Phase 2 study

Recruiting Phase 2

Sources: ClinicalTrials.gov Checked: 11 October 2026 Not medical advice

This trial at a glance

Status Recruiting
Phase Phase 2
Sponsor AstraZeneca
Registry number NCT06542250
Started 18 September 2024 Today 16 October 2026 Estimated completion 18 December 2029

Where this trial is running

Trial sites and the status recorded for each
SiteCityState or countryStatus at this site
Research Site Melbourne VIC Recruiting
Research Site Nedlands WA Recruiting

voxsanity.com.au · trial sites from public registries · registry record synced 11 October 2026 · not medical advice

Who can join

Age 18 Years and over
Sex Anyone, regardless of sex
Healthy volunteers Not accepted
Enrolment target 174

The official eligibility criteria

Registry text, reproduced exactly. These are the words the trial's sponsor published on ClinicalTrials.gov. They have not been edited, shortened or rewritten, and they are written for researchers rather than for patients.

Inclusion Criteria:

* ≥18 years of age;

* Histologically documented CD20+ mature B-cell neoplasm

* Large B-cell lymphoma

* Follicular lymphoma

* Mantle cell lymphoma

* Chronic lymphocytic leukemia

* Small lymphocytic lymphoma

* Relapsed, progressive and/or refractory disease following at least 2 prior lines of therapy;

* ECOG performance status of ≤ 2 (\< 2 in EU countries).

The above is a summary, other inclusion criteria details may apply.

Exclusion Criteria:

* Any neoplasm histology not specified in the IC section;

* Active CNS involvement in lymphoma;

* CNS pathology including but not limited to any history of seizure disorder/epilepsy;

* Prior allogeneic HSCT within 180 days, prior autologous HSCT within 90 days, or cell therapy within 90 days of start of therapy;

* History of Grade ≥ 3 CRS or Grade ≥ 3 ICANS;

* Active and uncontrolled infections;

* Unresolved AEs ≥2 Grade due to prior anticancer therapies, with some exceptions

The above is a summary, other exclusion criteria details may apply.

Dates on the record

Started 18 September 2024
Estimated completion 18 December 2029
Registry last updated 30 September 2026
Checked by Voxsanity 11 October 2026

Results, publications and the official record

Sources and dates

  • ClinicalTrials.gov – the record this page reformats
  • ClinicalTrials.gov processing date: 30 September 2026.
  • This page last checked by Voxsanity: 11 October 2026.

Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.

Not medical advice.

Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.

Letter for your doctor

A one-page summary of this trial to print or email to your GP. It carries the registry's own record of the trial and its eligibility criteria, and nothing Voxsanity has written about whether it suits you.