Phase 3 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) and your doctor has determined you need treatment
• Your cancer has come back or stopped responding to at least one previous treatment
• You have at least one measurable sign that the cancer is active in your body
• You are reasonably able to carry out daily activities (your doctor will assess this using a standard scale)
• Your doctor expects you to live for at least 3 more months
• You are able to swallow and keep down oral (by mouth) medication
• Your kidneys, liver, and other organs are working well enough, based on blood tests taken within the last 7 days before joining the study
• If you have hepatitis B, you may still be eligible if you have been on antiviral treatment for at least 4 weeks and the virus is undetectable in your blood
• If you have a history of hepatitis C, you may still be eligible if the virus is currently undetectable in your blood
• If you are living with HIV, you may be eligible if you meet all additional specific requirements (confirm with trial site)
• If you are able to father a child, you agree to use effective contraception or abstain from sex during and after treatment for a specified period
• If you were assigned female sex at birth, you are not pregnant or breastfeeding, and either cannot become pregnant or agree to use highly effective contraception and have a negative pregnancy test

Who may not be able to join:

• You currently have an active hepatitis B or hepatitis C infection
• You have a digestive or stomach condition that could affect how your body absorbs medication
• You have another cancer that is growing or has needed active treatment within the last 2 years
• Your CLL/SLL has transformed into a more aggressive type of lymphoma (Richter Transformation), or the cancer has spread to your brain or spinal cord
• You currently have an active infection that requires treatment with IV (intravenous) antibiotics
• You are HIV-positive and have had certain serious HIV-related conditions (such as Kaposi's sarcoma, Multicentric Castleman's Disease, or a severe opportunistic infection) in the past 12 months
• You have significant heart or blood vessel disease
• You have a known allergy or sensitivity to any of the study drugs (nemtabrutinib, venetoclax, or rituximab) or their ingredients
• You have a history of serious bleeding disorders, such as hemophilia
• You have received cancer treatment too recently before joining the study (the exact timeframe depends on the type of treatment — confirm with trial site)
• You have taken a specific type of drug called a BCL2 inhibitor within the last 12 months, or had radiotherapy within 2 weeks before starting the study
• You are currently taking certain other medications that could interact with the study drugs (confirm with trial site)
• You have received a live vaccine within 30 days before starting the study
• You have taken part in another clinical trial or used an experimental device within the last 4 weeks
• You have a mental health or substance use condition that might make it difficult to follow the study requirements
• You have not fully recovered from a major surgery, or you are still experiencing complications from a recent surgery

Important: Always verify eligibility with the trial site directly before applying.