Phase 1 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older.
• People who have a locally advanced or spreading solid tumour cancer that has a specific genetic change called a KRAS G12D mutation.
• For certain parts of the trial: People whose cancer has continued to grow despite previous standard treatments, who could not tolerate standard treatments, who are not suitable for standard treatments, who have chosen not to pursue available treatments, or for whom no standard treatment exists to improve their outcome.
• People who meet additional requirements specific to the particular group or stage of the trial, as defined in the trial protocol (confirm with trial site).
• People whose general health and ability to carry out daily activities falls within a certain range, measured by a standard medical scale called the ECOG score of 0 or 1 — meaning fully active or restricted in strenuous activity but able to carry out light work (confirm with trial site).

Who may not be able to join:

• People who have previously received any treatment that targets the KRAS G12D mutation.
• People who have been diagnosed with another invasive cancer within the past year before starting the trial.
• People who have a history of having received an organ transplant, including bone marrow or stem cell transplants.
• People who have a serious medical condition that is not well controlled.
• People who have a history of, or currently have, an abnormal heart rhythm reading on an ECG (a test that measures the heart's electrical activity).
• People whose organs such as the liver, kidneys, or bone marrow are not functioning at an adequate level.

Important: Always verify eligibility with the trial site directly before applying.