NCT00672295

Who might be able to join this trial:

• You have been diagnosed with ovarian, peritoneal, or fallopian tube cancer, confirmed by a lab test of tissue or cells
• Your cancer can be measured on a scan or other test
• You are over 18 years old
• Your doctor expects you to live for at least 3 more months
• You are well enough to carry out daily activities to a reasonable degree (based on a standard performance scale — confirm with trial site)
• Your bone marrow, kidneys, liver, and nerves are all working well enough (confirm with trial site)
• You have not had chemotherapy, radiation, biological therapy, hormone therapy, or experimental treatments in the last 28 days
• You have had no more than 3 previous chemotherapy treatments, which may have included carboplatin and paclitaxel
• You are able to read and sign a consent form agreeing to take part
• If you could become pregnant, you must have a negative pregnancy test before starting and use an effective form of birth control throughout the trial
• A stored sample of your tumour tissue is available for testing, or you are willing to have a small biopsy taken within four weeks before joining; you must also agree to a second biopsy after the second round of treatment

Who may not be able to join:

• Your ovarian tumour has been classified as "borderline" (low malignant potential)
• You have had another type of cancer (other than certain common skin cancers) in the last 5 years
• You have certain heart problems, including uncontrolled chest pain, a heart attack in the past 6 months, a specific heart rhythm condition called long QT syndrome, a history of serious irregular heartbeats, an abnormal heart rhythm reading on an ECG, or uncontrolled high blood pressure
• You have a significant bleeding disorder (either inherited or diagnosed within the last year) that is not related to your cancer
• You are currently taking certain medications known to affect heart rhythm — a detailed list should be confirmed with the trial site, but includes some antibiotics, antipsychotics, and heart medications among others
• Your kidneys are not working well enough, based on a specific blood test result
• You are taking blood thinners or medicines that affect how your blood clots
• You have previously had radiation therapy covering more than 30% of your bone marrow
• You have had a severe allergic reaction (grade 3) to paclitaxel or carboplatin in the past
• You have a serious active infection, severe illness, active hepatitis, or another serious uncontrolled medical condition

Important: Always verify eligibility with the trial site directly before applying.