Phase 2 Stomach Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You are generally able to carry out daily activities with little or no difficulty (your doctor can confirm your activity level score)
• You can provide a stored sample of your tumor tissue
• You have at least one tumor that can be measured on a scan
• Your doctor estimates you have a life expectancy of at least 12 weeks
• Your heart is functioning adequately and is stable
• Your bone marrow, liver, and kidneys are functioning well enough (based on blood tests)
• You weigh at least 35 kg (about 77 lbs)
• You are able to understand and sign a consent form agreeing to take part

For one part of the trial (Module 1) only:

• You have an advanced or spreading solid tumor of a specific type (such as melanoma, certain skin cancers, lung cancer, head and neck cancer, stomach cancer, kidney cancer, ovarian cancer, or triple-negative breast cancer) and have already received standard treatments

For another part of the trial (Module 2) only:

• You have Stage IV non-small cell lung cancer (NSCLC) and have received at least one prior treatment for it, OR you have not yet received treatment for your NSCLC and your tumor shows a certain protein marker (PD-L1) at 1% or higher

Who may not be able to join:

• You have serious or uncontrolled illnesses affecting your breathing, heart, or related to your cancer
• You have had, or are planned to have, an organ transplant or a stem cell transplant from a donor
• You have had or currently have an immune system disorder or inflammatory condition diagnosed within the last 3 years
• A previous immunotherapy treatment had to be permanently stopped because of side effects you experienced
• You are still experiencing significant side effects (moderate or worse) from a previous cancer treatment
• You have cancer that has spread to the brain, unless it has been treated, is stable, causes no symptoms, and you do not need ongoing steroid medication for it
• You have an untreated or symptomatic compression of your spinal cord caused by cancer, or cancer that has spread to the lining of the brain or spinal cord
• You have an active, uncontrolled, or ongoing infection with hepatitis B or hepatitis C
• You have previously had a serious (severe or life-threatening) lung inflammation not caused by infection
• You need ongoing medication that suppresses your immune system, including steroids above a low daily dose
• You have received a live vaccine within the last 30 days

For the Module 2 part of the trial only:

• You have previously been treated with a type of therapy called anti-TIGIT
• You have not yet received treatment for your NSCLC but your cancer has a specific genetic change (such as an EGFR mutation) for which a targeted therapy is available as a standard first treatment in your area

Important: Always verify eligibility with the trial site directly before applying.