCLC), confirmed by laboratory testing of tissue from the original tumour or a secondary site. People who have measurable areas of cancer and no more than 3 visible spots of cancer in the liver. People who have fluid around the lungs, but…

People who are 18 years of age or older. People who have been diagnosed with a cancer-related condition. People whose lung cancer (a specific type called non-small cell lung cancer) has spread or is advanced, tests positive for a gene change called ALK, and who have already been treated with one of the newer…

People who have been diagnosed with advanced non-small cell lung cancer that carries a specific genetic change called ALK-positive, confirmed through tissue or cell testing. People who have a general health status rated as fairly active to fully active (able to carry out daily activities with little to no limitation)…

The person must have given written consent before any trial-related steps are taken. The person must be between 60 and 80 years old. The person must have a confirmed diagnosis of non-small cell lung cancer (NSCLC) that is either locally advanced (stage IIIB–IIIC) or has spread to other parts of the body (stage IV)…

People who are older than 18 years of age. People of any gender. People who are able to read and sign a written consent form agreeing to take part. People who have been diagnosed with advanced non-small cell lung cancer (a type of lung cancer), specifically stage IV, based on an internationally recognised staging…

Adults between 18 and 85 years old. People who are scheduled to have a type of keyhole lung surgery (called thoracoscopic segment or lobe removal). People whose overall health before surgery falls within a standard risk rating of 1 to 3, as assessed by an anaesthesiologist using a common medical grading tool (the ASA…

People who have been diagnosed with non-small cell lung cancer (a specific type of lung cancer), confirmed by laboratory testing of tissue, and who have at least one of the following known gene changes before starting systemic treatment: EGFR exon 18-21, MET exon-14-skipping, ERBB2, ALK fusion, ROS1 fusion, RET…

People aged between 18 and 65 years old People with a body mass index (a measure of body weight relative to height) between 18 and 30 People rated as ASA Class I, II, or III (a standard medical scale used to assess overall health before surgery — confirm with trial site if unsure which category applies) People who are…

The person joining the trial, or their legal guardian, must be willing and able to provide written consent to participate. Participants must be 18 years of age or older (there is no upper age limit); both men and women are eligible. Participants must have a laboratory-confirmed diagnosis of non-small-cell lung cancer…

People who have survived non-small cell lung cancer and have finished their main course of treatment within the last 2 years. People who have received a sign-off from a healthcare provider confirming they are safe to do physical activity, have access to Wi-Fi at home, are able to give their agreement to take part in…

Adults between 50 and 80 years of age People who currently smoke or have smoked in the past People who have not had a low-dose CT (a type of chest scan) recorded in the last year People who have not previously been diagnosed with lung cancer People who are current patients at Ryan Health People who have a mailing…

People with advanced or metastatic solid tumours that cannot be cured, where standard treatments have stopped working, are not tolerated, or where a doctor has determined the person is not suitable for standard treatment (or the person has chosen not to have it). Eligible cancer types include relapsed or…

People with a type of lung cancer called non-small cell lung cancer (NSCLC) that can be removed with surgery People whose cancer has been assessed as being at an early stage (stage I or II) People whose pre-surgery scans and tests showed no signs of cancer spread to the lymph nodes

Participants must be a board-certified pathologist with specialist expertise in neuropathology, pulmonary pathology, urologic pathology, or general anatomical pathology. Participants must have at least 3 years of experience in clinical diagnosis. Participants must be currently working in a role that involves reviewing…

A laboratory test (biopsy) has confirmed a diagnosis of non-small cell lung cancer (a common type of lung cancer). After receiving pre-surgery treatment involving immunotherapy (with or without chemotherapy), the cancer has shrunk enough to meet the requirements for surgery to remove it. The cancer originally required…

People who were 18 years of age or older at the time of surgery to remove a brain metastasis (a cancer spread to the brain), and whose cancer has been confirmed by laboratory testing to be non-small cell lung cancer (NSCLC), with surgery on the brain metastasis serving as the starting point for the study. People for…

People who have been diagnosed with extensive-stage small cell lung cancer according to both Western medical standards and traditional Chinese medicine criteria (specifically a pattern described as kidney deficiency with qi deficiency and blood stasis) People who have been newly diagnosed with extensive-stage small…

People who are 18 years of age or older. People who have been diagnosed with a specific stage of non-small cell lung cancer (a common type of lung cancer), ranging from early to locally advanced stages, and for whom a planned surgery aims to remove the affected part of the lung (such as a segment, lobe, or the entire…

People who are 18 years of age or older. People with a body weight that falls within a moderate range (not underweight and not obese, based on a standard height-to-weight measurement). People who have given their formal written agreement to take part in the trial.

Adults between the ages of 50 and 77 People who currently smoke or have quit smoking within the last 15 years, and have smoked at least 20 pack-years in total (this is a measure of smoking history — confirm with trial site if unsure how this applies) People who own a smartphone that can send and receive text messages…

People aged between 50 and 80 years old. People who currently smoke, or who stopped smoking at some point within the last 15 years. People who speak English.

People who are male or female and at least 18 years old. People who agree to undergo several specific procedures, including a tissue sample of the affected area, a SPECT/CT scan, a baseline DCCT scan, a whole-body bone scan, and a follow-up DCCT scan if needed. People who have had a non-surgical biopsy or bronchoscope…

The person must be 18 years of age or older. A doctor has recommended ablation (a non-surgical procedure to destroy abnormal tissue) or an alternative to surgery for the person's condition. The person has either a non-small cell lung cancer tumour measuring 2cm or smaller (at an early, localised stage), or one or more…

People aged 18 or older. The nodule(s) are rated category 4A or higher on a standard lung nodule assessment scale called Lung-RADS version 1.1 (confirm with trial site). A risk calculation tool called the Brock model estimates a 5% or greater chance that the nodule(s) could be lung cancer (confirm with trial site).

People who have been diagnosed with non-small cell lung cancer (NSCLC) confirmed by a tissue sample (biopsy). People whose cancer tests show a PD-L1 score of 50% or higher (a marker measured on cancer cells that affects how certain treatments work). People with locally advanced NSCLC that cannot be removed by surgery…

A confirmed diagnosis of non-small cell lung cancer has been obtained through a biopsy of the main tumour. The tumour directly invades the chest wall at or above the level of the first rib (at least reaching the outer lining of the lung), or it directly invades the large blood vessels (subclavian artery or vein) near…

People diagnosed with early-stage non-small cell lung cancer (stages IIB to IIIB with N2 involvement) that has been confirmed through a tissue sample and is considered operable (suitable for surgery). People whose tumor has tested negative for certain specific gene mutations or fusions (EGFR, ALK, and ROS1) in the…

People who have had surgery to remove non-small cell lung cancer (NSCLC) at Stage IIA to IIIA, where the cancer was fully removed with clear margins, and who are within 10 weeks after that operation. People whose cancer has tested positive for a specific gene change called ALK-positive, confirmed by an approved…

People aged 18 or older. People who have an advanced solid tumour cancer with a specific genetic change called a BRAF V600 mutation, and whose cancer is melanoma, colorectal cancer, non-small cell lung cancer, or thyroid cancer. People whose cancer has not responded to standard treatments, for whom no proven treatment…

A diagnosis of small cell lung cancer confirmed by tissue or cell testing. Having fewer than 5 areas in the body where the cancer has spread (called "limited spread"). Having stage IV disease, or a large tumour or lymph nodes that cannot be included in a single radiation treatment plan due to their size or spread…

People who have given their signed informed consent to participate. People aged 18 to 70 years old. People who have been confirmed through tissue or cell testing to have small cell lung cancer (SCLC) that is at a limited stage and have not yet received any treatment for it. People with clinical stage IIB–III disease…

People who have chosen to take part voluntarily and have signed a consent form agreeing to join the study. People aged 18 to 75 years old, of any gender. People who have been diagnosed with advanced non-small cell lung cancer (a type of lung cancer), confirmed through a tissue or cell sample, or whose lung cancer has…

People who are able to give their own independent consent to participate. People whose bone marrow is working well enough, shown by blood counts meeting minimum levels for platelets, red blood cells (haemoglobin), and white blood cells (neutrophils). People whose kidneys are functioning well enough, based on a…

People who have been diagnosed with non-small cell lung cancer (a type of lung cancer), confirmed through a tissue or cell sample. People whose lung cancer is at stage III or stage IV (meaning it is advanced or has spread). People who are 18 years of age or older. People who have a general health and activity level…

Adults aged 18 or older, of any gender. People who have been diagnosed with lung cancer confirmed through laboratory testing of a tissue or cell sample. People who have had a specific type of advanced genetic testing (called next-generation sequencing) done on their tumour sample at an approved laboratory. People who…

Adults aged 18 years or older (male or female). People diagnosed with a specific type of lung cancer called non-squamous non-small cell lung cancer (NSCLC) that is locally advanced and not suitable for definitive treatment, has come back, or has spread to other parts of the body (Stage IV), confirmed by laboratory…

A laboratory test (using tissue or fluid samples) has confirmed a diagnosis of non-small cell lung cancer. Age is between 18 and 75 years old. The person is willing to take part in the study and sign a consent form agreeing to participate. The cancer has not yet been treated. The cancer does not have certain gene…

The person joining (or their legal representative) must be able to understand the study and be willing to sign a written consent form. Adults aged 18 years or older of any sex. People who are largely able to carry out daily activities with little or no restriction (confirm with trial site for exact fitness level…

The person must be willing and able to sign the consent form agreeing to take part in the trial. The person must be 18 years of age or older. The person must have a confirmed diagnosis of non-small cell lung cancer (a type of lung cancer), based on a tissue or cell sample taken by needle, and the cancer must be at a…

People who have voluntarily agreed to take part and have signed a written informed consent form. People aged 18 years or older at the time of signing the consent form. People whose general health and ability to carry out daily activities is rated as fully active or restricted only in physically strenuous activity (an…

Adults between 18 and 75 years of age. People with a laboratory-confirmed diagnosis of advanced or spreading non-small cell lung cancer (NSCLC) that cannot be treated with surgery or radiation, and whose cancer has a specific genetic change called an EGFR exon 19 deletion or exon 21 L858R mutation (alone or alongside…

People diagnosed with a type of lung cancer called lung adenocarcinoma that can be removed with surgery, at a stage between IIA and IIIA. People whose lung cancer has a specific genetic change known as an EGFR sensitizing mutation (either Ex19del or L858R). People whose treatment plan includes a drug called…

People who are enrolled one after another, without selection (consecutive patients). People with lung cancer who were treated with surgery alone, without any other cancer treatments.

Adults aged 18 or older who have been diagnosed with a specific type of advanced lung cancer (non-squamous non-small cell lung cancer that has spread to other parts of the body), confirmed by tissue testing. People whose cancer got worse while being treated with a combination of immunotherapy (anti-PD-1/PD-L1…

The person joining (or their legal representative, if applicable) must be willing and able to give written consent to take part in the trial. The person must have measurable disease according to a standard measurement system called RECIST 1.1, including lesions in previously treated areas if those lesions have shown…

People who are willing to sign a consent form and complete the study as planned. People aged between 18 and 80 years old. People who have a good level of physical fitness and are able to carry out normal daily activities with little or no limitation (confirmed by a score of 0 or 1 on a standard fitness scale used by…

People who are willing and able to sign a consent form agreeing to take part in the study. People who are 18 years of age or older. People who have been diagnosed with non-small cell lung cancer (a type of lung cancer) confirmed by a tissue or cell sample from a needle biopsy, and whose cancer is at stage II to IIIB…

Adults aged 18 or older. People with a type of lung cancer called EGFR-mutated non-small cell lung cancer (NSCLC) that has either spread locally (stage IIIB) or spread to other parts of the body (stage IV). People who have previously been confirmed to have a specific gene change (EGFR Ex19del, L858R, or T790M…

Adults aged 18 years or older, both male and female. People who have been diagnosed with non-small cell lung cancer (a specific type of lung cancer) confirmed by imaging scans and tissue testing, following recognised 2022 diagnostic guidelines. People whose lung cancer is at an advanced stage (classified as Stage III…

Adults aged 18 or older, of any sex People diagnosed with a specific type of advanced lung cancer (non-squamous non-small cell lung cancer, stage IV) confirmed by a lab test of tissue or cells People who have not yet received any cancer treatments such as targeted therapy, chemotherapy, or immunotherapy — those who…

People who are able to give informed consent and agree to follow the rules and requirements of the trial. People who have been diagnosed with a type of lung cancer called non-squamous non-small cell lung cancer (NSCLC) that has spread locally or to other parts of the body. People whose lung cancer has a specific gene…

People aged 18 or older, of any gender. People who have been diagnosed with locally advanced or metastatic non-small cell lung cancer (a type of lung cancer) that has been confirmed by laboratory testing and is not suitable for surgery or radiation therapy to cure it. People whose lung cancer has a specific change in…

People who are able to give written consent that is signed and dated. Adults aged 18 to 75 years. People whose general health and ability to carry out daily activities meets a specific performance standard (ECOG score of 0 or 1 — confirm with trial site). People with a predicted life expectancy of at least 12 weeks.…

People who are scheduled to have part of a lung removed (a segment or a lobe) using keyhole-style surgery for non-small cell lung cancer or a suspected cancerous growth. People aged 18 or older. People who are able to follow the requirements of the trial and who, or their legal guardian, have given written agreement…

People who have given signed and dated written consent before any study procedures begin (declining the optional research or genetic parts of the study will not affect participation in the rest of the trial). People who are at least 18 years old. People who have a confirmed diagnosis (through tissue or cell testing)…

People who have given written consent before the study begins. People aged 18 to 75 years, regardless of sex. People whose non-small cell lung cancer (a type of lung cancer) has been confirmed through a tissue sample test. People who have at least one tumour that can be measured on a scan, according to standard…

People aged between 18 and 75 years old. People who have been diagnosed with extensive-stage small cell lung cancer (a type of lung cancer that has spread), confirmed by a tissue sample test. People who are willing and able to sign a written consent form before any study-related procedures begin. People who have not…

Patients who have signed the informed consent form agreeing to take part in the study. Adults aged 18 years or older. People who have been diagnosed with non-small cell lung cancer (a type of lung cancer) confirmed by a tissue or cell sample, assessed as stage III or stage IVA, and found to have a specific gene change…

People who are willing to take part voluntarily and sign a consent form agreeing to join the study. People diagnosed with a type of lung cancer called non-small cell lung cancer (NSCLC) that can be removed by surgery, at a specific stage (stage II to IIIB), with certain limitations on how far it has spread. People…

Adults aged 18 or older. People who are generally active and able to care for themselves, with little or no limitation on daily activities (as measured by a standard medical scoring system called ECOG, with a score of 0 or 1). Non-small cell lung cancer (NSCLC) that cannot be removed by surgery and is at an advanced…

Adults aged 18 or older (male or female). People with a good general level of physical functioning, as measured by a standard medical scale (ECOG score of 0 or 1). People with non-small cell lung cancer that can be surgically removed and that has specific gene mutations known as "driver mutations." People who have at…

Adults aged 18 to 80 years old, either male or female. People who have been diagnosed with extensive stage small cell lung cancer, confirmed by a laboratory test on a tissue sample. People who have never received any systemic treatment for extensive stage small cell lung cancer. People who have at least one measurable…

Adults aged 18 to 80 years old. People diagnosed with a specific type of lung cancer (non-small cell lung cancer, or NSCLC) that is mainly of the adenocarcinoma type, and that has spread to the brain with at least one measurable lesion there. People whose tumor tissue or blood sample has tested positive for a gene…

People who have been diagnosed with non-small cell lung cancer (a type of lung cancer) at stage I, II, or III, confirmed by laboratory testing of tissue. People who received radiation therapy as their main treatment (such as standard radiation, intensity-modulated radiation, arc therapy, or stereotactic body…

You are willing to take part, understand what the study involves, and can sign a consent form agreeing to participate. You are between 18 and 75 years old (inclusive), and there are no restrictions based on gender. You have been diagnosed with advanced or spreading non-squamous non-small cell lung cancer (a specific…

You must be 18 years old or older and willing to sign a consent form agreeing to take part. You should be generally well enough to carry out light activity or daily tasks (not severely limited by illness). You must have been diagnosed with advanced lung cancer (stage IIIB or IV, non-small cell type) that has continued…

People who are willing to take part voluntarily, have signed a consent form, and are able to follow the study requirements. People who have been confirmed through a tissue or cell sample to have limited-stage small-cell lung cancer (a specific early stage where the cancer has not spread widely, classified as T1-3…

People aged between 18 and 75 years old. People who have a confirmed diagnosis of non-small cell lung cancer (NSCLC) that is either locally advanced (a specific stage where the cancer has spread nearby but not widely) or has spread to other parts of the body (Stage IV), and where curative treatment is not suitable —…

People who have been diagnosed through tissue testing with locally advanced or spreading lung cancer (stage IIIB–IV) that shows certain abnormal neuroendocrine features — specifically, at least one positive marker (CD56, CgA, or Syn) on a special staining test, but without the typical neuroendocrine tumour appearance…

People who are older than 40 years and younger than 75 years, of any gender. People who are willing and able to sign a consent form agreeing to take part in the trial.

People aged 18 or older. People with non-small cell lung cancer whose cancer has spread to the lungs after previously receiving a type of cancer treatment called PD-1 immunotherapy. People who are willing to take part in the study and sign a consent form agreeing to participate. People who have lung metastases (areas…

People aged between 18 and 79 years. People with locally advanced (stage IIIB) or metastatic (stage IV) non-small cell lung cancer (NSCLC) that has a specific gene change called an EGFR mutation. People whose cancer has one of two specific EGFR mutations: an Exon 19 deletion or a change called L858R. People who have…

People aged 18 to 75 years old. People who have been diagnosed with a specific type of lung cancer (non-squamous non-small cell lung cancer, or NSCLC) that is locally advanced, has spread to other parts of the body, or has come back, at a stage confirmed by laboratory testing of tissue or cell samples, where surgery…

Adults aged 18 or older (male or female) People who have been diagnosed with non-small cell lung cancer (a type of lung cancer), confirmed through a tissue or cell sample People who have at least one measurable cancer lesion in the brain, as assessed using a specific measurement standard called RANO-BM People whose…

People who understand what the trial involves and are willing to sign a dated consent form. People aged 18 years or older. People who have been diagnosed with small cell lung cancer confirmed by tissue testing. People who have cancer that has spread to the membranes surrounding the brain or spinal cord (leptomeningeal…

Adults aged over 50 years old who have been diagnosed with non-small cell lung cancer (NSCLC), which is a common type of lung cancer.

People who fully understand the study, are willing to sign a consent form, and are able to complete all parts of the trial. People who are 18 years of age or older; both men and women are eligible. People who have been diagnosed (through tissue or cell testing) with a type of lung cancer called non-squamous non-small…

People with a type of lung cancer called non-small cell lung cancer (NSCLC) who have had testing done to look for a specific gene change called an EGFR mutation. People who are 18 years of age or older.

People who are able to understand and voluntarily sign a written consent form. People aged 18 years or older, of any gender. People diagnosed with non-small cell lung cancer that cannot be surgically removed and has either spread to nearby areas or to other parts of the body (stage IIIB, IIIC, or IV), confirmed by…

People who have signed the informed consent form agreeing to take part. Men or women aged 18 or older. People diagnosed with limited-stage small cell lung cancer (a specific type and stage of lung cancer) who have been assessed as unsuitable for surgery, or who have chosen not to have surgery. People with a good…

People aged 18 years or older. People who have been diagnosed with non-small cell lung cancer (NSCLC) confirmed by laboratory tissue testing, classified as stage IB to IIIB according to standard cancer staging guidelines. People who had surgery to remove their lung cancer, then received a targeted therapy drug (an…

People who are willing to voluntarily sign a consent form and agree to take part in the study. People who have been confirmed through tissue or cell testing to have extensive-stage small cell lung cancer (a type of lung cancer that has spread beyond one lung). People who are 18 years of age or older. People who the…

Adults aged 18 or older, of any sex. People who have been diagnosed with extensive-stage small cell lung cancer (a specific type and stage of lung cancer), confirmed through laboratory testing of tissue or cell samples. People who have not yet received any systemic (whole-body) treatment for this type and stage of…

People who are scheduled for a planned (non-emergency) lung biopsy because of a known or suspected cancer in the lung. People who are over the age of 21. People who are able to understand and agree to take part in the trial by giving their consent. Women who could potentially become pregnant and are sexually active…

People who are willing to take part voluntarily, have signed a consent form, and are able to attend follow-up visits as required. People aged between 18 and 75 years old (inclusive). People with a performance status score of 0–2 on the ECOG scale, which is a measure of how much a health condition affects daily…

You have been diagnosed with lung cancer and your doctor has determined that a freezing treatment (cryoablation) would be appropriate for you. You are willing to take part in the study and are able to sign a consent form agreeing to participate. You are unable to have surgery to remove the lung cancer because surgery…

People who are willing to sign and date a consent form before any study-related screening procedures begin. People who are 18 to 70 years old (male or female). People whose small cell lung cancer (a type of lung cancer) has been confirmed through a tissue or cell sample test. People who have received only one previous…

Adults aged between 18 and 75 years, with a good general activity level and an expected survival of more than 3 months. People who have been diagnosed with locally advanced or metastatic non-small cell lung cancer (a type of lung cancer that has spread or cannot be removed by surgery), confirmed by a tissue or cell…

Adults aged 18 or older who have signed a consent form before any trial-related procedures begin. People with a confirmed diagnosis (through tissue or cell testing) of non-small cell lung cancer (NSCLC) that cannot be surgically removed and has either spread locally or to other parts of the body. People whose NSCLC…

People with lung cancer who are receiving treatment at Shanghai Pulmonary Hospital. People with a general health and activity level rated as reasonably functional (ECOG performance status of 0–2, meaning able to carry out at least some daily activities — confirm with trial site). People without other serious medical…

People who are over 20 years of age. People who have been diagnosed with lung cancer of any stage or type as their primary condition. People who have been referred for surgery to remove lung cancer, either through open chest surgery or a keyhole camera-assisted procedure. People who are able to understand and agree to…

People who are 18 years of age or older. People having a specific type of lung surgery (called fissureless lobectomy) to treat lung cancer.

People who are having surgery for lung cancer, emphysema, interstitial lung diseases, or other breathing-related conditions. People who are receiving a lung transplant (where the removed lungs are used for the study). People who are 18 years of age or older. People who are able and willing to give their formal…

People who understand what the trial involves and are willing to sign and date a consent form. People aged 18 to 80 years old. People who have been confirmed through tissue or cell testing to have locally advanced or spreading non-small cell lung cancer (a type of lung cancer), with no prior systemic treatment, and…

Adults aged 18 to 70 years (male or female). People diagnosed with a type of lung cancer called non-small cell lung cancer (NSCLC) at stage II to IIIB(N2), confirmed by scans and tissue testing, where surgery is considered a possible treatment option. People who have at least one tumour that can be measured on a scan…

Adults between 18 and 75 years old. People who have been newly diagnosed with a type of lung cancer called non-small cell lung cancer (stages IIA to IIIB), confirmed by a tissue sample, and whose cancer does not have certain specific genetic changes known as "driver gene" mutations. People whose scans show at least…

People who are 18 years of age or older at the time they sign the consent form, of any sex, and willing to follow the study procedures. People with a performance status score of 0 or 1 on the ECOG scale, meaning they are fully active or have only minor limitations in physical activity (confirm with trial site). People…

People who have signed a consent form agreeing to take part in the study People who are over 18 years old at the time of joining the study People whose overall health and ability to carry out daily activities falls within a certain acceptable range, as measured by a standard cancer health scale (confirm with trial…

People who are 18 years of age or older People whose lung tumour is smaller than 3 centimetres in size People who have been diagnosed with Stage 1 Non-Small Cell Lung Cancer (an early-stage form of lung cancer) People whose scan results show the tumour is contained within one small section of the lung, meaning a…

People with advanced or metastatic non-small cell lung cancer (a type of lung cancer that has spread) that has a specific genetic change called EGFR-L858R, and whose cancer has not responded to standard treatments, who cannot tolerate standard treatments, have no remaining standard treatment options, or who have…

Patients who have signed the informed consent form, are aged 18 or older, and have a confirmed diagnosis of non-small cell lung cancer (NSCLC) through a tissue or cell sample, assessed by researchers as stage III to IVA. Patients whose genetic testing (NGS) has confirmed a specific MET gene change — either a MET exon…

People who are willing and able to sign a consent form agreeing to take part in the trial. People who are 18 years of age or older. People who have been diagnosed with small cell lung cancer (SCLC) through a tissue or cell sample, and whose cancer is either at an advanced (extensive) stage, has come back after…

Participants must have given written consent to take part in the study. Adults aged 18 to 70 years old, of any gender, may be considered. People who have been diagnosed (through tissue or cell testing) with a specific type of lung cancer called non-squamous non-small cell lung cancer (such as adenocarcinoma) that has…

People who are able to understand the study and are willing to follow its procedures, and who voluntarily sign the consent form before screening begins. People aged 18 to 75 years old (inclusive); any gender is eligible. People who are willing to provide a tumor tissue sample for genetic testing and analysis of unique…

People who have been diagnosed with advanced or metastatic non-small cell lung cancer (NSCLC) that has spread and cannot be treated with a combination of therapies, confirmed through a tissue or cell sample, and whose cancer has tested positive for a gene change called ALK through one of several approved tests. People…

People who have been diagnosed with advanced non-small cell lung cancer (a type of lung cancer) that has been confirmed by laboratory testing and carries a specific genetic marker called ALK-positive, detected through a genetic sequencing test. People who have been diagnosed with cancer that has spread to the brain…

People who are willing and able to sign a written consent form before any trial procedures begin. People aged 18 to 75 years old. People with a good general health status, able to carry out normal activity with little or no restriction (this is measured using a standard scale called ECOG, with a score of 0 or 1).…

People who are willing to take part, understand what the study involves, and are able to sign a written consent form. Men or women between 18 and 70 years of age (inclusive) at the time of signing the consent form. People with a good general health and activity level, rated 0 or 1 on a standard performance scale (ECOG…

Adults aged 18 or older (any gender) People who have been diagnosed with lung adenocarcinoma (a specific type of lung cancer), confirmed through a tissue or cell sample, that has spread to other parts of the body or is at an advanced stage where local treatment is not possible People who are currently receiving…

Adults between 18 and 75 years of age, of any gender. People who are able to communicate and understand information provided by the MITERA staff. People who have been diagnosed with the condition being studied in this trial. People whose condition is at an early stage and who have not yet started any treatment for it.…

People who have given written consent after being fully informed about the trial. People aged 18 years or older. People with a confirmed diagnosis of Extensive Stage Small Cell Lung Cancer (ES-SCLC), which means the cancer has spread beyond one lung. People with a good general health and activity level, able to carry…

People who have been diagnosed with lung cancer confirmed by a tissue sample or biopsy. People who are over 18 years of age. People who are currently receiving immunotherapy treatment for lung cancer. People who are able to communicate clearly by speaking. People who have given written agreement to participate, either…

People who are 18 years of age or older. People who have been diagnosed with non-small cell lung cancer, where the tumour is no larger than 3 cm across and there are no more than 3 tumours. People whose general health and ability to carry out daily activities meets a certain standard (known as an ECOG score of 2 or…

People who are older than 18 years of age. People who have given their documented, signed agreement to take part in the trial. People who have been diagnosed with non-small cell lung cancer (a type of lung cancer), confirmed by a tissue sample taken with a needle, and whose cancer has been classified as stage II or…

This study takes place at VA Medical Centers (VAMCs) across the country, and only VA sites that have agreed to take part are included.

People who fully understand the study and are willing to sign the consent form voluntarily. People aged 18 years or older. People with a specific type of lung cancer (non-small cell lung cancer, or NSCLC) that does not have certain genetic markers (EGFR wild-type, and no ALK or ROS1 gene fusions) — this includes both…

People who are willing to take part voluntarily and provide written consent to join the study. People aged between 18 and 70 years, of any sex. People who have been confirmed through a tissue or cell sample to have advanced or metastatic squamous non-small cell lung cancer (Stage IIIB, IIIC, or IV) without certain…

People who are at least 18 years old. People who have voluntarily signed a consent form before taking part in the study. People whose physical functioning is rated 0 or 1 on a standard cancer performance scale (meaning they are fully active or have only minor limitations), with no worsening in the week before…

People diagnosed with a type of lung cancer called non-small cell lung cancer (which includes subtypes such as adenocarcinoma, squamous cell carcinoma, adenosquamous cell carcinoma, large cell lung cancer, or others), confirmed by laboratory testing of cells or tissue. People with non-small cell lung cancer at any…

People who have been diagnosed with lung cancer that meets the classification standards set out in the TNM staging system (Ninth Edition). People who are willing to take part in the study and follow the research plan. People, or their legally authorised representatives, who are able to provide written consent as…

People who have been diagnosed with lung cancer that meets the classification standards set out in the TNM staging system (Ninth Edition). People who are willing to take part in the study and follow the research plan. People, or their legally authorised representatives, who are able to provide written consent that has…

People who have been diagnosed with lung cancer that meets the classification standards set out in the TNM system (Ninth Edition). People who are willing to take part in the study and follow the research plan. People, or their legal representatives, who are able to provide written consent that has been approved by the…

The person has been diagnosed with primary non-small cell lung cancer (a type of lung cancer), confirmed by laboratory tissue testing. The person is 18 years of age or older; any gender is eligible. The person has had their lung cancer staged according to a specific international staging system (AJCC/UICC 8th…

People aged between 18 and 75 years (any gender). People who have been diagnosed with limited-stage small cell lung cancer, confirmed through a tissue or cell sample test. People who have received no more than 2 cycles of standard chemotherapy before joining, or who have not yet had any cancer treatment. People with a…

People who are willing and able to sign and date a written consent form agreeing to take part in the study. People who are 18 years of age or older. People who have been diagnosed with a specific type of lung cancer (non-squamous non-small cell lung cancer) confirmed through a tissue or cell sample, with a documented…

People diagnosed with extensive stage small cell lung cancer (a type of lung cancer that has spread widely), confirmed by a tissue or cell sample — but not a mixed or combined type of small cell lung cancer. People aged 18 to 75 years old (inclusive) at the time of signing the consent form, either male or female.…

People aged 18 years or older. People who have been diagnosed with advanced lung cancer (either non-small cell or small cell lung cancer) or mesothelioma, where treatment is not aimed at curing the disease. People who rate their shortness of breath at 4 or higher on a scale of 0 to 10, using a standard symptom…

Adults who have been accepted to have lung removal surgery for lung cancer at the Cardiothoracic Department of Unidade Local de Saúde São João People who are not currently taking part in any type of prehabilitation program (a preparation program before surgery)

People aged between 18 and 70 years old People who have been diagnosed with cancer of the digestive system, breast, gynaecological organs, head and neck (ENT), or lungs People who have been receiving a cancer treatment for at least two months People who have given their written consent to take part, freely and with…

Adults aged 18 or older. People who are able to carry out most daily activities (based on a standard activity scale called ECOG, scored 0–2). People who are willing and able to sign a consent form to take part in the study. People who have been diagnosed with metastatic non-small cell lung cancer (a type of lung…

People who have recently been diagnosed with stage III or IV non-small cell lung cancer (NSCLC), confirmed by a tissue sample. People with stage III or IV NSCLC without cancer spread to the brain who have a specific genetic mutation identified through a standard lung cancer genetic test called PULMOL. People who are…

People who have been diagnosed with stage 4 lung cancer. People whose general physical functioning is rated at WHO level 2 or below (a scale used to measure how much a condition limits daily activity). People whose breathlessness is mild or less, rated at grade 2 or below on a standard breathlessness scale called the…

People who are 18 years of age or older. People who have had their cancer confirmed through tissue testing, cell testing, or medical imaging, in line with the specific cancer types this trial is targeting. People who have given written consent before any trial-related procedures begin.

People who are willing to sign a written consent form, are 18 years of age or older, and have a physical fitness level rated between 0 and 2 on a standard oncology scale (meaning they are fully active to capable of limited self-care). People whose doctors expect them to live at least 6 months, and who have been…

People diagnosed with stage IIIB or IIIC non-small cell lung cancer (a specific type and stage of lung cancer), confirmed by laboratory testing of tissue or cell samples using a recognised staging system. People whose cancer has tested negative for certain specific genetic changes (known as EGFR-sensitive mutations or…

People aged 18 or older, of any gender. People who have been diagnosed with peripheral lung cancer, where the largest tumor is no bigger than 3 cm across and there are no more than 3 tumors in total. People whose tumor(s) have been assessed by doctors as suitable for a bronchoscope-guided freezing treatment (a…

People aged 18 or older, of any gender. People who have been diagnosed with peripheral lung cancer (cancer located in the outer areas of the lung), where the largest tumor is no bigger than 3 cm across and there are no more than 3 tumors in total. People whose tumor has been assessed by doctors as suitable for a…

The person must be willing and able to sign a consent form agreeing to take part in the trial. The person must be 18 years of age or older. The person must have a confirmed diagnosis of non-small cell lung cancer (NSCLC) through a tissue or cell sample taken by needle, with the cancer at stage II or III as confirmed…

Adults aged 18 or older, both female and male. People who have been diagnosed with lung cancer, confirmed through a tissue sample or cell sample test.

You have been confirmed by a lab test to have stage IV non-squamous non-small cell lung cancer (a specific type of advanced lung cancer) that cannot be treated with surgery or radiation. Your cancer does not have certain specific genetic changes known as EGFR mutations, or ALK or ROS1 gene rearrangements. You have not…

People who are willing to take part voluntarily, have signed a consent form, and are able to attend follow-up appointments as required People aged between 18 and 75 years old at the time of signing the consent form, of any gender People with a physical fitness score of 0 or 1 on the ECOG scale, which means they are…

People who are 18 years of age or older. People who have given written consent to participate in the study. People who have been confirmed through laboratory testing (tissue or cell samples) to have a specific type of lung cancer called oligometastatic extensive-stage small cell lung cancer, where cancer has spread to…

People diagnosed with non-small cell lung cancer (a specific type of lung cancer) at a mid-to-advanced stage (clinical stage II to IIIB). People whose lung cancer does not have specific gene changes known as EGFR or ALK mutations. People aged 18 years or older. People who are planned to receive immunotherapy treatment…

People who have been diagnosed with a type of lung cancer called lung adenocarcinoma that tests positive for an ALK gene change, and whose cancer is at an advanced stage that cannot be removed by surgery (Stage III). People who have at least one area of cancer that can be measured on scans, according to standard…

People who have been diagnosed with metastatic non-small cell lung cancer (a type of advanced lung cancer) confirmed by a tissue sample, where laboratory testing shows a PDL1 score of 50% or higher. People for whom a treating doctor determines that the standard treatment pembrolizumab (an immune therapy drug) is…

People who are able to understand what the study involves and are willing to sign a consent form voluntarily. People aged 18 to 75 years, of any gender. People with a type of non-small cell lung cancer (NSCLC) that does not have certain gene changes ("driver gene-negative"), whose first-line standard treatment has…

People aged 18 or older, of any gender. People who have been diagnosed with advanced non-small cell lung cancer (a type of lung cancer) that cannot be removed by surgery or has spread to other parts of the body, confirmed by a tissue or cell sample. People whose cancer has gotten worse or who could not tolerate…

People who are willing and able to give informed consent before any study-related procedures take place. People who are at least 18 years old. People who have been diagnosed with non-small cell lung cancer (a type of lung cancer) confirmed by tissue or cell testing within the past 60 days. People who have a good…

People who are willing and able to give their informed consent to take part in the study. Adults aged 18 years or older. People who have been diagnosed with non-small cell lung cancer (a specific type of lung cancer) at an early to advanced stage (Stage I, II, or III), with or without the cancer having spread to…

People of any gender, aged between 35 and 80 years, who have been diagnosed with chronic obstructive pulmonary disease (COPD). A chest CT scan showing a type of lung nodule called a "ground-glass nodule," where the denser (solid) part makes up no more than 25% of the nodule. The lung nodule is smaller than 2cm and is…

People who have been confirmed through laboratory testing to have extensive-stage small cell lung cancer (a specific classification of advanced lung cancer). People who have not previously received any systemic (whole-body) treatment for extensive-stage small cell lung cancer. People who were previously treated for an…

People who are willing and able to sign a consent form and follow the study schedule and procedures. People who are male or female, aged 18 to 75 years old. People with an expected survival time of at least 6 months. People who have been diagnosed through tissue or cell testing with locally advanced (stage IIIB or…

People with a laboratory-confirmed diagnosis of advanced, spreading high-grade neuroendocrine cancer of the lung (small-cell lung cancer) or prostate (neuroendocrine prostate cancer) that has come back or continued to grow after at least one standard chemotherapy treatment. Prostate cancer patients may meet the…

People aged 18 or older People whose general health and ability to carry out daily activities falls within an acceptable range, as measured by a standard oncology scoring system called ECOG (scores 0, 1, or 2 — meaning fully active to capable of limited self-care) People diagnosed with advanced non-small cell lung…

Patients must be willing and able to sign the informed consent form agreeing to take part in the study. Patients must be aged 18 years or older. Patients must have a confirmed diagnosis of non-small cell lung cancer (a type of lung cancer) through a needle biopsy sample, at a stage classified as IB through IIIA…

People who are willing to take part, sign a consent form, follow the study requirements, and attend follow-up appointments People aged 18 or older People who have been confirmed through tissue or cell testing to have extensive-stage small cell lung cancer (a type of lung cancer that has spread beyond one side of the…

People who are 18 years of age or older at the time of joining the trial. People whose general health and ability to carry out daily activities falls within a certain range, as measured by a standard oncology scoring tool called the ECOG scale (scores 0–2, meaning fully active to capable of limited self-care — confirm…

People who are willing to take part voluntarily and agree to sign a consent form, including consent for testing of collected biological samples. People who have been confirmed through tissue or cell testing to have non-small cell lung cancer (NSCLC) and have not yet received any cancer treatment, including medications…

Adults aged 18 or older (men or women) People who have at least one tumour lesion that can be measured using standard imaging methods (as defined by RECIST 1.1 guidelines) People whose general health and ability to carry out daily activities meets a specific standard, rated 0 or 1 on a medical scale (confirm with…

CT scans showing mixed or solid lung spots that have been confirmed by laboratory tissue or cell testing as non-small cell lung cancer (NSCLC), at an early to mid stage (tumour 5 cm or smaller, not spread to nearby lymph nodes or other parts of the body), based on standard cancer staging guidelines. The cancer has a…

People who are able to understand and are willing to sign a written consent form. People who are at least 18 years old. People who have been diagnosed through a tissue or cell sample with locally advanced or metastatic non-small cell lung cancer (a specific type of lung cancer) at an advanced stage (stage IIIB to IV).…

People between 18 and 80 years old who are scheduled to have surgery to remove a lung nodule (a small growth in the lung). People whose lung nodule is smaller than 2 cm and needs to be marked or located before surgery. People whose lung nodule is in the outer third of the lung.

People who are willing to take part voluntarily, sign a consent form, follow the study requirements, and attend follow-up appointments. People aged 18 to 75 years (inclusive) at the time of signing the consent form, of any gender. People whose lung cancer has been confirmed as small cell lung cancer (SCLC) through a…

People who have signed a consent form agreeing to take part in the trial People who are 18 years of age or older at the time of signing consent People whose general health and ability to carry out daily activities is rated at a good to fully active level (a measure doctors use called ECOG score 0 or 1) People who have…

People who have been diagnosed with non-small cell lung cancer, confirmed through a laboratory test of tissue samples People for whom chemotherapy and/or immunotherapy has been recommended as a treatment People who own and are able to use a smartphone that has a step-counting feature People who are willing to carry…

Adults between 18 and 75 years of age. People who have been diagnosed with small cell lung cancer confirmed by a tissue sample (biopsy); combined/mixed types of small cell lung cancer are not allowed. People whose cancer has continued to grow or spread after receiving first-line chemotherapy combined with…

People who are able to give written consent before any trial procedures begin. People aged 18 or older. People who have been diagnosed through a tissue or cell sample with a specific type of advanced or returning lung cancer called squamous non-small cell lung cancer (NSCLC) that has spread (stage IV), cannot be…

People who are at least 18 years old at the time of signing the consent form, regardless of gender. People who have been diagnosed with widespread, recurrent small cell lung cancer (confirmed by tissue or cell sample) that has come back and is getting worse more than 3 months after receiving standard immunotherapy.…

People aged between 18 and 70 years old, of any gender. People with a good general health and activity level, able to carry out normal daily activities with little or no limitation (confirmed by a doctor using a standard performance scale called ECOG PS score 0–1). People who have not received any prior treatment for…

Adults aged 18 to 70 years old, of any gender. People with a good general health and activity level, rated 0 or 1 on a standard medical scale called ECOG (meaning fully active or able to carry out light activity). People who have not previously received any systemic cancer treatment and who agree to undergo surgery…

Group A: Adults over 18 years old who have a lung nodule or lung mass and either: are being monitored with routine CT scans without needing further tests yet, or are not in a standard screening programme but have been advised to have a follow-up CT scan rather than immediate further tests — as recommended by a…

People who are willing to take part voluntarily and are able to give written informed consent after being fully informed about the study. People aged between 18 and 75 years old (inclusive) at the time of screening, of any gender. People who have been diagnosed with stage IIIA non-small cell lung cancer (a specific…

People who have a suspected or confirmed invasive tumour, regardless of where it is in the body or how advanced it is. People who are 18 years of age or older. People who have given their informed, written, and explicit consent to take part. People who are enrolled in the French Social Protection System. If a tumour…

People diagnosed with a certain type of lung cancer (non-small cell lung cancer, or NSCLC) that cannot be surgically removed, has spread locally, or has spread to other parts of the body, and whose cancer has worsened or who could not tolerate previous treatments — with specific prior treatment requirements depending…

Adults aged 18 years or older. People who have been formally diagnosed with extensive-stage small cell lung cancer (a type of lung cancer that has spread). People whose cancer has not gotten worse after completing a standard first-line treatment combination involving platinum-based chemotherapy, etoposide, and an…

People aged 18 or older who are willing to voluntarily take part in the study People who have been confirmed through tissue or cell testing to have a specific early-stage lung cancer (non-small cell lung cancer, stage Ia, with a tumour between 1 cm and 3 cm), diagnosed during a cryoablation procedure — people with a…

People aged 18 to 75 years old, of any gender. People who have been confirmed through a tissue or cell sample test to have extensive-stage small cell lung cancer (a type that has spread beyond one lung area, based on a specific staging system called VALG). People who have not yet received any previous systemic…

Adults aged 18 to 75 years, of any gender. People who have been diagnosed with small cell lung cancer (SCLC) confirmed by laboratory tissue testing. People with SCLC (either limited or extensive stage) that has come back or gotten worse after one or two rounds of standard treatment. People who have at least one area…

People who are 18 years of age or older People who are willing to give their consent to participate in the trial People whose general physical functioning falls within a certain range, meaning they are able to at least care for themselves even if unable to do all normal activities (confirm with trial site) People who…

People who have a history of lung cancer and have finished their initial treatment (such as surgery, radiation, or chemotherapy) at least 8 weeks ago. People aged between 18 and 75 years old. People who have been diagnosed with fatigue related to their cancer. People whose doctors estimate they are likely to survive…

People who have signed a consent form and are willing to follow the study procedures. People aged 18 years or older. People with an estimated life expectancy of at least 3 months. People with a good general level of physical functioning (rated 0 or 1 on a standard scale used by doctors to measure how cancer affects…

Adults aged 18 or older. People who have been formally diagnosed (through tissue or cell testing) with a type of non-small cell lung cancer (NSCLC) that has a specific genetic change called ROS1+, and who also have cancer that has spread to the brain, confirmed before starting the drug lorlatinib. People whose cancer…

People who have been diagnosed with locally advanced (Stage IIIC) or metastatic (Stage IV) non-small cell lung cancer (NSCLC) that cannot be fully removed by surgery or treated with intensive radiation and chemotherapy combined, confirmed by tissue or cell testing. People who have been diagnosed with extensive-stage…

People aged 18 or older (any gender). People who have been diagnosed with metastatic lung cancer confirmed by laboratory tissue testing. People currently receiving a platinum- or gemcitabine-based chemotherapy treatment given in 21-day cycles, with at least 2 more cycles planned. People with a general health/activity…

Adults aged 18 to 75 years or older, of any sex. People who have been diagnosed with small cell lung cancer (SCLC), confirmed through a tissue or cell sample test. People whose cancer is classified as Stage II or Stage III (using the AJCC 8th edition staging system). People who have not previously received…

People who are having lung transplant surgery.

Adults aged 18 years or older. People who have been diagnosed with extensive-stage small cell lung cancer (a type of lung cancer that has spread widely), confirmed by a laboratory analysis of tumor tissue. People whose cancer came back or got worse either during their first round of platinum-based chemotherapy, or…

People aged 18 years or older. People with a performance status score (a measure of general health and ability to carry out daily activities) of 70 or above on the Karnofsky scale (confirm with trial site). People who have been diagnosed with lung cancer confirmed by laboratory testing of tissue. People who are…

People who are 18 years of age or older at the time of signing the consent form. People whose general health and ability to carry out daily activities falls within a specific range on a standard medical scale (a score of 0 or 1 on the ECOG scale, measured within 7 days before treatment starts). People who have been…

People who are willing and able to give their written agreement to take part in the trial. People who are at least 18 years old. People who have locally advanced or metastatic non-small cell lung cancer (a type of lung cancer that has spread or cannot be surgically removed). People whose cancer has continued to grow…

People who are between 18 and 75 years old at the time of joining the trial. People who have been diagnosed with non-small cell lung cancer (a common type of lung cancer) confirmed by laboratory testing of tissue or cell samples, at a stage ranging from stage II to stage IV. People whose tissue slide images meet the…

Cohort A People aged 50 to 80 years old at the time of joining the trial. Half of participants in this group are current smokers or people who quit within the last 15 years, with a smoking history of at least 20 pack-years (a measure of how much someone has smoked over their lifetime). The other half are people who…

People with a confirmed diagnosis of non-small cell lung cancer (a common type of lung cancer), at Stage II to IIIB (with specific lymph node involvement), who have not yet received any treatment for it — and where the tumour is classified as advanced based on its size only, not because it has grown into nearby…

People who have been newly diagnosed with metastatic (stage IV) non-small cell lung cancer (NSCLC) that cannot be treated with surgery or radiotherapy aimed at curing the disease People whose lung cancer has been confirmed through a tissue or cell sample (biopsy or similar test) People whose lung cancer does not have…

People who have signed an informed consent form agreeing to take part in the trial. People aged 18 or older. Imaging shows multiple or merged lymph nodes on the same side of the chest that are too large or have grown into surrounding organs to be fully removed surgically. Lymph nodes on the opposite side of the chest…

People who are able to fully understand and sign a consent form agreeing to the trial's requirements, or who have a legally authorised representative who can sign on their behalf. People who are 18 years of age or older. People who have been diagnosed with stage IV small cell lung cancer that has spread to other parts…

Adults aged 18 or older, of any gender. People who have been diagnosed with non-small cell lung cancer or small cell lung cancer, at any stage (early, locally advanced, or advanced), and regardless of whether they have previously had surgery, radiation, chemotherapy, or other treatments. People who have never received…

People aged 18 years or older. People whose CT scan shows multiple ground-glass nodules (small hazy spots) in the lung, with at least one nodule measuring between 0.5 cm and 3.0 cm across. People where at least one of these nodules has been confirmed as cancerous or pre-cancerous through a tissue or cell sample…

People who have voluntarily signed the consent form for the study. People aged between 18 and 75 years (inclusive), of any gender. People with a general health and activity level rated as 0 or 1 on a standard medical scale (meaning fully active or able to carry out light work), known as ECOG performance status. People…

People aged 18 or older at the time of signing the consent form. People who have had their non-small cell lung cancer (a type of lung cancer) completely removed by surgery, confirmed by laboratory testing, and classified as Stage II or IIIA. People who have received platinum-based chemotherapy (a specific type of…

People aged 20 to 79 years, of any gender. People whose CT or PET-CT scan shows a single lung nodule measuring 2 to 3 cm across, suspected to be non-small cell lung cancer, with no signs of spread to nearby lymph nodes, and not located in the middle lobe of the lung. People whose scan shows the nodule is mostly solid…

People whose CEA blood marker level was above 5 mg/l before surgery (CEA is a protein sometimes found at higher levels in people with certain cancers). People who had a specific type of molecular blood test, called MRD testing, carried out before their surgery. People whose main tumor was removed through surgery.…

A confirmed diagnosis of small cell lung cancer (SCLC) based on tissue or cell testing, with imaging showing the cancer has spread widely (classified as "extensive stage"). People who have not yet received any systemic treatment for advanced or metastatic SCLC, or people whose cancer returned after combined…

Adults aged 18 to 75 years, of any sex. People with a confirmed diagnosis of stage III or IV non-squamous non-small cell lung cancer (a specific type of lung cancer) that cannot be surgically removed, as determined by a specialist team. People whose lung cancer has a specific genetic change — either an "exon 19…

Adults between 18 and 75 years of age (any sex). People with a laboratory-confirmed diagnosis of advanced (stage III or IV) non-squamous non-small cell lung cancer (a specific type of lung cancer) that cannot be surgically removed, as determined by a specialist medical team. People whose lung cancer tests negative for…

Adults between 18 and 80 years old People for whom a surgeon has recommended removal of a small part of the lung (rather than a whole lobe) People who are able to safely undergo general anaesthesia People who have one or more small spots in the outer area of the lung, each smaller than 20mm People whose lung spots are…

People aged 18 years or older, of any sex. People who have been diagnosed with a type of lung cancer called non-small cell lung cancer (NSCLC) that was able to be removed by surgery, who received treatment including immune checkpoint inhibitors before surgery, and whose post-surgery tissue analysis showed that the…

People who are willing to take part, sign a consent form, and are able to follow the study procedures. People aged 18 to 75 years (men and women are both eligible). People who have been confirmed by laboratory testing (from tissue or cell samples) to have stage IV non-small cell lung cancer (NSCLC), based on a…

People who are 18 years of age or older People who were diagnosed between August 2014 and August 2024 with one of the following: Extrapulmonary Neuroendocrine Carcinoma (EP-NEC), Large-cell neuroendocrine carcinoma (LCNEC) or a mixed form, or Small Cell Lung Cancer (SCLC) or a mixed form People whose medical records…

Adults aged 18 to 80 years old at the time of signing the consent form, of any gender. People whose lung cancer has been confirmed by laboratory testing to be a non-squamous, non-small cell type with a specific gene change in the EGFR gene (a deletion in exon 19 or a change called L858R in exon 21). People whose…

People aged 18 to 75 years of any sex, whose lung cancer has been confirmed by laboratory testing of tissue or cells, and who have been diagnosed with a specific type and stage of lung cancer called limited-stage small-cell lung cancer (LS-SCLC). People who have either stored tumour tissue samples (a block or slides…

Adults between 18 and 75 years of age, of any gender. People who have been diagnosed through a tissue or cell sample with a specific type of cancer — small-cell carcinoma of the lung or cervix — that cannot be cured by surgery or a combination of radiation and chemotherapy. People who have already received at least…

People who have given their written consent before any study activities begin. People aged 18 or older who are willing and able to give informed consent. People who have a confirmed diagnosis (from a tissue test) of a specific type of lung cancer called non-squamous NSCLC, with certain genetic changes (mutations) in…

People who are 18 years of age or older. People with a performance status score of 0 or 1 on the Eastern Cooperative Oncology Group scale, meaning they are fully active or have only minor restrictions on physically strenuous activity (confirm with trial site). People diagnosed with a specific stage of non-small cell…

Adults aged 18 years or older. People with a relatively good level of physical functioning, able to carry out daily activities with at most limited restrictions (confirm with trial site). People who have been diagnosed with non-small cell lung cancer (NSCLC) that has spread to other parts of the body, confirmed by lab…

People aged 18 years or older, of any gender People who have been diagnosed with Stage III non-small cell lung cancer (a type of lung cancer) that cannot be removed by surgery, confirmed by a laboratory test of tissue or cell samples, with the goal of treatment being to cure the disease People whose lung cancer has…

People who are willing and able to sign a written consent form agreeing to take part. People aged 18 to 75 years (inclusive), of any gender. People with a good general health and activity level, rated 0 or 1 on a standard performance scale used by doctors (confirm with trial site). People who have been diagnosed with…

Adults aged 18 years or older. People who have been diagnosed with non-small cell lung cancer (a specific type of lung cancer) confirmed through a tissue or cell sample test. People whose cancer has already been treated with at least one previous treatment plan that included both a platinum-based chemotherapy and a…

Adults aged 18 or older, of any gender. People with a confirmed diagnosis of a specific type of lung cancer called non-squamous non-small cell lung cancer (NSCLC) that is advanced or has spread, and cannot be cured with treatment (stage IIIB/C or IV). People whose lung cancer has tested negative for certain genetic…

People who have been assessed as a low-to-moderate anaesthesia risk, falling into category I, II, or III on a standard scale used by anaesthesiologists. People with a body mass index (a measure of body weight relative to height) between 18.5 and 30 kg/m². People who are scheduled to have a minimally invasive keyhole…

Adults aged 18 or older People who have been diagnosed with early-stage non-small cell lung cancer (stage IA, meaning the tumour is 3 cm or smaller and has not spread to lymph nodes or other parts of the body), confirmed through a tissue or cell sample People who are planned to have surgery or a bronchoscopy-based…

People aged 18 to 75 years who have a relatively good level of physical functioning (as measured by a standard medical scale called ECOG, scored 0 to 2). People who have been diagnosed with stage IV non-small cell lung cancer or extensive-stage small cell lung cancer that has spread to the liver, with at least one…

People who are able to give written agreement to participate and can understand and follow the study requirements and visit schedule. People who are male or female, aged 18 years or older and under 80 years old at the time of signing the consent form. People who have been confirmed through tissue or cell testing to…

People aged 18 to 75 years. People whose lung cancer has been confirmed by laboratory tissue or cell testing as either squamous cell carcinoma or adenocarcinoma of the lung. People whose cancer is at stage IV, meaning it has spread to distant parts of the body, and who have at least 2 measurable tumour areas…

People who have lung cancer and are currently receiving standard cancer treatment. People who also have type 2 diabetes. People whose general physical functioning is rated at a certain level (a score of 0–2 on a standard medical scale that measures how much a person's illness affects their daily activities) (confirm…

A person (or their legal representative) has given written consent to take part in the study and to the use of their personal data. People aged 18 years or older, of any sex. People whose general physical functioning falls within a certain range, meaning they are able to care for themselves and may or may not be able…

People aged between 18 and 80 years old, of any gender. People who have lung nodules found on a chest CT scan that are suspected to be cancerous and that the researchers have determined need a needle biopsy to get a clear diagnosis. People whose lung nodule measures more than 8mm but no more than 30mm at its longest…

People aged between 50 and 80 years old. People who currently smoke, or who stopped smoking within the last 15 years. People who have taken part in, or are currently taking part in, a program to help them stop smoking. People who have a lifetime smoking history of at least 20 pack-years (a measure of how much a person…

People aged 45–74 (male) or 40–74 (female) who have a parent, brother, sister, or child who has been diagnosed with lung cancer. People aged 50–74 who have a significant smoking history (at least 20 pack-years) and are either still smoking or stopped smoking less than 15 years ago. Adults aged 40 or older who are…