Leukaemia

**Who might be able to join this trial:** - You must be older than 1 year and younger than 31 years of age. - You must have been newly diagnosed with a type of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL) or a related condition called T-cell lymphoblastic lymphoma (T-LLy) at stage II, III, or IV. -...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with a type of blood cancer called B-cell chronic lymphocytic leukemia (CLL), confirmed using standard medical guidelines - You have received no more than one previous round of chemotherapy - Your doctors expect you...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of blood cancer called chronic myeloid leukemia (CML) in an "accelerated phase," confirmed by certain genetic markers (Philadelphia chromosome positive or BCR/ABL positive). - Your CML has stopped responding to the drug imatinib (...

**Who might be able to join this trial:** - People who are able to understand and sign a consent form agreeing to take part in the study. - People who are 18 years old or older at the time of signing the consent form. - People who are able to attend all required study visits and follow the study rules. - People who ha...

**Who might be able to join this trial:** - People aged 12 months to 21 years old at the time of joining the study. - People who have a certain type of leukemia (ALL) with a high level of cancer cells in the bone marrow (25% or more), with or without cancer spread to other areas. - People whose leukemia has not respon...

**Who might be able to join this trial:** - You are 55 years of age or older (male or female) - You have been newly diagnosed with a specific type of blood cancer called acute myeloid leukemia (AML), either appearing on its own or developing from a previous blood disorder - Your AML has gone into first remission (meani...

**Who might be able to join this trial:** - People aged 18 or older at the time of signing the consent form - People who have been formally diagnosed with Myelodysplastic Syndromes (MDS), classified using a specific medical system called the FAB classification - People who have already received an adequate course of t...

**Who might be able to join this trial:** - You must be 65 years of age or older for most parts of the trial; however, for one specific group (Cohort C), you must be either 75 or older, OR between 60 and 74 with at least one health condition that makes you unable to tolerate intensive chemotherapy (confirm with trial...

**Who might be able to join this trial:** - You have been diagnosed with a type of blood cancer called Acute Myeloid Leukemia (AML) — but not the specific subtype called Acute Promyelocytic Leukemia with a particular genetic change called t(15;17) — or a condition called Myelodysplastic Syndrome (MDS) that is classifie...

Who might be able to join this trial: - People who are under 18 years of age - People who have been diagnosed with Chronic Myeloid Leukemia (CML) — a type of blood cancer — that has tested positive for specific genetic markers known as Philadelphia positive and/or BCR-ABL positive, at any stage of the disease Who may...

Who might be able to join this trial: - People who are currently taking part in another ibrutinib clinical study that is considered complete, and who have been taking ibrutinib alone for at least 6 months (people with less than 6 months may still be considered but would need more frequent safety check-ins at the start)...

**Who might be able to join this trial:** - People who have been diagnosed with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) — meaning the disease came back or stopped responding to treatment — and whose condition meets recognised international diagnosis guidelines. - P...

**Who might be able to join this trial:** - People newly diagnosed with acute lymphoblastic leukemia (a type of blood cancer affecting white blood cells) - People newly diagnosed with a mixed type of blood cancer (called MPAL) where one blood cell type is more dominant, or where the treating doctor has a clear medical...

**Who might be able to join this trial:** - People who have already been enrolled in a related screening study called APEC14B1 and have completed the eligibility screening step before joining this trial - People who are under 22 years of age at the time of joining the study - People who have been newly and freshly dia...

**Who might be able to join this trial:** - Adults aged 18 or older who have been diagnosed with AML (a type of blood cancer), confirmed by laboratory testing of tissue or cells - People who are able to understand the trial and sign a written consent form before any study procedures begin - People who are able to swal...

**Who might be able to join this trial:** - People who have been diagnosed with Acute Myeloid Leukemia (AML, but not a specific type called acute promyelocytic leukemia), a bone marrow condition called Myelodysplastic Syndrome (MDS), or a combined bone marrow condition called MDS/MPN, confirmed using 2016 World Health...

**Who might be able to join this trial:** - **Phase 1 only:** Children aged 2 to under 18 years (pediatric group), or adults aged 18 and older (other groups), depending on the cohort. - **Phase 1:** People with acute leukemia that has come back or stopped responding to treatment, and who have run out of other availabl...

**Who might be able to join this trial:** - People who have been formally diagnosed with chronic lymphocytic leukemia (CLL) — a type of blood cancer — and whose condition now needs treatment based on internationally recognised medical guidelines. - People who previously completed a first-line (initial) treatment cours...

Who might be able to join this trial: **Main Study** - People who have been diagnosed with advanced mastocytosis — specifically Aggressive Systemic Mastocytosis (ASM), Systemic Mastocytosis with an Associated Blood Cancer (SM-AHN), or Mast Cell Leukemia (MCL), as confirmed by the trial's Eligibility Committee - People...

**Who might be able to join this trial:** - People who have been diagnosed with chronic lymphocytic leukaemia (CLL) and whose condition has reached a point where treatment is needed, based on internationally recognised medical guidelines. - People who are reasonably active and able to care for themselves, with a fitne...

**Who might be able to join this trial:** - People who have already enrolled in a related study called APAL2020SC (NCT04726241) before joining this trial — this applies only to participants at sites in the USA, Canada, Australia, New Zealand, or Blood Cancer United territory. - Children, adolescents, and young adults...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of a blood cancer called CLL (Chronic Lymphocytic Leukaemia) or SLL (Small Lymphocytic Lymphoma) that requires treatment, based on established 2018 medical guidelines - For Part 1 of the trial: People whose cancer has been tested to dete...

**Who might be able to join this trial:** - People who have been diagnosed with chronic phase CML (a type of blood cancer) that tests positive for a gene change called BCR-ABL1, with or without a specific mutation called T315I. - In the US: People whose CML has stopped responding to, or who could not tolerate, at leas...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who are able to understand the study requirements and are willing to sign a consent form - People whose key organs (such as heart, liver, and kidneys) and blood clotting ability are functioning at a sufficient level - Women wh...

**Who might be able to join this trial:** - People aged 1 to 21 years old at the time of joining the study. - People who have a blood cancer (such as certain types of leukemia, lymphoma, or related conditions) that has come back or stopped responding to treatment. - People whose cancer cells show a specific protein on...

**Who might be able to join this trial:** - People aged 18 or older. - People with a confirmed diagnosis of myelodysplastic syndrome (MDS) rated as intermediate-2 or high risk on a standard medical scoring system (IPSS), OR a type of blood cancer called Acute Myeloid Leukaemia (AML) with 20–30% abnormal cells in the b...

Who might be able to join this trial: - People who are older than 18 years of age, either male or female. - People who have been formally diagnosed with acute myeloid leukaemia (AML) or acute lymphoblastic leukaemia (ALL) that has come back or has not responded to treatment. - People whose leukaemia is not suitable for...

**Who might be able to join this trial:** - People who have been newly diagnosed with a specific type of blood cancer called Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) - People whose doctors expect them to survive for at least 3 months - People who are reasonably able to carry out daily act...

**Who might be able to join this trial:** - People aged 18 or older - People who have a confirmed diagnosis of a blood cancer called CLL or SLL, who meet established medical guidelines for treatment, and who have been taking a specific type of targeted therapy called a BTK inhibitor on its own for at least 12 months -...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of CLL/SLL (a type of blood cancer) with active disease that doctors have clearly documented as needing treatment to begin. - People who have at least one measurable sign of disease burden (confirm with trial site for specific measures)....

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form - People whose daily functioning is not severely limited by their illness (based on a standard scoring system called ECOG, with scores ranging from 0 to 2) - People who have a confirmed diagnosis of a type of blo...

Who might be able to join this trial: - People aged 18 or older who provide written consent before any study procedures begin. - People diagnosed with acute myeloid leukaemia (AML) whose disease has returned or did not respond to their first round of treatment (with or without a stem cell transplant). - People in Group...

Who might be able to join this trial: - Adults aged 18 years or older. - People with a confirmed diagnosis of relapsed or refractory acute myeloid leukemia (a blood cancer that has come back or stopped responding to treatment), or related blood/bone marrow conditions (MDS/AML or MDS with excess blasts), who are unable...

Who might be able to join this trial: - People with a confirmed diagnosis of a specific blood cancer called B-precursor B-ALL, or a type of lymphoma called DLBCL or Burkitt lymphoma, as classified by the World Health Organization (WHO). - People with a confirmed diagnosis of neuroblastoma (a type of nerve tissue cancer...

**Who might be able to join this trial:** - People who have been diagnosed with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has not yet been treated, and whose condition meets specific medical guidelines (from 2018) that indicate treatment is needed, with a life expectancy of more than...

**Who might be able to join this trial:** - You have been newly diagnosed with a type of blood cancer called AML (acute myeloid leukemia) that has been confirmed by a lab test, and you have not yet received any treatment for it. - Your AML cells have any level of a protein called CD123 on their surface (confirm with t...

**Who might be able to join this trial:** - You have been diagnosed with a type of blood cancer called AML (but not a specific subtype called APL) or MDS, confirmed using standard medical guidelines. - If you have AML and have already received treatment that did not work or stopped working, you may be eligible. - If y...

**Who might be able to join this trial:** - People who have signed the official consent form for this study - People who have a confirmed diagnosis of chronic lymphocytic leukaemia (CLL), including less common forms with slightly different cell markers - People who have previously been treated with a cancer medication...

**Who might be able to join this trial:** - People who have been diagnosed with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL) and whose condition currently needs treatment, based on recognised medical guidelines. - People who have previously been treated for CLL or SLL with two specific types...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who have been diagnosed with a specific type of acute myeloid leukemia (a blood cancer) that has not yet been treated, involving particular gene changes (called KMT2Ar or NPM1m), with at...

Who might be able to join this trial: - You must already be taking part in a qualifying Lilly-sponsored clinical study that is testing a medicine called pirtobrutinib. Who may not be able to join: - The specific reasons that would stop someone from joining are set out separately in each individual study and may vary d...

Who might be able to join this trial: - People who have a confirmed diagnosis of CLL (Chronic Lymphocytic Leukemia) or SLL (Small Lymphocytic Lymphoma), confirmed according to internationally recognised diagnostic standards - People who have already received at least one previous treatment for CLL/SLL, where each treat...

**Who might be able to join this trial:** - You are 18 years of age or older - You are receiving strong chemotherapy to prepare for a stem cell transplant (using your own or a donor's cells) or a CAR T cell therapy, OR you are receiving chemotherapy to treat acute leukaemia - You developed a fever (temperature of 38°C...

Who might be able to join this trial: - The person's organs (such as liver and kidneys) must be working well enough to meet the trial's requirements. - The person (or their partner) must use contraception in line with local guidelines during the study. - For Module 1 – the person must have an advanced blood cancer, suc...

**Who might be able to join this trial:** - You have been recently diagnosed with AML (a type of blood cancer) that has not yet been treated, and your doctors consider you a candidate for intensive chemotherapy. - Your AML has a specific genetic change called an NPM1 mutation. - Your general health and ability to carry...

**Who might be able to join this trial:** - Adults who have been diagnosed with a type of blood cancer called CLL (chronic lymphocytic leukemia) that needs treatment, and who have not yet received any treatment for it - People whose general health and ability to carry out daily activities falls within an acceptable ran...

**Who might be able to join this trial:** - You have been diagnosed with acute myeloid leukemia (AML), confirmed by a lab test on a tissue or bone marrow sample. - Your AML has come back for a second time or more, OR it has not responded to at least two different treatment attempts. - A lab test (called flow cytometry...

**Who might be able to join this trial:** - You must be willing and able to sign a consent form before joining the study (for children, a parent or guardian will do this) - You must be aged 1 year old up to (but not including) 18 years old when you enroll - You must have been diagnosed with a specific type of leukemia...

**Who might be able to join this trial:** - People who have read, understood, and signed a written consent form before any study activities begin, and who understand the possible risks and side effects involved. - Adults aged 18 to 55 years (inclusive) at the time of screening. - People with a body mass index (a measu...

Who might be able to join this trial: - The patient's caregivers (and the patient themselves, where possible) have agreed in writing to take part in the trial. - The patient has a confirmed diagnosis of MDS (myelodysplastic syndrome) or JMML (juvenile myelomonocytic leukemia), confirmed through cell appearance and gene...

Who might be able to join this trial: - You have been diagnosed with untreated AML (a type of blood cancer) or a high-risk blood disorder called MDS, and your cancer cells have one of these specific genetic changes: t(8;21), inv(16), or t(16;16) - You are willing and able to sign a written consent form to take part in...

Who might be able to join this trial: - You have been diagnosed with chronic myeloid leukemia (CML) at any stage of the disease (early/chronic stage, accelerated stage, or advanced/blast stage) - You have previously been treated with at least one approved medication for CML (such as imatinib, dasatinib, or nilotinib) -...

Who might be able to join this trial: - People who have been diagnosed with a type of blood cancer called CLL (Chronic Lymphocytic Leukemia) or SLL (Small Lymphocytic Lymphoma), either currently receiving treatment, previously treated, or approaching the point where first treatment is about to begin - People who have b...

**Who might be able to join this trial:** - You have a suspected diagnosis of acute myeloid leukemia (a type of blood cancer) or a related blood condition, whether newly diagnosed or returning after previous treatment - You are 18 years of age or older (there is no maximum age limit) - You are willing and able to sign...

Who might be able to join this trial: - People who have been diagnosed with a specific type of blood cancer called APL (Acute Promyelocytic Leukaemia), confirmed by specific genetic tests showing a particular gene change called PML-RAR-alpha - People who are able to understand the study and are willing to sign a writte...

Who might be able to join this trial: **Cohort 1 (Newly diagnosed AML or high-risk MDS — generally age 60 and older)** - People diagnosed with AML (acute myeloid leukaemia) for the first time, or with high-risk MDS (a bone marrow condition with at least 10% abnormal cells or a high-risk score), who have not yet receiv...

**Who might be able to join this trial:** - People who have been diagnosed with recurring B-cell lymphoma or leukemia (ALL or CLL), or who were newly diagnosed but are unable to receive or complete standard treatment, or who have a form of aggressive B-cell lymphoma that has come back or stopped responding to treatmen...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who have been diagnosed with an advanced blood cancer that has a specific genetic change called an IDH1 R132 mutation, confirmed by laboratory testing. - People who are willing to provide repeated bone marrow, blood, and urin...

**Who might be able to join this trial:** - People who have been diagnosed with hairy cell leukemia, confirmed through a laboratory examination of their tissue samples - People whose hairy cell leukemia has been detected in the bone marrow and blood using specific laboratory tests that look for certain markers on the...

**Who might be able to join this trial:** - People who have been diagnosed with Fanconi anemia. - People who have one of the following blood-related conditions: (1) Severe Aplastic Anemia (very low bone marrow activity) or a severe drop in one type of blood cell, along with very low platelet counts, very low white blo...

Who might be able to join this trial: **For patients (to enter the study):** - People aged 6 months to 80 years - People who are planning to have, or have already had, a stem cell transplant from a donor (either full-strength or reduced-strength conditioning) - People diagnosed with high-risk AML (a type of blood canc...

**Who might be able to join this trial:** - People who do not have a brother or sister whose tissue type (HLA) is a full match, and whose medical team has recommended a stem cell transplant from another person but feels they are not a good fit for other currently open transplant studies at the institution - People who...

**Who might be able to join this trial:** - People who have been newly diagnosed with AML (a type of blood cancer called Acute Myeloid Leukaemia) - People who do not speak English may still be eligible, as a translated short consent form is available **Who may not be able to join:** - People who have a medical reason...

**Who might be able to join this trial:** **At the start of the trial (diagnosis stage):** - Adults aged 18 to 60 years old - People who have been newly diagnosed with acute myeloid leukaemia (AML), whether it developed on its own or arose from a prior blood condition or previous cancer treatment - People who have not...

**Who might be able to join this trial:** - People who have been newly diagnosed with or have had a return of acute leukemia, including those whose leukemia did not respond to initial treatment attempts. - People diagnosed with certain blood and bone marrow conditions — myelodysplastic syndrome (MDS), myeloproliferati...

Who might be able to join this trial: - People who have been diagnosed with one of the following blood and bone marrow conditions: Atypical chronic myeloid leukemia (aCML), chronic eosinophilic leukemia-not otherwise specified (CEL, NOS), chronic myelomonocytic leukemia (CMML), chronic neutrophilic leukemia (CNL), esse...

**Who might be able to join this trial:** - You are 18 years of age or older - If you are a woman who could become pregnant, you must be using reliable birth control during the study and for 30 days after your last dose of study medication, or you must have gone through menopause or had a surgical procedure that means...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of one of the following blood cancers: chronic lymphocytic leukaemia (CLL), B-cell or T-cell prolymphocytic leukaemia (B-PLL or T-PLL), small lymphocytic lymphoma (SLL), T-cell or NK-cell large granular lymphocytic leukaemia (T or NK-LGL...

Who might be able to join this trial: - People diagnosed with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who have a parent, child, or sibling (first-degree relative) or grandparent, grandchild, aunt, uncle, niece, nephew, or half-sibling (second-degree relative) who has been diagnosed with acute leu...

**Who might be able to join this trial:** - People aged 18 or older who have been diagnosed with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or a rare blood cancer called BPDCN, confirmed by laboratory testing according to 2016 WHO guidelines - People whose cancer cells have been tested within the pa...

**Who might be able to join this trial:** - People who have been diagnosed with a type of blood cancer called CLL (chronic lymphocytic leukemia) and whose cancer has specific high-risk genetic features — including a missing piece of chromosome 17 (del(17p)), a faulty TP53 gene, or a complex pattern of chromosome abnor...

**Who might be able to join this trial:** - You have been newly diagnosed with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL) that tests positive for a protein called CD-22 (but not the "Burkitt type" of ALL) - You are between 18 and 39 years old - You are reasonably well and able to carry out...

**Who might be able to join this trial:** - People who have been diagnosed with Acute Myeloid Leukemia (AML), including a specific type called acute promyelocytic leukemia, based on World Health Organization diagnostic standards. - People who are 18 years of age or older — there is no maximum age limit. - People who ar...

**Who might be able to join this trial:** - People who are older than 2 years of age - People whose cancer cells have been tested and show specific markers (called CD33, CD38, CD56, CD123, MucI, and CLL1) detected through laboratory testing of tissue or blood samples - People who are in reasonably good general health...

**Who might be able to join this trial:** **For the patient:** - Adults aged 18 or older - People who have a diagnosis of AML (a type of blood cancer) or MDS-EB (a bone marrow disorder) and whose medical team has determined they need a specific type of stem cell transplant called a haplo-HSCT - People for whom no full...

**Who might be able to join this trial:** - People who have chronic lymphocytic leukemia (CLL), which is a type of blood cancer, and are starting a medication called venetoclax as part of their treatment, in line with the approved guidelines for its use in their country. **Who may not be able to join:** - There are no...

**Who might be able to join this trial:** - People who are covered by a social security health scheme or an equivalent benefit program - People who have read, understood, and signed a written consent form agreeing to take part - People aged 60 to 74 years old who have been diagnosed with a new or secondary form of acut...

Who might be able to join this trial: - Adults aged 18 years or older who are being treated in a hematology (blood disorder) department - People with a type of blood cancer called AML (acute myeloid leukaemia) who are well enough to receive intensive treatment, including an initial treatment phase and follow-up intensi...

**Who might be able to join this trial:** - Adults aged 18 or older - People diagnosed with a specific type of blood cancer called Philadelphia chromosome-positive Chronic Myeloid Leukemia (CML) in its chronic (early) phase, whose previous treatment with targeted therapy drugs (including one called Imatinib) either st...

Who might be able to join this trial: - Adults over 18 years of age - People who are generally able to carry out daily activities with little or no limitation (confirmed by a standard medical assessment called ECOG performance status below 2) - People whose disease has a specific genetic change called IDH1-R132 mutatio...

Who might be able to join this trial: - People who have been diagnosed with a type of lymphoma called B-cell non-Hodgkin lymphoma (B-NHL) and have completed at least one round of chemotherapy treatment. - People with B-NHL whose cancer is in complete remission and who finished chemotherapy within the last 12 months. -...

Who might be able to join this trial: - People who have signed a consent form agreeing to take part and allowing their personal health information to be shared. - People who are 18 years of age or older at the time of signing the consent form. - People who are scheduled to receive, or to donate for, a stem cell transpl...

**Who might be able to join this trial:** - People who have been newly diagnosed (with no prior treatment) with a specific type of blood cancer called B-precursor acute lymphoblastic leukemia (ALL), confirmed by standard testing. - People whose leukemia has a specific genetic pattern called "Ph-like," identified throu...

Who might be able to join this trial: - People who have been diagnosed with acute myeloid leukemia (a type of blood cancer) that has not yet been treated, though some limited prior treatments are allowed (confirm with trial site). - People aged 50 years or older. People under 50 who are not suitable for standard intens...

**Who might be able to join this trial:** - People diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), high-risk myelodysplastic syndrome (MDS), or mixed/biphenotypic leukemia (MPAL) that fits one of several specific disease situations, including: being in first remission but still showing...

**Who might be able to join this trial:** - People diagnosed with a type of blood cancer called AML (acute myeloid leukemia), or a related leukemia that includes a myeloid component, whose cancer has not responded to or has come back after previous treatment — including cases where the leukemia is found outside the bo...

**Who might be able to join this trial:** - You are over 65 years old - Your doctors expect you to live for more than 1 year - You have been diagnosed with one of the following cancers: colon cancer, breast cancer, lymphoma, chronic lymphocytic leukaemia, chronic myeloid leukaemia, or myeloma - You are willing and able...

**Who might be able to join this trial:** - People who have been diagnosed with acute myeloid leukemia (AML) based on specific 2016 medical guidelines — but not the subtypes known as acute promyelocytic leukemia (APL) or biphenotypic AML. - People whose AML is at a very low, hard-to-detect level (called MRD-positive)...

Who might be able to join this trial: - People with acute leukemia who have a specific gene rearrangement (MLL-r, TLS-ERG, or SIL-TAL1) and whose leukemia was still detectable at a low level through testing done before a stem cell transplant Who may not be able to join: - People who are pregnant - People with a severe...

**Who might be able to join this trial:** - People aged 12 to 78 years (or 12 to 65 years, depending on the type of transplant and donor match — confirm with trial site) - People diagnosed with acute myeloid leukemia, acute lymphoblastic leukemia, mixed phenotype leukemia, or high/very high risk myelodysplastic syndro...

Who might be able to join this trial: - The patient must be a newborn baby - The baby must weigh between 2 and 6 kilograms - The baby must need, or already have, a special type of central line (a tube inserted into a large vein through the belly button, called an umbilical venous catheter) Who may not be able to join:...

**Who might be able to join this trial:** - People newly diagnosed with T-cell or B-cell precursor acute lymphoblastic leukaemia (ALL), confirmed by an approved laboratory at a participating cancer or blood disease centre. - People who are between 0 and 45 years old (up to the day before their 46th birthday) at the ti...

**Who might be able to join this trial:** - People who have been diagnosed with certain blood cancers or solid tumours confirmed by laboratory testing, including chronic myeloid leukaemia (CML), acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML), other leukaemias, lymphoma, brain tumours, or other soli...

**Who might be able to join this trial:** - You are willing and able to give written consent to take part voluntarily. - You are a man or woman between 18 and 75 years old. - You have been diagnosed with acute myeloid leukemia (AML) or a bone marrow condition called Myelodysplastic Syndrome (MDS) (this is for the firs...

**Who might be able to join this trial:** - Adults aged 18 to 75 years old - People who have been diagnosed with a type of blood cancer called CLL (Chronic Lymphocytic Leukaemia) or SLL (Small Lymphocytic Lymphoma), confirmed using standard diagnostic guidelines - People who have not previously received treatment for...

**Who might be able to join this trial:** - You have been diagnosed with a type of blood cancer called CLL (Chronic Lymphocytic Leukemia) or SLL (Small Lymphocytic Lymphoma). - Your disease is considered "active," meaning you have at least one of the following: lost 10% or more of your body weight in the last 6 months...

**Who might be able to join this trial:** - You must be older than 6 months of age. - Your leukemia (AML) cells must have been tested and confirmed to carry certain markers called CLL-1, CD123, and/or CD33, found through a lab test or bone marrow/blood analysis. - You must be in reasonably good general health, able to...

**Who might be able to join this trial:** - People who have been diagnosed with AML, MDS (including JMML), or certain bone marrow disorders (CMML, myelofibrosis, or MDS/MPN) that have come back or did not go away after a stem cell transplant, with measurable signs of disease still present. - People whose disease is st...

**Who might be able to join this trial:** - People who are older than 6 months of age. - People whose cancer cells have been confirmed, through laboratory testing, to carry a specific protein called CD7 (or similar surface proteins) on their surface. - People who are in generally good physical health, as measured by a...

**Who might be able to join this trial:** - People who are able to give written consent to participate in the study - People who have been diagnosed with acute myeloid leukemia (a type of blood cancer) - People who received a standard first-round chemotherapy treatment (known as "7+3") between 14 and 33 days before st...

**Who might be able to join this trial:** - People who are scheduled to receive a bone marrow transplant **Who may not be able to join:** - No specific exclusion criteria were listed in the official trial information (confirm with trial site) **Important: Always verify eligibility with the trial site directly before...

Who might be able to join this trial: - Adults aged 18 or older who have been diagnosed with a blood cancer involving a specific gene change called a FLT3 mutation (either FLT3-ITD or FLT3 D835 type), including certain types of leukaemia (AML) or related blood disorders (CMML or other MDS/MPN conditions rated as inter...

**Who might be able to join this trial:** - People who have been diagnosed with a type of blood cancer called acute myeloid leukaemia (AML) that has come back or stopped responding to treatment, and who are not eligible for standard treatment options. - People whose AML has returned after a first period of remission a...

**Who might be able to join this trial:** - People aged 18 or older - People in Cohorts 1–3 who have been diagnosed with MDS (myelodysplastic syndrome) according to standard medical guidelines, and whose disease is classified as low or intermediate-1 risk on standard scoring systems - People in Cohort 4 who have been...

**Who might be able to join this trial:** - People who are able to show they understand the trial and have voluntarily signed a consent form - People aged 18 years or older - People who have been diagnosed with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS), whose disease has come back or has...

**Who might be able to join this trial:** *For the monotherapy parts of the trial (Phase 2 and Phase 3 — for people with MDS, CMML, or related blood disorders):* - People with a confirmed diagnosis of MDS (myelodysplastic syndrome), CMML (chronic myelomonocytic leukemia), or a related blood disorder, where a doctor h...

**Who might be able to join this trial:** - You have been diagnosed with acute myeloid leukemia (AML) that has come back or stopped responding to treatment, or you have a high-risk form of a bone marrow condition called MDS, confirmed by a tissue test. - You are 18 years of age or older. - Your heart, liver, kidneys,...

**Who might be able to join this trial:** - People who have signed a consent form before any study procedures begin - Male and female patients who have been diagnosed with a type of blood cancer called B-cell acute lymphoblastic leukaemia (B-ALL) that has a specific marker called CD19 on the cancer cells - Patients in...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed with a type of blood disorder called a myeloproliferative neoplasm (MPN) — which may include polycythemia vera, essential thrombocythemia, primary or secondary myelofibrosis, or related conditions — and whose disease h...

**Who might be able to join this trial:** - You have been newly diagnosed with a type of blood cancer called acute lymphoblastic leukaemia (ALL) — either T-cell ALL or B-cell precursor ALL — confirmed by an approved laboratory. - You are between 0 and 45 years old at the time of diagnosis (with a specific exception fo...

**Who might be able to join this trial:** - Adults aged 18 or older; for those over 60, a health scoring tool (HCT-CI) must show a score of 5 or below; people aged 75 or older would need their case reviewed and approved at a special medical team meeting before joining - People diagnosed with a type of blood cancer cal...

**Who might be able to join this trial:** - People who have given written consent to participate in the study - People who have been newly diagnosed with a specific type of acute myeloid leukaemia (AML) — for the Phase I part (MODULE), this includes certain genetic subtypes (t(8;21), inv(16)/t(16;16), FLT3-ITD, or FLT...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with T-cell prolymphocytic leukemia (a rare type of blood cancer affecting white blood cells) **Who may not be able to join:** - People who have not signed the required consent form agreeing to take part in the trial...

Who might be able to join this trial: - People who are older than 6 months of age - People who have a B cell blood cancer that has come back after previously receiving a type of treatment that targets a protein called CD19 - People whose cancer cells carry at least one of the following markers on their surface: CD22, C...

**Who might be able to join this trial:** - People aged 14 years or older who have been diagnosed with acute leukemia of ambiguous lineage (a type of blood cancer that has features making it difficult to classify as one specific type) - People whose general physical functioning is rated at a level of 2 on a standard m...

Who might be able to join this trial: - Children who have been diagnosed with end-stage liver disease - Children who have received a liver transplant at the hospital running this trial - Families who have provided informed consent to participate - Families who are able to attend long-term follow-up appointments at the...

Who might be able to join this trial: - People who are reasonably active and able to care for themselves, with a daily functioning score rated at 0, 1, or 2 on a standard oncology scale (called ECOG performance status) - People whose cancer has been tested by a local lab and found to have a specific gene mutation calle...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with T-cell prolymphocytic leukemia (T-PLL) that has come back or stopped responding to treatment, still has signs of active disease, and who have already received at least one prior treatment - People who h...

**Who might be able to join this trial:** - People diagnosed (according to WHO 2016 criteria) with one of the following blood or bone marrow conditions: relapsed or treatment-resistant acute myeloid leukemia (AML), mixed phenotype acute leukemia (MPAL), chronic myelomonocytic leukemia (CMML), higher-risk myelodysplast...

**Who might be able to join this trial:** - People who have been diagnosed with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL) that now needs treatment again, and who previously had at least a partial response to treatment with venetoclax-rituximab or venetoclax-obinutuzumab as part of specifi...

**Who might be able to join this trial:** *For people with B-ALL (a type of blood cancer affecting B-cells):* - People aged 3 to 70 years - People who have been diagnosed with a type of B-cell leukemia called CD19+ B-ALL, confirmed by laboratory testing according to established medical guidelines - People whose cancer...

**Who might be able to join this trial:** *For people with B-cell acute lymphoblastic leukaemia (B-ALL):* - A confirmed diagnosis of a type of blood cancer called CD19-positive B-ALL, based on established medical guidelines - The cancer has come back or has not responded to treatment, meeting at least one of these sit...

Who might be able to join this trial: - People who meet the medical requirements for a blood cell collection procedure (called leukapheresis), or who have already had cells collected and stored according to recommended guidelines. - People (or their parent, guardian, or legal representative) who are willing and able to...

**Who might be able to join this trial:** - People who have been diagnosed with Chronic Lymphocytic Leukaemia (CLL) or Small Lymphocytic Lymphoma (SLL) according to established medical guidelines - People whose disease has reached a point where treatment is considered necessary according to current CLL guidelines - Pe...

**Who might be able to join this trial:** - You are 21 years old or younger and do not have a suitable matched donor available within the needed timeframe - You have been diagnosed with Acute Myeloid Leukemia (AML) that is in first or second remission, or has come back or not responded to treatment with very few cance...

Who might be able to join this trial: - Children between 1 month and 18 years of age who experience a cardiac arrest while already in hospital Who may not be able to join: - Children who are receiving mechanical heart or lung support (such as ECMO or a ventricular assist device) at the time of their cardiac arrest - C...

**Who might be able to join this trial:** - People who have been diagnosed with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL) that has transformed into a specific type of aggressive lymphoma called diffuse large B-cell lymphoma (DLBCL), confirmed by a biopsy - People who are 18 years of age o...

**Who might be able to join this trial:** - People aged 18 or older. - People who are able to understand and sign a written consent form. - People whose cancer has not significantly limited their ability to carry out daily activities (based on a standard performance scale scored 0, 1, or 2). - People with CLL or SLL (...

**Who might be able to join this trial:** - People aged 18 to 65 years old at the time of joining the trial - People who have a blood cancer or other cancer of the blood system - People whose doctors have determined they are suitable to receive a stem cell transplant from a donor, and are well enough to receive the sp...

**Who might be able to join this trial:** **Phase II (for people aged 18 to 70):** - People aged 18 to 70 years, including those who speak languages other than English - People diagnosed with acute myeloid leukaemia (AML) who have already received initial treatment, and who also have at least one higher-risk feature —...

**Who might be able to join this trial:** **For people with a blood or bone marrow condition (main study group):** - People diagnosed with low-risk Myelodysplastic Syndrome (a bone marrow condition where the bone marrow does not make enough healthy blood cells), classified as very low or low risk, with less than 5% ab...

**Who might be able to join this trial:** - People who have been diagnosed with B-cell acute lymphoblastic leukemia (a type of blood cancer) where testing of the bone marrow shows no detectable cancer cells remaining (less than 0.01%), AND who fall into at least one of these groups: their cancer came back and then wen...

Who might be able to join this trial: - People who are aged 18 years or older but under 65 years old - People who have active CLL (chronic lymphocytic leukaemia) or SLL (small lymphocytic lymphoma) that currently needs treatment, based on international guidelines from 2018 - People who have never previously received tr...

**Who might be able to join this trial:** - People who have been diagnosed with chronic phase chronic myeloid leukaemia (CML), a type of blood cancer, and were treated with a type of medication called a TKI (either alone or combined with other drugs such as interferon or a vaccine targeting the disease). - People who...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been newly diagnosed with AML (acute myeloid leukaemia) that has not yet been treated, including de novo (arising on its own), secondary (arising from another condition), or treatment-related AML - People who have AML...

**Who might be able to join this trial:** This trial has three groups. People may be considered for one of the following groups: **Group A (Healthy volunteers):** - Adults aged 18 or older - No previous history of cancer - A history of normal blood counts and vital signs on routine check-ups - Willing and able to pro...

Who might be able to join this trial: - People under 18 years of age who have been newly diagnosed with a type of blood cancer called APL (acute promyelocytic leukaemia), confirmed by a specific genetic marker known as the PML/RARα fusion gene - Cases where a parent or legal guardian has provided written consent for th...

**Who might be able to join this trial:** - Children from birth up to 18 years old - Children who have been diagnosed with Acute Lymphoblastic Leukaemia (ALL) for the first time - Children whose leukaemia has not been treated with chemotherapy before - Children whose leukaemia cell type is classified as FAB L1 or L2 (s...

**Who might be able to join this trial:** - People who have been diagnosed with acute myeloid leukemia (AML) or a related high-grade blood cancer, including certain mixed-type acute leukemias, based on recognised medical classification systems - For the first part of the trial (Phase I): People who are newly diagnosed...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have a measurable amount of disease that can be tracked during the trial - People with slow-growing (indolent) forms of non-Hodgkin lymphoma whose disease has reached a point where treatment is needed according to standard...

**Who might be able to join this trial:** This trial has two groups (Cohort A and Cohort B). Please read the section that may apply. --- **Cohort A — Large B-cell lymphoma:** Who might be able to join this group: - People aged 19 or older who are willing to give written consent to participate - People who have bee...

**Who might be able to join this trial:** - You are 18 years old or older - You are able to understand and agree to participate by signing a consent form - You are able to attend scheduled visits and follow the study's requirements - You have been diagnosed with cutaneous T-cell lymphoma (a type of skin cancer affecti...

Who might be able to join this trial: - Adults who have been diagnosed with, or are suspected of having, myelodysplastic syndrome (a type of blood/bone marrow disorder) at the time of diagnosis or during ongoing monitoring - People whose care is managed at the Cancer-Hematology Institute of Brest CHRU (a specific hospi...

**Who might be able to join this trial:** - People who are male or female and at least 12 years old. - People who weigh at least 40 kilograms (about 88 pounds). - People who have a confirmed diagnosis of AML (acute myeloid leukemia), ALL (acute lymphoblastic leukemia), or MPAL (mixed phenotype acute leukemia), and who...

**Who might be able to join this trial:** **For the cell donor (a family member):** - The donor must be 18 years of age or older - The donor must be a family member who is at least a partial match (at least 3 out of 6 markers) with the patient - The donor must test negative for HIV - Female donors of childbearing age...

**Who might be able to join this trial:** - A suitably matched unrelated donor is available for the person (either a 9 out of 10 or 10 out of 10 match) - The treating team is planning to use one of a specific set of reduced-intensity chemotherapy preparation regimens before the transplant (combinations involving fluda...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have given written consent to participate in the study. - People who have been diagnosed with a specific type of blood cancer called APL (Acute Promyelocytic Leukaemia), either as a first-time (primary) or treatment-related (secondary)...

Who might be able to join this trial: - Children and teenagers aged 1 to under 18 years old (for the pediatric medicine group), or teenagers aged 14 to under 18 and weighing at least 40 kg (for the adult medicine group). - People diagnosed with a specific type of chronic leukemia called Philadelphia chromosome-positive...

Who might be able to join this trial: - Adults aged 18 or older who have been diagnosed with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). - People whose CLL or SLL is considered active and needs treatment, shown by at least one of the following: worsening anaemia or low platelet counts; a ve...

**Who might be able to join this trial:** - People who are able to understand the study, follow its procedures, and give informed consent before any study-related steps begin — including keeping to a specific blood-testing schedule during the first treatment cycle. - People who have a confirmed cancer diagnosis, speci...

Who might be able to join this trial: - People aged 18 or older who are suspected of having a new diagnosis of AML (a type of blood cancer) or MDS (a bone marrow disorder), and for whom a specific type of diagnostic genetic test through Barnes-Jewish Hospital has been requested or is planned to be requested. - People w...

**Who might be able to join this trial:** - People who have been diagnosed with relapsed or treatment-resistant acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), or a related type of acute leukaemia, and whose disease has continued to grow after standard treatments have been tried. - At certain trial...

**Who might be able to join this trial:** - Adults over 18 years old who have been newly diagnosed with a specific type of blood cancer called AML (but not the M3 subtype), confirmed by tissue testing, including AML that developed from a previous blood disorder or as a result of prior cancer treatment - People whose A...

**Who might be able to join this trial:** - People diagnosed with a specific type of leukemia called CML (chronic myeloid leukemia) that is linked to a genetic change known as the Philadelphia chromosome or BCR-ABL, where diagnosis was made within the last 12 months (called "early chronic phase"). - People who have ha...

Who might be able to join this trial: - You have been diagnosed with B-cell Acute Lymphoblastic Leukemia (a type of blood cancer) that has come back or has not responded to treatment, and your cancer cells test positive for certain proteins called CD19, CD20, and/or CD22. - You are between 1 and 25 years old. - Your do...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form agreeing to take part in the study - People who are willing to follow all study procedures and are available for the full duration of the trial - People whose general health and ability to carry out daily activities meet...

**Who might be able to join this trial:** - You have been diagnosed with B-cell acute lymphoblastic leukaemia or lymphoma that has come back, did not respond well to initial treatment, or has shown signs of remaining disease after treatment, as measured by specific lab tests - Your leukaemia has certain high-risk gene...

**Who might be able to join this trial:** - People who have been diagnosed with T-cell acute lymphoblastic leukaemia or lymphoma that has come back after treatment (relapsed), where disease is detected in the bone marrow, the fluid around the brain and spinal cord, the eye, brain, testes, or other areas of the body. -...

**Who might be able to join this trial:** - People diagnosed with high-risk acute B cell lymphoblastic leukemia (a type of blood cancer) who have been recommended for a stem cell transplant from a donor - People who have a suitable donor available — this could be a matched brother or sister, an unrelated donor who is...

**Who might be able to join this trial:** - People aged 21 years or younger. - People diagnosed with acute myeloid leukemia (AML) or a related type of acute leukemia (called acute leukemia of ambiguous lineage) that has either not responded to at least two rounds of chemotherapy, or has come back after treatment — wit...

**Who might be able to join this trial:** - People aged 30 years or younger (note: the first three people enrolled must be at least 18 years old). - People whose AML cancer cells carry a protein called CD33 (detected by a lab test called flow cytometry), AND whose AML fits at least one of these situations: their leuka...

Who might be able to join this trial: - Adults diagnosed with Acute Myeloid Leukemia (a type of blood cancer) whose cancer has come back after receiving a stem cell or bone marrow transplant from a donor (whether a family member or an unrelated donor), where the transplant could have used bone marrow, blood stem cells,...

**Who might be able to join this trial:** - People who are adults (18 years of age or older). - People who are covered by a social security scheme (such as health insurance through a social security system). - People who have been diagnosed with Chronic Myeloid Leukemia (a type of blood cancer) and are currently taking...

**Who might be able to join this trial:** - Adults aged 18 or older - People who are willing and able to give their formal agreement to take part in the trial - People newly diagnosed with a type of blood cancer called chronic myeloid leukaemia (CML) in its early "chronic" stage, confirmed by a bone marrow test within...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who are willing and able to sign a consent form and follow the study's requirements, including screening tests and providing regular samples of bone marrow and blood. - People who have a confirmed diagnosis of AML (acute myel...

Who might be able to join this trial: - People who have been diagnosed with a type of blood cancer called CLL (chronic lymphocytic leukemia) or SLL (small lymphocytic lymphoma), confirmed using standard medical guidelines. - People whose cancer has come back after at least one previous treatment, and who currently need...

**Who might be able to join this trial:** - You are an adult who has recently been diagnosed with a type of blood cancer called AML (acute myeloid leukemia) that tests positive for a protein called "CD33," and your doctor has decided to treat you with a medication called Mylotarg® as part of your normal care, or has al...

**Who might be able to join this trial:** - You are 18 years of age or older and have been diagnosed with acute myeloid leukemia (AML) that has come back or stopped responding to available treatments - You are able to carry out basic daily activities, with your overall health and activity level falling within an accep...

**Who might be able to join this trial:** - You are between 10 and 30 years old - You are able to speak and understand English - You have been diagnosed with leukemia, aplastic anemia, bone marrow failure syndrome, or myelodysplastic syndrome, and received a bone marrow/stem cell transplant from a donor to treat it - I...

**Who might be able to join this trial:** - People who have been diagnosed with CLL (chronic lymphocytic leukemia) or SLL (small lymphocytic lymphoma) that doctors have determined needs treatment, based on established medical guidelines - People who are at least 18 years old - People whose cancer has at least one of t...

Who might be able to join this trial: **Dose Escalation Part:** - People with a confirmed diagnosis of acute myeloid leukemia (a type of blood cancer) who are on their second or third round of treatment - People with a confirmed diagnosis of myelodysplastic syndrome (a bone marrow disorder) that has not responded well...

**Who might be able to join this trial:** **For patients with leukemia or lymphoma:** - People who have been diagnosed with leukemia or lymphoma that has come back or has not responded to previous treatment, and who are scheduled to receive a type of treatment called CAR T-cell therapy at one of the participating hosp...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with chronic lymphocytic leukemia (a type of blood cancer) according to standard international diagnostic guidelines - People whose disease has come back or stopped responding to a treatment called venetoclax - People...

Who might be able to join this trial: - People who have been newly diagnosed with acute myeloid leukaemia (AML) that has not been treated before (a new, first-time diagnosis). - People whose AML does not have certain specific genetic changes (no MRC-defining cytogenetic lesions, no t(15;17), t(8;21), inv(16), or t(16;1...

**Who might be able to join this trial:** - People older than 6 months of age. - People whose cancer sample shows a high number of blast cells (at least 30% of cells are cancerous), which is needed to prepare the treatment used in this trial. - People whose cancer cells have been tested and shown to carry certain mark...

**Who might be able to join this trial:** - People aged 18 or older who have given written consent to participate. - People whose general physical functioning is rated at a moderate level or better on a standard oncology scale (ECOG score of 2 or less). - People with a life expectancy of more than 3 months. - People w...

Who might be able to join this trial: **Patients:** - People diagnosed with high-risk acute myeloid leukaemia (AML) that is newly diagnosed - People with AML that has not responded to initial treatment - People with AML that has come back after previous treatment - People who are functioning reasonably well in daily l...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of blood cancer called AML (but not the APL subtype), confirmed according to standard medical guidelines, and who have either received at least one prior treatment (for the relapsed/refractory groups) or have not yet receiv...

**Who might be able to join this trial:** - People who have been diagnosed with T cell acute lymphoblastic leukemia (T cell ALL) and whose cancer has gone into remission (complete or partial) after at least 2 rounds of intensive chemotherapy. - People whose cancer is in remission but where sensitive testing still dete...

**Who might be able to join this trial:** - People diagnosed with AML (a type of blood cancer) who have measurable disease in the bone marrow, and whose disease has come back after treatment, did not go into remission after it came back, or did not go into remission after at least two attempts to treat it from the sta...

**Who might be able to join this trial:** - People who have been diagnosed with Acute Myeloid Leukemia (AML), are not suitable for intensive chemotherapy, and meet the Greek Ministry of Health's requirements for receiving venetoclax as a first treatment. - People whose doctor has already decided, independently and befo...

**Who might be able to join this trial:** - People who are willing and able to give signed consent to participate - People who have been diagnosed with breast cancer, acute leukaemia, lymphoma (Hodgkin or non-Hodgkin), or sarcoma (bone, soft tissue, or Ewing sarcoma), confirmed by tissue testing, and who have been assi...

**Who might be able to join this trial:** *For patients:* - People diagnosed with intermediate-risk acute myeloid leukemia (a type of blood cancer) for the first time, where the disease is in complete remission at the molecular level (meaning no detectable cancer cells using sensitive tests) - People diagnosed with hi...

**Who might be able to join this trial:** - People who have been newly diagnosed with acute myeloid leukaemia (AML), or certain higher-risk blood/bone marrow conditions (higher-risk MDS or a specific type of CMML) — the trial team will confirm whether these related conditions qualify on a case-by-case basis - People w...

**Who might be able to join this trial:** **For people with blood/bone marrow conditions (MDS group):** - People of any age and either sex are eligible to be considered. - People who have been diagnosed with, or are suspected of having, certain bone marrow or blood conditions, including MDS (myelodysplastic syndromes)...

**Who might be able to join this trial:** - People aged 12 years or older who weigh at least 40 kg (approximately 88 pounds) - People who are reasonably functional in daily life (as assessed by a standard medical scale called the ECOG score of 2 or below — confirm with trial site) - People who have been newly diagnose...

**Who might be able to join this trial:** - Adults aged 18 or older - People diagnosed with a blood/bone marrow condition called MDS (myelodysplastic syndrome) or CMML (chronic myelomonocytic leukaemia) or MDS/MPN (a related overlap condition), confirmed using standard medical classification — with eligibility dependi...

**Who might be able to join this trial:** - People who have signed a consent form agreeing to take part in the study - Adults aged 18 years or older and younger than 75 years - People diagnosed with chronic myeloid leukaemia (CML) in the chronic phase or accelerated phase, confirmed by specific genetic markers in thei...

**Who might be able to join this trial:** - People between 0 and 22 years of age - People who have been diagnosed with leukemia or non-Hodgkin lymphoma - People for whom Spanish is the preferred language, or whose parent or guardian prefers Spanish - People who have received or are currently receiving care at the Cente...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of blood cancer called AML (but not the subtype called acute promyelocytic leukemia), as defined by current medical guidelines - Your AML is classified as high-risk or intermediate-risk and is in first remission, OR your AML is in...

**Who might be able to join this trial:** - People who have given written consent to take part in the study. - People diagnosed with acute myeloid leukaemia (AML) — a type of blood cancer — but not a specific subtype called acute promyelocytic leukaemia (APL). - People whose AML is either newly diagnosed or developed...

**Who might be able to join this trial:** **For the patient receiving the transplant:** - You have been diagnosed with a specific blood cancer (such as certain types of leukemia, lymphoma, myeloma, or related conditions) that has been confirmed by lab testing and meets specific stage or treatment history requirements...

**Who might be able to join this trial:** - People aged 18 to 70 years old (any gender) - People diagnosed with FLT3-positive acute myeloid leukemia (a specific type of blood cancer with a particular genetic marker) - People whose doctors expect them to live for more than 3 months - People with a physical functioning...

**Who might be able to join this trial:** - People who have been newly diagnosed with acute myeloid leukemia (AML) for the first time, with no prior treatment, where more than 20% of bone marrow cells are blast (abnormal) cells, as confirmed before joining the trial - People aged 18 or older but under 60 years old - P...

**Who might be able to join this trial:** - Children and teenagers aged 10 to 18 years who have received a heart transplant - At least 6 months must have passed since the heart transplant **Who may not be able to join:** - People who do not speak English, as communication during the exercise sessions is required - Peo...

**Who might be able to join this trial:** - People diagnosed with acute myeloid leukaemia (AML) that has come back after treatment, or AML that did not respond to at least two rounds of standard chemotherapy (including cases where the disease is still detectable at a very low level) - People whose AML is found only in...

**Who might be able to join this trial:** - You have been diagnosed with acute myeloid leukemia (AML) that has come back or has not responded to treatment. - Your AML did not respond to, or came back after, at least one round of intensive chemotherapy (a standard drug combination) or at least four cycles of a specific...

**Who might be able to join this trial:** - People who have been newly diagnosed with, or have had a return or worsening of, a blood cancer (either a myeloid or lymphoid type) that involves a specific gene change called an FGFR1 rearrangement, identified using the WHO-2016 diagnostic guidelines. - People with a general...

**Who might be able to join this trial:** - People aged 18 or older. - People who have been diagnosed with a specific type of blood/bone marrow condition called proliferative CMML, atypical CML, or MDS/MPN-NOS, with a high white blood cell count at the time of diagnosis (confirm with trial site if white blood cell cou...

Who might be able to join this trial: - People who have been diagnosed with chronic lymphocytic leukaemia (CLL), a type of blood cancer, and have not yet received any treatment for it - People who were started on a medication called acalabrutinib through the UK Early Access Programme (a scheme that allowed patients to...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form and follow all study procedures for the full duration of the trial - People aged 18 to 70 years who have been newly diagnosed with acute myeloid leukaemia (AML) of any risk level, as defined by standard medical guideline...

Who might be able to join this trial: - People who are suspected to have acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has not yet been treated. - People who are 18 years of age or older. - People who have not yet received any anti-cancer treatment for AML or MDS (a medication called hydroxyurea t...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of acute leukemia called acute monocytic leukemia (AML-M5), confirmed using a recognised classification system or by testing for certain markers on the cancer cells - People who are expected to live for at least 12 weeks at...

Who might be able to join this trial: - People aged 60 years or older who have been newly diagnosed with acute myeloid leukemia (AML), including AML that developed from a previous blood condition or as a result of past cancer treatment. - People whose doctor considers them well enough to receive intensive chemotherapy....

**Who might be able to join this trial:** - People diagnosed with Myelodysplastic Syndrome (MDS) — a bone marrow disorder — classified as intermediate, high, or very high risk based on a standard scoring system used by doctors - People diagnosed with a condition called CMML-2 (a type of blood cancer) with a white bloo...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of joining the trial - People who have been diagnosed with a specific type of blood cancer called acute myeloid leukemia (AML), either as a primary condition or developed from a prior blood disorder called myelodysplastic sy...

**Who might be able to join this trial:** - You must be 18 years old or older - You must be a healthy volunteer, confirmed by the study doctor based on your recent medical history, a physical exam, and blood test results (all done within the last 3 months) - Your blood test results must be within the normal range, or c...

**Who might be able to join this trial:** - People aged 18 or older who are able to swallow pills - People who have been diagnosed with T-cell Large Granular Lymphocytic Leukemia (T-LGLL), including rare types such as CD4+ T-LGLL and gamma/delta T-LGLL, confirmed by specific blood cell counts and a clonal T-cell recep...

**Who might be able to join this trial:** - People who have been diagnosed with Acute Myeloid Leukemia (AML) that has come back or stopped responding to at least one standard treatment. - People aged 18 or older. - People who are well enough to carry out basic daily activities, based on a standard medical scale that m...

**Who might be able to join this trial:** - People diagnosed with Acute Myeloid Leukemia (AML) that has come back or stopped responding to treatment, after trying at least one standard treatment and one further "rescue" treatment, or where further rescue treatment is not considered a suitable option - People diagnosed...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have given written consent to participate - People who have been diagnosed with a specific type of blood cancer affecting B-cells, including chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL), Waldenström's macroglobulinae...

**Who might be able to join this trial:** - People who have been diagnosed with acute myeloid leukemia (a type of blood cancer), confirmed by laboratory testing, who have not yet received treatment for it, and whose doctors consider standard intensive chemotherapy unsuitable due to age, other health conditions, or per...

Who might be able to join this trial: - People who were diagnosed with their condition at age 18 or younger - People whose diagnosis showed a specific genetic marker called the Philadelphia chromosome, confirmed by laboratory testing of the chromosomes, along with a specific gene change called BCR::ABL1 (either e13a2 o...

Who might be able to join this trial: - Adults between 18 and 75 years old, any gender - People who are willing to take part and have signed a consent form (either themselves or through a legal guardian) - People who have been diagnosed with T-cell lymphoma according to specific recognised medical guidelines - People w...

**Who might be able to join this trial:** - You are willing and able to sign a consent form and follow all study requirements for the full duration of the trial - You are 18 years of age or older - You have been diagnosed with acute myeloid leukemia (a type of blood cancer) that has been confirmed by a tissue sample, a...

**Who might be able to join this trial:** - Children, teenagers, and young adults (aged 1 to under 25) diagnosed with B-cell acute lymphoblastic leukemia (a type of blood cancer) that has come back after treatment or did not respond to initial treatment. - People whose cancer cells make up at least 5% of cells in the...

**Who might be able to join this trial:** - People aged between 16 and 70 years old - People who have been diagnosed with acute myeloid leukaemia (AML) that has come back after treatment or has not responded to treatment - People whose AML has not responded to at least 2 rounds of standard intensive chemotherapy, or w...

**Who might be able to join this trial:** - Children who were first diagnosed between 1 year old (at least 12 months) and 18 years old, and who are younger than 21 years old at the time of joining the trial. - Children under 6 years old who weigh at least 7 kg, and children 6 years or older who weigh at least 10 kg at...

**Who might be able to join this trial:** - People who have signed written informed consent (and for children, a parent or legal guardian must also sign) before any study procedures begin - Children and teenagers aged 3 to 18 years who weigh at least 10 kg - People whose acute lymphoblastic leukaemia (ALL) has come bac...

**Who might be able to join this trial:** - People aged 18 or older - People who are willing to sign a consent form (or have a legal representative do so on their behalf), including non-English speakers for whom interpreter support is available - People who are willing to allow the use of stored tumour tissue from a p...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who have been diagnosed with diffuse large B-cell lymphoma (DLBCL) — including certain subtypes — or follicular lymphoma Grade 3B, confirmed by a specialist tissue review at the participating hospital. - People whose lymphoma...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (CML) in its early ("chronic") phase, before starting treatment - People who are currently taking one of the following targeted cancer medicine...

Who might be able to join this trial: - People whose tumor has been referred for genetic sequencing as part of a specific pediatric cancer program (such as FMG2025 or an equivalent program), and who have given written agreement to take part in that program. - People who have given written agreement for the MAPPYACTS 2...

**Who might be able to join this trial:** - People aged 18 or older who have been diagnosed with a specific type of blood cancer called CD19-positive non-Hodgkin lymphoma (including many subtypes such as Diffuse Large B-cell Lymphoma, Follicular Lymphoma, Burkitt Lymphoma, Mantle Cell Lymphoma, and others listed in th...

**Who might be able to join this trial:** - People aged 18 to 65 years who have acute myeloid leukemia (a type of blood cancer) and are receiving a chemotherapy treatment plan that includes a drug type called anthracyclines. - People who have no signs of heart failure and whose heart pumping function (measured before c...

Who might be able to join this trial: - People aged 18 or older - People diagnosed with acute myeloid leukemia (AML) that has come back after treatment, shown by a certain level of leukemia cells in the bone marrow or blood - People with AML that has not responded to treatment, having tried no more than 2 prior attempt...

**Who might be able to join this trial:** - People aged between 18 and 60 years old - People diagnosed with acute myeloid leukemia (AML), except for a specific subtype called AML-M3 - People whose AML is considered refractory (hard to treat), meaning: standard chemotherapy did not achieve full remission after 2 rounds...

Who might be able to join this trial: - People who have given written consent to participate voluntarily - People aged 18 years or older - People who have been newly diagnosed with acute myeloid leukaemia (AML) and have been assessed as not suitable for intensive chemotherapy, either because they are 75 or older, or be...

**Who might be able to join this trial:** - People who have been diagnosed with, or had a return of, leukemia, lymphoma, myeloma, myelodysplastic syndromes (MDS), or myeloproliferative neoplasms (MPN). - People who are receiving, have received, or are planning to receive treatment for one of these blood cancers or diso...

**Who might be able to join this trial:** - People aged 60 or older - People diagnosed with acute myeloid leukaemia (AML) that is considered high or intermediate risk (for newly diagnosed cases), or AML that has come back after previous treatment (for relapsed cases, regardless of risk level) - People whose general phy...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who are willing and able to attend study visits and follow the study requirements - People who have been diagnosed with AML (a type of blood cancer) that has come back after treatment (r...

**Who might be able to join this trial:** - You have been diagnosed with AML (a type of blood cancer), ALL (another type of blood cancer), or MDS (a bone marrow disorder), and your doctors have decided you need a stem cell transplant from a partially matched donor. - You are 18 years of age or older at the time of sign...

Who might be able to join this trial: - People who have been diagnosed with acute myeloid leukaemia (a type of blood cancer). - People who are receiving intensive chemotherapy treatment that causes a significant drop in infection-fighting white blood cells (below 500 per cubic millimetre) lasting more than 7 days. - Pe...

**Who might be able to join this trial:** - People under 25 years of age, of any gender or race - People diagnosed with one of the following blood cancers, at the stage listed: - Acute myeloid leukemia (primary or secondary), with very low or undetectable levels of disease on sensitive testing (MRD negative, meaning...

**Who might be able to join this trial:** - People who have a confirmed diagnosis (proven by tissue testing) of one of the following blood cancers: AML (acute myeloid leukemia), MDS (myelodysplastic syndrome), a treatment-related myeloid cancer (tMDS/AML), Myeloid Sarcoma, or Acute Undifferentiated Leukemia — includin...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form before any study procedures begin - People diagnosed with MDS, CMML, or secondary AML (a type of blood cancer that developed from another blood condition) according to standard medical classification, with certain high-r...

**Who might be able to join this trial:** - People diagnosed with a specific type of blood cancer called AML (Acute Myeloid Leukaemia) that involves particular genetic changes known as MECOM rearrangements or atypical 3q26 rearrangements (confirm with trial site for exact details on what this means for a specific case)...

Who might be able to join this trial: - People who have recently been diagnosed with a cancer that is not in the brain or central nervous system, and who will be receiving chemotherapy at University Hospital Copenhagen, Rigshospitalet. - People who are between 7 and 29 years old at the time of their diagnosis. - Each p...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with a type of blood condition called a myeloproliferative neoplasm (MPN) — this includes essential thrombocythemia (ET), polycythemia vera (PV), early-stage myelofibrosis (pre-MF), myelofibrosis (MF),...

Who might be able to join this trial: - People who have been diagnosed with a condition called Aggressive Natural Killer-cell Leukaemia (ANKL), whether it is a new diagnosis or the disease has come back, based on internationally recognised diagnostic standards (WHO 2017 guidelines). Who may not be able to join: - Peop...

**Who might be able to join this trial:** **Arm A (one group within the trial):** - People aged 0 to 26 years old with a type of blood cancer called B cell precursor acute lymphoblastic leukemia (ALL) or B cell lymphoma - People whose cancer came back or did not respond to standard chemotherapy, and who have not recei...

Who might be able to join this trial: - People who have Acute Myeloid Leukaemia (AML) that has not responded to treatment or has come back, including: no remission after 2 rounds of initial treatment, relapse within 6 months of first remission, relapse that did not respond to further treatment, or multiple relapses - P...

**Who might be able to join this trial:** - People diagnosed with a specific type of acute leukaemia called APL that has a particular genetic marker (PML-RARα+) - People whose leukaemia has not gone into remission after receiving a standard treatment combination of retinoic acid and arsenic - People with a life expecta...

**Who might be able to join this trial:** - Adults aged 18 to 75 years old at the time of AML (acute myeloid leukemia) diagnosis who have not yet received treatment for their AML, and whose AML has certain specific genetic features — including a mutation in a gene called NPM1 (without certain other mutations), a rearr...

**Who might be able to join this trial:** - People aged 15 years or older - People who have been diagnosed with a specific type of leukaemia called Acute Leukaemia of Ambiguous Lineage (ALAL), based on the latest World Health Organisation diagnostic standards - People who have been newly diagnosed (not previously treat...

**Who might be able to join this trial:** - People who have signed (or are willing to sign) a written consent form to participate - People newly diagnosed with a specific type of blood cancer (AML) that tests positive for a protein called CD33 and has a change in a gene called NPM1, as classified by current medical st...

**Who might be able to join this trial:** - People who have been diagnosed with Acute Myeloid Leukemia (AML) that has not yet been treated - People whose AML has a specific gene change called IDH1 R132 - People who are considered unsuitable for intensive chemotherapy due to at least one of the following: being 75 year...

**Who might be able to join this trial:** - People who have been diagnosed with acute myeloid leukemia (AML), confirmed through bone marrow testing and cell analysis, meeting a specific international diagnostic standard. - People whose leukemia went into first-time complete remission (meaning no signs of active diseas...

Who might be able to join this trial: - People who have been diagnosed with Acute Myeloid Leukaemia (AML) confirmed through blood or bone marrow testing - People who have been newly diagnosed and are being considered for a new course of treatment - People who are 50 years of age or older - People who have a relatively...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have a type of blood cancer called AML (either newly diagnosed or developed from another condition) that is in complete remission at the time of transplant, or who have MDS/AML with a low level of abnormal cells in the bone marrow (5% or...

**Who might be able to join this trial:** - People aged 10 years or older - For the Phase 1 part of the trial: People with a solid tumour that has come back or stopped responding to previous treatment, where testing has confirmed a specific genetic change called a FET fusion (involving genes called EWSR1, FUS, or TAF1...

**Who might be able to join this trial:** - You are willing to sign a consent form and agree to follow the study requirements - You are between 18 and 75 years old - Your doctors expect you to live for at least 3 months - You have been diagnosed with acute myeloid leukemia (AML) that has come back or stopped respondin...

**Who might be able to join this trial:** - People who have given voluntary written consent (or whose legal representative has given consent) before any screening takes place - People who are older than 16 years of age - People who have started intensive treatment within the past three days for one of the following bl...

Who might be able to join this trial: - The patient must be between 3 and 18 years of age at the time of joining the trial. - The patient must have a newly diagnosed form of acute lymphoblastic leukemia (a type of blood cancer) involving B-cells, T-cells, or mixed cell types, confirmed by a laboratory report. - The pat...

**Who might be able to join this trial:** - People aged 15 to 65 years old - People diagnosed with a type of blood cancer called CD22+ B-cell acute lymphoblastic leukaemia (B-ALL), based on 2023 NCCN diagnostic standards - People with CD22+ B-ALL whose cancer has shown signs of returning (detected by a sensitive test...

**Who might be able to join this trial:** - Adults who have been diagnosed with a specific type of chronic leukemia called Philadelphia chromosome-positive chronic phase chronic myeloid leukemia (Ph+ CP-CML), and who are currently receiving or are about to receive a medication called Scemblix® as approved for use in th...

**Who might be able to join this trial:** - Adults aged 18 or older - People with a type of blood cancer called AML (acute myeloid leukemia) that is unlikely to be cured with currently available treatments - People whose AML has not gone into full remission (meaning the cancer has not fully responded to treatment), or...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who have voluntarily signed a consent form agreeing to take part in the study. - People whose doctors expect them to live for more than 12 weeks. - People diagnosed with advanced acute myeloid leukemia (AML) — including certa...

**Who might be able to join this trial:** - Adults aged 18 or older - People whose HLA tissue type (a biological marker) matches at two specific points called HLA B and C loci - People diagnosed with a type of blood cancer called AML, where at least 20% of the cancer cells carry a protein called CD123 (at any point du...

**Who might be able to join this trial:** - Adults aged 18 or older of any gender - People whose general health and ability to carry out daily activities meets a certain minimum standard, and whose condition has been stable for at least 2 weeks before starting the trial - People diagnosed with a specific type of chron...

Who might be able to join this trial: - People who are between 16 and 50 years old - People who have been newly diagnosed with a type of blood cancer called ALL (acute lymphoblastic leukemia) - People whose ALL does not have a specific genetic marker called the Philadelphia chromosome - People who have not yet received...

**Who might be able to join this trial:** - People who have been diagnosed with chronic lymphocytic leukaemia or small lymphocytic lymphoma (CLL/SLL) according to specific 2018 international diagnostic guidelines - People in the ibrutinib + venetoclax groups who have a general health and activity level rated as 0 or 1...

Who might be able to join this trial: - People who were diagnosed with Acute Myeloid Leukaemia (AML) — a type of blood cancer — after 1 January 2020 - People who have signed a consent form agreeing to take part in the trial Who may not be able to join: - People who are under 18 years of age Important: Always verify e...

Who might be able to join this trial: - People who have been diagnosed with acute myeloid leukemia (a type of blood cancer, but not the specific subtype called acute promyelocytic leukemia) and whose disease is currently in first complete remission (meaning treatment has worked and signs of cancer are no longer detecta...

**Who might be able to join this trial:** - You are older than 6 months of age. - Your leukemia (AML) cells have been tested and confirmed to carry certain specific markers called CLL-1, CD123, CD38, and/or CD33, identified through a lab test on a tissue or blood sample. - You are generally in good health and able to c...

Who might be able to join this trial: - People aged 18 to 75 years old (any gender) - People whose cancer cells have tested positive for a protein called CD123, detected through a blood/cell flow test - People diagnosed with either relapsed/refractory AML (a type of blood cancer that has come back or stopped responding...

**Who might be able to join this trial:** - People who have been diagnosed with acute myeloid leukemia (AML) according to a specific international classification system (WHO 2016) - People whose AML has a specific genetic change called a FLT3 mutation, detected at certain levels in testing - People whose AML either di...

**Who might be able to join this trial:** *For people with a blood disorder called MPN (110 participants):* - You have been diagnosed with one of three specific blood conditions: Polycythemia Vera (PV), Essential Thrombocythemia (ET), or Primary Myelofibrosis (PMF) - A specific type of DNA sample was collected from yo...

Who might be able to join this trial: - People aged 18 or older - People who have been diagnosed with acute myeloid leukaemia (AML) that has come back or stopped responding to previous treatment - People whose AML cells test positive for a specific protein called CLL1 - People who are in reasonably good general health...

Who might be able to join this trial: - People who have been diagnosed with AML (a type of blood cancer), B-ALL (another type of blood cancer), or MDS (a bone marrow disorder), confirmed through laboratory testing of tissue samples. - People whose condition has not responded to all available standard treatments, or whe...

**Who might be able to join this trial:** - People who have been recently diagnosed with a type of blood cancer called AML (acute myeloid leukaemia) for the first time, with the diagnosis confirmed within 28 days of symptoms starting. A prior treatment to reduce white blood cell counts (such as hydroxyurea) is permitt...

**Who might be able to join this trial:** - People who have been diagnosed with acute myeloid leukemia (a type of blood cancer, but not the specific subtype called acute promyelocytic leukemia) or high-risk myelodysplastic syndrome (a condition where the bone marrow doesn't make enough healthy blood cells), based on 2...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People diagnosed with acute myeloid leukaemia (AML) that has come back or stopped responding to previous treatment - People with a general health and activity level rated between 0 and 2 on a standard medical scale (meaning able to car...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of blood cancer called AML (acute myeloid leukemia), except for two particular subtypes known as Philadelphia chromosome-positive AML and acute promyelocytic leukemia (AML M3) - People aged 18 or older - People whose general...

Who might be able to join this trial: - People diagnosed with Shwachman-Diamond Syndrome (SDS), a similar condition, or an unidentified condition that shares features with SDS - People who have specific genetic changes (mutations) in genes known as SBDS, DNAJC21, EFL1, or SRP54 that are linked to SDS - People whose SDS...

**Who might be able to join this trial:** - You are an adult diagnosed with acute leukemia and are scheduled to receive a stem cell transplant from a donor (called an allogeneic transplant) - You are generally able to carry out daily activities, with little or no limitation caused by your illness (confirm with trial si...

**Who might be able to join this trial:** - Adults aged 18 to 65 years (male or female) - People diagnosed with a specific type of acute lymphoblastic leukaemia (ALL) that carries a genetic marker known as Philadelphia chromosome or BCR-ABL1 positive - People who have had little or no prior treatment — only limited ea...

**Who might be able to join this trial:** - You have been diagnosed with a type of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (LL), and your cancer cells show a specific marker called CD7 on more than 98% of the abnormal cells - Your cancer has come back (relapsed) at lea...

**Who might be able to join this trial:** - You have been diagnosed with a type of blood cancer called AML (Acute Myeloid Leukemia, but not the M3 subtype), and after receiving a stem cell transplant from a donor, tests still show small traces of cancer remaining (known as MRD positive) - You are 18 years of age or old...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form - People who are able to give written consent to participate in the study - People who have been diagnosed with a specific type of chronic myelomonocytic leukemia (CMML) that tests positive for a protein called...

Who might be able to join this trial: - People who are 19 years of age or older - People who are receiving oral azacitidine as directed by the approved prescribing guidelines - People who have received or are currently receiving oral azacitidine within the first 2 years after it received marketing approval (during this...

**Who might be able to join this trial:** - People aged 14 to 85 years who are expected to live longer than 3 months - People diagnosed with B-cell lymphoma or B-ALL (a type of blood cancer) where the cancer cells test positive for markers called CD19 and CD22 - People whose cancer has come back or has not responded t...

**Who might be able to join this trial:** - People aged 18 years or older. - People who have been diagnosed with chronic myeloid leukaemia (CML) in its early, stable phase, and whose condition is suitable for treatment with tablets or capsules taken by mouth. - People who are newly starting an oral (by mouth) treatment...

**Who might be able to join this trial:** - People aged 50 to 70 years old. - People aged 50 to 55 who have been assessed as not fit enough for the most intensive type of stem cell transplant preparation (based on a health scoring system called SORROR, with a score of 2 or higher). - People diagnosed with a blood canc...

Who might be able to join this trial: - People who are willing to take part and have given their written agreement to participate - People who are at least 18 years old at the time of screening - People of any sex - People who have been diagnosed with chronic myeloid leukaemia in the chronic phase (CML-CP) during the s...

Who might be able to join this trial: - People who have been diagnosed with cerebral palsy - People who are able to walk (classified at mobility levels I or II on the GMFCS scale, meaning they walk without assistive devices or with minimal limitations) - People who speak English or Spanish - People who have no planned...

Who might be able to join this trial: - People who have been diagnosed with B-cell acute lymphoblastic leukemia (a type of blood cancer) - People who are 16 years of age or older - People for whom medical records are available showing the status of their disease both before and after a stem cell transplant Who may not...

**Who might be able to join this trial:** - People who are willing to give their consent to take part and are expected to complete all required visits and procedures. - Adults aged 18 to 70 years old (inclusive), of any gender. - People who have been diagnosed with acute myeloid leukaemia (AML) — a type of blood cance...

Who might be able to join this trial: - People aged 18 or older who have been diagnosed with chronic myeloid leukaemia (CML), a type of blood cancer - People who have been taking a medication called ponatinib at a daily dose of 45mg, 30mg, or 15mg for more than 14 days - People who have agreed to take part in the study...

Who might be able to join this trial: - People aged between 18 and 70 years old - People who have been diagnosed with relapsed or refractory acute myeloid leukemia (AML) — meaning the leukemia has come back or stopped responding to treatment — whether it developed on its own or as a result of another condition - People...

**Who might be able to join this trial:** - The participant (and/or their legal guardian, if applicable) must have given written consent to take part in the study - Stored tumour tissue from a previous biopsy must be available for use, though exceptions may be considered with approval from the lead researcher - Partic...

**Who might be able to join this trial:** - People who have been diagnosed with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), or a condition classified as MDS/AML, and whose disease is considered high or very high risk of coming back after a stem cell transplant, based on specific medical scoring syste...

Who might be able to join this trial: - You have been diagnosed with Myelodysplastic syndrome (MDS) or Acute Myeloid Leukemia (AML) with a specific gene change called a TP53 mutation (confirm with trial site) - You had your first stem cell transplant from a donor, and a test done within the last 2 months showed no sign...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with a specific type of blood cancer called CML (chronic myeloid leukemia) in its early stage, known as "chronic phase" - Your diagnosis was made no more than 3 months (90 days) before joining the trial - Your diagno...

**Who might be able to join this trial:** - People who have acute myeloid leukemia (AML) that has come back or has not responded to previous treatment, based on specific 2022 medical guidelines - People aged 18 to 70 years - People whose overall health means doctors consider them able to tolerate intensive (strong) che...

**Who might be able to join this trial:** - People who have been newly diagnosed with ultra high-risk multiple myeloma, defined as one of the following: (1) "double hit" myeloma, meaning the cancer has two or more high-risk genetic features, (2) myeloma that has spread outside the bone marrow, or (3) a form called pri...

Who might be able to join this trial: - People who are 18 years of age or older at the time of signing the consent form - People who are willing and able to understand and sign a consent form before any study-related activities begin - People who are able and willing to attend study visits and follow the study schedule...

"Who might be able to join this trial: - Children who have been diagnosed with acute leukemia Who may not be able to join: - Children who have Multiple Organ Dysfunction Syndrome (MODS), a condition where several organs in the body are not working properly at the same time Important: Always verify eligibility with th...

**Who might be able to join this trial:** - Children and young people under 18 years old at the time of screening - Children weighing at least 6 kg at the time of screening - Children with a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has come back or has not responded to previous trea...

Who might be able to join this trial: - Adults aged 18 years or older, of any gender - People who have given written consent to participate - People who have been newly diagnosed with AML (a type of blood cancer), or whose AML has come back or stopped responding to treatment, and who are either considered too unwell fo...

**Who might be able to join this trial:** - Adults aged 18 or older - People who fully understand what the study involves and are willing to sign a consent form - People who have been diagnosed with non-Hodgkin lymphoma (NHL), acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML), or myelodysplastic syndr...

**Who might be able to join this trial:** - People who had at least one specific genetic marker (a fusion gene or blood cancer-related mutation) detected at the time of their original diagnosis, using a type of genetic testing, and where that marker is being used to monitor their cancer after transplant. - People whose...

**Who might be able to join this trial:** - People aged 1 to 30 years old who have been diagnosed with acute lymphoblastic leukemia (ALL) or lymphoma, where no other curative treatment options are available or have been declined. - People with B-cell ALL whose disease has not responded to, or has progressed after, two...

**Who might be able to join this trial:** - People who have been newly diagnosed with AML (acute myeloid leukemia) and have not yet received treatment for it - Children and young people under 18 years old - People who previously received hydroxyurea or a limited amount of a drug called cytarabine before their diagnosi...

**Who might be able to join this trial:** - People aged 18 or older who have signed a consent form before taking part in the study - People who have been diagnosed with acute myeloid leukemia (AML) that has come back or has not responded to treatment, confirmed by laboratory testing using 2022 World Health Organizatio...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with T-cell large granular lymphocytic leukemia (T-LGLL), a rare type of blood cancer - People who meet at least one of the following reasons for needing treatment: low red blood cell levels or dependence on blood tran...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with chronic myeloid leukemia (CML) in a stage called the chronic phase (CML-CP) - People who are currently being treated with one of these four cancer medications: imatinib, dasatinib, bosutinib, or nil...

**Who might be able to join this trial:** - People aged 12 or older who weigh at least 40 kg (about 88 pounds) - People whose general health and ability to carry out daily activities meets a certain minimum level (confirm with trial site) - People who have acute leukemia (of myeloid, lymphoid, or mixed type) that has...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of blood cancer called Acute Myeloid Leukemia (AML) — but not the subtype called acute promyelocytic leukemia (APL) — where the cancer has either a monocytic or monoblastic cell type, or a specific genetic change called a R...

**Who might be able to join this trial:** - People who have been newly diagnosed with acute myeloid leukemia (AML), based on the 2022 WHO diagnostic guidelines. - People aged between 18 and 60 years old. - People who are reasonably active and able to care for themselves, with only mild or no limitations on daily activ...

**Who might be able to join this trial:** - You are willing to take part, have read and signed the consent form, and are able to follow all study procedures. - You are between 18 and 74 years old (inclusive), of any gender. - You have been diagnosed with acute myeloid leukemia (AML), including AML that developed from...

Who might be able to join this trial: - People aged between 18 and 60 years old. - People diagnosed with a specific type of blood cancer called acute myeloid leukemia (AML), not including the subtype known as M3, whose cancer has gone into complete remission and who are about to receive follow-up (consolidation) chemot...

Who might be able to join this trial: - Children and young people aged 1 to 18 years old at the time of joining the study. - People with acute myeloid leukemia (AML), treatment-related AML, myelodysplastic syndrome (MDS), or a rare blood cancer called JMML (juvenile myelomonocytic leukemia), with or without Down syndro...