Phase 3 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with colorectal cancer (a type of bowel cancer) that has been confirmed by a lab test and has either spread to other parts of the body or cannot be removed by surgery (Stage III unresectable or Stage IV)
• For Part 2 of the trial only: People who have not yet received full systemic cancer treatment for their advanced colorectal cancer, though having received 1–2 cycles of a chemotherapy called FOLFOX, or 1 cycle of a chemotherapy called CAPOX, before or during screening is allowed
• People whose cancer has a specific genetic change called a KRAS G12C mutation
• People living with HIV, provided their HIV is well controlled with antiretroviral medication
• People who are carriers of Hepatitis B, provided they are on antiviral treatment and the virus is undetectable in their blood
• People with a history of Hepatitis C infection, provided the virus is currently undetectable in their blood

Who may not be able to join:

• People who have active inflammatory bowel disease (such as Crohn's disease or ulcerative colitis) that requires immune-suppressing medication, or who have a clear history of such conditions including chronic diarrhoea
• People who have serious, uncontrolled heart or blood vessel disease, or uncontrolled stroke-related conditions
• People who have a known deficiency (partial or complete) of an enzyme called DPD, which affects how certain chemotherapy drugs are processed by the body
• People living with HIV who have a history of a cancer called Kaposi's sarcoma or a condition called Multicentric Castleman's Disease
• People who have received other systemic cancer treatments or experimental treatments within 4 weeks before joining the trial (with an exception for the specific optional chemotherapy mentioned above)
• People who have one or more conditions that the treating doctor considers would make treatment with a drug called bevacizumab unsafe or unsuitable
• People who have another cancer that is still growing or has required active treatment within the past 3 years
• People who have cancer that has spread to the brain or the lining of the brain or spinal cord
• People who currently have an active infection that requires treatment through the bloodstream or by mouth
• People who have not fully recovered from major surgery, or who still have complications from a recent surgery
• People who have a history of non-infectious lung inflammation (pneumonitis or interstitial lung disease) that required steroid treatment, or who currently have this condition

Important: Always verify eligibility with the trial site directly before applying.