Printed from Voxsanity (voxsanity.com.au) — NCT06751329 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.
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Phase 1 Ovarian Cancer Trial, Recruiting
NCT06751329
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- You are 18 years of age or older at the time of signing the consent form.
- You are able to understand and willing to sign a written consent form agreeing to take part.
- You are reasonably active and able to care for yourself, with limited or no restriction on daily activities (based on a standard cancer performance scale scoring 0, 1, or 2).
- Doctors expect you to live for at least 3 more months.
- Your recent blood test results (taken within 7 days before starting the study drug) meet specific healthy ranges for blood cell counts, kidney function, liver function, and blood clotting — your doctor will check these for you.
- You have cancer that can be measured on a scan, following standard measurement guidelines.
- You are able to provide a tumor tissue sample taken within the last 3 years (if a new biopsy is not possible, the trial team should be contacted, as this may still be discussed).
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- You have had another active invasive cancer in the past 5 years (some exceptions may apply, such as certain skin cancers or non-invasive cancers that were fully treated — confirm with trial site).
- You have, or have had, a blood cancer (such as leukemia or lymphoma).
- You have received cancer treatments such as chemotherapy, immunotherapy, targeted therapy, or radiation recently — specific waiting periods apply depending on the treatment type (confirm exact timeframes with trial site).
- You have had major surgery within the last 4 weeks.
- You have cancer that started in the brain or has spread to the brain, unless it has been treated, is not growing, and you have been off high-dose steroids for at least 4 weeks.
- You have had a serious allergic reaction to a type of cancer drug called an antibody-drug conjugate (ADC), or you previously had to stop an ADC drug due to serious side effects.
- You have previously been treated with a specific type of ADC drug that uses a "topoisomerase I" component (confirm with trial site).
- You have taken an experimental drug within the past 4 weeks.
- You have an active, uncontrolled infection that requires intravenous (IV) antibiotics, antiviral, or antifungal treatment.
- You have a significant pre-existing lung condition (such as lung scarring, inflammation, or severe radiation-related lung damage) or a serious pre-existing eye condition.
- You have other serious uncontrolled health conditions, such as uncontrolled heart disease, immune disorders, diabetes, fluid build-up around the lungs or abdomen, or a mental health condition that would make it hard to follow the study requirements.
- Your heart's electrical activity shows a certain abnormality on an ECG (a heart tracing test) known as a prolonged QTc interval, or you are taking medicines known to affect this (confirm with trial site).
- Your heart's pumping strength is below 50%, as measured by a heart scan taken within the past 28 days.
- You have an active hepatitis B or hepatitis C infection (some people who are chronic carriers of hepatitis B or who have been successfully treated for hepatitis C may still be eligible — confirm with trial site).
- You have HIV that is not well controlled (people with well-controlled HIV meeting specific criteria may still be eligible — confirm with trial site).
- You have active tuberculosis (TB); if you are from a country where TB is common, you will be screened for it before joining.
- You have received a live vaccine within the past 30 days before starting the study drug.
- You still have significant side effects from previous cancer treatments that have not returned to a mild or baseline level (some stable, long-standing mild side effects may be acceptable — confirm with trial site).
- You are currently pregnant, breastfeeding, or planning to become pregnant during the study.
- You are able to have children but are unwilling to use effective contraception during the study and for up to 7 months after the last dose (for women) or 4 months (for men).
- You have taken certain medicines or foods that strongly affect how the body processes a specific liver enzyme (CYP3A4/5) within 2 weeks before starting the study drug (confirm specific substances with trial site).
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Status
Recruiting
Phase
Phase 1
Sponsor
Xadcera Biopharmaceutical (Suzhou) Co., Ltd.
Registry
ClinicalTrials.gov
Start date
17 February 2025
Est. completion
8 October 2027
Where this trial is recruiting
🇦🇺 Australia
🇺🇸 United States
3 site(s) in Australia. Confirm current status and contact details directly with the trial site.
Primary endpoints
Dose-limiting Toxicities (DLTs) of DM002; Maximum tolerated dose (MTD) for DM002
Can't join this trial?
Data last synced from ClinicalTrials.gov: 30 June 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.