Phase 3 study for people with Lymphoma
Recruiting Phase 3
This trial at a glance
Past estimated completion. The registry still lists this trial as open, and the date it gave for finishing has been and gone. Confirm with the official record before you act on it.
Where this trial is running
| Site | City | State or country | Status at this site |
|---|---|---|---|
| Border Medical Oncology Research Unit | Albury | Australia | Not yet recruiting |
| Royal Prince Alfred Hospital | Camperdown | Australia | Recruiting |
| Coffs Harbour | Coffs Harbour | Australia | Not yet recruiting |
| Concord Repatriation General Hospital | Concord | Australia | Recruiting |
| Tweed Valley Hospital | Cudgen | Australia | Not yet recruiting |
| The Canberra Hospital | Garran | Australia | Not yet recruiting |
| Royal Hobart Hospital | Hobart | Australia | Not yet recruiting |
| Liverpool | Liverpool | Australia | Recruiting |
| Bendigo | Melbourne | Australia | Not yet recruiting |
| Northern Health | Melbourne | Australia | Not yet recruiting |
| St Vincent's Hospital Melbourne | Melbourne | Australia | Recruiting |
| Western Health | Melbourne | Australia | Not yet recruiting |
| Fiona Stanley Hospital | Murdoch | Australia | Not yet recruiting |
| Orange Health | Orange | Australia | Not yet recruiting |
| Royal Perth Hospital | Perth | Australia | Not yet recruiting |
| Port Macquarie | Port Macquarie | Australia | Not yet recruiting |
| Prince of Wales Hospital | Randwick | Australia | Recruiting |
| Royal North Shore Hospital | St Leonards | Australia | Not yet recruiting |
| Sunshine Coast University Hospital | Sunshine Coast | Australia | Recruiting |
| Calvary Mater Newcastle | Waratah | Australia | Not yet recruiting |
| Westmead | Westmead | Australia | Recruiting |
voxsanity.com.au · trial sites from public registries · registry record synced 11 October 2026 · not medical advice
Who can join
The official eligibility criteria
Registry text, reproduced exactly. These are the words the trial's sponsor published on ClinicalTrials.gov. They have not been edited, shortened or rewritten, and they are written for researchers rather than for patients.
Inclusion Criteria:
* Age ≥80 years or frail ≥75 years, according to simplified comprehensive geriatric assessment
* Histologically confirmed lymphoma belonging to one of the following subtypes:
1. diffuse large B-cell lymphoma, including transformation from an indolent lymphoma
2. follicular lymphoma grade 3B
3. T-cell/histiocyte-rich LBCL
4. primary cutaneous DLBCL, leg type
5. EBV-positive DLBCL, NOS
6. primary mediastinal LBCL
7. high grade B-cell lymphoma with MYC/BCL2 rearrangement
* Stage II-IV disease
* At least 1 measurable site of disease (\>1.5 cm long axis)
* No previous treatment for lymphoma
* WHO performance status 0 - 3 (Grade 3 if related to DLBCL)
* Written informed consent
Exclusion Criteria:
* Severe cardiac disease: NYHA grade 3-4
* CNS involvement at diagnosis
* Uncontrolled serious infection
* Impaired liver (transaminases \> 3x normal upper limit or bilirubin \> 1.5 x normal upper limit, unless due to Gilbert´s syndrome) , renal (GFR\<30ml/min) or other organ function not caused by lymphoma, which will interfere with the treatment.
* Absolute neutrophil count (ANC) \<1000 cells/µL or platelets \<100,000 cells/µL, unless due to lymphoma
* Any other prior malignancy than non-melanoma skin cancer or stage 0 (in situ) cervical carcinoma, unless treated with curative intent, and without relapse since 2 years, or low grade prostate cancer, not in need of treatment
* Psychiatric illness or condition which could interfere with their ability to understand the requirements of the study
* Known hypersensitivity to rituximab, polatuzumab vedotin, cyclophosphamide, vincristine or doxorubicin, or HACA against rituximab
* Peripheral neuropathy grade ≥ 2
Dates on the record
Results, publications and the official record
- No results are posted on the official record yet.
- No publications are listed on the official record yet.
- Official record and contacts on ClinicalTrials.gov – contact details for each site are kept there, and are not copied onto this page.
Sources and dates
- ClinicalTrials.gov – the record this page reformats
- ClinicalTrials.gov processing date: 19 September 2024.
- This page last checked by Voxsanity: 11 October 2026.
Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.
Not medical advice.
Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.
Letter for your doctor
A one-page summary of this trial to print or email to your GP. It carries the registry's own record of the trial and its eligibility criteria, and nothing Voxsanity has written about whether it suits you.