Phase 3 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been receiving immunoglobulin (Ig) replacement therapy — either through a drip (IV) or under the skin (subcutaneous) — for at least 6 months in a row, to help prevent bacterial infections due to low antibody levels.
• People whose treating doctor believes it is appropriate for them to try stopping their Ig treatment as part of this trial.
• People who are willing and able to follow the requirements of both treatment options in the trial.

Who may not be able to join:

• People who have previously had, or are planning to have, a stem cell transplant from a donor.
• People who have had a serious infection (graded as severe or above) in the past 3 months, or who currently have an active infection being treated with antibiotics or other antimicrobial medicines.
• People who are already taking regular antibiotic medicines specifically to prevent bacterial infections (note: regular antiviral, antifungal, or PJP prevention medicines do not apply here).
• People who cannot tolerate any of the antibiotic options offered in either treatment arm of the trial.
• People for whom communication difficulties, ability to follow instructions, or practical/logistical barriers are likely to make it hard to take the trial antibiotics as required, or to seek urgent medical attention if signs of infection develop.
• People who are pregnant or breastfeeding.
• People with severely reduced kidney function (confirm with trial site).
• People who have previously had their spleen removed.
• People who have already taken part in this particular trial domain previously.
• People whose treating medical team considers that joining this trial domain would not be in their best interests.

Important: Always verify eligibility with the trial site directly before applying.