Phase 2 Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with an advanced or spreading solid tumor (including brain tumors) that has been confirmed by lab testing to have a specific gene change in ALK, ROS1, NTRK1, NTRK2, or NTRK3
• You are generally able to carry out daily activities with little to no limitation (as measured by a standard health performance scale)
• You are at least 18 years old for Phase 1, or at least 12 years old for Phase 2 (age requirements may vary depending on location)
• You are able to swallow capsules whole, without chewing, crushing, or opening them
• You have at least one area of cancer that can be measured on a scan
• You have had previous chemotherapy or immunotherapy (this is allowed, not required)
• Any side effects from previous cancer treatments have mostly gone away before joining the trial
• You have brain involvement from your cancer that is not causing symptoms, and meet other specific conditions set by the trial (confirm with trial site)
• Your blood test results meet certain minimum levels for blood cells, kidney function, and liver function (confirm with trial site for specific numbers)
• Your doctors expect you to live for at least 3 more months

Who may not be able to join:

• You are currently taking part in another clinical trial that involves a treatment
• Your cancer has spread to the brain or surrounding areas and is causing symptoms
• You have had another type of cancer in the past 2 years, unless it was a certain type of skin cancer or a contained cancer that was fully removed
• You have had major surgery within the last 4 weeks, or certain radiation therapy within the last 2 weeks before starting the trial
• You have had significant heart problems within the last 6 months, such as a heart attack, stroke, or certain types of heart failure
• Your heart's electrical activity (measured by an ECG) shows certain abnormalities or irregular patterns (confirm with trial site)
• You have an active infection, including HIV
• You have a digestive condition such as Crohn's disease, ulcerative colitis, or another condition that affects how your body absorbs medications
• You have moderate to severe nerve damage causing symptoms such as numbness, tingling, or pain in your hands or feet
• You have a significant history of serious lung scarring or lung inflammation (note: previous radiation-related lung inflammation does not automatically exclude you — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.