Phase 3 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been newly diagnosed with a specific type of blood cancer called Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
• People whose doctors expect them to survive for at least 3 months
• People who are reasonably able to carry out daily activities (measured by a standard medical scale called ECOG, with a score of 2 or lower — confirm with trial site if unsure what this means for a specific situation)
• People whose major organs (such as the liver and kidneys) are functioning at an adequate level

Who may not be able to join:

• People who have a history of a blood cancer called chronic myeloid leukemia (CML)
• People whose leukemia has spread to the brain or spinal fluid, or to other parts of the body outside the bone marrow — although swollen lymph nodes or an enlarged liver or spleen may still be permitted (confirm with trial site)
• People who have had or currently have a disease affecting the brain or nervous system
• People who have an autoimmune disease that may affect the brain or nervous system
• People who are taking full treatment doses of blood-thinning or anti-clotting medications (low doses may be permitted — confirm with trial site)
• People who are currently taking a medication that is known to interact with the trial drug, if taken within 7 days before starting the trial (or within 5 half-lives of that drug, whichever is shorter)
• People with heart disease that is not well controlled
• People who have had a blood clot in a vein — such as a deep vein thrombosis or a clot in the lungs — within the 6 months before joining the trial
• People who are taking medications that are not permitted under the trial rules
• People with an unstable medical condition that could affect their safety or ability to follow the study requirements
• People taking medications known to affect the heart's electrical activity in a specific way (called QT prolongation — confirm with trial site)
• People with an active infection that requires treatment throughout the whole body (such as antibiotics or antifungals)
• People with a condition that seriously affects their ability to swallow or absorb oral medications, or who have an active stomach or intestinal ulcer
• People for whom steroid medications (called glucocorticoids) are medically unsuitable
• People who have a bleeding disorder that is not related to their leukemia
• People who are planning to have major surgery during the trial period
• People who are allergic to any of the ingredients or similar substances in the trial medications
• People who are pregnant, breastfeeding, or planning to become pregnant during the study period
• People who have been diagnosed with another type of cancer within the past 2 years
• People with any other symptom, illness, or condition that the trial team considers would interfere with the study or make participation unsuitable

Important: Always verify eligibility with the trial site directly before applying.