Phase 2 Pancreatic Cancer Trial, Recruiting NCT06428409 Sponsor: Merck Sharp & Dohme LLC Condition: Pancreatic Cancer
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Phase 2 Pancreatic Cancer Trial, Recruiting

NCT06428409
Recruiting Phase 2 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have colorectal cancer that cannot be removed by surgery or has spread to other parts of the body, and you have already received at least one previous cancer treatment
  • You have advanced or metastatic pancreatic ductal adenocarcinoma (a specific type of pancreatic cancer), and you have already received at least one previous cancer treatment
  • You have advanced and/or inoperable biliary tract cancer (cancer affecting the bile ducts or gallbladder), and you have already received at least one previous cancer treatment
  • You have advanced and/or inoperable biliary tract cancer and have not yet received any previous cancer treatment
  • If you have had prior cancer treatment, any side effects from that treatment have cleared up or resolved before joining the trial

Who may not be able to join:

  • You have a history of serious eye disease
  • You have received any systemic (whole-body) cancer treatment — including experimental treatments — within the last 4 weeks before the trial would begin (confirm with trial site)
  • You have a history of non-infectious lung inflammation (pneumonitis or interstitial lung disease) that required steroid treatment, currently have this condition, or have suspected lung inflammation that cannot be ruled out by standard tests at the screening stage

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 21 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Medical Director, Merck Sharp & Dohme LLC

Phone: 1-888-577-8839

Australian sites

Westmead Hospital ( Site 0003), Westmead, New South Wales
+61288908935
Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Site 0001), Brisbane, Queensland
+61736467712
Epworth Freemasons ( Site 0005), East Melbourne, Victoria
+61394268996
Frankston Hospital-Oncology and Haematology ( Site 0004), Frankston, Victoria
+61397848152
One Clinical Research ( Site 0002), Nedlands, Western Australia
+61862799466

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
20 June 2024
Est. completion
16 October 2029

Where this trial is recruiting

🇦🇺 Australia 🇨🇦 Canada 🇨🇱 Chile 🇨🇳 China 🇮🇹 Italy 🇯🇵 Japan 🇰🇷 South Korea 🇪🇸 Spain 🇨🇭 Switzerland 🇹🇼 Taiwan Turkey (Türkiye) 🇬🇧 United Kingdom 🇺🇸 United States

5 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Number of Participants Who Experience a Dose-limiting Toxicity (DLT); Number of Participants Who Experience One or More Adverse Events (AEs); Number of Participants who Discontinue Study Treatment due to an AE; Objective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as Assessed by Blinded Independent Central Review (BICR)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov