Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People with relapsed or returned non-Hodgkin's lymphoma (NHL) who have already tried at least 2 previous treatments (including a drug called rituximab), and whose doctor determines there are no other known effective treatments available — or people with a specific type of lymphoma called AITL that has come back or gotten worse after standard treatment (this applies to Parts A and B of the trial).
• People with a specific type of aggressive lymphoma called DLBCL or a related large B-cell lymphoma that developed from follicular lymphoma, who have already had two or more rounds of treatment (this applies to Parts C and D of the trial).
• People who have at least one measurable area of disease — larger than 1.5 cm in a lymph node, or larger than 1.0 cm outside of lymph nodes.
• People who are generally well enough to carry out daily activities with little or no limitation, as measured by a standard medical scale (score of 0 or 1) — though in Part A only, people with a slightly lower activity level (score of 2) may be considered if their lymphoma has spread to the brain or spinal cord.
• People with bone marrow, kidney, and liver function that meet the trial's minimum health requirements.

Who may not be able to join:

• People with a current or past history of abnormally high levels of a type of white blood cell called eosinophils, related disorders, or a serious drug reaction involving eosinophils and organ symptoms (known as DRESS).
• People who have previously had an allogeneic stem cell transplant (a transplant using cells from a donor) or a solid organ transplant (such as a kidney or liver transplant).
• People who have had another active cancer within the past 3 years — though certain treated skin cancers, early-stage melanoma, non-invasive breast or cervical cancer, and prostate cancer under active monitoring may be exceptions (confirm with trial site).
• People who have experienced any of the following in the past 6 months: a heart attack; long QT syndrome (a heart rhythm condition) or a family history of it; a dangerous heart rhythm called Torsade de Pointes; significant irregular heartbeats; serious problems with the heart's electrical system or major blockages; unstable chest pain; bypass surgery on heart or leg arteries; significant heart failure; a stroke or mini-stroke; a blood clot in the lungs; or other serious blood clot events.
• People with active inflammation of the digestive tract, ongoing chronic diarrhoea, or who have had stomach removal surgery or lap band (weight loss) surgery.
• People with high blood pressure that cannot be controlled even with medication.
• People with a history of heart muscle inflammation (myocarditis).
• People who are unable to follow the trial's rules about avoiding certain other treatments.
• People whose heart tracing (ECG) shows abnormalities that could affect their safety or the trial's results.
• People whose heart pumping function is below 45% (as measured by a heart scan).

Important: Always verify eligibility with the trial site directly before applying.