NCT07472517

Who might be able to join this trial:

• You have been diagnosed with small cell lung cancer that has spread widely in the body (called "extensive-stage"), and this has been confirmed through a tissue test (biopsy).
• You have not had any previous systemic (whole-body) cancer treatments for this widespread stage of the disease — or, if you were treated at an earlier stage, that treatment finished more than 6 months before your current diagnosis.
• A stored sample of your tumour tissue is available and can be sent to a central laboratory for testing, and the results of that test must be ready before you are enrolled in the trial.
• If you have cancer that has spread to the brain but is not causing symptoms, you may still be eligible — either if brain treatment was completed at least 14 days ago and you have been stable without steroids or seizure medicines for at least 7 days, or if your brain metastases are untreated but stable and you have not needed steroids or seizure medicines for at least 28 days.
• You are generally able to carry out light activity and care for yourself (a standard fitness scale score of 0 or 1, confirm with trial site).
• You are able to continue receiving the standard first-line chemotherapy and immunotherapy combination (carboplatin, etoposide, and atezolizumab) within 28 days of starting your first treatment cycle.
• You are able to receive full doses of all three standard treatments (carboplatin, etoposide, and atezolizumab) according to approved guidelines.

Who may not be able to join:

• You have cancer that has spread to the lining around the brain or spinal cord (a condition called leptomeningeal disease or carcinomatous meningitis).
• You have previously received any treatment specifically targeting a protein called DLL3 (such as certain antibody or cell-based therapies).
• You have received any radiotherapy (radiation treatment) to any part of your body within the 14 days before enrolment.
• You still have significant side effects from previous cancer treatments that have not improved to a mild level — with some specific exceptions (confirm with trial site).
• You have an active autoimmune disease (where your immune system attacks your own body) or a history of one that requires ongoing systemic treatment such as steroids or immune-suppressing medicines — though certain milder conditions like stable thyroid problems or controlled Type 1 diabetes may be acceptable depending on the doctor's assessment.

Important: Always verify eligibility with the trial site directly before applying.