Phase 1 Leukaemia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a type of blood cancer called AML (but not a specific subtype called APL) or MDS, confirmed using standard medical guidelines.
• If you have AML and have already received treatment that did not work or stopped working, you may be eligible.
• If you have AML and have never been treated before, you must be either 60 years of age or older, OR between 18 and 59 years old with certain health conditions that make standard intensive chemotherapy unsuitable for you (confirm with trial site).
• If you have MDS (either newly diagnosed or previously treated and not responding), your disease must be rated as higher risk using a standard scoring system, and you must have at least 5% abnormal cells in your bone marrow (confirm with trial site).
• Doctors expect you to live for at least 12 weeks or more.
• Your kidneys must be working well enough, as measured by a standard kidney function test.
• Your liver must be functioning at an adequate level.

Who may not be able to join:

• You have a form of AML or MDS that did not respond to, or you could not tolerate, certain specific prior treatments (azacitidine or BCL-2 inhibitor drugs) (confirm with trial site).
• You have been diagnosed with the specific AML subtype called acute promyelocytic leukemia (APL).
• The blood cancer has spread to your brain or spinal cord.
• You currently have an active hepatitis B or hepatitis C infection.
• You have a history of a weakened immune system, or you have tested positive for HIV.
• You have had another type of cancer in the past 2 years, unless it was fully cured with treatment.

Important: Always verify eligibility with the trial site directly before applying.