Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who are able to give informed consent
• People whose general health and blood test results meet the required standards set by the trial
• People who have a stored tumour tissue sample available, or who are able to have a fresh tumour biopsy taken; people for whom a fresh biopsy is not safely possible may still be considered eligible (confirm with trial site)
• People diagnosed with certain cancers that cannot be removed by surgery, have spread locally, or have spread to other parts of the body — including head and neck squamous cell cancer, oesophageal squamous cell cancer, lung cancer (several types), bladder cancer, sarcoma, endometrial cancer, melanoma, prostate cancer that no longer responds to hormone therapy, breast cancer, ovarian cancer, cervical cancer, colorectal cancer, stomach or gastroesophageal cancer, pancreatic cancer, clear cell kidney cancer, or liver cancer
• People with measurable disease according to a standard measurement system called RECIST v1.1; people with prostate cancer that no longer responds to hormone therapy but without measurable disease may also be considered eligible
• People who are willing to use highly effective contraception from the time of joining the trial until 7 months after stopping the study treatment
• People who are not pregnant and not breastfeeding

Who may not be able to join:

• People with a medical or psychiatric condition that could affect their ability to receive or follow the planned treatment or study procedures
• People who have been treated for another cancer within the past 2 years, with some exceptions for certain low-risk cancers such as adequately treated non-melanoma skin cancer, low-grade localised prostate cancer, or carcinoma in situ
• People with a history of cancer that has spread to the brain or central nervous system, unless it has been treated, is not causing symptoms, is not currently being treated, and has not been getting worse on recent scans — people with a history of cancer spreading to the lining of the brain or spinal cord compression are also not eligible
• People who have recently received surgery, systemic cancer treatment, immunotherapy, CAR-T cell therapy, or anti-hormonal therapy within timeframes specified by the trial protocol (confirm with trial site)
• People who have previously received any treatment that specifically targets a protein called B7-H3, or any antibody-drug treatment that uses a topoisomerase-based payload
• People who have previously had a stem cell transplant (their own or from a donor) or a solid organ transplant
• People with significant heart, lung, or gastrointestinal conditions
• People with an active serious infection requiring intravenous treatment within one week before the first dose of the study drug
• People with a known history of hepatitis B or C infection, or who test positive for certain hepatitis B or C markers
• People who test positive for HIV or have a history of AIDS
• People with a history of a primary immune deficiency condition
• People who have had major surgery or a serious injury within 4 weeks before the first dose of the study drug
• People with a known allergy or sensitivity to recombinant proteins

Important: Always verify eligibility with the trial site directly before applying.