NCT00738062

Who might be able to join this trial:

• You took part in the earlier Droxidopa study called Protocol 302
• You are willing and able to give written consent to participate, and understand you can leave the study at any time without it affecting your future care

Who may not be able to join:

• You are currently taking the medications ephedrine or midodrine (you must have stopped these at least 2 days before your first study visit)
• You are currently taking blood pressure-lowering medication (although short-acting blood pressure medication taken only at bedtime may be allowed — confirm with trial site)
• You are currently taking tricyclic antidepressants or similar medications that affect a brain chemical called norepinephrine
• You have changed the dose, frequency, or type of any of your regular medications within the two weeks before the study starts (not counting ephedrine or midodrine)
• You have a history of more than moderate alcohol use
• You have a known or suspected history of drug or substance misuse
• You are a woman who could become pregnant and are not using an accepted form of birth control (such as an IUD, hormonal contraceptives, or double barrier methods like condoms with spermicidal gel)
• You are a man who is sexually active with a partner who could become pregnant, and you are unwilling to use condoms during the study and for 30 days after the last dose
• You are pregnant or breastfeeding
• You have a known or suspected allergy to the study medication or any of its ingredients
• You already have consistently very high blood pressure (180/110 mmHg or above when sitting down)
• You have atrial fibrillation (an irregular heartbeat) or another significant heart rhythm problem, in the opinion of the study doctor
• You have any other serious illness affecting your overall health, liver, heart, or kidneys
• You have diabetes (either type — confirm with trial site)
• You have a history of a specific type of eye condition called closed-angle glaucoma
• You have a known or suspected cancer
• Your blood test shows a kidney-related measure called serum creatinine is above 130 umol/L
• You have a stomach or digestive condition that may affect how your body absorbs the study drug, in the opinion of the study doctor
• You have significant abnormal results on a physical examination or laboratory tests, in the opinion of the study doctor
• Your personal or family situation makes it difficult for you to participate fully, in the opinion of the study doctor
• You have a mental health condition that could interfere with the study, such as schizophrenia, major depression, or dementia, in the opinion of the study doctor
• You are unable or unwilling to follow the study requirements for the full duration of the trial

Important: Always verify eligibility with the trial site directly before applying.