Colorectal Cancer

Who might be able to join this trial: - You have been diagnosed with colorectal cancer (cancer of the colon or rectum) that has spread to other parts of the body, confirmed by a laboratory test of a tissue or cell sample - You have not yet received any treatment for your cancer that has spread, but your doctor has reco...

**Who might be able to join this trial:** - You are generally active and able to carry out daily activities with little to no limitation (confirm with trial site for exact fitness level required) - You have been diagnosed with colorectal cancer that has come back or spread to other parts of the body, confirmed by a tis...

**Who might be able to join this trial:** - You have been diagnosed with colorectal cancer (a type of bowel cancer) that has spread to other parts of the body or cannot be removed by surgery, confirmed by a tissue biopsy. - Your cancer did not get worse (it stayed stable or improved) after receiving at least 6 rounds...

Who might be able to join this trial: - You must be willing to sign a consent form to take part in the study - You must be able to have up to 60 ml of blood drawn (about 4 tablespoons) without it being a health risk for you - You must be 18 years old or older - You must be willing to collect 1 to 2 stool samples and co...

Who might be able to join this trial: - People who have been referred for surgical removal of large, flat or spreading growths in the colon. - People who are able to give their informed consent to take part in the trial. Who may not be able to join: - People who have previously had a removal procedure attempted or com...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who have signed the specific consent form for their group (cohort) in the trial - People whose tumour has been tested for certain genetic markers/mutations using an approved, certified l...

**Who might be able to join this trial:** - Adults over 18 years of age who are scheduled to have a colonoscopy and have given written consent to take part in the trial - People who have at least one flat or slightly raised abnormal growth (lesion) in the colon or rectum that appears non-cancerous based on its surface...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal cancer (cancer of the colon or rectum) that has spread to other parts of the body or cannot be surgically removed, confirmed by a laboratory test on a tissue or cell sample. - People who are able to provide a stored tumour tissu...

**Who might be able to join this trial:** - People who have signed a written consent form agreeing to take part. - Adults aged 18 or older, of any gender. - People who are relatively well and able to carry out daily activities, as measured by a standard medical scale (ECOG score of 0 or 1 — confirm with trial site). -...

**Who might be able to join this trial:** - People who have been diagnosed with colon cancer (a specific type called adenocarcinoma) that has not yet been treated - People whose colon cancer has been confirmed by a pathology test (laboratory analysis of tissue) - People whose cancer is considered removable by surgery,...

Who might be able to join this trial: - People who have been diagnosed with squamous cell carcinoma (a type of cancer) of the anal canal or anal margin, confirmed by a tissue test. This includes certain related cancer cell types (such as basaloid or cloacogenic). - People whose cancer is at a stage that has not spread...

Who might be able to join this trial: - People who have been diagnosed with colorectal cancer that has spread to other parts of the body (metastatic), confirmed by a lab test to have a specific gene change called KRAS p.G12C mutation. - People whose KRAS p.G12C mutation has also been confirmed by the trial's central la...

Who might be able to join this trial: - Adults aged 18 or older who are scheduled to have planned (non-emergency) major surgery for colon or rectal cancer, with the goal of curing the cancer - People who have an appointment with a colorectal cancer surgeon at least one week before their scheduled surgery date Who may...

Who might be able to join this trial: - People who have been diagnosed with colorectal cancer (a type of bowel cancer) that has been confirmed by a lab test and has either spread to other parts of the body or cannot be removed by surgery (Stage III unresectable or Stage IV) - For Part 2 of the trial only: People who ha...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal cancer (a type of bowel cancer) that has come back or spread to other parts of the body, confirmed by a tissue sample, and have not yet received treatment for this advanced stage of the disease. - People whose cancer cannot be r...

Who might be able to join this trial: - People aged 18 or older who are expected to live for more than 3 months - People who have been diagnosed with a specific type of colorectal cancer (confirmed by tissue testing) that cannot be removed by surgery, has certain molecular features (known as MSS and/or pMMR), and has c...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who have been diagnosed with advanced or returning colorectal cancer (CRC) that has been confirmed by laboratory tissue testing, has at least one measurable area of disease, and has been...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have been diagnosed with colorectal cancer, small bowel cancer, or anal cancer confirmed by a tissue test, or where imaging results strongly suggest one of these cancers. - People who have given their consent to have their health inform...

Who might be able to join this trial: - People who have been diagnosed with rectal cancer (a specific type called adenocarcinoma, at any stage from I to IV), confirmed through a laboratory test of tissue, where surgery aimed at curing the cancer is planned or has already taken place - People who are able to read and wr...

**Who might be able to join this trial:** - People who have had colorectal cancer (a cancer of the large bowel or rectum) confirmed by a biopsy taken during normal medical care - People who have been diagnosed with colorectal cancer that has come back in the pelvic area (the lower part of the abdomen) - People who have...

Who might be able to join this trial: - Adults between 18 and 89 years old (note: for people enrolled after September 1, 2021, the age range is generally 18 to 69, though older age groups may be included under certain parts of the study — confirm with trial site) - Both men and women are eligible - People who have been...

Who might be able to join this trial: - People who have had a temporary loop ileostomy (a surgical opening in the abdomen to divert the bowel) created during rectal cancer surgery - People whose doctors have determined that closing the ileostomy is medically appropriate and safe based on standard clinical practice Who...

Who might be able to join this trial: - People who have rectal cancer that has been assessed by MRI scan and meets at least one of these features: the tumour has grown significantly into or beyond the rectal wall, cancer has spread into nearby blood or lymph vessels as seen on MRI, cancer has spread to nearby lymph nod...

"Who might be able to join this trial: - People who have been diagnosed with colorectal cancer (cancer of the colon or rectum) Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with trial site) Important: Always verify eligibility with the trial site directly befor...

**Who might be able to join this trial:** - People who have been diagnosed with stage IV colorectal cancer through tissue testing, and who have had surgery with the aim of completely removing the cancer. - The tissue sample removed during surgery must have been collected and sent to a specific laboratory (IRST IRCCS)...

**Who might be able to join this trial:** - People who have been diagnosed with rectal cancer that has been confirmed by a tissue biopsy (adenocarcinoma type) - People whose tumour is located in the lower part of the rectum (below a certain point in the abdomen) - People whose rectal cancer is considered treatable with...

Who might be able to join this trial: - Men and women aged 18 or older who had major bowel or colon surgery at the University of Arkansas for Medical Sciences during either January 1, 2014 to December 31, 2014, or June 1, 2015 to November 30, 2016. - People who, at the time of their surgery, were rated as relatively he...

Who might be able to join this trial: - People who have been diagnosed with colorectal cancer (specifically adenocarcinoma) that cannot be removed by surgery, not including cancer of the appendix or anal canal - People aged 18 or older at the time of giving consent to participate - People whose general physical conditi...

Who might be able to join this trial: - You have been tested and found to carry a known gene change (mutation) that causes Lynch syndrome, specifically in one of these genes: MLH1, MSH2, MSH6, PMS2, or EPCAM. - You are between 18 and 80 years old at the time of joining the trial. Who may not be able to join: - You als...

**Who might be able to join this trial:** - People between 18 and 75 years old (male or female) - People who have had surgery to remove colorectal cancer for the first time, within the last two months, where lab results after surgery confirmed the cancer was at stage IIB, IIC, or III - People with a general health and...

Who might be able to join this trial: - People who are over 18 years old - People whose rectal cancer has been confirmed by CT scan and MRI as a specific stage (a tumour that has grown through the bowel wall and may or may not have spread to nearby lymph nodes, but has not spread to distant parts of the body) - People...

Who might be able to join this trial: - People who have been diagnosed with rectal cancer (confirmed by biopsy) that is at a certain stage (T3-4 and/or has spread to nearby lymph nodes), has not been treated before, can be removed by surgery, and is located within 12 cm of the anal opening - Men or women who are not pr...

**Who might be able to join this trial:** - People who have been newly diagnosed with locally advanced rectal cancer (confirmed by tissue testing), at a stage that their doctor has classified as Stage 2 or 3, or Stage 1 where surgery to preserve the sphincter muscle is not possible, and whose treatment plan includes a...

**Who might be able to join this trial:** - People who have been diagnosed with rectal cancer (a type of gland-based cancer located in the lower part of the bowel, below a certain internal boundary called the peritoneal reflection), confirmed through a tissue test - People whose cancer is classified as Stage III - Peo...

**Who might be able to join this trial:** - People who have been diagnosed with rectal adenocarcinoma (a specific type of rectal cancer), confirmed through laboratory testing of tissue. - People whose cancer is considered suitable for surgery with the goal of removing it completely (curative resection). - People whose...

**Who might be able to join this trial:** - People who are scheduled for surgery aimed at curing colorectal cancer, including advanced colon cancer (called cT4), rectal cancer that has grown into or through the bowel wall (cT3 or cT4), colorectal cancer that has come back, or colorectal cancer that has spread to the li...

**Who might be able to join this trial:** - People who have been diagnosed with locally advanced or metastatic colorectal cancer, or another type of solid tumour cancer, confirmed through a tissue sample test. - People whose tumour has tested positive for a specific genetic feature known as MMR deficiency or MSI-H (a m...

**Who might be able to join this trial:** - People aged between 18 and 75 years old - People who have been diagnosed with rectal cancer (specifically a type called adenocarcinoma), confirmed by tissue testing - People whose tumour is located close to the anal opening (5 cm or less away) and where the cancer has grown...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal cancer (cancer of the colon or rectum) that has spread to other parts of the body and cannot be removed by surgery, confirmed through a tissue biopsy. - People whose cancer has come back or continued to grow after receiving at l...

**Who might be able to join this trial:** - People aged 12 to under 85 years with Ewing sarcoma, or aged 18 to under 85 years with other cancer types included in the trial - People with Ewing sarcoma that has spread, cannot be removed by surgery, has come back, or has stopped responding to treatment, and who have had...

Who might be able to join this trial: - People who have been diagnosed with rectal cancer that has been confirmed by a tissue sample (biopsy), and the cancer has not spread to other parts of the body - People whose cancer care team has recommended radiation therapy or a combination of radiation and chemotherapy before...

**Who might be able to join this trial:** - People who, before surgery, were assessed as having stage III colorectal cancer (cancer that has spread to nearby lymph nodes but not to distant organs) - People whose colorectal cancer was confirmed as a specific type called adenocarcinoma through a biopsy taken during a col...

**Who might be able to join this trial:** - People who have been diagnosed with adenocarcinoma (a specific type of cancer) of the colon - People whose cancer has not spread to nearby lymph nodes or other parts of the body (classified as Stage II) - People whose cancer can be surgically removed - People who are mentall...

**Who might be able to join this trial:** - People aged 18 or older at the time of signing the consent form - People in Cohort A: those with a benign or cancerous colorectal (bowel) growth (ranging from early to moderate stage) who are suitable for surgery, and who have not previously received any cancer-fighting medi...

**Who might be able to join this trial:** - People aged 20 to 80 years old - People who are scheduled for surgery to remove colon or rectal cancer, with the goal of curing the cancer - People who have a single colon or rectal cancer tumour, confirmed by a full colonoscopy and biopsy - People who have no signs of cancer...

Who might be able to join this trial: - People who have been diagnosed with stage 4 colorectal cancer (bowel cancer that has spread to other parts of the body). Who may not be able to join: - People who have agranulocytosis (a condition where the body has very low levels of a type of white blood cell that fights infec...

**Who might be able to join this trial:** - People who are willing and able to sign a written consent form - People who have been confirmed, through a tissue or cell sample, to have cancer of the colon or rectum (adenocarcinoma) - People whose tumor has been tested and found to have a specific genetic feature known as...

**Who might be able to join this trial:** - You are aged 18 or older but under 80 years old - You have recently been diagnosed with colon or rectal cancer within the last 48 hours, confirmed by a camera examination of the bowel and a laboratory analysis of tissue samples - Your blood clotting and general blood test res...

**Who might be able to join this trial:** - Adults aged 18 or older. - People who have been diagnosed with rectal cancer (a specific type called rectal adenocarcinoma), confirmed by tissue testing, for which a combination of chemotherapy and radiation therapy before surgery has been recommended. - People whose general...

Who might be able to join this trial: - People who have been newly diagnosed with colorectal cancer that has spread to other parts of the body (metastatic), or whose colorectal cancer has come back in a spreading form at least 3 months after finishing treatment for an earlier, non-spreading form of the disease. - Peopl...

Who might be able to join this trial: - People who are being treated at the Montpellier Cancer Institute, for any type of treatment (such as medication-based cancer treatment, radiation therapy, or surgery) - People who are over 18 years of age - People who have signed a consent form agreeing to take part in the study...

**Who might be able to join this trial:** **Part B (before surgery):** - People who have been newly diagnosed with colorectal cancer (confirmed by tissue testing) and are scheduled for surgery aimed at curing the cancer, with no signs of the cancer having spread to other parts of the body - People whose tissue testing...

**Who might be able to join this trial:** - You are female - You have been diagnosed with squamous anal cancer, confirmed through a tissue sample (biopsy) - Your doctor has recommended radiation therapy as your main treatment or after surgery - You are reasonably active and able to care for yourself (your doctor will a...

**Who might be able to join this trial:** - People who have been diagnosed with cancer in the lower or middle part of the rectum (confirmed by laboratory testing of tissue), at stage II or stage III - People who are planned to receive pre-surgery treatment, such as a combination of radiation and chemotherapy, chemother...

Who might be able to join this trial: - People who are 18 years of age or older - People who have previously been diagnosed with colorectal cancer, or where there is a strong suspicion of colorectal cancer based on clinical and imaging results - People who have stored tissue samples from their colorectal cancer diagnos...

"Who might be able to join this trial: - People who have been diagnosed with colorectal cancer (cancer of the colon or rectum) Who may not be able to join: - People who do not have a diagnosis of colorectal cancer Important: Always verify eligibility with the trial site directly before applying."

Who might be able to join this trial: - People who are willing to attend and complete all follow-up appointments required by the study. - People who are between 22 and 65 years old at the screening visit, or between 66 and 70 years old with no more than one heart, metabolic, or lung condition for which medication has b...

**Who might be able to join this trial:** - People who are older than 18 years old - People who have signed a consent form agreeing to take part - People diagnosed with colon cancer that has not spread (non-metastatic) and can be operated on straight away, or people whose colon cancer has spread to the liver at the sam...

**Who might be able to join this trial:** **Group A:** - People aged 30 or older who are able to agree to take part in the study - People attending a colonoscopy through the Bowel Cancer Screening Programme (for example, following a positive stool test, a bowel scope conversion, or as part of ongoing monitoring) - Peo...

**Who might be able to join this trial:** - You have a suspected or confirmed colon cancer that has been seen on a colonoscopy and CT scan, located in a specific part of the large bowel (the upper right side or the right two-thirds of the middle section of the colon) - You are 18 years of age or older, able to make you...

**Who might be able to join this trial:** - People who are willing and able to sign a written consent form agreeing to take part - People who are older than 18 and younger than 70 years of age - People who have been diagnosed with a specific type of rectal cancer (adenocarcinoma) confirmed by tissue testing, located w...

**Who might be able to join this trial:** - People aged 18 or older - People diagnosed with colorectal cancer or non-small cell lung cancer - People whose cancer is locally advanced, cannot be removed by surgery, and/or has spread to other parts of the body - People whose general health and ability to carry out daily...

Who might be able to join this trial: - People who are 18 years of age or older - People who have rectal cancer that has come back in the same area after previous surgery to remove rectal or lower colon cancer, confirmed either by tissue biopsy or by scans and clinical assessment agreed upon by a specialist team - Peop...

**Who might be able to join this trial:** - You must be at least 18 years old - You have been diagnosed with a specific type of anal cancer (squamous cell carcinoma of the anal canal), confirmed by a tissue sample, that has not been treated before - Your cancer must be at a certain stage — not too small, and not yet sp...

**Who might be able to join this trial:** - You have rectal cancer and at least one swollen lymph node in the side of your pelvis that is either 7mm or larger, or between 5–7mm but shows one or more signs of concern (such as a round shape, uneven edges, mixed appearance, or loss of normal structure) on a scan. **Who m...

**Who might be able to join this trial:** **For the YOGI group (database and questionnaire):** - People who have been diagnosed with a gastrointestinal cancer, confirmed by a tissue or cell sample test - People who were between 18 and 49 years old at the time of agreeing to take part - For the stool sample collection...

**Who might be able to join this trial:** - People (male or female) who have been diagnosed with rectal cancer (a specific type called adenocarcinoma), confirmed by a tissue sample, located in the rectum within a certain distance from the anal opening - People whose cancer staging has been assessed using a high-resolu...

**Who might be able to join this trial:** - People with a confirmed diagnosis of colorectal cancer (CRC) or a type of stomach/digestive tract cancer called gastric adenocarcinoma, where the cancer has spread or cannot be removed by surgery (Cohort A); or people with confirmed colorectal cancer with specific genetic fe...

Who might be able to join this trial: - People who have been newly diagnosed with rectal cancer (confirmed by biopsy), where the lowest part of the tumour is within 16 cm of the opening of the back passage, measured using a special viewing instrument. - People whose cancer is locally advanced and shows at least one hig...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal cancer (a type of bowel cancer) that has spread to other parts of the body or come back, and cannot be removed by surgery — confirmed by lab testing of tissue samples - People whose doctors estimate they are likely to live for a...

**Who might be able to join this trial:** - People who are being referred for a colorectal ESD (a procedure used to remove abnormal tissue from the colon or rectum) **Who may not be able to join:** - People who have formally stated they do not wish to take part, after reading the information notice provided about the...

**Who might be able to join this trial:** - People who have been diagnosed with rectal cancer (adenocarcinoma) confirmed by a laboratory tissue test - People whose cancer has a specific genetic feature called dMMR or MSI-H (a marker found through tumour testing), whether or not they have Lynch syndrome - People who ha...

**Who might be able to join this trial:** - You have been diagnosed with rectal cancer (a specific type called adenocarcinoma), confirmed by a tissue sample test - Your tumour has a specific genetic feature called "dMMR" or "MSI-H," identified through laboratory testing of your tumour tissue - Scans show your tumour i...

**Who might be able to join this trial:** - People who have been diagnosed with rectal adenocarcinoma (a specific type of rectal cancer) confirmed by tissue biopsy within the past 90 days, where at least part of the tumour is in the lower section of the rectum - People whose cancer has been staged using the AJCC 8th e...

**Who might be able to join this trial:** - People aged 18 or older who are able to make their own legal decisions - People who have colorectal cancer that has spread to other parts of the body (metastatic), with a specific genetic change called the BRAF V600E mutation, and who have already received at least one previo...

**Who might be able to join this trial:** - People who are 18 years of age or older, of any gender, race, or ethnic background - People who are willing and able to sign a written consent form agreeing to take part - People who have been diagnosed with a specific type of rectal cancer called rectal adenocarcinoma - Peop...

Who might be able to join this trial: - People who have been diagnosed with Familial Adenomatous Polyposis (FAP), either through a genetic test showing a specific gene mutation, or because they were found to have more than 100 growths in the large bowel along with a family history of FAP - People who have already had s...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal cancer (cancer of the colon and/or rectum) that has spread to other parts of the body, confirmed by laboratory testing of tissue samples. - People whose tumor has a specific genetic feature called MGMT promoter methylation (conf...

Who might be able to join this trial: - People who are scheduled to have a permanent colostomy (a surgical opening created in the abdomen for waste to leave the body, using part of the large intestine called the sigmoid colon) Who may not be able to join: - People who do not speak Swedish - People who have a condition...

**Who might be able to join this trial:** - People who have been diagnosed with rectal cancer (a specific type called adenocarcinoma) confirmed by a tissue sample. - People whose cancer has been classified by MRI scan as either Stage II (a certain tumour size with no spread to nearby lymph nodes) or Stage III (varying...

**Who might be able to join this trial:** - People aged 18 or older - People who have been confirmed through a tissue or cell sample to have colorectal adenocarcinoma (a type of bowel cancer) - People with colorectal adenocarcinoma at any stage where treatment aimed at curing the disease is being considered, including...

**Who might be able to join this trial:** - Adults between 18 and 80 years old (male or female) - People whose tissue sample (biopsy) from a colonoscopy has confirmed a type of bowel cancer called colorectal adenocarcinoma - People whose tumour is located close to the lower end of the bowel — within a specific distanc...

**Who might be able to join this trial:** - You have given written consent to take part - You are currently receiving a chemotherapy regimen called Folfirinox - You are 18 years of age or older - Your general health and activity level meets a certain minimum standard as rated by your doctor (confirm with trial site) -...

Who might be able to join this trial: - People who have been diagnosed with colon cancer - People who are older than 18 and no more than 79 years of age - People who are able to understand and agree to participate by signing a consent form - People whose treatment plan includes a chemotherapy combination called FOLFOX...

**Who might be able to join this trial:** - People who have metastatic colorectal cancer (cancer of the colon or rectum that has spread to other parts of the body) and whose doctors have recommended palliative chemotherapy (chemotherapy aimed at managing the disease rather than curing it) - People who are scheduled to...

**Who might be able to join this trial:** - People who are over 18 years old - People in Cohort A: those who have had a positive stool blood test during bowel cancer screening (a test that detects blood in the stool) or who have visible bleeding, and colorectal cancer is suspected — OR people in Cohort B: those who hav...

**Who might be able to join this trial:** - People who have been diagnosed with one of the following: low-grade appendiceal mucinous neoplasm, pseudomyxoma peritonei, appendiceal cancer that has spread to the lining of the abdomen, or colorectal cancer that has spread to the lining of the abdomen - People whose genera...

Who might be able to join this trial: - Adults over 18 years of age - People who have been diagnosed with anal squamous carcinoma (a specific type of anal cancer) within the last 2 months Who may not be able to join: - People who are unable or unwilling to provide informed consent (formal written agreement to particip...

Who might be able to join this trial: - People aged 18 or older - People who have been diagnosed with rectal cancer (specifically a type called adenocarcinoma), confirmed by a tissue or cell sample - People whose cancer has been assessed as stage I, II, or III (meaning it has not clearly spread to other parts of the bo...

Who might be able to join this trial: - People who have had a colonoscopy performed at a Hospital Authority (HA) hospital during the study period. Who may not be able to join: - People who have a documented personal history of colorectal cancer that was diagnosed before the study period began. Important: Always verif...

Who might be able to join this trial: - You have a medical reason to have a colonoscopy - At least one polyp (a small growth) between 10 and 15 mm was found in your colon during a colonoscopy - You have read and signed a consent form agreeing to take part Who may not be able to join: - You have been assessed by an ana...

**Who might be able to join this trial:** - You have been diagnosed with high-risk polyps through a colorectal cancer screening programme, a family history-based prevention programme, or you are already being monitored after polyps were previously found — and your situation includes at least one of the following: 10 o...

**Who might be able to join this trial:** - People who are able and willing to provide written consent before any study procedures begin - People whose general health and ability to carry out daily activities falls within an acceptable range, as measured by standard medical scoring tools (confirm with trial site) - Peo...

Who might be able to join this trial: - People who have been assessed by an anaesthesia specialist and rated as having a general health status of Grade I, II, or III (meaning from healthy to having some serious but controlled medical conditions). - People diagnosed with cancer in the right side of the colon (from the c...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People who are generally well enough to carry out daily activities with little or no limitation (as assessed by a standard medical scale called ECOG-WHO, with a score of 0 or 1) - People who have been diagnosed with squamous cell canc...

**Who might be able to join this trial:** - People who have been diagnosed with colon cancer (or certain types of rectal cancer that was removed without needing radiation), confirmed by a tissue or cell sample analysis - People with Stage II, Stage III, or Stage IV colorectal cancer who have had surgery with the goal...

Who might be able to join this trial: - People who are 18 years of age or older and are able to understand and agree to participate in the trial. - People who have been diagnosed with rectal cancer (a type of cancer called adenocarcinoma) that has been confirmed by examination or scans, has not spread to nearby lymph n...

**Who might be able to join this trial:** - Adults aged between 18 and 80 years old (inclusive) - People who have been diagnosed with colon adenocarcinoma (a specific type of colon cancer), confirmed through laboratory testing of tissue - People who have had surgery to fully remove stage I, II, or III colorectal cancer...

**Who might be able to join this trial:** - You have been diagnosed with rectal cancer that has been confirmed through a laboratory test of tissue samples - You are having or have had surgery to remove the rectum using a specific technique called Total Mesorectal Excision (TME) (confirm with trial site) - You are under...

"Who might be able to join this trial: - People who have been diagnosed with cancer of the colon (specifically the ascending, transverse, descending, or sigmoid sections) confirmed through a tissue sample test. Who may not be able to join: - People who do not wish to take part in the trial. - People whose colon cancer...

**Who might be able to join this trial:** - People who are between 50 and 65 years old. - People who have had at least one advanced polyp (a type of growth in the colon of a certain size or with specific cellular features) or at least three smaller polyps found and fully removed during a routine bowel cancer screening...

**Who might be able to join this trial:** - People aged between 18 and 75 years - People whose overall health has been assessed by an anaesthesiologist and falls within a low-to-moderate risk range (ASA score I to III) - People who have had a biopsy that confirmed a diagnosis of colorectal cancer (cancer of the colon o...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal cancer (cancer of the colon or rectum) that has spread to other parts of the body and cannot be removed by surgery, confirmed by laboratory testing of tissue. - People whose tumor has been tested and does not have a specific gen...

**Who might be able to join this trial:** - People who are older than 18 years and younger than 85 years old. - People who have been diagnosed with a type of rectal cancer called rectal adenocarcinoma, confirmed by a biopsy or tissue test before surgery. - People for whom surgeons plan a specific type of rectal surgery...

**Who might be able to join this trial:** - Adults aged 18 or older - People whose general health and ability to carry out daily activities meets a certain minimum level (confirm with trial site) - People who have been diagnosed with rectal cancer (a specific type called adenocarcinoma, confirmed by biopsy) where the...

**Who might be able to join this trial:** - Adults aged 18 or older who have given their signed consent to take part - People who have been diagnosed with colorectal cancer (cancer of the colon or rectum) confirmed by tissue testing, which has spread to other parts of the body (metastatic), with at least one area of c...

**Who might be able to join this trial:** - People aged 18 or older who have given their written consent to participate. - People who have been confirmed through a tissue biopsy to have colorectal cancer (cancer of the colon or rectum) that is classified as adenocarcinoma. - People whose colorectal cancer has spread (...

**Who might be able to join this trial:** - People who have been diagnosed with rectal adenocarcinoma (a specific type of rectal cancer), confirmed through a tissue sample analysis - People who are 18 years of age or older - People who are generally well enough to carry out daily activities with little to no limitatio...

**Who might be able to join this trial:** - People in the "Case Group" who have a confirmed diagnosis of colorectal or breast cancer, verified through laboratory tissue testing - People in the "Control Group" who have not been diagnosed with any form of cancer **Who may not be able to join:** - People in the "Contro...

**Who might be able to join this trial:** - Men between 18 and 70 years of age who have given their informed consent to participate - People whose tumour is located between 6 and 12 centimetres from the opening of the back passage, as measured by a specialised scope - People who have been diagnosed with rectal cancer c...

**Who might be able to join this trial:** - Adults aged 18 years or older - People scheduled for a screening colonoscopy, which may be due to a positive bowel cancer screening test, a family or personal history of colon cancer or growths in the bowel, a history of inflammatory bowel disease, or symptoms such as bowel c...

Who might be able to join this trial: - People who have anal cancer that has come back after previous treatment - The cancer has been confirmed by a tissue biopsy as a type called squamous cell carcinoma - A radiation treatment plan from the original radiotherapy course is available - The person has previously received...

Who might be able to join this trial: - People who are already scheduled to have a colonoscopy (whether for routine screening, follow-up monitoring, or because they have symptoms). - People aged 18 years or older at the time of signing the consent form. - People who are able to understand, sign, and date the consent fo...

Who might be able to join this trial: - Adults aged 19 years or older at the time of signing the consent form - People who have been diagnosed with colorectal cancer confirmed by a tissue or cell sample test - People whose colorectal cancer has spread to other parts of the body and cannot be removed by surgery - People...

**Who might be able to join this trial:** - People aged 18 or older who are willing and able to follow the study procedures and give written consent to participate. - People who are in good general health and able to carry out normal daily activities with little to no limitation (as measured by a standard performance...

Who might be able to join this trial: - People who are scheduled to have a type of keyhole surgery performed through the back passage (called transanal endoscopic surgery) at the QEII Health Sciences Center in Halifax, carried out by one of their specialist bowel surgeons Who may not be able to join: - People who have...

**Who might be able to join this trial:** - You are over 18 years old - You are scheduled for a planned (non-emergency) surgery to remove part of the left side of your colon or the upper part of your rectum for cancer, where the two ends of the bowel will be joined back together inside the abdomen - You are willing and...

Who might be able to join this trial: - People who are in good general health, able to carry out normal daily activities with minimal limitations (rated 0 or 1 on a standard medical fitness scale called ECOG). - People who have been confirmed by lab testing to have Stage IIB, IIC, or Stage III colon cancer (a type call...

Who might be able to join this trial: - People who speak English - People aged 45 years or older - People who are not currently up to date with colorectal cancer screening - People who have access to a working telephone - People who are able to give informed consent to participate Who may not be able to join: - People...

**Who might be able to join this trial:** - You are between 20 and 70 years old and are generally able to carry out daily activities with minimal limitations, OR you are between 71 and 75 years old and fully able to carry out all normal daily activities without any restrictions - Your colon cancer has been confirmed b...

**Who might be able to join this trial:** - People who have been diagnosed with cancer or high-grade pre-cancerous changes in the colon (located higher up in the large bowel, not the lower rectum), confirmed by a tissue sample and/or clear imaging scans. - People whose tumour has a specific genetic profile — tested th...

**Who might be able to join this trial:** - People who have been diagnosed with colon or rectal cancer (confirmed by tissue testing) that has a specific genetic feature called MMR deficiency or MSI-high, detected through laboratory testing. - People who are in good general health (able to carry out normal daily activi...

**Who might be able to join this trial:** - Your rectal cancer has been assessed by MRI scan and is at a stage where it has grown into or through the rectal wall, or has spread to nearby lymph nodes - Your cancer has been confirmed by a tissue sample (biopsy) to be a specific type of rectal cancer called adenocarcinoma...

**Who might be able to join this trial:** - Women who have been diagnosed (confirmed by laboratory testing) with a serious pre-cancerous or cancerous condition of the cervix, vulva, or vagina linked to a virus called HPV — this includes conditions graded as level 2 or higher, or a history of cervical, vaginal, or vulva...

**Who might be able to join this trial:** - People aged 21 or older who have been diagnosed with colorectal cancer at an early to non-spreading stage (in situ, Stage I, II, or III) - People who are mentally well and able to think clearly - People who are able to read or speak Mandarin or Taiwanese, as the study materia...

Who might be able to join this trial: - People who have been diagnosed with, or are suspected to have, a type of bowel cancer called colorectal adenocarcinoma, at stages I through IVA - People who are planning to have, or have already had, surgery to remove a tumour in the colon or rectum with the goal of curing the di...

**Who might be able to join this trial:** - People who have been diagnosed with locally advanced rectal cancer (a specific type called adenocarcinoma) confirmed by a lab test, who are planned to receive a full course of treatment before surgery, with the goal of curing the cancer. - People whose rectal cancer has been...

Who might be able to join this trial: - People who are 18 years of age or older - People being treated for colon cancer at the Montpellier Regional Cancer Institute, where surgery is not an option for either the main tumour or any spread of the cancer, whether currently receiving treatment or not - People whose colon c...

**Who might be able to join this trial:** - People who have been diagnosed with colon cancer that has spread to other parts of the body, confirmed by a biopsy - People whose doctors are planning to treat them with a second or later round of chemotherapy that includes a drug called irinotecan, starting at a specific do...

**Who might be able to join this trial:** - People aged 18 years or older - People with suspected metastatic colorectal cancer (cancer that has spread from the colon or rectum to other parts of the body), either at the same time as the original diagnosis or later — but only if a biopsy is needed as part of their usual...

**Who might be able to join this trial:** - People who are male or female and aged 18 or older. - Women who either test negative for pregnancy and are not breastfeeding, or who are not able to become pregnant (for example, due to menopause for at least 2 years, a hysterectomy, or bilateral tubal ligation). - Women who...

**Who might be able to join this trial:** - People who live permanently in Yangzhou - People aged between 40 and 74 years old (based on the date of birth on their ID card) - People who are able to make their own decisions - People who are willing to complete a colorectal cancer risk factor questionnaire and take part i...

**Who might be able to join this trial:** - You have been diagnosed with colorectal cancer that was confirmed through a tissue sample (biopsy) - You have had surgery to remove your colorectal cancer (with no cancer left behind) at stage II, III, or IV, and have finished all planned treatments aimed at curing the cance...

**Who might be able to join this trial:** - People aged 50 to 75 with no special risk factors who have been referred for a colonoscopy as part of bowel cancer screening. - People aged 30 to 80 who have a close family member who has had bowel cancer, and who have been referred for a colonoscopy as part of bowel cancer...

Who might be able to join this trial: - You need to be scheduled for a procedure to remove a growth in your large intestine (colon or rectum) using a special camera-guided technique (such as endoscopic mucosal resection or endoscopic submucosal dissection) for either a large pre-cancerous polyp or an early-stage bowel...

**Who might be able to join this trial:** - People who are 74 years old or younger - People who have at least one risk factor for bowel cancer that would typically lead to a doctor recommending a colonoscopy, such as: a personal history of low-risk bowel polyps, a personal history of high-risk bowel polyps, or a family...

"Who might be able to join this trial: - People who have been diagnosed with colorectal cancer (confirmed through a lab test of tissue) and are scheduled to have surgery with the goal of curing the cancer, followed by standard medical check-ups. Who may not be able to join: - People who are unable or unwilling to sign...

**Who might be able to join this trial:** - People who are scheduled for a planned colonoscopy for colorectal cancer screening, monitoring of previously found polyps, or investigation of symptoms such as anaemia, changes in bowel habits, or abdominal pain - People who are 18 years of age or older - People who have prov...

**Who might be able to join this trial:** - People who have been diagnosed with Lynch syndrome, either through a confirmed genetic mutation in one of the DNA mismatch repair genes (MLH1, MSH2/EPCAM, MSH6, or PMS2), or through a personal history of certain bowel growths or cancers that show signs of a mismatch repair p...

Who might be able to join this trial: - Adults between 18 and 75 years old, of any gender - People who have been diagnosed with colorectal cancer confirmed by a laboratory tissue or cell test - People with colorectal cancer who have had surgery to remove the cancer and need follow-up treatment afterward, and who have n...

Who might be able to join this trial: - People who have been diagnosed with a type of colon cancer called adenocarcinoma, confirmed by a biopsy - People who are healthy enough to undergo surgery - People who are able to understand the trial and are willing to take part by signing a consent form Who may not be able to...

Who might be able to join this trial: - You have been diagnosed with anal cancer that has been confirmed by a biopsy (a small tissue sample taken and examined in a lab) - Your doctors have determined that radiotherapy (radiation treatment) is suitable for you with the goal of curing the cancer - You are willing and abl...

**Who might be able to join this trial:** - People who are 45 years of age or older - People with no previous history of colorectal cancer or colon polyps - People who have no close family members (parents, siblings, or children) diagnosed with colorectal cancer before the age of 60 - People who are not currently exper...

Who might be able to join this trial: - People who have been diagnosed with colorectal cancer that has spread to other parts of the body, confirmed by a tissue sample (biopsy), and whose cancer has continued to grow after one round of chemotherapy treatment. - People whose first treatment for their spreading cancer inc...

**Who might be able to join this trial:** - People who have been diagnosed with locally advanced or metastatic colorectal cancer (cancer that has spread beyond the colon or rectum), confirmed by a tissue sample, and whose cancer has stopped responding to or who could not tolerate standard treatments — and, where appli...

**Who might be able to join this trial:** - People who are 40 years of age or older - People who are able to make their own decisions and give informed consent - People who are able to complete a colorectal cancer risk factor questionnaire and take part in yearly follow-up interviews after joining - People who are able...

**Who might be able to join this trial:** - You are 70 years old or older - You have been diagnosed with a type of colon cancer called adenocarcinoma that has not spread to other parts of the body - Your surgery is not needed as an emergency - You are reasonably active and able to care for yourself to a moderate degree...

Who might be able to join this trial: - People who are willing and able to provide written consent to participate - People who have been diagnosed with colon adenocarcinoma (a type of colon cancer) confirmed by a tissue sample, or people who have been diagnosed with two cancers occurring at the same time and have not y...

**Who might be able to join this trial:** - People who have been diagnosed with rectal cancer (a specific type called adenocarcinoma), confirmed through a tissue sample (biopsy) - People whose cancer has reached certain stages of spread within or around the rectum, based on specific scan findings (confirm with trial s...

Who might be able to join this trial: - People aged 18 or older who have been diagnosed with colorectal cancer that has spread to the lining of the abdomen (known as peritoneal metastases) - People who have had a specific type of surgery to remove as much cancer as possible (called cytoreductive surgery) at The Christi...

**Who might be able to join this trial:** - People who have a clinical suspicion of rectal cancer, or who have had a colonoscopy showing signs of rectal cancer - People who are over 18 years of age - People who have given their informed consent by reading and signing a consent form **Who may not be able to join:** - P...

Who might be able to join this trial: - People who are 18 years of age or older and work as staff members at one of the partnering clinic sites listed in the trial locations. - Staff members whose roles include administrative leadership, population health management, data analysis, quality improvement, nursing, nurse m...

**Who might be able to join this trial:** - You have been diagnosed with colorectal cancer (a specific type called adenocarcinoma) confirmed by a lab test - You are between 18 and 80 years old (any gender) - You are scheduled to have surgery to fully remove your colorectal cancer - You have not received any cancer trea...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You have been diagnosed with colon cancer (a specific type called adenocarcinoma) confirmed by a tissue sample test - After surgery, your cancer was found to be at a stage II with certain higher-risk features, or stage III — stage II with...

Who might be able to join this trial: - People who have been diagnosed with stage I or stage II colorectal cancer (without high-risk features), confirmed by laboratory testing of tissue. - People aged 18 or older at the time of signing the consent form, of any gender. - People who are scheduled to have surgery to remov...

Who might be able to join this trial: - You must be 18 years old or older. - The tumor being studied must be at least 1 cm (about half an inch) across, as seen on a scan. - You must be able to lie still in a PET/CT scanner for at least 70 minutes. - You must have had a recent scan (such as an MRI or CT) that shows the...

Who might be able to join this trial: - People aged between 18 and 80 years old, either male or female - People who have had a biopsy confirming a type of cancer called adenocarcinoma - People whose cancer is located in the rectum or at the junction where the rectum meets the sigmoid colon - People whose cancer is the...

**Who might be able to join this trial:** *Colorectal Cancer Group:* - People aged 18 to 49 years old - People who have been diagnosed with a type of colorectal cancer called colorectal adenocarcinoma, confirmed by a lab test - People who are scheduled for, or have already had, surgery, a biopsy, or a colonoscopy (inc...

**Who might be able to join this trial:** - People aged 18 to 70 years old - People who have been diagnosed with colorectal adenocarcinoma (a specific type of bowel cancer), confirmed by tissue testing - People whose general health and ability to carry out daily activities meets a specific functional standard (known a...

Who might be able to join this trial: - People diagnosed with squamous cell carcinoma of the anal canal (a type of anal cancer) who are scheduled to receive radiotherapy, with or without chemotherapy, as their main treatment - People aged 18 years or older - People who have given their agreement to take part, both in w...

**Who might be able to join this trial:** - Adults between 18 and 75 years of age - People who are generally well enough to carry out light activity and care for themselves (a measure doctors use called ECOG score 0–1) - People who have been diagnosed with rectal cancer (a specific type called adenocarcinoma) confirme...

**Who might be able to join this trial:** - People who are suspected of having colorectal cancer and for whom a colonoscopy has been recommended by their doctor. - People between 50 and 75 years old who have no current digestive symptoms, and for whom a follow-up colonoscopy has been recommended (for example, as part o...

Who might be able to join this trial: - People aged between 18 and 80 years old. - People with a BMI (a measure of body weight relative to height) between 18.5 and 27.9. - People whose planned surgery is one of the following: removal of rectal cancer, removal of right colon cancer, removal of left colon cancer, or remo...

**Who might be able to join this trial:** - People who speak English or Spanish - People who have a personal history of colorectal polyps (growths found in the large intestine) - People whose most recent colonoscopy found 2 or fewer polyps that were not classified as advanced - People who are currently due, or will be...

**Who might be able to join this trial:** - People aged 18 to 75 years old at the time of signing the consent form. - People with a good general health and activity level, rated at 0 or 1 on a standard medical scale (meaning fully active or able to carry out light work). - People whose cancer has come back in the pelv...

**Who might be able to join this trial:** - People who are considered high risk for recurring colorectal polyps (adenomas), meaning they have been diagnosed with Familial Adenomatous Polyposis (FAP), OR had more than 5 small polyps (under 1 cm) found on a colonoscopy in the past 5 years, OR had 3 or more polyps with a...

Who might be able to join this trial: - People who have given written consent after having the study fully explained to them - People who have been confirmed through a tissue test (biopsy) to have rectal adenocarcinoma (a specific type of rectal cancer) - People whose cancer has not spread to distant parts of the body,...

Who might be able to join this trial: - You are between 18 and 100 years old - You can read English or Spanish at around an eighth-grade level or higher - You come from a racial or ethnic background that has historically been underrepresented in cancer research, such as Black or African American individuals, or Hispani...

**Who might be able to join this trial:** - People aged 18 or older - People diagnosed with colorectal cancer (bowel cancer) that has spread or cannot be surgically removed, and who will be treated with a chemotherapy drug called irinotecan, with or without an additional targeted therapy - People whose overall health a...

Who might be able to join this trial: **For patients:** - Adults aged 18 or older - Have been diagnosed with colorectal cancer - Expected to live for more than 12 months - Currently receiving chemotherapy treatment - Are experiencing at least two symptoms affecting mood, thinking, or energy (such as fatigue, depressio...

Who might be able to join this trial: - People who are willing and able to sign a written consent form for the trial. - People who are 18 years of age or older at the time of signing the consent form. - People who are generally well enough to carry out daily activities with little or no limitation (a performance level...

Who might be able to join this trial: - People who have been diagnosed with colorectal cancer that has spread to other parts of the body (metastatic), confirmed by a tissue sample. - People whose cancer does not have a specific genetic marker called microsatellite instability (MSI) (confirm with trial site). - People w...

**Who might be able to join this trial:** - People aged between 18 and 70 years old - People who have been diagnosed with colorectal cancer at stage III or stage IV - People who have at least one tumour or lesion outside the brain that can be measured using standard imaging criteria - People whose cancer has stopped r...

Who might be able to join this trial: - Adults who are 18 years of age or older - Healthcare professionals working as consultants or registrars in medicine, surgery, or gastroenterology Who may not be able to join: - People who are under 18 years of age - People who are not willing to sign a consent form Important: A...

Who might be able to join this trial: - People who have been diagnosed with rectal or anal cancer - People who are scheduled to have a robot-assisted surgery to remove the rectum and surrounding tissue (a procedure called abdominoperineal resection) - People whose surgery plan includes rebuilding the pelvic floor and/o...

**Who might be able to join this trial:** - People who have been diagnosed with advanced cancer that has spread to other parts of the body, confirmed by a lab test on a tissue or cell sample. - During the dose-finding stage, people with a solid tumour that either has a specific gene marker called MGMT promoter hyperme...

Who might be able to join this trial: - You have had surgery to remove cancer in the pelvic area (the lower part of your abdomen/hip region) where more than one organ in that area was removed during the operation. Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm wi...

Who might be able to join this trial: - People who have an inherited genetic change (called a pathogenic germline variant) in one of four specific DNA repair genes — MLH1, MSH2/EPCAM, MSH6, or PMS2 — which are linked to a condition known as Lynch syndrome Who may not be able to join: - People under 18 years of age - P...

**Who might be able to join this trial:** - People who have been diagnosed with cancer in the right side of the colon (specifically the cecum, ascending colon, or hepatic flexure), confirmed by a tissue sample test - People whose surgery will follow a specific surgical technique called Complete Mesocolic Excision (CME)...

Who might be able to join this trial: - Adults aged 18 or older - People who have started immunotherapy (a type of cancer treatment) within the past 12 weeks - People who are mentally alert and aware of who they are, where they are, and what time it is, as assessed by the recruiting team - People who can speak and unde...

**Who might be able to join this trial:** - People who have an advanced solid tumour cancer that has spread or cannot be removed by surgery, confirmed by pathology records or a current biopsy. - For the single-drug (monotherapy) part of the trial, people with one of these cancer types may be considered: certain types...

**Who might be able to join this trial:** **Pre-screening stage:** - People who have been diagnosed (confirmed by laboratory testing of tissue) with advanced or metastatic bowel or rectal cancer that has spread and cannot be surgically removed - People who are currently receiving or have previously received treatment...

**Who might be able to join this trial:** - People who are willing and able to sign a written consent form agreeing to take part. - Adults aged 18 to 75 years old. - People who have been confirmed through a tissue or cell sample test to have a type of rectal cancer called adenocarcinoma. - People who have not previous...

**Who might be able to join this trial:** - You are willing to receive treatment before surgery (called neoadjuvant therapy). - You are 18 years old or older. - Your tumor is located in the rectum, no more than 12 cm from the opening of the anus, confirmed by physical exam, colonoscopy, and MRI scan. - Your cancer has...

Who might be able to join this trial: - People diagnosed with colorectal cancer (specifically adenocarcinoma) that has spread or cannot be surgically removed, confirmed by tissue or cell testing. - People whose cancer has been tested and confirmed to be of a specific type called "pMMR/MSS or MSI-L," meaning the cancer...

**Who might be able to join this trial:** - People with a general health status rated as good to moderately functional (ECOG score of 0, 1, or 2) - People with rectal cancer that has been confirmed through tissue testing (biopsy) - People whose cancer meets specific staging criteria — either the tumour has grown into s...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with stage II or III colon cancer, confirmed by a tissue test (biopsy) - You have already had surgery to remove the cancer with the goal of curing it - You are planning to start chemotherapy - You currently do less than...

**Who might be able to join this trial:** - You have a rectal polyp or tumour that is larger than 2cm and are due to have surgery or a medical assessment, or your doctor suspects you may have one - You have been diagnosed with rectal cancer and are due to have surgery or a medical assessment, including if you have alre...

**Who might be able to join this trial:** - People of any sex, aged between 18 and 75 years old - People who have had surgery and whose tissue sample has confirmed a specific stage of colorectal cancer (called pT3-4N2 colorectal adenocarcinoma) - People whose overall physical health and ability to carry out daily activ...

**Who might be able to join this trial:** - People taking part in the dose escalation phase must have a laboratory-confirmed cancer that has spread or cannot be surgically removed, and that has continued to grow after standard treatments that included the drugs fluorouracil (5-FU) or capecitabine. - People with colore...

**Who might be able to join this trial:** - People who have been diagnosed through a tissue biopsy with a specific type of anal canal cancer (squamous, basaloid, or cloacogenic carcinoma) - People whose cancer meets certain size or spread criteria based on medical staging — specifically a tumour larger than 4 cm, or ca...

**Who might be able to join this trial:** - People aged 70 years or older who have been diagnosed with colorectal cancer - People who a medical team (multidisciplinary board) has assessed as suitable for colorectal surgery, and who have given their consent to have the surgery **Who may not be able to join:** - People...

**Who might be able to join this trial:** - People aged 18 or older. - People who are generally able to carry out daily activities and are either fully active or able to carry out light work (this is measured using a standard scale called the ECOG scale, with a score of 0 or 1). - People who have been diagnosed with c...

Who might be able to join this trial: - People aged 18 to 84 years old - People who have been assessed by an anaesthesiologist as being in a generally healthy to mildly-to-moderately compromised health state before surgery (known as ASA class I, II, or III — confirm with trial site if unsure) - People who have been dia...

Who might be able to join this trial: - People diagnosed with advanced rectal cancer (a type of cancer in the last part of the large intestine) that has spread to nearby tissues or lymph nodes in specific ways, such as growing into surrounding structures, being very close to certain surgical margins, spreading to parti...

**Who might be able to join this trial:** - You have been diagnosed with advanced colorectal cancer (confirmed by lab testing) and are receiving your first round of treatment for this advanced cancer - You are 18 years of age or older (any gender) - You are reasonably active and able to care for yourself, with only mil...

**Who might be able to join this trial:** - People who identify as Black or African American - People between 45 and 75 years old - People who are not current with recommended colorectal cancer screening (confirm with trial site for specific guidelines) - People who are willing to provide contact details for follow-up...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People whose general health and ability to carry out daily activities meets a certain minimum level, as measured by standard scoring tools used by doctors (confirm with trial site) - People whose scans before surgery showed no clear s...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with colorectal cancer (bowel cancer that has spread), confirmed by a tissue or cell sample - Your cancer has spread to other parts of the body (stage 4), and you have either tried all standard treatments available,...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People who are in good general health, with a performance score showing they are fully active or have only minor restrictions on physical activity (ECOG score of 0 or 1) - People who have been diagnosed through a tissue biopsy with ca...

Who might be able to join this trial: - People aged 18 to 75 years old. - People who have been diagnosed through lab testing with a specific type of colon cancer called MSS or pMMR-type colon adenocarcinoma. - People whose tumor is located more than 12cm from the anus (measured by a camera scope exam), and where the tu...

Who might be able to join this trial: - You are 18 years of age or older - You have been recently diagnosed with locally advanced rectal cancer (stage II or III) and a decision has been made within the last 8 weeks to treat it with more than one type of treatment - You are able to complete the study activities in Engli...

**Who might be able to join this trial:** - People who have been diagnosed with rectal cancer that has grown locally into surrounding tissues but has not spread widely (known as locally advanced rectal cancer) **Who may not be able to join:** - People whose cancer has spread to other parts of the body in a way that ca...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have been confirmed by tissue testing to have a type of rectal cancer called infiltrating rectal adenocarcinoma. - People whose tissue testing showed a rectal polyp or very early-stage cancer, but where additional tests (camera examinat...

Who might be able to join this trial: - People who have had a colorectal polyp larger than 10mm removed during a colonoscopy using a therapeutic removal technique - People who have signed a consent form agreeing to take part in the study and to undergo colonoscopy Who may not be able to join: - People who have been di...

Who might be able to join this trial: - People who are between 45 and 75 years old - People who have never been screened for bowel cancer (colorectal cancer), or whose bowel cancer screening is no longer current - People who are not considered high risk for bowel cancer (for example, people who do not have inflammatory...

Who might be able to join this trial: - Women who have been diagnosed with stage I, II, or III rectal cancer or cancer at the junction of the rectum and sigmoid colon - The cancer's surgical join (anastomosis) must be located less than 15 cm from the anal opening - People who have had surgery to remove the cancer, with...

Who might be able to join this trial: - People who have been recently diagnosed with anal cancer for the first time, or whose anal cancer has come back after previous treatment Who may not be able to join: - People who do not have a diagnosis of anal cancer - People for whom taking a tissue sample (biopsy) or blood sa...

**Who might be able to join this trial:** - People who have been fully informed about the study and have provided written consent to participate. - People whose rectal cancer has been confirmed as adenocarcinoma (a specific type of cancer) through tissue testing. - People whose cancer has not spread to distant parts o...

**Who might be able to join this trial:** - Adults between 18 and 75 years old (men or women) - People who have been diagnosed with rectal cancer before surgery, where the tumour is located very close to the lower part of the rectum (within 3cm of a specific internal landmark, as measured by MRI) - People who do not ha...

Who might be able to join this trial: - People who have been diagnosed (confirmed by lab testing of tissue or cells) with a moderate or poorly differentiated cancer of the appendix or colon/rectum that was initially considered treatable with surgery. - People whose cancer has spread to the lining of the abdomen (perito...

Who might be able to join this trial: - People who are older than 18 years of age. - People who have been diagnosed with colorectal cancer confirmed by a tissue sample (biopsy or surgical specimen). - People whose scans (such as a CT scan with contrast dye or a PET-CT scan) have shown that the cancer has spread to the...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal adenocarcinoma (a type of bowel cancer) confirmed through laboratory testing of tissue samples - People who have had surgery to fully remove their primary bowel cancer tumour - People whose cancer is classified as high-risk Stag...

**Who might be able to join this trial:** - You are 18 years of age or older and are expected to live for at least 12 more weeks - You have been diagnosed with a specific type of colorectal cancer (called RAS and BRAF wild-type, MSS metastatic colorectal adenocarcinoma) confirmed by a tissue or cell sample — this excl...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with colorectal cancer (a type of bowel cancer) confirmed by a tissue test showing it is an adenocarcinoma (a specific cancer cell type) - People whose cancer started on the left side of the colon or rectum and has spr...

Who might be able to join this trial: - People who have a confirmed harmful genetic mutation in one of the following genes: MLH1, MSH2, MSH6, PMS2, or EpCAM - People who are of legal adult age at the time their colonoscopy is prescribed - People who agree to take part in the study - People who are enrolled in or covere...

**Who might be able to join this trial:** - People who have rectal cancer (a specific type called adenocarcinoma) and have completed a course of chemotherapy combined with radiation therapy, with follow-up scans showing no signs of remaining cancer - People whose overall physical health falls within a standard fitness...

**Who might be able to join this trial:** - People who have been diagnosed with rectal adenocarcinoma (a specific type of rectal cancer) confirmed by a biopsy - People whose cancer has been staged before treatment as a locally advanced rectal cancer (stages T3-4N0M0 or T1-4N1-2M0 under an international staging system...

**Who might be able to join this trial:** - You have been diagnosed with colorectal cancer that has spread (metastatic) and cannot be surgically removed, and lab tests confirm it is a specific type (MSS/pMMR with a RAS gene mutation) - You are generally active and able to care for yourself, with only mild limitations...

**Who might be able to join this trial:** - People aged 18 to 75 years who have been newly diagnosed - People whose rectal cancer has been confirmed by a pathology test (tissue sample analysis) as a type called adenocarcinoma - People whose tumor is located within 15cm of the anal opening - People whose MRI scan shows...

**Who might be able to join this trial:** - You are 18 years old or older at the time of signing up - You have been diagnosed with Stage I–IV colorectal cancer or another gastrointestinal cancer at some point in the last 10 years - You can speak, read, and write in English well enough to take part in the program - You...

**Who might be able to join this trial:** - People who are able to understand and voluntarily sign a consent form agreeing to take part in the study. - People who are 18 years of age or older on the day they sign the consent form, of any gender. - People who have been diagnosed with colorectal cancer (a type of bowel...

**Who might be able to join this trial:** - People who have signed a consent form agreeing to take part before any screening tests are done (non-English speakers may be eligible with the help of a language assistance service). - People who are 18 years of age or older at the time of signing the consent form. - People...

Who might be able to join this trial: - People who have previously had a polyp detected in the rectum and have been referred to have it removed. - People who are able to provide written agreement to take part in the trial. Who may not be able to join: - People who are considered at high risk of serious complications s...

Who might be able to join this trial: - The patient, or someone representing them, must have agreed to take part and signed a consent form after being fully informed about the trial - The patient must be covered by a health insurance plan - The patient must have a confirmed diagnosis of colorectal cancer - The patient...

**Who might be able to join this trial:** - Veterans who were alive at age 75 at some point between 2005 and 2019, and who had a qualifying colonoscopy in the 10 years before turning 75 - Veterans whose colonoscopy records are in a format that can be read and processed by the study's data system - Veterans aged 75 or...

**Who might be able to join this trial:** - You are willing and able to give written consent to take part and can follow the study requirements, including attending scheduled visits and treatment sessions. - You have colorectal cancer that has spread to other parts of the body (metastatic) and is getting worse, and yo...

**Who might be able to join this trial:** - You have been diagnosed with multiple separate colorectal cancers occurring at the same time, confirmed by a tissue sample (biopsy) - Lab tests on at least one of your tumors show a specific genetic feature called "mismatch repair deficiency" (dMMR) or "high microsatellite i...

Who might be able to join this trial: - People aged 18 to 70 years old at the time of signing the consent form - People who have been diagnosed with colorectal cancer that has spread to other parts of the body (metastatic), confirmed by a tissue or cell sample - People whose cancer has a specific genetic change called...

**Who might be able to join this trial:** - People aged 18 to 70 years - People whose rectal cancer has been confirmed by a tissue biopsy to be a type called adenocarcinoma - People whose cancer has reached a certain stage of growth or has spread to nearby lymph nodes, but has not spread to distant parts of the body (b...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You have had a local surgical removal of a rectal cancer (adenocarcinoma) using one of several specific procedures (such as TEM, TAMIS, EMR, ESD, or polypectomy — confirm with trial site if unsure which applies to you) - Your tumor meets...

Who might be able to join this trial: - People who have been diagnosed with a type of bowel cancer called adenocarcinoma, confirmed through laboratory testing of tissue samples - People whose cancer has been reviewed by a specialist medical team who have recommended surgery as the appropriate treatment - People who are...

Who might be able to join this trial: - People aged 40 or older who have had a colon polyp or early colon cancer removed by endoscopy (using tools such as a snare, forceps, or tissue removal techniques), where the edges of the removed tissue showed cancer cells very close to or at the margin - The removed cancer was lo...

**Who might be able to join this trial:** - You are between 45 and 84 years old at the time of signing up - You are already scheduled to have a routine screening colonoscopy as part of your normal healthcare - Your doctor or healthcare provider considers you to be at average risk for colorectal cancer - You are willing...

Who might be able to join this trial: - Adults who have been diagnosed with breast cancer or colorectal cancer, or adults who have no cancer (referred to as healthy controls) - People who are able to have a blood draw after fasting (going without food for a period of time before the test) - Pregnant women are also welc...

**Who might be able to join this trial:** **Part I – Surgery** - People who have been diagnosed with colon or rectal cancer at an early to intermediate stage (stage I, II, or III) - People who are able to understand and sign a written consent form agreeing to take part - People who are scheduled for surgery with the g...

Who might be able to join this trial: - People who have a tumour very low in the rectum and have had a specific type of surgery (called intersphincteric resection) along with a temporary bowel diversion (called a preventive ileostomy). - People who are willing to take part in the study and have signed a consent form ag...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People who have been diagnosed with colorectal cancer confirmed by laboratory tissue testing, at stage II (TNM classification) - People who had surgery to fully remove the colorectal cancer (called R0 resection) within the 12 weeks be...

Who might be able to join this trial: - People with advanced or locally advanced colorectal cancer that has a specific genetic feature known as dMMR or MSI-H - People who are expected to receive, or are already receiving, a type of cancer treatment called immune checkpoint inhibitor therapy - People who are in reasonab...

**Who might be able to join this trial:** - Adults aged 18 or older - People who are generally well and able to carry out daily activities with little or no limitation (as measured by a standard health scale used by doctors) - People who have a blockage-causing colon cancer that has been managed with a temporary openi...

**Who might be able to join this trial:** - People who have fully understood the study and have signed a consent form agreeing to take part - People aged 18 or older, of any gender - People who have been diagnosed with advanced or metastatic colorectal cancer (a type of bowel cancer that has spread), confirmed by a ti...

**Who might be able to join this trial:** - People who are at least 18 years old - People whose general health and ability to carry out daily activities falls within an acceptable range for this trial (rated on a standard scale used by doctors — confirm with trial site) - People who have been diagnosed with a specific...

**Who might be able to join this trial:** - People who have been diagnosed with stage 4 (metastatic) colorectal cancer, confirmed through a tissue sample test - People aged between 18 and 65 years old, male or female - Women who could become pregnant must be using an accepted form of contraception - People who are wel...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal cancer (cancer of the colon or rectum), confirmed through laboratory testing of tissue, at any stage of the disease - People aged 18 years or older - People who are willing and able to sign a consent form agreeing to take part -...

Who might be able to join this trial: - People who have been diagnosed with colorectal cancer that has spread to other parts of the body, confirmed by a tissue sample test. - People who have already received, were unable to receive, or chose not to receive two standard treatment courses for their cancer (specific drug...

**Who might be able to join this trial:** - People who have signed a written consent form before any study procedures begin - People aged 18 to 75 years old - People who have been diagnosed with advanced (Stage IV) colorectal cancer, confirmed through a tissue or cell sample - People whose cancer has a specific geneti...

Who might be able to join this trial: - Endoscopists (doctors who perform a type of internal examination using a flexible camera) at any level of experience, from beginners to experts Who may not be able to join: - Adults who do not give their consent to participate in the trial Important: Always verify eligibility w...

Who might be able to join this trial: - People whose rectal cancer has been confirmed by laboratory testing as a specific type called adenocarcinoma - People whose tumor is located within 12 centimetres of the opening of the rectum (the anus) - People whose primary tumor has been fully removed by surgery - People who r...

**Who might be able to join this trial:** - People who have been confirmed by tissue testing to have a type of bowel cancer called colorectal adenocarcinoma. - People whose colorectal cancer has spread to other parts of the body, as confirmed by CT scan and MRI. - People who have already received a first round of chem...

**Who might be able to join this trial:** - People who have been diagnosed with early-stage or metastatic colon or rectal cancer - People who were between 18 and 50 years old at the time of their cancer diagnosis - People who do not have major surgery planned in the 12 weeks after joining the trial (having a port plac...

**Who might be able to join this trial:** - People who are aged 18 to 70 years old at the time of signing the consent form - People whose general physical functioning is rated as good (scored 0 or 1 on a standard oncology scale), with this rating remaining stable in the 2 weeks before joining, and with an expected sur...

**Who might be able to join this trial:** - People who have been diagnosed through a biopsy with a type of rectal cancer called invasive rectal adenocarcinoma that is well or moderately developed (not the most aggressive type), and whose cancer has a normal DNA repair system. - People whose cancer stage, as seen on an...

Who might be able to join this trial: **Cohorts A and B (older adults group):** - People aged 70 years or older - People whose general health and ability to carry out daily activities falls within a certain range, as assessed using a standard medical scale (ECOG score of 0–2) - People who have been confirmed through a...

**Who might be able to join this trial:** - People aged 18 or older at the time of signing the consent form. - People who are able to understand and sign the consent form for the study. - People who are willing and able to attend all scheduled visits, follow the treatment plan, complete lab tests, and follow study pro...

**Who might be able to join this trial:** - People aged between 18 and 75 years old. - People whose general health and ability to carry out daily activities falls within an acceptable range, based on a standard medical scoring system (called ECOG performance status 0–1). - People who have been confirmed through labora...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You are generally able to carry out daily activities, with little or no limitation due to your illness (confirm with trial site) - You have been diagnosed with a specific type of colon cancer (adenocarcinoma) confirmed by a tissue sample,...

Who might be able to join this trial: - People who are willing and able to give their informed consent to participate - People who have been diagnosed with Lynch syndrome - People who are between 50 and 75 years of age at the time of joining the study Who may not be able to join: - People who currently have a type of...

**Who might be able to join this trial:** - People who are willing to sign a written consent form agreeing to take part in the study. - People aged between 18 and 75 years old (any gender). - People whose general physical fitness is rated as 0 or 1 on a standard cancer performance scale, meaning they are fully active...

Who might be able to join this trial: - People who have been diagnosed with a condition affecting the large bowel or rectum that requires urgent open abdominal surgery through a cut down the middle of the abdomen. - People who start with keyhole (laparoscopic) surgery urgently but need to be switched to open abdominal...

**Who might be able to join this trial:** **For the "Case" group (people with a diagnosis):** - Adults aged 18 or older - People who have been diagnosed with colorectal cancer or a significant colon polyp (advanced adenoma) confirmed by colonoscopy and tissue testing - People who have agreed to take part by signing a...

**Who might be able to join this trial:** - People who have signed an informed consent form before any trial-related procedures begin. - People aged 18 or older. - People who are reasonably active and able to care for themselves, with only limited physical limitations (this is measured using a standard scale called EC...

**Who might be able to join this trial:** - People who have given written consent and chosen to take part voluntarily - Adults aged 18 to 75 years old (men or women) - People diagnosed with locally advanced rectal cancer (a specific type called adenocarcinoma), confirmed by a tissue test - People whose pelvic MRI scan...

**Who might be able to join this trial:** - People who have signed an informed consent form before any study procedures begin - People aged 18 to 75 years old, of any gender - People whose general health and ability to carry out daily activities is rated at a good level (ECOG score of 0 or 1), with a life expectancy o...

**Who might be able to join this trial:** - People between 18 and 75 years of age, of any gender - People whose tumor is located in the colon, where the bottom edge of the tumor is more than 12 cm away from the anus - People who have already had surgery to remove the tumor, and whose cancer was confirmed by laboratory...

**Who might be able to join this trial:** - People who have given written consent before any trial procedures begin (if someone is physically unable to sign, a trusted person of their choice may confirm consent in writing on their behalf) - People with a confirmed diagnosis of adenocarcinoma of the colon, rectum, lowe...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with locally advanced rectal cancer and have been assessed as suitable for a "watch and wait" approach (where treatment response is monitored rather than proceeding straight to surgery), based on international guideli...

**Who might be able to join this trial:** - People aged 18 to 70 years old. - People who have been diagnosed with a specific type of colon cancer called MSS colon adenocarcinoma, confirmed through laboratory testing (either genetic testing or tissue staining methods). - People whose tumor is located less than 12cm fro...

"Who might be able to join this trial: - People who have colon cancer and are scheduled to have surgery to fully remove the cancer from the colon - People who have signed a form agreeing to take part in the trial Who may not be able to join: - People who do not wish to participate in the trial Important: Always verif...

Who might be able to join this trial: - People aged 18 or older. - People whose overall health before surgery is assessed by an anaesthesiologist as being in a low-to-moderate risk category (known as ASA physical status I, II, or III). - People who are scheduled for a planned (non-emergency) open bowel or colon surgery...

**Who might be able to join this trial:** - You have been diagnosed with stage IV colorectal cancer (on the left side of the colon) that cannot be removed by surgery, confirmed by lab testing, and your cancer has specific genetic features called "RAS and BRAF wild-type" - You are in generally good physical health and...

Who might be able to join this trial: - People who have statutory (government-provided) health insurance and have visited at least one outpatient doctor in Bavaria between 2021 and 2023 - People who live in Bavaria Who may not be able to join: - There are no listed exclusion criteria for this trial Important: Always...

Who might be able to join this trial: - People who have been diagnosed with, or are suspected of having, colorectal cancer, bowel polyps (adenoma), inflammatory bowel disease, complications from bowel diverticulosis, or other conditions that require surgical removal of part of the colon or rectum - People who are sched...

**Who might be able to join this trial:** - People who are willing to take part voluntarily and agree to follow the study requirements - People aged 18 or older - People who have been diagnosed with colorectal cancer (a specific type called adenocarcinoma) that cannot be removed by surgery, confirmed by a laboratory t...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of colon cancer (adenocarcinoma) confirmed by biopsy, including cancers in the upper part of the rectum if radiotherapy is not needed for that area - People whose cancer has spread to nearby tissue or lymph nodes but not to...

Who might be able to join this trial: - People who are over 18 years old. - People who are scheduled for planned (non-emergency) bowel or rectal surgery aimed at treating or removing a condition, such as removal of part of the colon, rectal surgery (with or without a temporary stoma bag), full colon removal, or related...

**Who might be able to join this trial:** - You must be 18 years of age or older - You have colorectal cancer that has spread locally or come back, and you are scheduled to have surgery - You are able to have CT and MRI scans - You are well enough to carry out some daily activities (your doctor will assess your general...

Who might be able to join this trial: - People who are 18 years of age or older and have been scheduled for a colonoscopy - People who are able to understand and sign a written consent form agreeing to take part in the study Who may not be able to join: - People who are under 18 years old - People who are unable to un...

Who might be able to join this trial: - People who have been diagnosed with colorectal adenocarcinoma (a specific type of bowel cancer), including those with inherited bowel cancer conditions such as Lynch syndrome, familial adenomatous polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, or serrated polypos...

Who might be able to join this trial: - People aged 50 to 69 who are part of a colorectal cancer (bowel cancer) screening program and have had a positive stool test result (a test that checks for hidden blood in the stool, with a result above 100ng/ml) - People who have given their written agreement to take part in the...

Who might be able to join this trial: - People who have been diagnosed with stage II (high-risk) or stage III colorectal cancer, based on a specific internationally used staging system (TNM classification, 8th edition). - People who have gone through the standard tests and treatments recommended by their local medical...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with colorectal cancer (a type of bowel cancer) that has spread to other parts of the body - Your cancer has been confirmed through a tissue sample (biopsy) to be a specific type called adenocarcinoma - A blood test...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed through a tissue sample with high-grade abnormal cells in the anal area (AIN2+) or invasive anal cancer - People who have been diagnosed through a tissue sample with low-grade abnormal cells in the anal area (AIN1) -...

Who might be able to join this trial: - People who have been diagnosed with rectal cancer (a type of cancer starting in the rectum) confirmed by a laboratory tissue test - People whose cancer showed a complete response — meaning no signs of cancer were found after initial treatment given before surgery (called neoadjuv...

Who might be able to join this trial: - People who have been referred for a colonoscopy after receiving a positive result from a FIT (bowel cancer stool) screening test at one of the participating screening centres Who may not be able to join: - People who have been diagnosed with colorectal cancer (bowel cancer) with...

Who might be able to join this trial: - People who have had any type of surgical removal of adenomas (growths in the bowel) larger than 20 mm, or who have had an early-stage bowel cancer (T1) removed by endoscopy (a camera procedure). - People who agree to follow the treatment and follow-up program for this trial. - Pe...

**Who might be able to join this trial:** - People who have been diagnosed with metastatic colorectal cancer (a type of colon or rectal cancer that has spread to other parts of the body, such as the liver or lungs), confirmed by a lab test, with a specific genetic feature called "microsatellite stable" (MSS) and any K...

**Who might be able to join this trial:** - People who were diagnosed with colorectal cancer (at any stage, from Stage I to Stage IV) before the age of 50. - People who went through the standard tests and procedures to diagnose and assess their cancer, and had at least one blood or tissue sample taken before starting a...

Who might be able to join this trial: - You have been diagnosed with a primary cancer (a cancer that started there, not spread from elsewhere) in the colon or rectum, confirmed by laboratory testing of tissue. - The surgery you are having or have had meets the specific definition set out in a medical guideline called t...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who are willing and able to give informed consent and follow the study's instructions throughout the trial. - People who have been diagnosed with colorectal cancer (bowel cancer) and, after having their cancer completely remo...

Who might be able to join this trial: - People who are at least 18 years old - People who have squamous cell carcinoma of the anal canal (a specific type of cancer affecting the anal canal) - People whose cancer has spread to a limited extent (described as "low burden of metastatic disease") at the time of diagnosis -...

**Who might be able to join this trial:** - You have been diagnosed with locally advanced rectal or anal cancer and are receiving a long course of radiotherapy. - You are receiving treatment that combines both chemotherapy and radiotherapy. - You are able to understand and fill in questionnaires as part of the study. -...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form. - People with a laboratory-confirmed diagnosis of colorectal cancer (CRC) that cannot be surgically removed and has spread locally or to other parts of the body — or, depending on the trial phase, people with o...

Who might be able to join this trial: - People between the ages of 45 and 75 who have been diagnosed with a high-risk neoplasm (an abnormal growth found during bowel screening) in the past 5 years — some of whom had a follow-up colonoscopy and some who did not (for the interview part of the study) - Primary care doctor...

Who might be able to join this trial: - People who have been diagnosed with rectal adenocarcinoma (a specific type of rectal cancer) confirmed by laboratory testing of tissue - People whose cancer has been assessed by MRI scan as Stage II (cancer has grown into or through the rectal wall but has not spread to nearby ly...

Who might be able to join this trial: - People of Chinese ethnicity aged between 18 and 75 years, male or female - People who have been diagnosed with colorectal cancer confirmed by a tissue biopsy, with a measurable tumour as assessed by standard imaging criteria - People whose general physical fitness and ability to...

**Who might be able to join this trial:** - People aged 18 to 65 years old at the time of screening, or people aged 66 to 70 years old who have no more than one heart, metabolic, or lung condition for which they are currently prescribed medication. - People who have been diagnosed with cancer of the rectum or the lowe...

**Who might be able to join this trial:** - People who have fully understood the study, agreed to take part, and signed a consent form. - People aged 18 to 70 years old. - People who are generally well enough to carry out daily activities with little or no limitation (as rated by a standard medical scale called ECOG,...

Who might be able to join this trial: - People who are at least 60 years old - People whose overall physical health before surgery has been rated by a doctor as falling within a low-to-moderate risk category (ASA physical status I to III) - People whose body weight falls within a healthy range for their height, specifi...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who have been diagnosed with colorectal cancer that has spread to other parts of the body (metastatic), confirmed by a laboratory test on tissue or cell samples - People whose tumour has...

**Who might be able to join this trial:** - People who have been diagnosed with advanced or spreading colorectal cancer that has a specific gene change called KRASG12C, confirmed through laboratory testing of tumour tissue, and who have already received at least one round of chemotherapy for their cancer. - People who...

Who might be able to join this trial: - People who have been diagnosed with colorectal cancer that has spread to other parts of the body (confirmed by a tissue test), and whose cancer has continued to grow after receiving standard treatments, or who are not suitable candidates for those treatments. - People with a lif...

**Who might be able to join this trial:** - People diagnosed with advanced colorectal cancer (that has spread or cannot be removed by surgery), or advanced bile duct cancer (that is locally advanced, has come back, spread, or cannot be removed by surgery) - People whose cancer tests positive for a protein called HER2,...

Who might be able to join this trial: - Adults aged 18 or older - People who have given consent to participate in the PLCRC registry, including agreement to extra blood draws, use of tissue samples for research, and being contacted about future research studies - People already enrolled in a related observational study...

**Who might be able to join this trial:** - You have been diagnosed with colorectal cancer that has spread to other parts of the body (metastatic), and testing has shown a specific gene change called a RAS mutation in your tumour - You are generally well enough to carry out light activity and care for yourself (rated 0...

Who might be able to join this trial: - People aged 18 years old or younger, of any gender - People diagnosed with colorectal cancer that has spread to other parts of the body or has grown into nearby tissues, confirmed by a tissue or cell sample test - People whose cancer can be measured on scans according to standard...

Who might be able to join this trial: - Adults aged 18 years or older who live in the UK. - People who have been diagnosed with inherited bowel cancer, or who doctors believe may have inherited bowel cancer, and who have been offered a genetic test because of this. - People who are able to understand the study and agre...

Who might be able to join this trial: - Adults aged 18 or older, of any gender - People who have been diagnosed with cancer of the colon or rectum, confirmed through laboratory testing of tissue samples - People whose colorectal cancer has spread to the brain, confirmed through laboratory testing of tissue samples - Pe...

**Who might be able to join this trial:** - Adults between 18 and 75 years old, of any gender - People whose cancer has been confirmed by laboratory testing to be a type called adenocarcinoma - People whose tumour is located close to the opening of the bowel (within 7 cm) - People who have already had a local surgical...

**Who might be able to join this trial:** - People aged between 18 and 75 years old - People who have been diagnosed with a type of colon cancer called adenocarcinoma, confirmed by laboratory testing of tissue - People whose tumor is located in a specific part of the large bowel — from the cecum (the start of the larg...

**Who might be able to join this trial:** - You are between 18 and 75 years old, are generally able to care for yourself or do light activity, and are expected to live for more than 3 months - You have been diagnosed with advanced colorectal cancer (a type called adenocarcinoma) confirmed by a tissue biopsy, and your...

**Who might be able to join this trial:** - People aged 18 or older at the time of giving consent. - People who have signed a consent form agreeing to take part and allowing their health information to be used. - People whose general physical health and ability to carry out daily activities meets a certain standard, a...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have had open or keyhole surgery that preserved the sphincter muscle and involved joining parts of the bowel together, where the join is within 15 centimetres of the anal canal - People who can adequately understand the lan...

Who might be able to join this trial: - You are 18 years of age or older (male or female) - You have been diagnosed with colorectal cancer that has spread to other parts of the body, confirmed by a lab test on a tissue or cell sample - You are generally able to carry out daily activities with little to no limitation (c...

**Who might be able to join this trial:** - People who have given written consent to take part in the study. - People aged between 18 and 75 years old. - People who have been diagnosed with colorectal cancer (a type of bowel cancer) that has spread to other parts of the body and cannot be removed by surgery, confirmed...

**Who might be able to join this trial:** - People who have been diagnosed with colorectal cancer by a doctor. - People aged 60 or older. - People who are able to read and write, or hold a conversation, in Mandarin or Taiwanese. - People who are fully alert and have no mental health or memory/thinking difficulties. - P...

Who might be able to join this trial: - People who have been referred for a colonoscopy procedure for medical reasons Who may not be able to join: - People who are pregnant - People who have a weakened immune system - People who have previously been diagnosed with a disease of the colon or rectum - People who have had...

**Who might be able to join this trial:** - People who have given written consent to take part in the study and its related tests - People who have been confirmed by tissue testing to have colorectal cancer that started on the left side of the colon and has spread to other parts of the body - People whose cancer has s...

Who might be able to join this trial: **CRC (Colorectal Cancer) Group:** - People aged 18 or older who have been diagnosed with colorectal cancer based on a colonoscopy result - People whose doctor has already decided they need a colonoscopy - People who are willing to have a stool test, colonoscopy, and tissue sample...

**Who might be able to join this trial:** - People who have given written consent to take part in the study - People aged between 18 and 75 years old, of any gender - People who have been diagnosed with a specific type of rectal cancer (called pMMR/MSS rectal adenocarcinoma) confirmed by tissue testing - People whose...

Who might be able to join this trial: - You are able to understand and agree to take part in the study by signing a consent form - You are having a keyhole (minimally invasive) surgery to remove part of the lower rectum (bowel) Who may not be able to join: - You do not wish to take part in the study - You want to do p...

Who might be able to join this trial: - You have been diagnosed with colorectal cancer that has a specific genetic feature called dMMR and/or MSI-H, and you have had surgery to remove the tumor - Your cancer has been confirmed by a pathologist as Stage II (specifically T3 or T4, with no spread to lymph nodes), AND you...

**Who might be able to join this trial:** - People who are willing and able to sign a written consent form agreeing to take part in the study. - People who have been diagnosed with a specific type of advanced (metastatic) colorectal cancer confirmed by laboratory testing — known as pMMR or MSS mCRC (confirm with trial...

Who might be able to join this trial: - People aged 18 years or older - People who have been diagnosed with colorectal cancer (bowel cancer) at any stage (I through IV), confirmed through a laboratory tissue test - People for whom blood samples can be collected from two specific locations during surgery, as well as a s...

**Who might be able to join this trial:** - People aged 18 or older at the time of signing the consent form - People who are generally well enough to carry out daily activities with little or no limitation (based on a standard medical fitness scale called ECOG, with a score of 0 or 1) - Women who could become pregnant...

**Who might be able to join this trial:** - You are between 16 and 90 years old - You have been diagnosed with cancer (primary, returned, or spread to other parts of the body) confirmed by a tissue test - Your doctors expect you to live for more than 3 months - You are reasonably active and able to care for yourself (...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with rectal adenocarcinoma (a specific type of rectal cancer), confirmed through a tissue sample - People whose rectal cancer falls within certain staging categories based on tumour size and lymph node invol...

**Who might be able to join this trial:** - People who are having a specific type of bowel surgery called an ileal pouch-anal anastomosis (IPAA) — a procedure that creates an internal pouch to replace the rectum — for either ulcerative colitis or a condition called familial adenomatous polyposis (FAP), and whose bowel...

**Who might be able to join this trial:** - You are willing and able to give written consent to take part in the study. - You are a man or woman between 18 and 75 years old. - You have been diagnosed with colorectal cancer (a type of bowel cancer) that has spread to other parts of the body, confirmed by a tissue or ce...

Who might be able to join this trial: - People between the ages of 45 and 64 - People who are due for colorectal cancer screening (a check to look for signs of bowel cancer) - People who have visited the clinic at least once in the last 6 months - People whose primary language is English or Spanish - People who have a...

**Who might be able to join this trial:** - People aged between 18 and 80 years old. - People with a general health status rated as fully active or able to carry out light work (confirm with trial site for exact rating scale used). - People who have been diagnosed with advanced or returning colorectal cancer (a type o...

Who might be able to join this trial: - You are older than 18 years of age - You are of any sex (male or female) - You have been diagnosed with cancer in the rectosigmoid area (the lower part of the large intestine where it meets the rectum) - You have been diagnosed with cancer in the upper part of the rectum Who may...

Who might be able to join this trial: - You have been diagnosed with a specific type of colorectal cancer that has spread (called MSS metastatic colorectal cancer), confirmed by laboratory testing, and it has stopped responding to a type of immunotherapy drug that targets PD1/PDL1 - Alternatively, you have a different...

Who might be able to join this trial: - Adults who are scheduled to have a colonoscopy procedure Who may not be able to join: - People who are unable to receive health education or who do not wish to take part in follow-up appointments Important: Always verify eligibility with the trial site directly before applying.

Who might be able to join this trial: - Adults aged 18 to 80 years old who have been diagnosed with colorectal or anal cancer Who may not be able to join: - People who have a disease affecting the nerves or muscles (such as muscular dystrophy or similar conditions) - People who have severe conditions present from birt...

**Who might be able to join this trial:** - People who have given written or electronic consent to take part. - Adults aged 18 years or older, of any gender. - People who have been diagnosed with colorectal cancer that has spread (metastatic colorectal adenocarcinoma), confirmed by a tissue or cell sample, with a docu...