Phase 1 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older.
• People with advanced solid tumour cancers that have been confirmed by laboratory testing of tissue or cell samples, where the cancer has continued to grow despite standard treatment, or where no standard treatment exists.
• People who are largely able to carry out daily activities with little or no restriction (as assessed by a standard medical scoring tool called ECOG, with a score of 0 or 1).
• People whose cancer can be measured using standard medical imaging criteria (called RECIST v1.1).
• People whose heart, liver, kidneys, and bone marrow are functioning adequately (confirm with trial site).
• People who have waited at least 28 days since any major surgery, previous immunotherapy, or radiotherapy (minor procedures may have exceptions — confirm with trial site).
• Women who could potentially become pregnant must have a negative pregnancy test before joining.
• People who agree to use effective contraception throughout the treatment period and for 3 months afterwards.
• People who are able to give informed consent and follow the requirements of the study.

Who may not be able to join:

• People who have previously been treated with a type of cancer therapy called an oncolytic virus.
• People with a current or recent vaccinia virus infection, or who have received a smallpox or monkeypox vaccination within the past 10 years.
• People with an active, uncontrolled infection that currently requires treatment with systemic medicines (such as antibiotics or antifungals).
• People with a history of hepatitis B, hepatitis C, or HIV, unless specific conditions set out in the trial protocol are met (confirm with trial site).
• People who still have unresolved side effects of Grade 2 or higher from previous cancer treatments, with the exception of hair loss or certain stable ongoing conditions.
• People with an active autoimmune disease causing symptoms that requires ongoing systemic treatment.
• People with cancer that has spread to the brain or spinal cord (central nervous system) that is untreated or causing symptoms, unless it meets specific stability criteria outlined in the protocol (confirm with trial site).
• People with significant heart disease, such as moderate to severe heart failure (NYHA Class III or IV).
• People with a history of lung inflammation (pneumonitis) that required steroid treatment, or an ongoing lung condition called interstitial lung disease.
• People who require long-term use of medicines that suppress the immune system.
• People with severe skin conditions or a history of pancreatitis (inflammation of the pancreas).
• People with bleeding disorders, or who have recently experienced a serious blood clot event.
• People with any medical or mental health condition that could interfere with safely taking part in the study.

Important: Always verify eligibility with the trial site directly before applying.