Lymphoma

Who might be able to join this trial: - You must be newly diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-NHL) at stage II, III, or IV. - You must be enrolled in a related study called AALL08B1 before joining this trial (for T-ALL patients). - Your diagnosis must be confir...

**Who might be able to join this trial:** - Two partially matched umbilical cord blood (UCB) units must be available for you that meet specific tissue-matching (HLA) requirements and contain enough cells for transplant (confirm with trial site for exact details) - You have a type of blood cancer called acute myeloid l...

**Who might be able to join this trial:** - You have measurable areas of disease that can be tracked (for example, tumors that show up on scans) - You have recovered from any previous chemotherapy treatments - Your doctors estimate you have a life expectancy of at least 12 weeks - Your liver is functioning well enough,...

**Who might be able to join this trial:** - You have been diagnosed with a type of lung cancer (non-squamous cell carcinoma) that has spread or come back and cannot be treated with local treatments like surgery or radiation. - Your cancer has tested positive for a specific gene change involving the ALK gene. - You hav...

Who might be able to join this trial: - You have been diagnosed with a specific type of blood cancer called Diffuse Large B-Cell Lymphoma (DLBCL), confirmed by a tissue sample test. - Your lymphoma has come back or stopped responding to treatment that included at least two types of chemotherapy combinations (one of whi...

**Who might be able to join this trial:** - You have been diagnosed with Waldenström's Macroglobulinemia (WM), either newly diagnosed or previously treated — if previously treated, your disease must have gotten worse or not responded to your most recent treatment - Your WM diagnosis has been confirmed through a centra...

**Who might be able to join this trial:** - You are 21 years old or younger when you were first diagnosed with ALL (acute lymphoblastic leukemia), and at least 1 year old (or at least 1 month old for Phase 2) when starting treatment in the study - You have been diagnosed with ALL that has come back or has not responde...

**Who might be able to join this trial:** - You have been diagnosed with follicular lymphoma (a type of slow-growing blood cancer) confirmed by a tissue sample, at stage II or higher, and your cancer cells test positive for a marker called CD20, with a grade of 1, 2, or 3a. - Your lymphoma is considered "low tumor bur...

**Who might be able to join this trial:** *Please note: Strata I, II, and III are now closed to new participants. Only Stratum IV is still accepting new medical record submissions.* **Stratum IV – People who developed heart problems after cancer treatment:** - People who were diagnosed with cancer before the age of...

**Who might be able to join this trial:** - People who have non-Hodgkin's lymphoma (NHL) that has come back after treatment or has not responded to treatment. - People whose NHL has been confirmed by lab testing to be one of these specific types: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), lymphopl...

**Who might be able to join this trial:** **For people with B-cell acute lymphoblastic leukaemia (B-ALL):** - People who have a confirmed diagnosis of B-ALL that has come back or stopped responding to treatment, and whose cancer cells carry a protein called CD19 on their surface. **For people with certain types of no...

**Who might be able to join this trial:** - You have active acute leukemia with cancer cells detected in your bone marrow or blood, or a specific type of leukemia with certain genetic changes (KMT2A rearrangement, NUP98 rearrangement, or NPM1 mutation) with detectable disease in the bone marrow. - For Phase 2, your le...

**Who might be able to join this trial:** - People aged 1 year old up to and including 30 years old at the time of joining the trial - People who have had their first relapse (return) of a type of blood cancer called CD19-positive B-cell acute lymphoblastic leukaemia (B-ALL), where the cancer has come back in the bone...

**Who might be able to join this trial:** - People who are physically well enough to carry out basic daily activities (based on a standard medical scale called ECOG, scored 0 to 2), assessed within 7 days before starting the study treatment - People whose doctor estimates they have a life expectancy of at least 3 mont...

**Who might be able to join this trial:** - Children and young people aged 12 months to 21 years old at the time of joining the study. - People whose cancer was confirmed by a tissue sample (biopsy) at first diagnosis or when the cancer came back — with exceptions for certain brain tumours where imaging or specific pr...

**Who might be able to join this trial:** - Adults aged 18 or older who are willing and able to sign a written consent form - People whose general health and ability to carry out daily activities meets a certain standard (rated on a medical scale; a lower level of fitness may still be considered with approval from the...

**Who might be able to join this trial:** - People who have been diagnosed with classic Hodgkin lymphoma (confirmed by tissue testing) whose cancer has come back or stopped responding to chemotherapy that included a drug type called anthracycline, and who are considered suitable candidates for high-dose chemotherapy f...

**Who might be able to join this trial:** - People with advanced solid tumors (confirmed by lab testing) that cannot be removed by surgery, where the cancer has continued to grow after at least one previous systemic treatment (such as chemotherapy) — this applies to the dose-finding stage of the trial. - People with c...

Who might be able to join this trial: - People with a confirmed diagnosis of a B-cell blood cancer (such as diffuse large B-cell lymphoma, follicular lymphoma, or chronic lymphocytic leukemia), with disease that can be measured on scans and requires treatment. - People whose blood and organ function test results fall w...

Who might be able to join this trial: - People who are 18 years of age or older. - People who have been confirmed through a tissue or cell sample to have a specific advanced blood cancer — either acute myeloid leukaemia (AML) that has come back or stopped responding to treatment, or mantle cell lymphoma (MCL) that has...

**Who might be able to join this trial:** - People aged 18 years or older - People who are willing and able to sign a written consent form - People who have been diagnosed with a type of large B-cell lymphoma (a blood cancer) confirmed by laboratory testing, as defined by recognised international classification system...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who have a confirmed diagnosis of Mantle Cell Lymphoma (MCL), diagnosed according to recognised international medical guidelines - People who have at least one area of measurable disease that has not previously been treated with radiati...

**Who might be able to join this trial:** - You have been diagnosed with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) and your doctor has determined you need treatment - Your cancer has come back or stopped responding to at least one previous treatment - You have at least one measurable sign th...

**Who might be able to join this trial:** - People diagnosed with certain types of mature B-cell non-Hodgkin lymphoma (B-NHL), specifically including Diffuse Large B-Cell Lymphoma (DLBCL), Burkitt Lymphoma, primary mediastinal large B-cell lymphoma, or related types, confirmed by tissue biopsy at first diagnosis. - Pe...

**Who might be able to join this trial:** - You have been diagnosed (confirmed by a tissue sample/biopsy) with a type of blood cancer involving mature T-cells or NK-cells that has either never been treated, has come back after treatment, or has stopped responding to treatment. - Most subtypes of a group of cancers call...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of follicular lymphoma (FL, Grades 1–3a) that is CD20-positive, and is either Stage II with a large tumour mass, or Stage III/IV - People whose condition has been assessed as needing treatment, according to the trial's guid...

**Who might be able to join this trial:** - People with a type of aggressive lymphoma called DLBCL that tests positive for a protein called CD20, who have either never been treated for lymphoma before, or whose lymphoma has come back or stopped responding to treatment and for whom the trial doctor determines no other...

**Who might be able to join this trial:** *General requirements for all groups:* - People whose overall physical health and ability to carry out daily activities meets a minimum level, as assessed using standard medical scoring tools appropriate for their age. - People whose organs (such as liver and kidneys) and bone...

**Who might be able to join this trial:** - People diagnosed with a solid tumour, brain/central nervous system tumour, or lymphoma that has continued to grow or spread despite standard treatment, or where no effective standard treatment exists. - People who are under 21 years old at the time of joining; people aged 21...

**Who might be able to join this trial:** - You are between 6 and 25 years old - You have recently been diagnosed with Hodgkin Lymphoma or Non-Hodgkin Lymphoma (a new diagnosis) - You are able to swallow medications by mouth, or receive them through a feeding tube placed through the nose - You (or your parent/guardian...

Who might be able to join this trial: - People diagnosed with a type of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL), as defined by World Health Organization guidelines, where the cancer has come back, has not responded to treatment, or where testing shows rem...

Who might be able to join this trial: - You must be 18 years of age or older - You must be willing and able to sign a consent form agreeing to take part in the trial - You have been diagnosed with a type of blood cancer called large B-cell lymphoma (LBCL) or chronic lymphocytic leukemia (CLL) that has come back or stop...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who have been diagnosed with classic follicular lymphoma, confirmed through tissue testing, according to the 2022 WHO classification system - People whose physical functioning is rated a...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form - People with a confirmed diagnosis of certain types of T-cell lymphoma (PTCL-NOS, FHTCL, or sALCL), confirmed by tissue testing, as classified under the International Consensus Classification - People whose can...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of CLL (chronic lymphocytic leukaemia) or SLL (small lymphocytic lymphoma), as defined by established 2018 medical guidelines. - **Part 1 (previously treated patients):** People who have received at least 1 but no more than 3 prior treat...

**Who might be able to join this trial:** - People diagnosed with certain B-cell blood cancers (a type of cancer affecting white blood cells), confirmed by standard diagnostic criteria. For the first part of the trial (dose escalation), eligible cancer types include mantle cell lymphoma, marginal zone lymphoma, Walden...

**Who might be able to join this trial:** - You are generally able to carry out some daily activities and are not completely disabled (your doctor will assess this using a standard scale) - Your main organs (such as kidneys, liver, and heart) are working well enough, and you have not had a recent blood transfusion or...

**Who might be able to join this trial:** - People who have been confirmed through a tissue biopsy to have a type of blood cancer called diffuse large B-cell lymphoma (DLBCL), diagnosed according to standard medical guidelines - People whose cancer shows up as active on a PET scan (a type of imaging test), scoring 4 o...

**Who might be able to join this trial:** - People who have been diagnosed with locally advanced or metastatic non-small cell lung cancer (a type of lung cancer that has spread or cannot be treated with a combination of treatments) confirmed by a lab test on a tissue or blood sample - People whose lung cancer has a sp...

**Who might be able to join this trial:** - You are 18 years of age or older - You are able to understand and sign a consent form agreeing to take part - You have been diagnosed with cutaneous T-cell lymphoma (CTCL), confirmed by a tissue sample (biopsy) - Your disease is at Stage 1b or higher - You have already tried...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of CLL (chronic lymphocytic leukemia) or SLL (small lymphocytic lymphoma) that requires treatment, based on 2018 international guidelines. - People whose CLL/SLL has come back or stopped responding to previous treatment that included a sp...

**Who might be able to join this trial:** - Your cancer can be measured or detected on scans at the time you enter the study - You have been diagnosed with one of the following blood cancers, confirmed by a tissue sample (biopsy): Diffuse large B-cell lymphoma (DLBCL), grade 3b follicular lymphoma, or lymphoma that ha...

**Who might be able to join this trial:** - People who are at least 16 years old (Module 1; in the US, at least 18 years old) or at least 12 years old (Module 2) - People who have been diagnosed with CD22-positive B-cell acute lymphoblastic leukemia (B-ALL), as defined by World Health Organization guidelines - People...

Who might be able to join this trial: - Adults aged 18 or older - People who have been diagnosed with a type of blood cancer called B-cell non-Hodgkin lymphoma (B-NHL), confirmed by a tissue biopsy and classified according to the World Health Organization's 2022 guidelines - In the early phase of the trial, most B-NHL...

Who might be able to join this trial: - People who are 80 years of age or older, OR people aged 65 to 79 who have been assessed as being in a weaker state of health and are not considered suitable for a standard full-dose chemotherapy treatment called R-CHOP - People who have been diagnosed with a specific type of bloo...

Who might be able to join this trial: - People who are currently actively taking part in a specific related study called J2N-MC-JZNN/LOXO-BTK-20020 Who may not be able to join: - No specific exclusion criteria have been listed for this trial Important: Always verify eligibility with the trial site directly before app...

**Who might be able to join this trial:** - People diagnosed with a specific type of B-cell non-Hodgkin lymphoma (a blood cancer affecting B-cells) that has come back or stopped responding to treatment, and where no other more suitable approved treatments are available according to the treating doctor - People with on...

Who might be able to join this trial: - You have been diagnosed with a type of slow-growing B-cell lymphoma (a blood cancer), confirmed by a tissue sample test. - Your specific type of lymphoma must be one of the following: Follicular Lymphoma (Grade 1, 2, or 3a), Small Lymphocytic Lymphoma (SLL), Lymphoplasmacytoid Ly...

**Who might be able to join this trial:** - People who have T cell acute lymphoblastic leukaemia (ALL) or T cell lymphoblastic lymphoma that has not previously been treated, including those whose cancer did not respond to one initial round of chemotherapy, or those whose cancer is in remission after no more than two ro...

**Who might be able to join this trial:** - Adults aged 60 or older who have a type of blood cancer called pre-B ALL (a form of acute lymphoblastic leukaemia) that has not been treated before, including both Philadelphia chromosome-positive and Philadelphia chromosome-negative types. A small amount of prior treatment...

**Who might be able to join this trial:** **To donate a blood sample for cell preparation (procurement stage):** - People of any age or sex who have a type of lymphoma (Hodgkin's or non-Hodgkin's) or a related blood condition linked to a virus called EBV (Epstein-Barr virus), or a serious long-term EBV illness - Peopl...

Who might be able to join this trial: - People who are already planned to receive high-dose therapy followed by either a bone marrow transplant using their own cells (autologous) or donated cells from another person (allogeneic), as part of their standard medical care Who may not be able to join: - People who are curr...

**Who might be able to join this trial:** - People with CD30-positive Hodgkin lymphoma or Non-Hodgkin lymphoma whose cancer has come back after a stem cell transplant using their own cells, or whose cancer has not responded to at least two multi-drug treatment plans and/or an anti-CD30 antibody treatment. - People new...

**Who might be able to join this trial:** - People who have acute leukemia or high-risk myelodysplastic syndrome (a blood/bone marrow disorder) that has come back or stopped responding to treatment, and where standard treatments are not expected to produce a lasting remission - People aged 18 or older - People who hav...

Who might be able to join this trial: - Children and young adults aged 24 or younger who have a type of blood cancer called acute lymphoblastic leukaemia (ALL) that has specific markers on the cancer cells (called CD19+ and CD22+), AND meet at least one of the following high-risk conditions: - The cancer did not respon...

**Who might be able to join this trial:** - A participant or their legal representative has agreed to take part by signing a consent form - The person is over 18 years of age - The person has advanced heart failure with severe symptoms (classified as Stage III or IV), has a mild leaky tricuspid heart valve (a valve on...

**Who might be able to join this trial:** - Girls aged 3 to 14 years old - Girls who are receiving treatment to prepare for a bone marrow transplant, or who are having radiation therapy to the pelvic area (considered high risk for effects on ovarian function) - Girls being treated with chemotherapy for certain cancers...

Who might be able to join this trial: - People who have been newly diagnosed with a type of cancer called non-Hodgkin's lymphoma (NHL), confirmed by a tissue biopsy. Who may not be able to join: - People whose lymphoma has spread to areas of the body outside the brain, the lining of the brain and spinal cord (meninges...

**Who might be able to join this trial:** - People who have been referred to Kamuzu Central Hospital (KCH) because their doctors suspect they may have lymphoma. - People who are older than 5 years of age, or children aged 5 years and under only if lymphoma has already been confirmed by laboratory testing. - People who...

**Who might be able to join this trial:** - People who have been newly diagnosed with a type of blood cancer called non-Hodgkin's lymphoma (NHL), confirmed by a tissue biopsy. **Who may not be able to join:** - People whose lymphoma has spread to areas of the body other than the brain, the lining of the brain (meninge...

"Who might be able to join this trial: - People who have been diagnosed with Hodgkin lymphoma or non-Hodgkin lymphoma Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with trial site) Important: Always verify eligibility with the trial site directly before applyin...

Who might be able to join this trial: - People diagnosed with Acute Lymphoblastic Leukemia (ALL), any subtype, who are being treated following ALL treatment protocols - People with certain other types of leukemia (including NK Cell Lymphoma/Leukemia or Biphenotypic Acute Leukemia) who are being treated following ALL tr...

**Who might be able to join this trial:** - People who have been diagnosed with Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL) that has come back or stopped responding to treatment - People whose cancer cells test positive for a protein called CD30, confirmed by a certified pathology laboratory - People whose blo...

Who might be able to join this trial: - People who have been diagnosed with a specific type of lymphoma (a blood cancer) called Diffuse Large B-Cell Lymphoma (DLBCL), confirmed by a tissue sample test. - People whose treating doctor considers them suitable for radiation therapy after completing a chemotherapy regimen c...

Who might be able to join this trial: - Adults aged 18 or older who are part of the Amish or Mennonite community - Children from the Amish or Mennonite community whose parent or guardian gives permission for them to take part Who may not be able to join: - Amish or Mennonite adults aged 18 or older who do not speak En...

Who might be able to join this trial: - A person must have given documented informed consent (or have a legally authorised representative do so on their behalf). - A person must be enrolled in the Revlimid REMS program, which is a required safety monitoring program for the drug lenalidomide. - A person must have a perf...

**Who might be able to join this trial:** - People who have been diagnosed with a recurring T-cell blood or lymph node cancer, specifically one of these types: T-cell acute lymphoblastic leukemia (T-ALL), T-cell acute lymphoblastic lymphoma (T-LLy), or certain types of T-cell non-Hodgkin lymphoma (including AITL, EATL...

Who might be able to join this trial: - People who have been diagnosed with Hodgkin lymphoma or non-Hodgkin lymphoma, confirmed by laboratory testing of tissue. - People who are 20 years of age or older. - People whose doctors have determined they need chemotherapy given throughout the body, with the goal of curing the...

**Who might be able to join this trial:** - People who have been diagnosed with Non-Hodgkin's Lymphoma (NHL) where the cancer has responded to chemotherapy, with eligibility depending on the specific type of NHL and how many treatment rounds have been completed (confirm with trial site for details on specific sub-type...

"Who might be able to join this trial: - Adults aged 18 years or older, of any gender - People who have given written consent to participate - People with a confirmed diagnosis of Hodgkin disease, non-Hodgkin lymphoma, or myeloma Who may not be able to join: - People whose diagnosis of Hodgkin disease, non-Hodgkin lym...

**Who might be able to join this trial:** - Adults aged over 18 years at the time of signing the consent form - People who have been diagnosed with a type of blood cancer called Peripheral T-Cell Lymphoma (PTCL), either newly diagnosed or that has come back or stopped responding to treatment, confirmed by a tissue tes...

**Who might be able to join this trial:** - People who have been diagnosed with follicular lymphoma (a type of slow-growing blood cancer), grades 1, 2, or 3a, confirmed by lab testing at the NCI - People whose disease can be seen and measured on CT or PET scans — this includes scans taken at any point since diagnosis,...

Who might be able to join this trial: - People who have been diagnosed with lymphoma - People who are receiving treatment in the Czech Republic - People who have signed a consent form agreeing to take part in the trial Who may not be able to join: - People who have not signed the consent form agreeing to take part - P...

Who might be able to join this trial: - People aged 18 years or older - People who are being assessed or treated for cancer or non-cancerous tumours at the Developmental Therapeutics Clinic at the NIH Clinical Center - People who are willing and able to sign a written consent form agreeing to have data from their tissu...

**Who might be able to join this trial:** - Adults aged 18 years or older, of any gender - People who have been formally diagnosed with a type of blood cancer called a mature B-cell tumor, as defined by World Health Organization (WHO) 2008 guidelines - People who are able and willing to attend and follow all required s...

**Who might be able to join this trial:** - You are 18 years of age or older - Doctors expect you to live for at least 3 months - You are able to carry out basic daily activities, even if you have some limitations (confirm with trial site for exact activity level required) - You have been confirmed to have Primary Cen...

**Who might be able to join this trial:** - You have been diagnosed with Mycosis Fungoides (MF), a type of skin lymphoma, confirmed by a tissue sample (biopsy), and it affects your skin. - You have at least one skin lesion that can be seen and measured during a physical exam. - If you were previously diagnosed with MF...

**Who might be able to join this trial:** - You have a confirmed solid tumor, or you have a newly found growth that doctors strongly believe is a solid tumor. - You have leukemia and doctors are concerned there may be a specific area of abnormality in one of your organs (confirm with trial site). - If you are under 18,...

**Who might be able to join this trial:** - People who have been diagnosed with prostate cancer that continues to grow despite having very low testosterone levels (known as castration resistant prostate cancer), confirmed through a tissue or cell sample. - People who are reasonably active in daily life and able to care...

**Who might be able to join this trial:** - Children and young people under 21 years of age who are already receiving certain medications as part of their regular medical care, as prescribed by their doctor **Who may not be able to join:** - Those for whom the required consent has not been given (this may include cons...

**Who might be able to join this trial:** - Your cancer has been confirmed through a lab test (tissue sample) to be a specific type called Diffuse Large B-Cell Lymphoma (DLBCL) - Your lymphoma has come back or stopped responding to previous treatment - You are 18 years of age or older - Your overall health and ability...

Who might be able to join this trial: - People who have been diagnosed with classical Hodgkin lymphoma (a specific type of blood cancer), confirmed by laboratory testing of tissue. - People whose kidneys, liver, lungs, and general body chemistry are functioning within normal ranges. - People (or their legal guardians,...

**Who might be able to join this trial:** **Observational Arm (monitoring only, no assigned treatment):** - People with a type of blood cancer called ALL (acute lymphoblastic leukemia) who are undergoing a full-intensity stem cell transplant and still have detectable traces of cancer before the transplant (detected b...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time treatment begins - People who have a type of B-cell non-Hodgkin lymphoma (a blood cancer) confirmed by a tissue test, specifically follicular lymphoma (but not a subtype called grade 3B), mantle cell lymphoma, or marginal z...

**Who might be able to join this trial:** *For people with Mycosis Fungoides (MF) or Sézary Syndrome (SS):* - A confirmed diagnosis of mycosis fungoides or Sézary syndrome at the enrolling hospital, with disease at stage IB or higher (meaning patches, plaques, or papules covering at least 10% of the skin, or affectin...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of blood cancer — CD19-positive, BCR-ABL1-positive acute leukemia (including B-cell ALL, mixed phenotype acute leukemia, or CML in lymphoid blast crisis with a certain level of abnormal cells) — confirmed through laboratory...

**Who might be able to join this trial:** - People aged 4 to 80 years - People who have been diagnosed with a high-risk blood cancer — specifically acute lymphocytic leukemia, acute myeloid leukemia, ambiguous lineage leukemia, or myeloma — where the disease has come back or has not responded to treatment - People who...

Who might be able to join this trial: **Adults (aged 18 and over):** - People aged 18 or over with a confirmed type of blood cancer that carries a specific protein called CD19 — this includes certain types of leukaemia (ALL, CLL) or lymphoma (DLBCL, FL, or MCL) - People with ALL (a type of leukaemia) whose cancer has...

**Who might be able to join this trial:** - People who have been newly diagnosed with a specific type of aggressive lymphoma called DLBCL (Diffuse Large B-Cell Lymphoma) that is at a limited (early) stage and is not considered "bulky" (very large), confirmed using standard lymphoma staging tests including a PET scan a...

**Who might be able to join this trial:** - People diagnosed with one of the following blood cancers or related conditions, who the trial site doctor considers a suitable candidate for a stem cell transplant from a donor (allogeneic HCT): - Acute lymphoblastic leukemia (ALL) with less than 5% abnormal cells in the b...

**Who might be able to join this trial:** - People under 25 years of age - People who have not previously had a stem cell transplant from a donor (this would be their first one) - People diagnosed with certain blood cancers that carry a high risk of coming back, including acute myeloid leukemia (AML), acute lymphoblas...

**Who might be able to join this trial:** - People who are willing to sign a consent form agreeing to follow all study procedures for the full length of the study. - People aged 12 years or older. - People who have been diagnosed with a type of blood cancer involving CD4+ T cells, where the cancer has come back after...

Who might be able to join this trial: - People who have signed the consent form to participate in the REALYSA study. - People who are 18 years of age or older at the time of joining. - People who have been diagnosed with lymphoma within the last 6 months (180 days). - People whose lymphoma is one of these seven specifi...

Who might be able to join this trial: **For young people (AYA participants):** - People aged 14 to 29 years old - People who have been diagnosed with acute lymphoblastic leukemia (ALL) or lymphoma (cancers affecting blood cells or the lymphatic system) - People who are in the maintenance phase of their treatment, have...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of blood cancer called diffuse large B-cell lymphoma (DLBCL), confirmed through laboratory testing of tissue samples - People who have received exactly two prior standard treatment courses for DLBCL, which must have include...

**Who might be able to join this trial:** - People who have been diagnosed with an aggressive type of B-cell lymphoma (specifically certain subtypes of diffuse large B-cell lymphoma or high-grade B-cell lymphoma), confirmed by a specific laboratory at the NCI, who have not yet received any treatment for this diagnosis...

**Who might be able to join this trial:** - People who have been diagnosed with a type of cancer called non-Hodgkin's lymphoma in the brain, confirmed through a brain biopsy. - People whose MRI or CT brain scan shows a specific pattern of abnormal lesions that appear in a way consistent with primary CNS lymphoma (lymph...

Who might be able to join this trial: - People whose transplant information is registered with the Center for International Blood and Marrow Transplant Research (CIBMTR), a large research database for blood and marrow transplant patients - Adults aged 18 or older who have been diagnosed with either Cutaneous T-Cell Lym...

**Who might be able to join this trial:** - People who have recently been diagnosed with lymphoblastic lymphoma for the first time - Children and young people under 18 years of age - People who are being treated at a hospital or centre that is part of this trial - People (aged over 14, or as required by local rules) an...

**Who might be able to join this trial:** - People who have been clinically diagnosed with cutaneous T-cell lymphoma or peripheral T-cell lymphoma that affects the skin, confirmed by a laboratory examination of skin tissue samples. - People who have measurable areas of skin disease, as assessed using a specific skin s...

**Who might be able to join this trial:** - People who are able to give their consent to take part - People with a general health and activity level rated as reasonably functional (confirm with trial site) - People who have been diagnosed with a relapsed or treatment-resistant blood cancer, specifically Non-Hodgkin Lym...

Who might be able to join this trial: - People aged 18 or older at the time of signing consent forms. - People who have signed a consent form agreeing to take part and allowing their personal health information to be used. - People with a type of lymphoma called CD30-positive peripheral T-cell lymphoma, confirmed by a...

Who might be able to join this trial: - People who have been diagnosed with a mature B-cell tumour, as defined by the World Health Organisation's 2008 classification guidelines - People who are 18 years of age or older Who may not be able to join: - People who have previously received chemotherapy treatment - People w...

**Who might be able to join this trial:** - You must be 18 years of age or older - You must be scheduled to receive one of the following approved CAR T cell treatments for lymphoma: axicabtagene ciloleucel, tisagenlecleucel, lisocabtagene maraleucel, or brexacabtagene autoleucel - Your heart, lungs, blood, liver, and k...

**Who might be able to join this trial:** - People who have been diagnosed with a type of blood cancer called CLL or SLL and whose disease meets medical guidelines indicating treatment is needed. - People in Group 1 (first-time treatment): Those who have not yet been treated AND have at least one higher-risk feature o...

Who might be able to join this trial: - Adults aged 18 to 60 years who have been newly diagnosed with a type of blood cancer called Philadelphia chromosome-negative acute lymphoblastic leukaemia (ALL) — meaning their leukaemia does not have a specific genetic marker called the Philadelphia chromosome - People whose gen...

Who might be able to join this trial: - People who have been diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN), confirmed by tissue testing, who have either never received treatment or whose disease has come back or stopped responding to treatment. - People who are starting their first treatment may h...

**Who might be able to join this trial:** **For people with B-cell Acute Lymphoblastic Leukaemia (B-ALL):** - People aged 3 to 69 years old - People who have a laboratory-confirmed diagnosis of a type of blood cancer called CD19+ B-ALL - People whose cancer has come back or has not responded to treatment, such as: sta...

**Who might be able to join this trial:** - People who have been confirmed by biopsy or cell testing to have one of the following types of T-cell lymphoma: mycosis fungoides (MF), Sézary Syndrome (SS), primary cutaneous CD30+ anaplastic large cell lymphoma (cALCL), peripheral T-cell lymphoma not otherwise specified (P...

**Who might be able to join this trial:** - People diagnosed with Mycosis Fungoides (MF) or Sézary Syndrome (SS) at Stage IB through Stage IV - People who have already received at least one standard treatment for their condition - People who previously had a specific type of full-body radiation therapy (called LD-TSEB...

Who might be able to join this trial: - People who have been diagnosed with lymphoma (based on the WHO 2017 classification guidelines) - People with a life expectancy of at least 3 months - People willing to sign a written informed consent form to participate Who may not be able to join: - People who have a history of...

**Who might be able to join this trial:** - People who have been diagnosed with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) within the past 18 months, confirmed using 2018 international diagnostic guidelines. - People whose CLL has been assessed using a recognised risk-scoring system (called...

Who might be able to join this trial: **For people joining the study going forward (prospective group):** - People who have recently been diagnosed with a type of aggressive blood cancer called Diffuse Large B Cell Lymphoma and are starting their first course of standard treatment - People who are able to give written...

**Who might be able to join this trial:** - People diagnosed with Acute Leukemia (AML or ALL) whose disease has gone into complete remission, with or without full blood count recovery - People who have a fully matched related donor (matched at 8 out of 8 markers) who is willing and medically cleared to donate blood st...

**Who might be able to join this trial:** - People who have been diagnosed with extranodal natural killer/T-cell lymphoma, nasal type, confirmed by a tissue biopsy - People who have been newly diagnosed and whose disease is at an early stage (stage I or II) - People who have at least one measurable area of disease that...

Who might be able to join this trial: - People who have not objected to being included in the trial - People who have been diagnosed with one of the following specific types of lymphoma (a blood cancer affecting the lymph system): DLBCL, Follicular Lymphoma, Classic Hodgkin Lymphoma, T-cell Lymphoma, or Mantle Cell Lym...

**Who might be able to join this trial:** - People who are able to understand the study and are willing to sign a written consent form before any study-related procedures begin. - People who are willing and able to attend scheduled visits, follow the treatment plan, and complete required tests throughout the study. -...

Who might be able to join this trial: - The child has been diagnosed with Burkitt's Lymphoma (a type of cancer), in any location in the body - The diagnosis has been confirmed by a laboratory test looking at cells or tissue samples - The child is not able to receive or complete the full standard treatment Who may not...

Who might be able to join this trial: - People who are older than 6 months of age - People who have a type of B cell lymphoma where the cancer cells carry specific markers on their surface (called CD19, CD22, CD70, PSMA, CD13, CD79b, or GD2) - People whose general health and ability to carry out daily activities is sco...

**Who might be able to join this trial:** - People diagnosed with a type of non-Hodgkin's lymphoma (a blood cancer) that has come back or stopped responding to treatment, confirmed by lab testing to have a specific protein marker called CD19 on the cancer cells. - People whose cancer cells test positive for a protein...

**Who might be able to join this trial:** - People who have been confirmed by a tissue biopsy to have Diffuse Large B-cell Lymphoma (DLBCL) or Follicular grade IIIb lymphoma, as classified by the 2017 World Health Organization guidelines. - People aged 65 or older. - People who have had a full geriatric (older adult h...

**Who might be able to join this trial:** - People aged 18 or older - People who are being monitored and treated in a blood disorder (hematology) unit - People who have already received their first round of chemotherapy for a type of blood cancer called diffuse large B cell lymphoma or follicular lymphoma - People who...

**Who might be able to join this trial:** - People aged 18 or older who are able to understand and sign a written consent form agreeing to take part in the study. - People who agree to allow the trial to use stored tumor tissue samples from a previous biopsy (exceptions may be possible with approval from the study lea...

Who might be able to join this trial: - People diagnosed with one of the following types of B-cell blood cancer: Burkitt lymphoma, Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Mantle Cell Lymphoma, Marginal Zone Lymphoma, Transformed Follicular Lymphoma, Richter syndrome, or CD20+ Hodgkin Lymphoma. - People whos...

Who might be able to join this trial: - People aged 18 years or older - People who have been diagnosed with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or stopped responding to previous treatment, according to specific medical guidelines - People whose cancer has spread to...

**Who might be able to join this trial:** *For people with B-ALL (a type of blood cancer affecting B cells):* - People aged 3 to 70 years old - People who have been diagnosed with B-ALL confirmed through laboratory testing, following recognised medical guidelines - People whose B-ALL has come back or has not responde...

**Who might be able to join this trial:** - People who have been diagnosed with a solid tumour or lymphoma (confirmed by a tissue or biopsy test), whether newly diagnosed, returned, or recurring, and where the cancer has not spread into the bone marrow. - People whose doctor has determined they are suitable to receive...

**Who might be able to join this trial:** - You are between 10 and 18 years old - You have had surgery to repair a moderate to complex congenital heart defect (a heart condition you were born with) **Who may not be able to join:** - You do not speak English, as communication during the exercise sessions is required -...

Who might be able to join this trial: - Adults aged 18 or older (and for some groups, teenagers aged 12–18 who weigh at least 40 kg) who are willing to give written consent before any screening tests are done - People with blood cancers (such as AML, CLL/SLL, or certain lymphomas) that have come back or stopped respond...

**Who might be able to join this trial:** - You have been diagnosed with a type of brain or spinal cord lymphoma (primary central nervous system lymphoma) confirmed by a tissue test, and after completing standard chemotherapy, your cancer has fully or partially responded to treatment. - You are not able to have a stem...

**Who might be able to join this trial:** - People who have been diagnosed with classical Hodgkin Lymphoma (a type of blood cancer), confirmed by a tissue sample test - People who have not yet received any treatment for this condition - People between the ages of 18 and 55 years old (confirm with trial site, as the up...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with a lymphoma or solid tumour that has come back or has not responded to previous treatment - People whose general physical health and ability to carry out daily activities is rated as fully active or restricted in st...

**Who might be able to join this trial:** - People who are over 18 years old and expected to live for more than 12 weeks. - People who have been diagnosed with a specific type of brain/central nervous system lymphoma called DLBCL-type (confirmed by a tissue biopsy). - People in Group 1: Those whose CNS lymphoma has co...

**Who might be able to join this trial:** - People aged 18 or older, any gender - People newly diagnosed with high-risk Large B-cell Lymphoma, which includes: (1) a specific type called DLBCL with a risk score of 3 or higher at diagnosis, (2) a high-grade B-cell lymphoma with certain gene changes involving MYC and BCL...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of blood cancer called diffuse large B-cell lymphoma, or a slow-growing B-cell lymphoma that has recently changed into a faster-growing type - You have either not yet started treatment, or have received no more than 2 cycles of ch...

Who might be able to join this trial: - People who have agreed to take part in the research study - People who have a suspected or confirmed diagnosis of cutaneous leishmaniasis (a skin infection caused by a parasite spread through sandfly bites) Who may not be able to join: - No exclusion criteria were listed in the...

**Who might be able to join this trial:** - Adults aged 18 to 65 years old - People who have acute lymphoblastic leukemia (ALL) that has come back or has not responded to treatment, meeting at least one of these situations: the leukemia came back within 12 months of first going into remission; the leukemia did not go...

**Who might be able to join this trial:** - You have been recently diagnosed with a specific type of blood cancer called Ph+ B-cell Acute Lymphoblastic Leukemia (ALL) and have not yet received treatment for it, with a certain protein (CD22) present on at least 20% of your cancer cells. - You are 18 years of age or old...

Who might be able to join this trial: **All groups (Cohorts 1, 2, and 3):** - Adults aged 18 or older, of any gender - People who are willing to voluntarily take part, sign a consent form, and follow the trial's treatment and visit schedule - People with a general health status rated as reasonably functional (scored 0...

**Who might be able to join this trial:** - Adults aged 18 or older - People newly diagnosed with a specific type of blood cancer called primary mediastinal large B-cell lymphoma, confirmed by a tissue biopsy analysed according to standard international guidelines (WHO 2016 classification) - People at any stage of thi...

**Who might be able to join this trial:** - People who have been confirmed through laboratory testing to have advanced cancer that has stopped responding to standard treatments, or where no standard treatment is available — any number of previous treatments is permitted. - During the dose-finding stage of the trial, p...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with a type of slow-growing blood cancer called follicular lymphoma (FL), confirmed by a tissue sample, that is classified as Grade 1, 2, or 3a, and tests positive for a marker called CD20 - People whose cancer has stop...

**Who might be able to join this trial:** - People aged 18 to 60 years (main group), or aged 61 and older if a doctor determines they are suitable for a specific treatment combination called AVD based on an overall health assessment (exploratory group) - People who have recently been diagnosed with classical Hodgkin l...

"Who might be able to join this trial: - People who have been diagnosed through a tissue biopsy with classic Hodgkin lymphoma (a type of blood cancer) that has either come back for the first time after treatment, or that never responded to treatment in the first place. Who may not be able to join: - People whose Hodgk...

Who might be able to join this trial: - People who have been formally diagnosed with Waldenstrom's macroglobulinemia (WM) or lymphoplasmacytic lymphoma (LPL), with a measurable level of IgM protein in the blood (at least 500 mg/dL). - People whose baseline disease tests were completed within 28 days before signing up f...

**Who might be able to join this trial:** - Adults aged 18 or older - People with previously untreated follicular lymphoma (grade 1–3a) with a low amount of disease spread, as measured by specific medical guidelines called GELF criteria - People with previously untreated follicular lymphoma (grade 1–3a) with a high am...

**Who might be able to join this trial:** - People whose doctors estimate they have a life expectancy of at least 12 weeks. - People who have been diagnosed with large B-cell lymphoma (including certain related types called transformed follicular lymphoma and follicular lymphoma Grade 3B) that has come back or stopped...

**Who might be able to join this trial:** - People aged 18 or older - People with a confirmed diagnosis of a CD19-positive B-cell blood cancer (a specific type of cancer affecting immune cells) that has come back or stopped responding to treatment, including certain types of non-Hodgkin lymphoma or chronic lymphocytic...

Who might be able to join this trial: - Adults aged 18 to 100 years old - People who have been diagnosed with Mycosis Fungoides (MF) or Sézary Syndrome (SS) at any stage (I through IV), confirmed through a tissue sample analysis using a recognised international classification system - People with a general health statu...

Who might be able to join this trial: - People who are able to understand and are willing to sign a written consent form before any study-related activities begin. - People who are willing and able to attend scheduled visits, follow the treatment plan, and complete required tests throughout the study. - People who are...

Who might be able to join this trial: - People who are over 18 years old - People who have a type of blood cancer called DLBCL (Diffuse Large B-Cell Lymphoma) and for whom a specific cell-based treatment (called CAR-T cell therapy) has already been scheduled outside of any clinical trial - People who are being followed...

**Who might be able to join this trial:** - People who have been diagnosed with certain types of peripheral T-cell lymphoma (PTCL) confirmed by a tissue sample, including subtypes such as PTCL not otherwise specified, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, enteropathy-associated T-cell lym...

Who might be able to join this trial: - People who are older than 15 years and 3 months, were diagnosed with lymphoma at Nîmes University Hospital from 1999 onwards, and whose original tumour tissue samples from diagnosis are still available. Who may not be able to join: - People aged 18 or older who have already said...

**Who might be able to join this trial:** - People aged 0 to 39 years old - People with T-cell acute lymphoblastic leukaemia (a type of blood cancer) who are in their second or later remission, meaning less than 5% cancer cells are detected in the bone marrow - People with relapsed T-cell lymphoblastic lymphoma (a rel...

**Who might be able to join this trial:** - People diagnosed with follicular lymphoma (a type of slow-growing blood cancer) confirmed as grade 1, 2, or 3A through laboratory testing of tissue samples - People who have already received at least one prior treatment for their lymphoma - People who have at least one measur...

**Who might be able to join this trial:** - People diagnosed with relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL) or Follicular Lymphoma (FL) who have already received 2 standard lines of treatment, and whose doctor believes they need further treatment. - People diagnosed with other relapsed or refractory...

**Who might be able to join this trial:** - People aged 18 or older who are able to give signed agreement to take part in the trial. - People who are willing and able to follow all parts of the trial plan. - People whose general physical functioning is rated at 0 or 1 on a standard cancer performance scale (meaning th...

Who might be able to join this trial: - You are 18 years of age or older - You have received radiation treatment to the brain for a blood cancer (such as lymphoma affecting the brain, leukemia, or myeloma) - You are able to read, speak, and complete tests in English - You have claustrophobia (fear of enclosed spaces),...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of lymphoma called CD20-positive Diffuse Large B-Cell Lymphoma (DLBCL), confirmed by laboratory testing using the 2016 WHO classification system - People whose lymphoma went into complete remission (no signs of cancer detec...

**Who might be able to join this trial:** - People who have been diagnosed (confirmed by tissue testing) with a WHO Grade II or III meningioma (a type of brain tumour) that has either remained after surgery, grown again, or come back, after having both surgery and radiation therapy. Spread of the meningioma to other a...

**Who might be able to join this trial:** **For people joining as a "case" participant (those with a relevant health condition):** - People who are either a survivor of acute lymphoblastic leukemia (a type of blood cancer), or are currently living with a chronic lung disease related to being born premature, or have ha...

**Who might be able to join this trial:** - The patient was diagnosed with Acute Lymphoblastic Leukemia (ALL) when they were between 1 and 365 days old (i.e., during their first year of life) - The patient is starting their initial treatment (induction therapy) within the timeframe that the study is currently enrolling...

**Who might be able to join this trial:** This trial has two groups: a **main study group** and a **control group**, each with their own criteria. **Main study group — who may be eligible:** - Adults aged 18 or older - People newly diagnosed with a specific type of brain lymphoma called Primary Central Nervous System...

**Who might be able to join this trial:** - People who have been diagnosed with classical Hodgkin lymphoma, confirmed by a tissue sample (biopsy). - People who are 12 years of age or older. - People who have received one or two prior treatment regimens (chemotherapy or immunotherapy), and fall into one of two groups:...

**Who might be able to join this trial:** **For lymphoma survivors (Phase 1 and Phase 2):** - People who have been diagnosed with lymphoma (including indolent non-Hodgkin lymphoma, aggressive non-Hodgkin lymphoma, or classic Hodgkin lymphoma) - People aged 18 or older - People who finished their first course of treatm...

Who might be able to join this trial: - Adults aged 18 or older who have had, or are being considered for, a stem cell transplant using their own cells (called an autologous stem cell transplant), and who are enrolled in a specific named drug program (called the BV HL NDP) where treatment is given according to the appr...

Who might be able to join this trial: - People who have signed a consent form to participate in the study - People who have been diagnosed with a specific type of blood cancer called Ph-negative acute lymphoblastic leukaemia (ALL) and have not yet received any treatment for it Who may not be able to join: - People who...

**Who might be able to join this trial:** - People aged 18 or older. - People who have been diagnosed with a type of blood cancer called CLL or SLL (confirmed by laboratory testing), and who have measurable signs of the disease, such as enlarged lymph nodes or an enlarged spleen. - People whose doctors estimate they a...

**Who might be able to join this trial:** - You have been diagnosed with Sézary syndrome at a specific stage (stage IVA1) - You are considered suitable to receive a treatment called extracorporeal photopheresis (ECP), where blood is treated with light outside the body - It has been at least 3 weeks since your last canc...

Who might be able to join this trial: - Adults aged 18 or older - People whose ability to carry out daily activities is rated at a functional level of 0, 1, or 2 on a standard cancer performance scale (where 0 means fully active and 2 means capable of self-care but unable to work) - People with a confirmed diagnosis of...

**Who might be able to join this trial:** - People who have been diagnosed with chronic lymphocytic leukaemia (CLL), follicular lymphoma (FL), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), non-Hodgkin lymphoma (NHL, not otherwise specified), or Waldenström's macroglobulinaemia (WM) - People with CLL who fi...

**Who might be able to join this trial:** - People who have been diagnosed with relapsed or refractory peripheral T-cell lymphoma (a type of blood cancer that has come back or stopped responding to treatment), confirmed by laboratory testing, with measurable tumours larger than 1.5cm — and whose disease meets at least...

**Who might be able to join this trial:** **Naive Cohort (people who have never been treated for CLL):** - People who have been officially diagnosed with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL) according to 2018 international medical guidelines - People aged 18 years or older - People w...

**Who might be able to join this trial:** - Children in primary school from first grade onwards, between 6 and 12 years old - Children whose IQ score is above 70, as measured by a standard intelligence test called the WASI-II - Children identified as having a mathematical learning disability, meaning scores below the...

**Who might be able to join this trial:** - People aged between 18 and 75 years old (inclusive) - People diagnosed with diffuse large B-cell lymphoma (a type of blood cancer) where the disease has come back or worsened in the central nervous system (brain or spinal cord), confirmed by scans and/or tissue or fluid test...

**Who might be able to join this trial:** - You have a type of blood cancer called Acute Lymphoblastic Leukemia (ALL) that has come back or stopped responding to treatment, and the cancer cells test positive for a protein called CD19, and you are under 26 years old - Your leukemia has come back in the bone marrow for...

**Who might be able to join this trial:** - People aged 18 or older who have been diagnosed with Non-Hodgkin Lymphoma (NHL), Hodgkin Lymphoma (HL), or breast cancer - People who are scheduled to receive chemotherapy that includes a high cumulative dose of a drug type called anthracyclines (at least 240 mg/m²) - People...

**Who might be able to join this trial:** - People who have been newly diagnosed with one of the following types of T-cell lymphoma (and have not yet received treatment): angioimmunoblastic T-cell lymphoma, follicular helper T-cell lymphoma, or peripheral T-cell lymphoma with follicular helper T-cell type - People who...

Who might be able to join this trial: - You have been diagnosed with a type of B-cell Non-Hodgkin lymphoma that has come back or stopped responding to treatment - You need further treatment for your lymphoma, and you have already had at least one previous round of treatment - You are 60 years of age or older (there is...

**Who might be able to join this trial:** - People who have been newly diagnosed with mantle cell lymphoma (a type of blood cancer) that has not yet been treated, and whose diagnosis has been confirmed by a tissue sample showing a specific marker called CD20+ - People aged 70 or older, or people aged 60–69 if a doctor...

**Who might be able to join this trial:** - People who have been diagnosed with Mantle Cell Lymphoma (MCL), confirmed by a tissue biopsy, according to the 2017 WHO classification - People aged 18 to 84 years old - People whose MCL has come back or stopped responding to one, two, three, or four previous rounds of treat...

Who might be able to join this trial: - People who have been newly diagnosed with a mature B-cell non-Hodgkin lymphoma or classical Hodgkin lymphoma, confirmed by a tissue or cell sample test, and who fall into one of the specific categories below - People with Burkitt lymphoma, Burkitt-like lymphoma with an 11q chromo...

**Who might be able to join this trial:** - You have been diagnosed with follicular lymphoma, large B-cell lymphoma (including certain related types), or mantle cell lymphoma, confirmed through standard laboratory testing - You are scheduled to receive a commercially approved CAR-T cell therapy that matches FDA guidel...

**Who might be able to join this trial:** - People aged 18 to 70 years old. - People with certain types of large B-cell lymphoma who are receiving an autologous stem cell transplant (a transplant using the patient's own stem cells) or an FDA-approved CAR T-cell therapy (a specialised immune cell treatment). The specif...

**Who might be able to join this trial:** - People aged between 18 and 75 years - People whose general health and ability to carry out daily activities falls within an acceptable range for this trial (rated on a standard scale as 0, 1, or 2) (confirm with trial site) - People who have been diagnosed with diffuse large...

**Who might be able to join this trial:** - People who have been diagnosed with one of the following blood cancers confirmed by tissue testing: Diffuse Large B Cell Lymphoma (DLBCL), Primary Mediastinal B Cell Lymphoma, Follicular Lymphoma that has transformed into a more aggressive form, High Grade B Cell Lymphoma (e...

**Who might be able to join this trial:** - You have been diagnosed with a blood cancer (such as leukemia or lymphoma) that has come back or has not responded to treatment - You were first diagnosed before the age of 18, and you are younger than 25 years old at the time of joining the trial - You are being treated in...

**Who might be able to join this trial:** - People older than 6 months of age. - People whose bone marrow sample shows a high number of abnormal (cancer) cells — at least 30% — which is needed for certain laboratory testing and treatment preparation. - People whose cancer cells show certain specific proteins on their...

**Who might be able to join this trial:** - People diagnosed with certain blood cancers — specifically CD19-positive B-cell lymphoma (including Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Mantle Cell Lymphoma, Chronic Lymphocytic Leukaemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma) or B-cell Acute...

**Who might be able to join this trial:** - People aged 18 or older - People who currently have, or have previously had, any type of lymphoma - People who, if previously treated, have been off chemotherapy that affects bone marrow for at least 2 months, with no chemotherapy planned — or people who have never been trea...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with a type of skin lymphoma called mycosis fungoides (MF), confirmed by a biopsy reviewed at Memorial Sloan Kettering Cancer Center (MSKCC) - Your condition is at Stage IB or more advanced, based on standard staging...

**Who might be able to join this trial:** - People aged 18 to 60 years old (the upper age limit of 60 applies to the first phase of the trial only) - People who have been diagnosed with classical Hodgkin lymphoma (cHL), confirmed by a tissue biopsy - People whose Hodgkin lymphoma has come back after treatment, has not...

**Who might be able to join this trial:** - People who have been diagnosed with a type of cancer called non-Hodgkin lymphoma, confirmed by a tissue test, where the disease has come back after at least 2 previous treatments, has not responded to chemotherapy, or has returned within 12 months after a stem cell transplan...

**Who might be able to join this trial:** - People aged 18 or older who have been diagnosed with a type of blood cancer called T-cell Non-Hodgkin lymphoma (T-NHL), confirmed through a tissue biopsy. - People who are willing and able to give written consent to take part (or have a legal representative do so on their be...

**Who might be able to join this trial:** - People who have been newly diagnosed with a blood or bone marrow cancer or related condition — including acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), high-risk myelodysplastic syndrome (HR-MDS), or myelofibrosis related to a blood disorder — and have n...

Who might be able to join this trial: - People who are adults (18 years of age or older) - People who have been receiving a treatment called extracorporeal photopheresis (ECP) for at least 1 month, used for one of the following conditions: a complication called graft-versus-host disease (GVHD) after a bone marrow or st...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with CLL (chronic lymphocytic leukemia) or small lymphocytic lymphoma (SLL) according to established medical guidelines - You have never received chemotherapy, immunotherapy, or targeted therapy for CLL/SLL (limited...

**Who might be able to join this trial:** - People diagnosed with B cell non-Hodgkin lymphoma, as classified by the World Health Organization (WHO) 2017 guidelines - People whose cancer has come back or gotten worse, and for whom standard treatments are no longer an option due to reasons such as intolerance, the treat...

**Who might be able to join this trial:** - People aged 18 to 65 (in the dose escalation phase) or aged 18 and over (in the dose expansion phase), of any gender - People whose general health and ability to carry out daily activities meets a standard scoring level known as ECOG performance status 0 or 1 (confirm with t...

**Who might be able to join this trial:** - A tissue biopsy has confirmed a diagnosis of Diffuse Large B-Cell Lymphoma (DLBCL) according to World Health Organization classification (not including primary central nervous system lymphoma or lymphoma related to HIV). - Tumour lesions are visible and measurable on a PET/C...

**Who might be able to join this trial:** - People who have a type of lymphoma called diffuse large B-cell lymphoma (DLBCL) that has come back and is affecting the brain, spinal fluid, or eyes, confirmed by imaging, eye examination, or spinal fluid testing. - People whose lymphoma also exists outside the brain and ner...

**Who might be able to join this trial:** - You have been diagnosed with Hodgkin Lymphoma (HL) or Acute Myeloid Leukemia (AML) that has come back or gotten worse after previous treatment (previous immunotherapy treatments are allowed) - If you have HL that has spread beyond the lymph nodes to other parts of the body -...

**Who might be able to join this trial:** - People who are 18 years of age or older - For the early phases of the trial, people with an advanced or spreading solid tumour or lymphoma where standard treatments have stopped working, are not available, or do not apply to their situation - People with advanced or spreadin...

**Who might be able to join this trial:** - People who have been diagnosed with mycosis fungoides (a type of skin lymphoma) confirmed by biopsy, at any stage from I to IV, including those who have some abnormal Sézary cells in their blood at diagnosis or at enrollment, as long as the count is below 1,000 cells per mic...

Who might be able to join this trial: - A doctor has determined that the person is a suitable candidate for the specific medical device being studied, based on its approved intended use. - The person is able to attend and complete all required follow-up appointments for the duration of the study. - The person is willin...

**Who might be able to join this trial:** - People who have signed an informed consent form (or had a legal representative sign on their behalf) - People aged 18 or older who are well enough to carry out basic daily activities (confirmed by a doctor using a standard health scale) - People with a confirmed diagnosis of...

**Who might be able to join this trial:** - People who have given written consent to take part (or whose legal representative has done so on their behalf) - People who are willing and able to follow all the steps required by the study - People aged 18 or older - People whose general physical functioning is rated at a...

**Who might be able to join this trial:** - People who are eligible for the related core clinical study called CLC3/S1925 (confirm with trial site) - People who have signed a consent form before enrolling, agreeing to take part in the trial in line with local and legal requirements - People who are able and willing to...

Who might be able to join this trial: - People who have previously received Pell's lentiviral-based gene-edited immune cell treatment, either on its own or combined with other treatments, as part of a clinical trial. - People whose last dose of this gene-edited immune cell treatment was received within the past 15 year...

**Who might be able to join this trial:** - People who have signed the required consent forms and are able to follow all study procedures, in the opinion of the study doctor - People aged 18 or older - People whose general physical functioning falls within an acceptable range on a standard medical scale (ECOG score of...

**Who might be able to join this trial:** - People who have been diagnosed with a type of blood cancer called B-cell non-Hodgkin lymphoma (NHL), confirmed by tissue or cell testing, and whose cancer has one or more of these features: cancer cells found in the fluid around the brain or spine; a high risk of the cancer...

Who might be able to join this trial: - People who have been diagnosed with a condition called BPDCN (Blastic Plasmacytoid Dendritic Cell Neoplasm), which is a rare type of blood cancer. - People who have signed a consent form agreeing to take part in the study (for those enrolling going forward). Who may not be able...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender, with a type of B-cell non-Hodgkin's lymphoma that has come back or stopped responding to treatment - People whose doctors estimate they are likely to live for more than 12 weeks - People with a general health status rated as reasonably...

**Who might be able to join this trial:** - You have been diagnosed with a confirmed B cell blood cancer (B-cell ALL), a type of leukemia that has changed into a form of blood cancer (CML transformed to ALL), or a fast-growing lymphoma (such as Burkitt's lymphoma, diffuse large B-cell lymphoma, or a slow-growing lymph...

**Who might be able to join this trial:** - You have signed and agreed to take part, and are able to follow the study procedures. - You are 18 years of age or older. - You have been diagnosed with B cell or T cell lymphoma (confirmed by a tissue sample) that has come back or stopped responding to treatment. - You have...

**Who might be able to join this trial:** - People diagnosed with relapsed or refractory diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, transformed indolent B-cell lymphoma, or high-grade B-cell lymphoma - People who received a standard-of-care, FDA-approved CAR T-cell therapy (targeting CD19) out...

Who might be able to join this trial: - Adults between 18 and 70 years old who have a performance status score of 0–2 (a measure of how much the illness affects daily activity — confirm with trial site) - People whose doctors estimate they are likely to live for more than 6 months - People who have been confirmed by a...

Who might be able to join this trial: - Children and young people who are older than 1 year old and no older than 18 years old at the time of joining the trial - People who have not received any previous treatment for their condition - People whose diagnosis of ALL (a type of blood cancer called Acute Lymphoblastic Leu...

Who might be able to join this trial: - People who are patients at one of the participating medical centres that have passed a data review by the National Clinical Center for Skin and Immune Diseases. - People who have received a confirmed diagnosis of primary cutaneous lymphoma (a type of lymphoma that starts in the s...

**Who might be able to join this trial:** - People diagnosed with non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body (stage IIIB to stage IV) - People whose overall health and ability to carry out daily activities falls within the range measured by a standard medical sca...

**Who might be able to join this trial:** - People who have been diagnosed with mantle cell lymphoma (MCL), a type of blood cancer, confirmed by a tissue biopsy. - People who are able to swallow and digest oral (by mouth) medications. - People whose MCL has come back or stopped responding to treatment, including those...

**Who might be able to join this trial:** - You must be 18 years of age or older (there is no upper age limit) - You must be well enough to carry out basic daily activities — you may need some help but should not be completely unable to care for yourself (confirm with trial site) - You must have been diagnosed with B-...

**Who might be able to join this trial:** - People aged over 18 years. - People who have been confirmed by a tissue biopsy to have one of the following specific types of large B-cell lymphoma: DLBCL not otherwise specified, T cell/histiocyte rich large B-cell lymphoma, EBV-positive DLBCL, Grade 3b Follicular Lymphoma,...

**Who might be able to join this trial:** - People aged 18 to 75 years old (inclusive). - People who have been diagnosed through a biopsy with a type of B-cell non-Hodgkin lymphoma (a blood cancer) that tests positive for a protein called CD19, including specific subtypes such as diffuse large B-cell lymphoma (DLBCL),...

**Who might be able to join this trial:** - Adults aged 18 or older, or children aged 2 to 17 years old - People diagnosed with a type of blood cancer called precursor B-cell acute lymphoblastic leukemia (B-ALL), with more than 5% cancer cells found in the bone marrow - People with B-ALL that does not involve a geneti...

Who might be able to join this trial: - People aged 18 to 69 with a reduced ability to carry out daily activities (as assessed by their doctor), or people aged 70 and older, who are not suitable for a stem cell transplant in their doctor's judgment - People who have been newly diagnosed with a type of brain cancer call...

**Who might be able to join this trial:** - People who have Hodgkin lymphoma that has come back or stopped responding to ABVD chemotherapy, and whose condition is considered high risk - People aged 18 to 90 years old - People whose liver is working well enough, based on specific blood test results being within accepta...

**Who might be able to join this trial:** - People who are generally well enough to carry out daily activities with little to no limitation (measured by a standard scale called ECOG, scoring 0 or 1) - People diagnosed with a type of B-cell lymphoma (a blood cancer) that has come back or stopped responding to treatment...

**Who might be able to join this trial:** - People who have been diagnosed with relapsed CD20+ Follicular Lymphoma (grade 1–3a) — this applies to the safety run-in phase only - People who have been diagnosed with relapsed CD20+ diffuse large B-cell lymphoma — this applies to both phases of the trial - People whose lym...

**Who might be able to join this trial:** - People aged 18 or older. - People who are able to understand and sign a consent form approved by an ethics review board. - People who have been diagnosed with a type of blood cancer called B-cell non-Hodgkin lymphoma (NHL), confirmed by a tissue sample, that tests positive f...

**Who might be able to join this trial:** - People who are able to understand the study and are willing to sign a written consent form (non-English speakers may be able to use an interpreter during early steps while a translated form is arranged) - People who agree to allow the use of stored tissue samples from a prev...

**Who might be able to join this trial:** - People aged 18 to 75 years old (inclusive). - People with a reasonable level of physical functioning and a life expectancy of more than 3 months. - People with locally advanced or metastatic solid tumours, or relapsed/returned or treatment-resistant lymphomas, confirmed by l...

**Who might be able to join this trial:** - People aged 18 or older. - People with a life expectancy of at least 6 months. - People with a laboratory-confirmed diagnosis of Mantle Cell Lymphoma (MCL), showing specific genetic or protein markers associated with the disease. - People with Stage II, III, or IV MCL that c...

**Who might be able to join this trial:** - People who have been diagnosed with certain types of large B-cell lymphoma (confirmed by tissue testing), including specific subtypes defined by a standard medical classification system, whose cancer has come back or stopped responding to at least 2 previous rounds of treatm...

**Who might be able to join this trial:** - People diagnosed with relapsed or refractory B-cell acute lymphoblastic leukaemia (B-ALL) — meaning the cancer has come back or has not responded to treatment — where cancer cells are still detectable in the bone marrow, and the person has either relapsed, not responded to t...

**Who might be able to join this trial:** - You are already scheduled to receive a specific type of medical imaging scan (called an 18F FDG PET/CT scan) as part of your normal medical care - You are 18 years old or older and able to make your own decisions about taking part **Who may not be able to join:** - You have...

**Who might be able to join this trial:** - Adults aged 18 to 75 years old, of any gender - People whose ability to carry out daily activities falls within a certain range of functioning (a medical score from 0 to 3 — confirm with trial site what this means for a specific situation) - People who have been diagnosed wi...

**Who might be able to join this trial:** - People aged 18 years or older, of any gender - People who have been diagnosed with a specific type of aggressive blood cancer called diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma, where the cancer has come back after treatment or did not respond to trea...

**Who might be able to join this trial:** - People who have been officially diagnosed with NK/T-cell lymphoma through laboratory testing, as defined by the 2016 World Health Organization classification - People aged between 14 and 70 years old - People whose general physical health and ability to carry out daily activ...

**Who might be able to join this trial:** - People who have been diagnosed with Peripheral T-cell lymphoma, confirmed through a laboratory analysis of tumour tissue - People who have tumour tissue available (either previously collected and stored, or newly collected) that can be used for genetic testing before the stud...

**Who might be able to join this trial:** - Children older than 2 years, or adults of any gender - People whose cancer cells show a specific marker called CD1a on at least 20% of the abnormal cells, confirmed by laboratory testing - People diagnosed with a type of blood cancer called T-cell acute lymphoblastic leukaem...

**Who might be able to join this trial:** - People who have been diagnosed (confirmed by tissue testing) with primary CNS lymphoma, diffuse large B cell lymphoma that has spread to the brain, B cell non-Hodgkin's lymphoma confirmed by fluid testing, or ocular (eye) lymphoma with measurable tumour in the brain - People...

**Who might be able to join this trial:** - People who have been newly diagnosed with a type of blood cancer called T-lineage lymphoblastic lymphoma (T-LBL) at Stage II, III, or IV **Who may not be able to join:** - People who have Down syndrome or a condition that causes the immune system to not work properly from bi...

Who might be able to join this trial: - People who have a type of aggressive blood cancer called CD20+ B-cell non-Hodgkin lymphoma (B-NHL), and whose cancer has continued to grow or come back after at least two different treatment courses that included specific types of cancer-fighting drugs (an anti-CD20 antibody and...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People who have been diagnosed with a specific type of lymphoma called Nodal Marginal Zone Lymphoma (NMZL), confirmed by a lymph node tissue sample taken after January 1st, 2000 - People for whom a stored tumour tissue sample from a ly...

**Who might be able to join this trial:** - People who have given their informed consent to participate - People aged 18 years or older - People who have been clinically diagnosed with HLH (Hemophagocytic Lymphohistiocytosis — a serious condition where the immune system becomes dangerously overactive) - People who have...

**Who might be able to join this trial:** - Children who were first diagnosed between 1 year old and 18 years old, and who are younger than 21 years old at the time of joining the trial. - People whose general health and ability to carry out daily activities meets a minimum level, as measured by standard scoring tools...

**Who might be able to join this trial:** - Children and teenagers aged 1 to under 18 years old. - People who have been diagnosed with a first relapse (the cancer has come back for the first time) of a specific type of leukaemia called B-cell precursor ALL, classified as either high-risk or very high-risk based on whe...

Who might be able to join this trial: - People who have given written consent before any study-related procedures begin - People aged 18 or older - People willing to provide a stored or fresh tumour sample if one is available (providing a sample is not required to start treatment) - People whose bone marrow, liver, and...

**Who might be able to join this trial:** - People who are willing to sign a consent form and are able to follow the study requirements - People aged 18 to 70 years, of any gender - People diagnosed with a type of B-cell non-Hodgkin's lymphoma that tests positive for a protein called CD20, specifically: Diffuse Large...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form. - People who have been diagnosed (confirmed by tissue testing) with one of the following blood cancers that has come back or stopped responding to treatment: Chronic Lymphocytic Leukemia (CLL),...

**Who might be able to join this trial:** - People who have been diagnosed with relapsed or refractory CLL (chronic lymphocytic leukaemia), or SLL (small lymphocytic lymphoma, in the phase II part of the trial only), meaning the disease has come back or stopped responding to treatment after at least one previous cours...

**Who might be able to join this trial:** *For children with acute leukemia (AL):* - The child has been newly diagnosed with acute lymphoblastic or myeloblastic leukemia (two types of blood cancer) - The child has not yet received any treatment for their blood condition - The child is between 1 and 15 years old - Both...

**Who might be able to join this trial:** - People who have been diagnosed with an aggressive B cell non-Hodgkin lymphoma (NHL), confirmed by tissue testing — including diffuse large B cell lymphoma (DLBCL), primary mediastinal large B cell lymphoma, follicular or marginal zone lymphoma that has transformed into DLBCL...

**Who might be able to join this trial:** - People who have been diagnosed with a type of aggressive blood cancer called CD20-positive Diffuse Large B-Cell Lymphoma (DLBCL) or a closely related type, and have not yet received treatment for it. - People whose cancer has been classified under one of several specific sub...

**Who might be able to join this trial:** - People who have given their written agreement to take part (or whose legal representative has done so on their behalf) - Adults aged 18 years or older - People whose general health and ability to carry out daily activities meets a minimum level, as measured by standard scori...

**Who might be able to join this trial:** - The person joining the trial must give documented informed consent (or have a legally authorised representative do so on their behalf) - People must agree to allow the trial to use stored tumour tissue from a previous biopsy (exceptions may be possible with approval from the...

**Who might be able to join this trial:** - You are willing and able to sign a consent form and follow the study rules - You are 18 years of age or older - You have been diagnosed with a type of blood cancer called CD20+ B-cell Non-Hodgkin Lymphoma that came back or did not respond to at least one previous treatment th...

**Who might be able to join this trial:** - Adults who have been diagnosed with B-cell lymphoma that has come back or has not responded to treatment, and who have already completed an initial course of treatment with a therapy called Relma-cel. - People who have had at least one check-up to assess their disease after...

Who might be able to join this trial: - People who are already enrolled in the FIL_FOLL12 clinical trial, confirmed by having signed that trial's informed consent form. - People for whom biological samples are available, including bone marrow fluid, blood samples, and/or a preserved tissue sample taken at the time of d...

**Who might be able to join this trial:** - People who are able to understand the study's purpose and risks, and who are willing to sign a consent form agreeing to how their health information will be used. - People who are willing and able to attend all required study visits and procedures, including being able to sw...

**Who might be able to join this trial:** - People who were 1 year old or younger, or older than 22 years old, at the time their leukemia came back (confirm with trial site, as this age range is unusual — it may mean between 1 and 22 years old) - People who have been diagnosed with a specific type of blood cancer call...

Who might be able to join this trial: - People who are able to give their own consent to take part, or where a person's ability to consent is affected by their condition, a legal representative or consultee may be able to provide consent on their behalf in line with English or Scottish law - People who have been diagno...

**Who might be able to join this trial:** - People who have been diagnosed by a doctor with certain subtypes of peripheral T-cell lymphoma (PTCL), a type of blood cancer, as defined by a standard medical classification system — but not the skin-based or blood-based forms of these cancers. - People who have at least on...

Who might be able to join this trial: - Adults aged 18 or older who are able to give written consent to take part. - People who are willing and able to follow the trial's procedures and schedule. - People with a reasonable level of physical fitness and ability to carry out daily activities (assessed using a standard sc...

**Who might be able to join this trial:** - People aged 18 years or older - People of any sex or gender - People who are able to give informed consent to participate - People who can read or understand English or Spanish - People who have been diagnosed with untreated Non-Hodgkin or Hodgkin lymphoma that requires at l...

**Who might be able to join this trial:** - People whose doctors suspect they may have a type of eye lymphoma (lymphoma affecting the inside of the eye), and for whom a surgical procedure to examine the jelly-like fluid inside the eye (called a vitrectomy) has already been recommended as part of their diagnosis. - Peop...

Who might be able to join this trial: - People who are willing to take part voluntarily and sign a consent form - Adults aged 18 to 75, of any gender - People who have been diagnosed (confirmed by tissue testing) with certain types of B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL), transformed follicu...

**Who might be able to join this trial:** - People aged 18 or older at the time of enrollment - People who have signed a consent form agreeing to take part in the study - People with Stage III or Stage IV follicular lymphoma who have already received at least one round of systemic (whole-body) treatment for their condi...

Who might be able to join this trial: - The patient must be 365 days old or younger at the time of diagnosis. - The patient must have a newly diagnosed blood cancer called acute lymphoblastic leukemia (ALL) or acute undifferentiated leukemia, where the cancer cells test positive for a protein called CD19. - Patients wi...

Who might be able to join this trial: - People who have been diagnosed with follicular lymphoma (grade 1–3a) that has come back or stopped responding to treatment, confirmed by a biopsy taken within 3 months of joining the trial - People aged 18 years or older - People whose lymphoma has advanced to a stage where their...

Who might be able to join this trial: - People who were between 15 and 25 years old when they were diagnosed with their condition - People who were previously treated at the Paediatric Hematology and Oncology Institute (IHOPe) and/or the Leon Berard cancer centre (CLB) in the AYA (Adolescents and Young Adults) Departme...

**Who might be able to join this trial:** - People who are able to understand the purpose of the study and have provided written consent to participate - People aged 18 years or older - People who have been diagnosed with mantle cell lymphoma (a type of blood cancer) that has come back or stopped responding to treatme...

Who might be able to join this trial: - Children and adolescents who have been diagnosed with acute lymphoblastic leukaemia (ALL) or Lymphoma, and who are being treated under the officially approved treatment plans for these conditions in Denmark Who may not be able to join: - Children and adolescents who do not meet...

**Who might be able to join this trial:** - You speak English. - You are between 18 and 80 years old. - For certain parts of this study, you have been diagnosed with a type of slow-growing blood cancer called indolent non-Hodgkin lymphoma (including CLL/SLL), confirmed through a laboratory test of tissue or cells. **W...

**Who might be able to join this trial:** - People diagnosed with Acute Myeloid Leukemia (AML) who are in their first full remission but have features that make relapse more likely, such as a previous blood disorder, leukemia caused by prior cancer treatment, leukemia that spread outside the bone marrow, needing more...

**Who might be able to join this trial:** - People who have been diagnosed with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), confirmed by a specialist pathologist. - People with newly diagnosed NLPHL at stage IB through stage IV, or people who have already received treatment for NLPHL at any stage. - Peopl...

**Who might be able to join this trial:** - People who are willing to take part and give written consent to participate - People who are 18 years of age or older - People who have a confirmed diagnosis of relapsed or returned/treatment-resistant classical Hodgkin lymphoma or primary mediastinal B-cell lymphoma, where...

**Who might be able to join this trial:** - People who are able to understand and are willing to sign a consent form - People aged 18 or older - People who have a confirmed advanced solid tumour that has stopped responding to standard treatments, has no standard treatment available, or who have a type of blood cancer...

Who might be able to join this trial: - People who have lymphoma and also show signs of a serious immune overreaction called HLH (haemophagocytic lymphohistiocytosis), meeting at least one of the following two sets of conditions: - People whose condition meets 5 out of 8 specific medical signs listed in the HLH-2004 di...

**Who might be able to join this trial:** - People aged 18 years or older. - People who have already had a leukapheresis procedure (a process where white blood cells are collected from the blood) and are scheduled to receive one of two specific CAR T-cell therapies (axicabtagene ciloleucel or lisocabtagene maraleucel)...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with a type of blood cancer called mantle cell lymphoma (MCL), confirmed by a specific genetic marker or protein abnormality in their cancer cells - People whose MCL has come back or stopped responding to at least one...

**Who might be able to join this trial:** - People over 18 years old who have received a type of chemotherapy called anthracycline-based therapy for breast cancer or lymphoma within the last 30 days - People who also meet at least one of the following additional conditions: have had previous radiation treatment to the...

**Who might be able to join this trial:** - You have been diagnosed with Follicular Lymphoma grade 1 to 3A, confirmed by a tissue sample (biopsy) - Your lymphoma is at an early stage (Stage IA, IIA, or IE) and is not large (less than 7 cm), and fits within a single radiation treatment area - If you had a PET scan befo...

**Who might be able to join this trial:** - Adults aged 18 or older with stage I or II marginal zone lymphoma (including cases where the pathology report indicates "low grade B cell lymphoma, favour marginal zone lymphoma"). - People whose treatment plan does not include any systemic therapy (such as chemotherapy or i...

**Who might be able to join this trial:** - People who have been diagnosed with a type of blood cancer called peripheral T-cell lymphoma (PTCL), including certain NK/T-cell lymphomas, but not the type that tests positive for a protein called ALK — and whose cancer responded to their first round of treatment (either co...

Who might be able to join this trial: - People who have been diagnosed with primary central nervous system lymphoma (a type of lymphoma affecting the brain or spinal cord), confirmed by a pathology test using 2016 WHO standards, and who have already received at least one round of chemotherapy but whose disease has come...

Who might be able to join this trial: - People who have been newly diagnosed with a specific type of lymphoma called Double Expression Diffuse Large B-cell Lymphoma - People aged between 18 and 70 years old - People whose general health and ability to perform daily activities falls within an acceptable range (a score o...

**Who might be able to join this trial:** - People aged 18 to 50 years old at the time of their first treatment - People who have been diagnosed with classical Hodgkin lymphoma (cHL), Diffuse Large B-cell lymphoma (DLBCL), or Primary mediastinal large B-cell lymphoma (PMBCL) - People whose cancer went into complete rem...

**Who might be able to join this trial:** - People who have been confirmed by laboratory testing to have one of three specific types of lymphoma (PMBCL, EBV+ DLBCL, or THRLBCL) at one of the participating hospitals. - People for whom a tumour tissue sample is available — either one already stored from a previous proce...

**Who might be able to join this trial:** - Adults aged 18 to 75 years old - People who have given written agreement to take part before any screening tests begin - People diagnosed with a type of blood cancer called peripheral T-cell lymphoma that has come back or stopped responding to treatment, confirmed by a tissu...

**Who might be able to join this trial:** - People aged 18 or older of any gender, race, or ethnic background - People who are able to swallow and keep down oral (by mouth) medication - People who have been diagnosed with CLL (chronic lymphocytic leukaemia) or SLL (small lymphocytic lymphoma) that has not yet been tre...

**Who might be able to join this trial:** - People whose doctors estimate they have a life expectancy of more than 12 weeks. - People with a body mass index (a measure of body weight relative to height) between 18 and 32. - People whose general physical ability and daily functioning falls within a certain range, rated...

**Who might be able to join this trial:** - People who are 80 years of age or older at the time of screening, OR people aged 65 to 79 who have been assessed as not suitable for standard chemotherapy combined with immunotherapy - People who have been diagnosed with a specific type of lymphoma called Diffuse Large B-Cel...

**Who might be able to join this trial:** - People who have been diagnosed with a type of blood cancer called Diffuse Large B-Cell Lymphoma (DLBCL) - **Group 1:** People with DLBCL who are considered too unwell or frail for standard treatment — this includes people aged 80 or older, or younger people whose other healt...

**Who might be able to join this trial:** - People aged 18 or older at the time of giving consent. - People who have signed a consent form agreeing to take part and allowing their personal health information to be used for the study. - People who are reasonably active and able to care for themselves, as measured by a...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of lymphoma called nodal T-follicular helper (TFH) cell lymphoma, confirmed by a tissue sample test. - People who are older than 18 years of age. - People whose blood counts and organ function meet specific levels — includi...

**Who might be able to join this trial:** - People who have been diagnosed with CD19-positive B cell Non-Hodgkin Lymphoma (a type of blood cancer), Chronic Lymphocytic Leukemia, or Small Lymphocytic Lymphoma, confirmed by laboratory testing, and who have already received at least 2 previous treatments. - People enroll...

Who might be able to join this trial: - People who have signed a consent form before any trial-related procedures begin. - People who are 18 years of age or older at the time of signing the consent form. - People who have a reasonable level of physical functioning (rated on a standard scale from 0 to 2) and whose condi...

**Who might be able to join this trial:** - Adults aged 18 or older who are able and willing to give informed consent to participate - People who have a type of lymphoma (a blood cancer) that has come back or stopped responding to treatment, have already received at least 2 different rounds of treatment, and are not s...

Who might be able to join this trial: - You are 18 years old or older - You can be male or female - You have been diagnosed with a type of lymphoma called Peripheral T-Cell Lymphoma (PTCL) - You have already received a medication called chidamide as a maintenance therapy after your first round of treatment Who may not...

**Who might be able to join this trial:** - People who have been diagnosed with mantle cell lymphoma (a type of blood cancer), confirmed by laboratory testing of tissue samples showing specific markers or genetic changes linked to this disease — including some rarer forms of mantle cell lymphoma confirmed by other mar...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of lymphoma called classical Hodgkin Lymphoma (cHL), confirmed by a tissue biopsy, and who have tissue samples or slides available for the study's central review process. - People aged 65 or older who are not considered sui...

Who might be able to join this trial: - People who are willing and able to provide written consent to participate. - People who have a recent or archived tissue sample from their tumour available, or who are willing to have a new tissue sample taken. - People who have been formally diagnosed with one of the following t...

Who might be able to join this trial: - People who have been diagnosed with a lymphoproliferative disease (a type of condition affecting the cells of the immune system, such as lymphoma or leukaemia) - People who are 18 years of age or older - People who have received chemotherapy, biological treatment, or a combinatio...

**Who might be able to join this trial:** - Adults aged 18 to 80 years who have a type of B-cell non-Hodgkin Lymphoma (a blood cancer) that has come back or stopped responding to treatment. - People diagnosed with one of these specific lymphoma types: Diffuse Large B-Cell Lymphoma (DLBCL) and related subtypes, Mantle...

**Who might be able to join this trial:** - People older than 6 months of age - People whose cancer cells have been confirmed, through laboratory testing, to carry a specific protein called CD7 along with other surface markers - People who are in generally good physical condition (as measured by a standard health scori...

**Who might be able to join this trial:** - People who have been diagnosed with primary central nervous system (CNS) lymphoma (a type of cancer affecting the brain or spinal cord), confirmed by a tissue or fluid sample, including those with eye involvement or cancer cells in the spinal fluid, as long as brain involvem...

**Who might be able to join this trial:** - People who have signed an informed consent form agreeing to take part in the study. - People diagnosed with a type of blood cancer called CD20-positive diffuse large B-cell lymphoma, mantle cell lymphoma, or indolent (slow-growing) lymphoma that has come back or stopped resp...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of joining the trial - People who were between the ages of 15 and 39 when they were first diagnosed with Hodgkin lymphoma or non-Hodgkin lymphoma (two types of blood cancer) - People whose cancer treatment has been complete...

**Who might be able to join this trial:** - People who have a confirmed diagnosis of marginal zone lymphoma (MZL) — a type of slow-growing blood cancer — in one of several forms: extranodal (affecting tissues outside lymph nodes), nodal (affecting lymph nodes), splenic (affecting the spleen), or widely spread (dissemi...

**Who might be able to join this trial:** - People aged 6 months to 65 years old at the time of giving consent. - People with a type of blood cancer called acute myeloid leukemia (AML) whose cancer is in remission (first or later remission), with less than 5% abnormal cells in the bone marrow at the time of transplant...

**Who might be able to join this trial:** - People who have signed and dated a consent form and are willing and available to follow all study requirements for the full duration of the trial. - People aged 18 or older, of any gender. - **For the dose-escalation (early) phase:** People with a type of blood cancer called...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form agreeing to take part - People who are 18 years of age or older at the time of signing the consent form - People whose general health and ability to carry out daily activities meets a certain minimum standard (rated on a...

Who might be able to join this trial: - People who are 18 years of age or older - People who have a confirmed diagnosis of the specific type of non-Hodgkin lymphoma (NHL) the trial is studying - For living patients, a signed consent form is required — for those taking part in the patient-reported outcomes (survey) port...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with follicular lymphoma (a type of slow-growing blood cancer), Grade 1 to 3A, confirmed by a tissue biopsy — people with a history of this lymphoma transforming into a faster-growing type may also be considered at the...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed through a tissue biopsy with one of the following: Diffuse large B-cell lymphoma (not otherwise specified), High-grade B-cell lymphoma (including types with MYC and BCL2 gene rearrangements), or T cell/histiocyte-rich...

**Who might be able to join this trial:** - People aged 16 years or older. - People who are able to give written, signed, and dated consent and are able to cooperate with treatment and follow-up visits. - People with a confirmed diagnosis of B-cell non-Hodgkin lymphoma (a type of blood cancer), diagnosed according to...