Phase 1 Prostate Cancer Trial, Recruiting NCT07277270 Sponsor: GlaxoSmithKline Condition: Prostate Cancer
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Phase 1 Prostate Cancer Trial, Recruiting

NCT07277270
Recruiting Phase 1 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People whose general health and ability to carry out daily activities is rated at a good level (scored 0 or 1 on a standard health scale), with no worsening in the 2 weeks before starting the trial
  • People whose organs (such as kidneys and liver) are functioning adequately
  • People who have been confirmed by laboratory testing to have colon or rectal cancer that cannot be removed by surgery, or that has spread to other parts of the body (this applies to one group in the trial, called Cohort A)
  • People who have been confirmed by laboratory testing to have prostate cancer (this applies to a second group in the trial, called Cohort B)

Who may not be able to join:

  • People who have had another cancer (other than the one being studied in this trial) that has grown or needed active treatment in the past 24 months — though certain treated skin cancers or early-stage cancers that were fully removed with no signs of return may be acceptable
  • People who have had major surgery within 28 days before starting the trial
  • People who have had significant bleeding or a strong tendency to bleed within the past month before starting the trial
  • People who have had a serious infection within 4 weeks before starting the trial
  • People who have cancer that has spread to the brain or central nervous system and has not been treated, or where that spread has gotten worse
  • People who currently have, or have previously had, a lung condition called interstitial lung disease or pneumonitis that required high-dose steroid treatment
  • People who have a history of an autoimmune disease (where the immune system attacks the body) that required ongoing medical treatment within the 2 years before screening
  • People who have taken immune-suppressing medications within 30 days before starting the trial, or who need to take them long-term — though low-dose steroids at a small daily amount may be permitted (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 15 July 2026
Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: 877-379-3718

Australian sites

GSK Investigational Site, Tugun, Queensland
877-379-3718

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 1
Sponsor
Registry
ClinicalTrials.gov
Start date
3 December 2025
Est. completion
13 July 2026

Where this trial is recruiting

🇦🇺 Australia 🇪🇸 Spain 🇺🇸 United States

1 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Number of participants with adverse events (AEs), Serious AEs (SAEs), AE of special interest (AESIs) and AEs leading to dose modifications; Number of participants with AEs, SAEs, AESIs, and AEs leading to dose modifications by severity; Number of participants with dose limiting toxicities (DLTs); Number of participants with clinically significant changes in Vital Signs, Body Weight, Laboratory Tests [Hematology, Clinical Chemistry, Urinalysis], Cardiac Function [ECG], and Eastern Cooperative Oncology Group (ECOG) performance status

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov