Parkinson's Disease

You must have been diagnosed with idiopathic Parkinson's disease (the most common form of Parkinson's, not caused by another condition) using a specific set of medical guidelines called the UK Parkinson's Disease Society Brain Bank Criteria. You still have ongoing movement problems (such as periods where your…

You are able to give your own consent to take part in the study You have been diagnosed with Parkinson's disease and your doctor has recommended you receive, or you have already received, a specific type of deep brain stimulation (DBS) device called the Infinity system, with leads placed on both sides of a specific…

You have been diagnosed with Parkinson's Disease and have had symptoms for at least 1 year. You have been diagnosed with Parkinson's Disease along with mild memory or thinking problems, or Parkinson's-related dementia, based on recognized medical guidelines. Your score on a standard memory and thinking test (called…

You have been diagnosed with Parkinson's Disease that responds to a medication called levodopa Your doctor feels your Parkinson's symptoms are not well enough controlled by your current treatment You experience noticeable periods when your medication is working well ("On" time) and periods when it is not working as…

You have been diagnosed with a rare disease, a disease where the number of people affected is unknown, or you have not yet received a diagnosis for your condition You have been identified as a carrier of a rare or uncommon disease, meaning you carry the gene for a condition but may not have symptoms yourself

You are scheduled to have a new brain stimulation device implanted, or have an existing device's battery replaced, using an Abbott deep brain stimulation system, within the next 180 days. You (or a legal representative on your behalf) are willing and able to sign a written consent form before any study activities…

People who have been diagnosed with Parkinson's Disease and also have mild memory problems (a condition called mild cognitive impairment) People who have been diagnosed with Parkinson's Disease but do not have memory problems Healthy volunteers with no Parkinson's Disease diagnosis All participants must be able to…

People who have read and signed a consent form showing they understand the study, including its risks, before any study activities begin Healthy men or women aged between 30 and 89 years old at the time of screening People with a body mass index (a measure of body weight relative to height) between 18 and 32 People…

You are willing and able to give written consent and follow the study's rules and requirements You are between 30 and 85 years old (any sex) You have been diagnosed with Parkinson's disease (PD) according to recognised medical guidelines Your Parkinson's diagnosis was made within the last 7 years Your body weight is…

You have been officially diagnosed with Parkinson's disease (PD) according to recognised international medical guidelines You are between 45 and 75 years old at the time of signing up for the trial Your Parkinson's symptoms clearly and strongly improve when you take dopamine-related medication (confirmed by a standard…

People who have been diagnosed with Parkinson's disease according to a recognised set of medical guidelines called the MDS Criteria People whose Parkinson's disease is at a mild to moderate stage (rated as Stage I, II, or III on a scale called Hoehn and Yahr) People who have at least some difficulty with walking, as…

People whose body weight is between 40 and 110 kilograms (about 88 to 242 pounds) and whose body mass index (a measure of body weight relative to height) falls between 18 and 34 People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's disease with no known cause) based on recognised Movement…

People aged between 40 and 80 years old at the time of screening. People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's that developed on its own, not caused by another condition), meeting specific recognised diagnostic criteria that include slowness of movement with a particular pattern…

You must be older than 30 years of age. You have been diagnosed with dementia or a brain-related condition such as Alzheimer's disease, Parkinson's disease, Lewy body dementia, Niemann-Pick type 2, or vascular dementia (people without these conditions who are of a similar age and sex may also be invited to take part…

People aged 18 to 55 years who are in general good health (Parts 1 and 2 include both men and women; Part 4 details to be confirmed with trial site) Women of childbearing potential with a negative pregnancy test at screening (Parts 1 and 2 only) Women who are post-menopausal, confirmed by a specific hormone blood test…

You must have already completed a previous clinical trial called SP889.

You have been diagnosed with Parkinson's disease and show at least two of these signs: shaking at rest, muscle stiffness, slowness of movement, or balance problems Your Parkinson's medications have stayed the same for at least 4 weeks before joining the study You have not taken any antidepressant or antipsychotic…

People of any age who have been diagnosed with a lysosomal storage disorder, or who carry the gene for one, may be considered for this trial. Family members of someone already diagnosed with a lysosomal storage disorder may be considered for this trial. Healthy adults aged 18 and over, recruited through the NIH…

People who have been diagnosed with Parkinson's Disease.

People who have been diagnosed with Parkinson's Disease, Essential Tremor, dystonia, or Multiple Sclerosis. People who are scheduled to have a Deep Brain Stimulation (DBS) electrode implanted, a pulse generator implanted, or an existing pulse generator replaced through surgery. People whose neurological condition is…

You have been diagnosed with one of the following conditions: a brain tumor, epilepsy, migraine, mild cognitive impairment (including concussion), mild traumatic brain injury, multiple sclerosis, neuropathy, Parkinson's disease, restless legs syndrome, or stroke. You are able to receive one of the three treatments…

People who are 21 years of age or older. People who have been diagnosed with Parkinson's disease. People who have been assessed as a suitable candidate for deep brain stimulation (a type of brain surgery that uses electrical signals to help manage symptoms).

People diagnosed with idiopathic Parkinson's disease (the most common form, with no known external cause), confirmed using a standard set of medical criteria used in the UK. People whose Parkinson's disease falls within stages 2 to 4 on a standard scale used to measure how the condition affects movement and daily…

A person must have signed a consent form agreeing to take part in the study. A person must have been diagnosed with Parkinson's disease for at least 4 years, based on a specific set of recognised diagnostic standards. A person's symptoms must improve by at least 30% when taking levodopa (a common Parkinson's…

People who are over the age of 21. People who have symptoms that suggest a neurodegenerative disease or a related condition.

People who are male or female and over 45 years of age. People who are seen at a memory clinic or are taking part in an observational study. People who have a caregiver or family member available to assist and take part in the study. People who have been diagnosed as being on the Alzheimer's disease (AD) biological…

A person must have been diagnosed with idiopathic Parkinson's disease, meaning Parkinson's that has no known cause, showing at least 2 of the main features: tremor (shaking), rigidity (stiffness), or bradykinesia (slowness of movement). A person must be scheduled to have deep brain stimulation (DBS) surgery as a…

People who are 18 years of age or older at the time of enrolling in the trial People who have been diagnosed with idiopathic (no known cause) Parkinson's disease at a mid-range level of severity (Hoehn and Yahr stages 2 to 4) (confirm with trial site if unsure which stage applies) People who are fluent in English…

A neurologist has confirmed the person's diagnosis. The person is male or female, aged 45 to 85 years. The person has provided signed informed consent to take part. The person meets the ROME IV criteria for irritable bowel syndrome (IBS) at the time of recruitment (confirm with trial site). The person has had IBS…

People aged 50 to 68 years old (inclusive) at the time of signing the consent form, either male or female. People who have been diagnosed with Parkinson's disease using a specific set of recognised diagnostic guidelines (the Movement Disorder Society criteria), meeting the definition of "clinically probable"…

The person must have already received the treatment called BRT-DA01 as part of a previous related study called MSK-DA01-101, and must have either finished or left that study. The person must be willing and able to sign a written consent form for this study, and must be able to attend all required visits and follow all…

People who are having a deep brain stimulator (a small device that sends electrical signals to the brain) surgically placed in a specific area of the brain to treat Parkinson's disease, where a specialised recording technique is being used during surgery to help find the exact correct location. People who are older…

People who are right-handed, as measured by a standard assessment called the Edinburgh Inventory. People who are able to attend the scheduled TMS (brain stimulation) sessions. People who have given their consent to take part in the trial. People who are independent in their day-to-day activities.

People with Parkinson's disease who are at least 50 years old and have been diagnosed with the standard form of Parkinson's disease (not caused by another condition). People without Parkinson's disease who are at least 50 years old, have no close family members (such as a parent or sibling) with Parkinson's disease…

A neurologist has confirmed the person has a diagnosis of Parkinson's Disease The person's Parkinson's Disease is rated at Stage 1, 2, or 3 on the Hoehn & Yahr scale, which covers mild to moderate stages (confirm with trial site) The person is between 18 and 89 years old The person is able to walk and move around…

Eligibility is determined through a separate, ongoing related study called the KET-PD trial (reference number NCT04944017 / HIC 2000030394), so the criteria for joining this trial are set by that parent study (confirm with trial site)

People who are between 40 and 75 years old at the time they agreed to take part in a related study called ANPD001-01. People who met all the requirements to be included in that related study (ANPD001-01). People who were diagnosed with Parkinson's disease at least 4 years ago. People whose movement symptoms clearly…

People between the ages of 55 and 80, of any sex. People who have been diagnosed with Parkinson's disease by a neurologist, based on the Movement Disorder Society's 2015 diagnostic guidelines. People who have had a Parkinson's disease diagnosis for at least 5 years. People whose motor symptoms respond to…

People who are over 18 years old. People who have been diagnosed with Parkinson's disease according to the Movement Disorder Society 2015 guidelines. People whose Parkinson's disease symptoms started before the age of 70, and/or who have a family history of Parkinson's disease. People who have had genetic testing…

You must be 21 years of age or older You must be able to speak English You must be a registered attendee of the advanced 7-day meditation retreat You must be willing to wear a Garmin wearable device for the entire duration of the retreat You must agree to and sign the research consent form to take part in the study…

People who have already been diagnosed with Idiopathic Parkinson's Disease (a common form of Parkinson's Disease with no known cause). People who have already been diagnosed with Essential tremor (a condition that causes uncontrollable shaking). People who are healthy and have not been diagnosed with either…

People with Parkinson's disease who have already completed one of two specific related studies (STUDY00007253 or STUDY00008239) at the University at Buffalo. People who are willing and able to sign a consent form and follow the study procedures.

Men and women between 40 and 80 years of age People who were diagnosed with their condition less than 5 years ago People with normal vision or vision that is fully corrected (for example, with glasses or contact lenses) People who score 20 or higher on a standard memory and thinking test called the MoCA People who are…

People aged 18 or older. People who have been diagnosed with Parkinson's disease and have already had deep brain stimulation (DBS) devices surgically placed on both sides of a specific area of the brain called the subthalamic nucleus. People who received their DBS surgery at least three months before the study begins…

People with Parkinson's disease at an early to moderate stage (classified as Hoehn and Yahr stage 1 or 2). People who are able to understand the study requirements and cooperate with the study procedures. People whose main symptom is slowness of movement (known as bradykinesia). People whose symptoms started on the…

People who have been diagnosed with Parkinson's disease and meet the standard medical requirements for a type of brain surgery called deep brain stimulation (DBS) on both sides of the brain. People who experience severe "freezing of gait" (a sudden inability to move the feet when walking) when their Parkinson's…

People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's disease with no known outside cause). People between 18 and 80 years of age. People who have had deep brain stimulation (DBS) electrodes placed on both sides of the brain in an area called the subthalamic nucleus (STN).

People between 50 and 70 years of age. Both men and women are included. People who have been diagnosed with Parkinson's disease at a mild to moderate stage (known as Hoehn and Yahr stage 1 to 3). People who are able to stand for at least 10 minutes without help from another person. People who are able to walk, either…

People who have been diagnosed with Parkinson's disease based on a specific set of standard diagnostic guidelines known as the UK Brain Bank criteria. People who are members of the Asociación Parkinson Madrid organisation. People whose Parkinson's disease is at a minimal or mild stage, as measured by a standard rating…

The person must be able to give their informed consent to take part in the study. Movement disorder symptoms must be severe enough, even with the best available medicines, that a specialist considers brain stimulation surgery to be appropriate. The person must have requested surgery using deep brain stimulation for…

People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's disease with no known external cause). People aged 40 years or older. People who are willing and able to take part in high-intensity interval training (HIIT) exercise classes.

Participants must be right-handed. Participants must be monolingual native Italian speakers. Participants must be between 50 and 85 years old. Participants must have normal vision, or vision that is fully corrected with glasses or contact lenses. Participants must give written and verbal consent to take part in the…

People who are willing to take part in the study voluntarily People who have a confirmed diagnosis of Parkinson's disease People aged between 40 and 80 years old People whose Parkinson's disease falls within Stage I to IV on the Hoehn & Yahr scale, which is a standard measure of how far the condition has progressed…

People aged between 50 and 80 years old. People who have had one or more strokes (either a blockage or bleeding in the brain), with the most recent stroke happening at least 6 months ago. People who can walk on their own without a cane or walking aid, but have a noticeable unevenness or imbalance in their walking…

People between 50 and 70 years of age. Both men and women are eligible. People who have been diagnosed with Parkinson's disease at a mild to moderate stage (Hoehn and Yahr stage 1 to 3). People who are able to stand for at least 10 minutes without help from another person. People who are able to walk, whether or not…

People who are over 50 years old People who have been diagnosed with Parkinson's disease by a doctor People whose Parkinson's disease falls within stages 1 to 4 on the modified Hoehn-Yahr scale, which is a standard scale used to measure how advanced the condition is (confirm with trial site) People who have scored 24…

People who are older than 40 years old and have recently been diagnosed (or had their diagnosis confirmed) with Parkinson's disease People who have not changed their Parkinson's medications in the last 2 months People who are able to walk, whether or not they use a walking aid such as a cane or walker

People with Parkinson's Disease who are scheduled to have a specific type of brain stimulation surgery (called bilateral subthalamic nucleus Deep Brain Stimulation) at the University of Colorado Hospital, using a Medtronic system with specific components (Percept™ battery and SenSight™ electrode), and whose…

People aged between 60 and 85 years old. (For people with a diagnosed condition — "cases") People with a diagnosis of Alzheimer's disease dementia based on clinical assessment and supported by biological markers, such as results from a spinal fluid test or a specialised brain scan. (For people with a diagnosed…

People who have been diagnosed with idiopathic Parkinson's disease (a specific form of Parkinson's not caused by another condition) according to recognised medical guidelines. People who do not have dementia, as shown by a score of 22 or more out of 30 on a standard memory and thinking test called the Montreal…

People diagnosed with Parkinson's disease according to Chinese diagnostic guidelines (2016 version), confirmed by two neurologists. People whose Parkinson's disease falls within a certain range of severity, known as Hoehn-Yahr stage 1.5 to 4 (confirm with trial site if unsure where a diagnosis falls on this scale).…

The person is willing and able to give their informed consent to take part in the study. The person is male or female, aged 18 years or older. The person has had a Medtronic Percept or similar deep brain stimulation (DBS) device implanted as part of their normal medical care — specifically one that can record a type…

People who are currently enrolled in a community-based brain rehabilitation program in Stockholm, Sweden People who have mild to moderate thinking or memory difficulties caused by a brain injury or a disease affecting the nervous system People who score 21 or higher on a standard memory and thinking test called the…

People who have been diagnosed with primary Parkinson's disease according to MDS (Movement Disorder Society) criteria. People whose Parkinson's disease is at a relatively early stage (Hoehn & Yahr stage below 3, meaning symptoms are not yet severely limiting balance or mobility). People whose Parkinson's disease…

Group 1 – Parkinson's disease without cognitive impairment: People aged 18–89 with a Parkinson's disease diagnosis, a memory and thinking score above 26 on a standard test (MoCA), whose Parkinson's medication has been stable, and who can walk independently and make their own decisions. Group 2 – Parkinson's disease…

People who have been diagnosed with Idiopathic (no known cause) Parkinson's disease, confirmed by a specialist in movement disorders, with the key symptom of slowness of movement plus at least one of: resting tremor or muscle stiffness. People who have anxiety related to Parkinson's disease, based on a score of 14 or…

People who have been diagnosed with primary Parkinson's disease according to recognised diagnostic standards (the Movement Disorder Society criteria). People whose Parkinson's disease is rated at stage 3 or below on a standard scale that measures how much the condition affects movement and balance (the Hoehn & Yahr…

People who have been diagnosed with a neurological disease that involves protein build-up in the brain, such as Alzheimer's disease and its variants, Parkinson's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis (ALS), Tauopathies, or other related neurological conditions. People who have a caregiver who…

People living with Parkinson's Disease or a condition called Multiple System Atrophy (Parkinsonian type) who are currently enrolled in, or have previously been part of, a clinical study involving a treatment called AB-1005, and who agree to participate by signing a consent form.

People who have been diagnosed with Parkinson's disease using recognised medical diagnostic criteria, and who have already had a specific Medtronic brain stimulation device (called Percept DBS) with directional leads surgically placed in a particular area of the brain on both sides (called the globus pallidus internus…

People who are 18 years of age or older People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's not caused by another condition) confirmed by a neurologist Both men and women who have gone through menopause are eligible to take part People who are able to understand and agree to…

People aged between 40 and 80 years old. People who have been diagnosed with idiopathic Parkinson's disease according to specific 2015 diagnostic guidelines, with the condition present for at least 3 years, and not at the most severe stage of the disease (Hoehn & Yahr stage below 4). People whose Parkinson's…

People who are aged between 45 and 70 years old. People who have been diagnosed with Parkinson's disease by a specialist neurologist who focuses on movement disorders. People whose Parkinson's disease has been confirmed on one side of the body only, through a specific brain scan called a DaT scan. People who are at an…

People who have been diagnosed with a neurological disease that involves protein build-up in the brain, such as Alzheimer's disease (including its variants), Parkinson's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis (ALS), Tauopathies, or other related neurological conditions. People who have a…

Adults over 18 years old who are willing to give a blood sample. People who have completed a full clinical and psychological assessment. Brain imaging scans may be included if available and appropriate, but this is not required for everyone. Healthy volunteers who do not have a muscle or nerve disease diagnosis…

People who are 40 years of age or older People who have been diagnosed with Parkinson's disease People who are able to attend testing sessions and dance classes, either on their own or with the help of a caregiver or family member

Adults over 18 years old who are willing to give a blood sample. People who have completed a full clinical and psychological assessment. Brain imaging scans may also be used if available, though this is not required as it is not suitable for everyone. People without a muscle disease or neurological disease diagnosis…

People who have been diagnosed with Parkinson's disease and are currently taking a medication called levodopa. People whose Parkinson's disease is considered mild to moderate, based on a standard rating scale called Hoehn and Yahr, at stages I, II, or III. People who are older than 45 years of age. Both men and women…

People who are able to give their consent to take part in the study. People who have already had a specific investigational deep brain stimulation (DBS) device called the Summit RC+S implanted. People who do not have significant memory or thinking difficulties, shown by a score of 21 or higher on a standard cognitive…

People who have been diagnosed with Parkinson's disease by a neurologist using a specific set of recognised diagnostic guidelines called the United Kingdom Brain Bank criteria. People who are 40 years of age or older. People whose Parkinson's disease falls within a mild-to-moderate range of severity, as measured by a…

People who have a confirmed diagnosis of a neurological condition, such as traumatic brain injury, cerebral palsy, brain injury caused by lack of oxygen, stroke, or another disorder affecting the brain or nervous system. People who have already received, or are planned to receive, a nose-delivered therapy using a…

You are 18 years old or older You have been diagnosed with idiopathic Parkinson's disease (Parkinson's that does not have a known cause) Your Parkinson's symptoms fall within a mild to moderate range, known as Hoehn and Yahr stage 1 to 3 (confirm with trial site) Your Parkinson's medications have been stable and…

People who have mild to moderate Parkinson's disease, based on standard medical scoring (confirm with trial site for specific score details) People who are older than 18 years of age People who have signed a written consent form agreeing to take part

People who have been diagnosed with Parkinson's disease, assessed by a specialist neurologist who focuses on movement disorders, and for whom a specific type of brain surgery (called deep brain stimulation, or DBS) has been medically recommended — these people would also go through a series of screening assessments…

People who are willing and able to give written consent to participate People aged between 40 and 90 years, male or female People who have been diagnosed with Parkinson's disease and are also experiencing symptoms of depression People whose Parkinson's disease is rated at stage 1, 2, or 3 on the Hoehn and Yahr scale…

People who have been referred by their doctor for a standard PET scan as part of their usual medical care, for one of the conditions covered by this trial.

People aged between 40 and 80 years who have been diagnosed with Parkinson's disease or a related condition, based on recognised international diagnostic guidelines. People who have been taking levodopa or similar Parkinson's medications at a stable, unchanged dose for at least 4 weeks before joining, and whose…

People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's with no known specific cause) based on recognised international diagnostic guidelines. People who are older than 18 years of age. People whose Parkinson's symptoms improved by more than 24% in a pre-surgery test involving…

People who have been clinically diagnosed with a specific movement or brain condition — either a possible or probable form of PSP, at least probable Parkinson's disease, at least probable MSA (as defined by recognised medical guidelines), or people who are healthy volunteers with no such diagnosis. People aged 18 to…

People who have been diagnosed with Parkinson's disease using a specific standard diagnostic system called the UK Parkinson's Disease Society Brain Bank criteria. People who are able to walk independently along a 10-metre corridor without assistance. People with a normal level of cognitive (thinking and memory)…

People who have been diagnosed with Parkinson's disease based on a specific set of recognised diagnostic guidelines (known as UKPDSSB criteria). People who experience fluctuations in their symptoms and/or involuntary movements (dyskinesia), and whose treating doctor has determined they need an advanced treatment such…

People who have signed and dated a consent form agreeing to take part in the trial People who are between 45 and 70 years old (inclusive) at the screening stage People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's that arises on its own, without a known cause) according to a recognised set…

People who have been diagnosed with Parkinson's disease based on the Movement Disorder Society's diagnostic criteria. People who are older than 45 and younger than 90 years of age. People whose Parkinson's disease is rated at Stage 2 or 3 on the Hoehn and Yahr scale, which generally reflects early-to-mid stage disease…

People aged 18 years or older People who have been diagnosed with idiopathic Parkinson's disease at Hoehn and Yahr stage I (an early stage of Parkinson's disease — confirm with trial site if unsure which stage applies) People who are fluent in English People who have appropriate social support available, if needed…

People aged between 35 and 92 years old at the time of joining the trial. People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's disease that does not have a known cause). People who have had a surgical treatment for Parkinson's disease that does not involve Deep Brain Stimulation.…

People who have been clinically diagnosed with established or probable Parkinson's disease, based on recognised Movement Disorders Society diagnostic criteria. People who are aged 40 or older at the time of screening. People who score between 17 and 30 on the Montreal Cognitive Assessment (MoCA), a standard test of…

Adults who have been diagnosed with Alzheimer's disease, related dementias, mild cognitive impairment, Parkinson's disease, or multiple sclerosis, as recorded in their electronic health record. Adults who are being diagnosed and treated for one of the conditions listed above and are invited to take part. People who…

People who are 50 years of age or older. People who have been identified as having mild cognitive impairment (MCI — a level of memory or thinking difficulty that is more than normal aging but less than dementia), confirmed by study staff using a standard memory test with a score in a specific range. People who are…

People who have been diagnosed with clinically established Parkinson's disease, confirmed by a specific brain imaging scan called a DaTscan. People who are able and willing to sign and date a consent form before the study begins. People who are between 40 and 75 years of age (inclusive). Women who could become…

People who have been diagnosed with Parkinson's disease for more than 5 years, are under 75 years old, show a meaningful improvement in movement of at least 30% when taking levodopa (a common Parkinson's medication), and have been assessed as suitable for a specific type of brain surgery called deep brain stimulation…

People who have been diagnosed with Parkinson's disease with noticeable symptoms, or healthy people of a similar age who are participating as a comparison group. People who can understand spoken or written information given in English well enough to take part. People who are willing and able to formally agree to…

A doctor has diagnosed the person with idiopathic (no known cause) Parkinson's disease, based on having at least two of the three main movement symptoms: slowness of movement, shaking at rest, or muscle stiffness — and at least one of those must be shaking at rest or slowness of movement. The person's Parkinson's…

People aged 18 or older People who have been diagnosed with idiopathic Parkinson's Disease (a form of Parkinson's where no specific external cause has been identified) People who are fluent in English People whose Parkinson's motor symptoms, measured during an "off" period (when medication is less effective), scored…

People between the ages of 35 and 92 at the time of joining the trial. People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's with no known cause) at a mid-range stage of the condition, based on a standard medical scale called Hoehn and Yahr stages 2 to 4 (confirm with trial site for the upper…

People aged between 40 and 80 years old. People who meet the established medical diagnostic criteria for Parkinson's disease (based on Postuma et al., 2015 guidelines). People whose first movement-related symptom (such as stiffness, slowness, or tremor) began less than 36 months ago (for the Parkinson's disease…

People aged between 30 and 79 years old (inclusive) who have been diagnosed with Parkinson's disease within the last 2 years, using a standard diagnostic checklist called the UK Brain Bank Criteria. People whose Parkinson's disease is at an early stage (rated as Stage I or II on a standard scale called Hoehn and Yahr)…

People who have been clinically diagnosed with Parkinson's disease. People who speak English as their first language. People whose hearing and vision are good enough for their age to complete the tasks involved in the trial. People who are able to give their own written consent to participate.

People who have been diagnosed with Idiopathic Parkinson's Disease (the most common form of Parkinson's, with no known cause). People who take five or more doses of levodopa (a common Parkinson's medication) each day. People who experience changes in their ability to move, including periods where their medication is…

People diagnosed with Parkinson's disease who are 40 years of age or older. People with Parkinson's disease who either have no memory or thinking concerns, or who have some concerns but these do not affect their ability to carry out daily activities.

People with movement disorders who are admitted to a neurology ward or attending a neurology clinic. People who are being considered for a type of brain surgery called a lesioning procedure. People of any age or sex may be considered.

People aged 18 years or older. People who have been diagnosed with Parkinson's disease according to a specific set of international diagnostic guidelines called the MDS criteria. People whose Parkinson's disease has been rated as stage 1.5 to 3 on a scale called the Hoehn and Yahr scale, which measures how far the…

People who are over 40 years of age.

People who have been diagnosed with REM Sleep Behavior Disorder (RBD), confirmed by a sleep study called a polysomnography. People who are able to use a smartphone that works with the study's app. People who have a care partner (such as a spouse or family member) who shares their bedroom at night. Healthy volunteers…

People who have been identified as likely being in the early stage before Parkinson's disease fully develops, based on specific pre-set criteria. People who have been diagnosed with Parkinson's disease at a mild to moderate level (rated between 1 and 2.5 on a standard disease severity scale called Hoehn & Yahr).…

People diagnosed with Parkinson's disease at an early to mid stage (known as Hoehn & Yahr stage I–III). People between the ages of 30 and 85. People whose overall health condition is stable, who take their medications consistently, and who are able to follow instructions.

People who have been diagnosed with idiopathic Parkinson's disease, stroke, multiple sclerosis, arthritis, or osteoporosis. People with Parkinson's disease who are able to report a history of daily walking difficulties such as freezing (sudden stopping) or festination (short, shuffling steps), or people with other…

People who have been diagnosed with Parkinson's disease according to recognised international diagnostic guidelines, with a disease severity rating of Stage 1 to 3 (meaning the condition ranges from mild to moderate). People whose walking ability is affected to at least some degree, as measured by a standard…

People who work as a physiotherapist or kinesiologist in the public sector, private sector, or both People who have been qualified in their profession for at least one year People who run exercise rehabilitation programs with patients who have long-term conditions and who agree in writing to take part People who are…

Adults aged 18 or older. People diagnosed with idiopathic (no known cause) Parkinson's disease with symptoms rated between stages 2 and 4 on the Hoehn and Yahr scale, which measures how advanced the condition is (confirm with trial site). People who are fluent in English. People who take medication that affects brain…

People who have been diagnosed with Parkinson's disease. People who are between 50 and 80 years of age. People whose Parkinson's disease falls within a mild-to-moderate range of progression, as measured by a standard medical scale called the Modified Hoehn and Yahr (stages 1.5 to 3) (confirm with trial site). People…

People who have been assessed as suitable candidates for a deep brain stimulation procedure for Parkinson's disease. People who have given their informed consent to take part in the trial.

People who developed movement control problems (such as stiffness, tremor, or slowness) at or before the age of 40, or who have a family history of similar conditions. People whose condition has been confirmed by a specific brain scan (called a DaTscan®) that shows reduced activity in the part of the brain that uses…

Adults aged 18 or older at the time of enrolling in the trial. People diagnosed with idiopathic Parkinson's disease (Parkinson's with no known cause) at a mid-range stage of the condition, specifically between Hoehn and Yahr stages 2 and 4 (confirm with trial site if unsure which stage applies). People who are fluent…

People who are 40 years of age or older. People whose Parkinson's disease has been diagnosed according to Movement Disorder Society standards. People who have not changed their Parkinson's medication in the 4 weeks before the trial starts and who will not change it during the treatment period. People whose motor…

People between 45 and 75 years of age. People who have been diagnosed with Parkinson's disease according to a specific set of international diagnostic guidelines known as the MDS criteria. People who have had Parkinson's disease for between 4 and 20 years. People whose Parkinson's disease severity falls within a…

People who have a confirmed diagnosis of Parkinson's disease (PD) People who have access to the internet and email People who are willing to complete thinking and memory tests, fill out questionnaires, wear a movement-tracking wristband device, and be randomly assigned to a study group People who are not currently…

A person must have been diagnosed with Parkinson's disease according to the guidelines set by the Movement Disorders and Parkinson's Disease Group of the Chinese Society of Neurology. A person must have a reduced sense of smell, measured as scoring at least one standard deviation below the normal range for their age…

Adults (18 years of age or older) are eligible to be considered. Both men and women are included. People who have been diagnosed with Parkinson's disease according to a specific set of international medical guidelines (MDS criteria, 2015). People who have lived with Parkinson's disease for at least 5 years. People who…

People aged between 40 and 70 years old. People who have been diagnosed with Parkinson's disease by a specialist movement disorder neurologist, using a recognised set of diagnostic standards. People who have had fewer than 3 natural bowel movements per week (not caused by laxatives or other rescue medicines) for the…

People who have been diagnosed with Parkinson's disease.

People who have been diagnosed with Parkinson's disease. People who are between 40 and 85 years of age. People who do not have any other neurological or musculoskeletal conditions that affect the limb muscles being studied.

People who have been diagnosed with Parkinson's disease (according to a standard set of medical criteria called the UKPDSBB criteria) for at least 1 year before joining the trial. People aged between 35 and 75 years old, male or female. People who have a moderately severe level of impulse control disorder (ICD)…

Men and women between 50 and 85 years old at the time of the on-site visit (those aged 81–85 will be considered individually by the lead researcher). People who have given their signed agreement to take part in the study. People who are willing and able to follow the study procedures, including swallowing a special…

Men and women (who are not pregnant) between the ages of 45 and 80 at the time of joining the trial. People who are able and willing to provide their informed consent to participate. People who have been diagnosed with probable idiopathic (no known cause) Parkinson's disease based on United Kingdom Parkinson's Disease…

Adults between 18 and 80 years old People diagnosed with early-stage Parkinson's Disease that developed on its own (not caused by another condition), with symptoms present for 3 years or less People whose Parkinson's Disease is rated at stage 2.5 or below on a standard scale used to measure how advanced the condition…

People who are willing to take part and sign a consent form agreeing to participate. Part A: Adults aged 18 to 45 years (male or female). Part B: Adults aged 65 years or older (male or female). People who weigh at least 50 kg (for men) or at least 45 kg (for women), and whose body mass index (BMI) is between 18.5 and…

People who have been diagnosed with Parkinson's disease People who are scheduled for planned (non-emergency) brain surgery to have deep brain stimulation (DBS) electrodes and a pulse generator device implanted People who are 18 years of age or older

People who have been diagnosed with Parkinson's disease according to a recognised set of medical guidelines (the Movement Disorders Society criteria). People whose Parkinson's symptoms are not at the most severe stage, as measured by a standard rating scale called the Hoehn and Yahr scale (a score below 4). People who…

People aged between 35 and 80 years old at the time of giving consent to join the study. People who have been diagnosed with Parkinson's disease (PD) by a neurologist for at least 6 months but no longer than 4 years before the start of screening. People whose Parkinson's disease is at a mild stage, as measured by a…

People who have been diagnosed with Parkinson's disease for at least 3 years, following recognised diagnostic guidelines, and whose condition is at a moderate stage when their medication is working. People between 30 and 80 years of age. People who have experienced motor fluctuations (periods where their medication…

People who are able to give their signed agreement to take part and follow the study procedures People who are between 39 and 75 years of age at the time of signing the agreement to take part People who have been diagnosed with Parkinson's disease for more than 5 years People who are taking levodopa and experiencing…

People diagnosed with Parkinson's disease according to the International Movement Disorders Association (MDS) guidelines, who are between 50 and 70 years old, have had the condition for 5 years or less, and whose disease is at stage 3 or below on the Hoehn & Yahr scale (a standard measure of Parkinson's progression).…

People who are inpatients or outpatients at the Movement Disorders clinic at the Neuropsychiatry Hospital of Assiut University. People who are over 40 years of age.

People aged 40 to 75 years old who have been diagnosed with Parkinson's disease (PD) or a related condition called a Parkinson's-plus syndrome (PPS), which includes Dementia with Lewy Bodies (DLB), Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), or Corticobasal Degeneration (CBD) with movement…

People who have been diagnosed with primary Parkinson's disease by a neurologist. People whose Parkinson's disease falls within a mild to moderate range, as measured by a scale called the Modified Hoehn and Yahr Scale (stages I to III). People aged between 45 and 85 years old. People who score 24 or above on a…

People who are willing and able to give informed consent to participate. People who are 18 years of age or older. People who have been diagnosed with idiopathic Parkinson's disease that responds to levodopa (a common Parkinson's medication). People whose Parkinson's disease is at a moderate stage (Hoehn and Yahr stage…

People who have been diagnosed with Parkinson's Disease. People who are fluent in English. People who are able to walk on their own, without a walking aid, for at least 10 minutes. People who do not have any other cognitive or neurological conditions, such as brain tumours, a recent concussion, stroke, or brain injury.

Adults aged 19 years or older who have been diagnosed with Parkinson's disease (based on established clinical criteria). People who have been cleared by their doctor to participate in exercise. People who score 3 or below on the modified Hoehn & Yahr scale, meaning they are physically independent and may have mild to…

People who have been diagnosed with mild Parkinson's Disease (at a specific stage of the disease, known as Hoehn & Yahr stage II-III). People who have also been diagnosed with Mild Cognitive Impairment (MCI) related to their Parkinson's Disease, based on recognised diagnostic guidelines. People who are 18 years of age…

Adults aged 18 or older who have been diagnosed with idiopathic Parkinson's disease and attend the Movement Disorders or Speech Therapy outpatient clinics at a quaternary health care hospital. People who are participating in the project titled "Validation and applicability of the Test of Mastication and Swallowing…

People aged between 55 and 75 years. People who have been clinically diagnosed with Idiopathic Parkinson's Disease using a specific standard set of diagnostic guidelines known as the UK Parkinson's Disease Society Brain Bank Criteria. People whose Parkinson's disease is at a mild to moderate stage, rated between 1 and…

People who have been clinically diagnosed with Parkinson's disease People who had a type of brain surgery called deep brain stimulation, targeting one of two specific brain areas (the subthalamic nucleus or ventral intermediate nucleus) People whose surgery was performed at CHRU of Nancy (a hospital in France) People…

People aged 40 to 75 years who have been diagnosed with Parkinson's disease (using a standard set of diagnostic criteria called the UK Brain Bank criteria) within the past three years. People who have been on a stable, optimised Parkinson's medication plan — using dopamine agonists, levodopa, MAOB inhibitors, or a…

People who are aware of where they are and what time/date it is (oriented to place and time). People who identify themselves as the main caregiver for the person with the condition. People who understand the Italian language. People who have given their consent to take part in the study. People who provide unpaid…

People who have been diagnosed with Parkinson's Disease People who are 18 years of age or older People who score 19 or above on a standard memory and thinking test called the Montreal Cognitive Assessment (MoCA) People who have an abnormal forward bending of the upper or lower back while standing and walking, which…

People aged between 50 and 80 years old. People who have been diagnosed with Alzheimer's disease, frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), or Parkinson's disease dementia (PDD), based on specific established diagnostic guidelines for each condition. People whose scores on standard memory and…

People aged 40 to 68 years old (inclusive). People who have at least one of the following risk factors for heart or stroke-related disease: being a male aged 55 or older, or a female aged 65 or older; currently smoking or having quit smoking within the past 3 months; having diabetes (type 1 or 2); having high blood…

People diagnosed with Parkinson's disease at a mild to moderate stage (rated stage 1 to 3 on a standard scale called Hoehn & Yahr). People who are able to walk with at least some level of independence, as measured by a walking ability assessment called the Functional Ambulation Category (FAC score of 3 or higher).…

Adults aged 18 years or older. People who have been diagnosed with Parkinson's disease. People whose Parkinson's disease falls within stages I to III on the Modified Hoehn and Yahr scale, which generally reflects mild to moderate disease (confirm with trial site). People who are willing to take part and sign a consent…

People who have been diagnosed with Parkinson's disease, as defined by an internationally recognised set of clinical diagnostic criteria. People who have severe apathy (a significant lack of motivation or emotional engagement), as determined by established clinical criteria for apathy. People whose apathy falls within…

People who have previously been found through genetic testing to carry the LRRK2 G2019S or GBA N370S gene variant People aged 50 years or older People who are able to understand and communicate in English People who are able to walk around inside their home without using a walking aid such as a cane or walker People…

A doctor has diagnosed the person with Parkinson's disease using a standard set of medical criteria called the UK Brain Bank criteria The person's Parkinson's disease is rated at a moderate stage (stages 2 to 3 on a standard scale) when their Parkinson's medication is working The person reports episodes of freezing of…

People who are willing and able to give their informed agreement to take part in the study. People who are able to walk 30 metres, with or without the help of a walking aid. People who have been formally diagnosed with Parkinson's disease by a healthcare professional.

Adults aged 30 years or older at the time of screening. People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's disease with no known cause) at a moderate stage of the condition (Hoehn and Yahr stage II to III). People who have not taken dopamine agonist medications in the past 30 days, or who…

People aged between 50 and 75 years old, male or female. People who are able to understand the purpose of the trial and sign a consent form agreeing to take part. People who have been diagnosed with Parkinson's Disease according to recognised international diagnostic guidelines (2015), and have had Parkinson's Disease…

People who have been diagnosed with Parkinson's disease according to the MDS (Movement Disorder Society) diagnostic criteria. People who carry one copy of a severe GBA gene mutation known to be linked to Parkinson's disease (confirmed by genetic testing). If recruitment is slow after 6 months, the trial may also…

A diagnosis of Parkinson's disease that meets the Movement Disorder Society's standard diagnostic criteria. Motor fluctuations (changes in movement ability throughout the day) confirmed by a specialist in movement disorders. Enough physical ability to wear and operate the study's wearable device and its app. Enough…

People whose Parkinson's disease has been rated as Stage 3 or Stage 4 on the Hoehn and Yahr Scale, which measures how advanced the condition is People who scored higher than 24 on the Mini Mental Test, a short assessment of memory and thinking ability People whose medications have remained unchanged for at least the…

People who have had Parkinson's disease for more than 4 years People between the ages of 46 and 83 People who experience motor fluctuations (changes in movement ability throughout the day), based on specific scores on a standard Parkinson's assessment scale People who take levodopa (a common Parkinson's medication) at…

People who have been clinically diagnosed with idiopathic (primary) Parkinson's Disease, based on recognised Chinese (2016) or international MDS (2015) diagnostic guidelines. People between the ages of 40 and 65 (inclusive), of any gender. People who have had Parkinson's Disease for 5 years or more. People whose…

People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's with no known cause) for at least 5 years. People whose Parkinson's medication has remained the same for at least 4 weeks. People who show no signs of cognitive (thinking or memory) impairment based on a standard mental…

People who have been diagnosed with Parkinson's disease (PD) according to a specific set of widely used diagnostic guidelines known as the UK Brain Bank criteria. People whose Parkinson's disease is at a moderate stage, specifically stage II or III on a standard scale used to measure how advanced the condition is (the…

A person must have been diagnosed with Parkinson's disease using a specific set of recognised diagnostic standards known as the UK Parkinson's Disease Society Brain Bank criteria. A person must be between 35 and 80 years of age. A person's Parkinson's symptoms must fall within a mid-range of severity (neither very…

People diagnosed with Parkinson's disease who have deep brain stimulation (DBS) devices placed on both sides of the brain in a specific brain region called the subthalamic nucleus (STN). People who had their current DBS system (the Percept™ PC or RC device) implanted at least 6 months ago. People who still experience…

People who have been diagnosed with Parkinson's disease (with no known cause) for at least one year and are currently attending a Movement Disorder Clinic

People who have been diagnosed with Parkinson's disease based on a specific set of recognised diagnostic criteria (called MDS-UPDRS, Groups 1 and 2). People whose Parkinson's medication dose has been stable for at least 4 weeks before the start of the study. People who are enrolled in a social security or equivalent…

A person has signed the informed consent form agreeing to take part in the study A person is aged 18 years or older but under 75 years old A person has a normal blood pressure reading in the clinic (below 140/90 mmHg) Women who could become pregnant must be using, or willing to use during the study, a reliable…

People who are 18 years of age or older. People who have been diagnosed with or treated for a neurological disease. People who are currently admitted to hospital or attending as an outpatient in the Department of Neurology at UKSH Campus Kiel. People who are able to understand spoken and written study information, and…

People who have at least 5 years of experience caring for patients with Parkinson's disease, including involvement in deep brain stimulation (DBS) implantation, in both teaching and non-teaching settings. People who have previously taken part in guideline development or have authored at least one peer-reviewed…

People who have been diagnosed with Parkinson's disease by a neurologist who specialises in movement disorders. People who score 7 or higher on a bladder symptom questionnaire (called the ICIQ-OAB), meaning they experience significant overactive bladder symptoms such as sudden urges to urinate, needing to urinate…

People who have been diagnosed with Parkinson's disease according to an established set of medical diagnostic standards (MDS criteria). People whose Parkinson's disease was diagnosed between 5 and 10 years ago. People aged between 40 and 80 years old. People whose Parkinson's disease is rated at stage 2 or 3 on a…

People who have been diagnosed with Parkinson's disease according to the standards set by the Movement Disorder Committee. People whose Parkinson's disease is at a mild to moderate stage, known as Hoehn and Yahr stages II or III. People who report having difficulty starting to walk, as measured by a specific question…

People aged over 50 years People who are fluent in Danish People who have completed at least 7 years of schooling People who have been diagnosed with either mild cognitive impairment (MCI) or Alzheimer's disease (AD) at the SUH memory clinic within the 6 months before joining the trial People aged over 50 years People…

Adults aged between 60 and 80 years old. People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's disease without a known external cause). People who can understand spoken and written Swedish. People who are able to give their own consent to take part in the study. People who have at…

People who are able to give informed consent and follow the study procedures. People who are between 55 and 75 years of age at the time of signing the consent form. People who have been diagnosed with Parkinson's disease for more than 5 years. People who are currently taking levodopa and experiencing complications…

Adults who are 55 years of age or older People who live in urban or suburban communities in the United States People who are able to give their informed consent to take part People who are willing to attend follow-up assessments over a 3-year period People who are able to complete cognitive (thinking and memory)…

People who are between 45 and 75 years old at the time of signing the consent form. People who were diagnosed with Parkinson's disease (PD) more than 10 years before joining the trial. People who have slowness of movement (bradykinesia) plus at least one of the following: muscle stiffness, a tremor at rest, or…

People who have been diagnosed with Parkinson's disease. People who have recently had a deep brain stimulation device (made by Boston Scientific) implanted, or who are about to have one implanted. People who are willing to temporarily stop taking their regular Parkinson's medications during certain research visits…

People for whom a doctor has determined that Foslevodopa/Foscarbidopa (a Parkinson's medication given by infusion) is an appropriate treatment option under the approved guidelines and any relevant coverage rules in their country. People who have been diagnosed with Parkinson's Disease that responds to a medication…

People who have been diagnosed with a neurodegenerative disease, such as Parkinson's disease or dementia. People aged between 50 and 85 years old. People who are able to walk at least 10 metres, even if their walking is unsteady or they have a history of falls. People who are able to understand what the trial involves…

People who fully understand the study procedures, are willing to take part voluntarily, and have signed the consent form. People who are aged 18 or older and under 75 years old at the time of signing the consent form — any gender may apply. People who have had a confirmed diagnosis of primary Parkinson's disease for…

People aged between 22 and 75 years at the time of enrolling in the trial. People who have been diagnosed with Parkinson's disease (PD) affecting both sides of the body, with at least 2 of these symptoms present: resting tremor (shaking when still), muscle stiffness, or slowness of movement. People who have had…

People who are between 55 and 75 years old. People who have been diagnosed with Parkinson's disease by a neurologist. People whose Parkinson's disease is at a mild to moderate stage (rated between Stage I and Stage III on a standard scale used by doctors). People who are able to understand and follow simple…

People aged 20 or older. People who have been diagnosed with Parkinson's disease using a specific set of medical guidelines called the MDS criteria. People who are currently taking levodopa as their only Parkinson's medication and are experiencing "motor fluctuations" (periods where the medication wears off and…

People who have been diagnosed with moderate to severe Parkinson's disease by a neurologist. People whose Parkinson's disease medications have been at a stable dose for a period of time. People who are able to walk on their own without using a frame or walking stick. People who are able to walk for more than 10…

Adults aged 18 to 75 years (inclusive) at the time of signing the consent form. People who have been diagnosed with idiopathic Parkinson's disease, meaning Parkinson's that has no known external cause, with slowness of movement plus at least one of: muscle stiffness, a tremor at rest, or problems with balance and…

People who have been diagnosed with Parkinson's disease. People who are 18 years of age or older. People who score 19 or above on a standard memory and thinking test called the Montreal Cognitive Assessment (MoCA). People whose Parkinson's symptoms are rated at a moderate level (stages II to IV) on a standard scale…

People who are between 40 and 75 years old People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's disease that arises on its own, without a known cause) People whose Parkinson's medications have remained unchanged for at least the past month People whose Parkinson's disease is at a…

People who have previously taken part in a related study involving a treatment called RGL-193 and received that treatment as part of it. People who are willing to take part in this trial and have signed a written consent form agreeing to participate.

People who are willing and able to give written consent and follow the study's requirements and restrictions People who are willing to undergo genetic testing and analysis related to Parkinson's disease (PD) People of any sex, aged between 30 and 85 years old People with a body mass index (BMI) between 18 and 40, and…

People who have served in the military as veterans. People who have been clinically diagnosed with Parkinson's disease, confirmed through medical records and diagnosis codes. People who are currently on a steady, unchanged medication routine for managing Parkinson's disease.

People who are between 50 and 80 years old at the time of joining and have been diagnosed with idiopathic Parkinson's disease (Parkinson's that does not have a known external cause) according to a specific set of recognised diagnostic guidelines. People who are currently taking no more than 2 medications that work on…

People aged between 30 and 80 years old (inclusive). People who have been diagnosed with Parkinson's disease of unknown cause (idiopathic PD), based on a specific set of diagnostic guidelines, within the last 3 years. People whose Parkinson's disease is at a mild to moderate stage (Hoehn and Yahr stages 1–3) and who…

People who are able to give informed consent and are between 30 and 85 years old. People in the RBD group: those who have been diagnosed with isolated REM sleep behavior disorder (a sleep condition where people act out their dreams) confirmed by a sleep study. People in the Parkinson's group: those with an early to…

People diagnosed with idiopathic Parkinson's Disease (Parkinson's that does not have a known external cause), confirmed using a standard set of medical guidelines called Gelb's criteria People whose Parkinson's symptoms fall within Stage II to Stage IV on a standard scale used to measure how far the condition has…

People who have been diagnosed with Parkinson's disease, confirmed by a neurologist. People whose Parkinson's disease severity has been classified as Stage III on the Hoehn & Yahr scale (a specific measure of Parkinson's progression). People aged between 45 and 75 years. People who are medically stable, with normal…

People who have been diagnosed with Idiopathic Parkinson's Disease (a specific type of Parkinson's Disease with no known cause). People who are at least 21 years old. People who are planned to receive, or have already received, a specific brain stimulation device called the Boston Scientific Vercise Genus Rechargeable…

Adults between 35 and 90 years of age who have swallowing difficulties People who have been diagnosed with, or are suspected of having, Idiopathic Parkinson's Disease (either the tremor-dominant or rigidity-dominant type) People whose Parkinson's disease disability level has been rated as Stage II or III on the Hoehn…

A neurologist has formally diagnosed the person with Parkinson's disease. The person has been taking Parkinson's medication regularly and at a stable dose for at least three months. The person is aged 40 years or older. The person's Parkinson's disease falls within a moderate to moderately severe range of progression…

People who are between 30 and 70 years of age. People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's disease with no known external cause), confirmed using a standard set of medical diagnostic guidelines. People whose condition has been assessed by a doctor as suitable for a type of brain…

People who have a confirmed clinical diagnosis of Parkinson's Disease. People whose Parkinson's Disease is rated as mild to moderate severity (Stage 3 or below on a standard scale used by doctors to measure balance and disability). People who are able to walk on their own for around 5 minutes, with or without walking…

People who are between 50 and 70 years old. People who can understand both Filipino and English. People who score above 27 on a memory and thinking test called the Montreal Cognitive Assessment – Philippines (MoCA-P) (confirm with trial site). People who can complete a short walking and turning test in under 10…

People who are aged 50 years or older. People who have been diagnosed with idiopathic Parkinson's disease according to a specific set of clinical diagnostic criteria (the Movement Disorder Society 2015 guidelines), with a disease severity rating between stage 1 and stage 4 on a standard scale called Hoehn & Yahr.…

People aged 50 years or older. People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's not caused by another known condition) according to specific 2015 diagnostic guidelines, with symptoms that include tremor and difficulty walking. People who have had their Parkinson's diagnosis for…

People who have been diagnosed with Parkinson's disease according to a specific set of internationally recognised diagnostic guidelines (the Movement Disorder Society criteria). People whose Parkinson's disease falls within a certain range of severity, from moderate to moderately severe, as measured by a standard…

A neurologist has confirmed the person has Parkinson's disease (PD). The person has had a Parkinson's disease diagnosis for at least one year. The person is between 51 and 80 years of age. German is the person's first language (mother tongue). The person has been diagnosed with mild cognitive impairment related to…

People aged 30 to 70 years (inclusive) at the time of signing the consent form, either male or female. People who have been diagnosed with Parkinson's disease caused by a mutation in the GBA1 gene, confirmed through medical history and meeting recognised international diagnostic criteria, with at least one confirmed…

People who have been diagnosed with Parkinson's Disease by a neurologist, using recognised international diagnostic guidelines People aged between 18 and 75 years old People who are able to understand the study and its questionnaires, and follow the study requirements People who have signed a consent form agreeing to…

Adults who have been diagnosed with Parkinson's disease (whether or not they experience visual hallucinations), or healthy volunteers without a neurological condition. People aged between 18 and 85 years. People who agree to take part in the trial.

People who had an electrophysiology (heart electrical system) study performed between 2005 and 2023 at San Raffaele Scientific Institute in Italy. People who were referred for that heart study because doctors suspected a type of fast heart rhythm problem called paroxysmal supraventricular tachycardia, either with or…

People who have been diagnosed with Parkinson's disease by a specialist in movement disorders. The diagnosis was made using a specific standard set of criteria called the UK Brain Bank Diagnostic Criteria. People whose Parkinson's symptoms are at a mild to moderate stage (rated 1 to 3 on a standard scale) while taking…

People with a diagnosis of Parkinson's disease may be relevant to this trial (confirm with trial site)

People between 40 and 80 years of age People who have been diagnosed with Parkinsonism by a doctor People whose Parkinsonism is at a moderate stage, meaning some movement difficulties but still able to walk without assistance (confirm with trial site) People whose Parkinsonism medication has remained the same for at…

People aged between 50 and 75 years People who have been clinically diagnosed with Parkinson's disease People whose Parkinson's disease has been rated at a mild to moderate stage on the Hoehn and Yahr scale (stages 1–3), which measures how far the condition has progressed People whose movement and daily living…

People who have been diagnosed with Parkinson's Disease based on the Movement Disorder Society's official diagnostic guidelines. People whose Parkinson's Disease is rated as mild to moderate severity (Hoehn & Yahr Stage I–III). People aged between 45 and 65 years. People who are right-handed, whose Parkinson's…

People who have been diagnosed with Parkinson's Disease. People aged between 40 and 80 years old. People with a UPDRS (a standard Parkinson's rating scale) level of 2 and a score between 20 and 60 (confirm with trial site). People who are able to walk on their own or with only a small amount of help. People who are…

People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's disease without a known external cause). People who have been on a stable dose of their Parkinson's medications for at least two weeks. People whose Parkinson's disease is rated as stage I, II, or III on the Modified Hoehn and Yahr scale…

People aged 18 or older, of any gender People who have been diagnosed with Parkinson's disease following a specific 2015 medical guideline, meaning they have slowness of movement plus at least one of either muscle stiffness or a tremor at rest, with no other known cause for their symptoms People whose Parkinson's…

Adults aged 19 years or older who have been diagnosed with Idiopathic Parkinson's Disease using recognised international diagnostic guidelines. People whose Parkinson's disease is at a mild to moderate stage, as measured by a standard rating scale called the Hoehn and Yahr scale (stages 1 to 2.5). People whose…

People aged between 40 and 70 years (inclusive), of any gender People who have been diagnosed with primary Parkinson's disease rated at a severe level (H&Y grade 4 or 5) People whose Parkinson's disease was diagnosed at least 5 years ago People whose symptoms have responded to levodopa (a common Parkinson's…

People who have been diagnosed with Parkinson's disease and have shown a specific type of word or language difficulty based on specialised memory and language tests (confirm with trial site for exact test score thresholds). People aged between 50 and 90 years old. People who are able to understand and agree to take…

People who have been diagnosed with idiopathic Parkinson's Disease (a form of Parkinson's where no external cause has been identified). People who have previously been identified as experiencing "Freezing of Gait," which is when a person with Parkinson's suddenly feels unable to move their feet while walking. People…

People who have been diagnosed with Parkinson's disease People whose brain scans (a specific type of PET scan) have confirmed a buildup of a protein called amyloid in the brain People who have mild memory or thinking difficulties, based on neuropsychological testing (scored at CDR 0.5 or 1, which indicates mild…

People aged 18 to 70 years, of any gender. People who understand the study, are willing to follow its procedures, and have signed a consent form agreeing to take part. People who have been diagnosed with primary (non-secondary) Parkinson's disease according to recognised international diagnostic standards, and who…

Adults between 45 and 75 years of age (inclusive) at the time of signing the consent form, both male and female. People who have been diagnosed with Parkinson's disease within the past 4 to 10 years (inclusive). People who have slowness of movement, plus at least one of the following: muscle stiffness, shaking at…

People who have been newly diagnosed with Parkinson's disease within the last month (as a patient participant). Patient participants must be over 18 years of age. People who are the main carer for someone newly diagnosed with Parkinson's disease within the last month (as a caregiver participant) — note that if a…

People who are able to walk without any aids or assistance. People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's that does not have a known cause). People who score 21 or higher out of 30 on a standard memory and thinking test called the Montreal Cognitive Assessment, which indicates…

People who are 30 years of age or older at the time of screening. People who have been clinically diagnosed with established or probable Parkinson's disease. People who are currently taking levodopa medication at a stable dose for at least 4 weeks before the study begins, at a daily amount equivalent to at least 400…

A person must have been diagnosed with Parkinson's disease according to specific Chinese medical guidelines for Parkinson's disease (2016), with the diagnosis confirmed by at least two nerve specialists. The diagnosis must confirm a clear case of parkinsonism, with at least two supporting signs of Parkinson's disease…

The person must be able to give informed consent and follow the study procedures. The person must have been on a stable dose of Levodopa and/or dopamine-boosting medications for at least 4 weeks before joining the study. The person must have a clinical diagnosis of Parkinson's disease (PD), or Parkinson's disease with…

People who have been clinically diagnosed with idiopathic Parkinson's disease (Parkinson's disease with no known cause) according to a standard set of medical guidelines called the UK Brain Bank Criteria. People who have had Parkinson's disease for 5 years or more, to help make sure the diagnosis is accurate. People…

People who have been assessed by a doctor as having suspected neurological movement disorder (parkinsonism) that may be related to Parkinson's disease or a related condition, showing slowness of movement plus at least one of: muscle stiffness or a tremor at rest. People aged between 40 and 80 years. People who have…

People who have been diagnosed with idiopathic Parkinson's disease (a specific form of Parkinson's not caused by another condition) confirmed by a neurologist People in Hoehn & Yahr stages I, II, or III (these are early to mid stages of Parkinson's disease — confirm with trial site if unsure which stage applies)…

People who have been diagnosed with idiopathic Parkinson's disease (a form of Parkinson's that does not have a known external cause) according to a specific set of recognised medical diagnostic guidelines. People aged 50 years or older. People who are able to understand and respond to questionnaires and rating scales…

People who are 60 years of age or older at the time of joining the trial People who have been diagnosed with Parkinson's disease by a specialist in movement disorders People who are expected to live for at least six months People who have been taking an oral antimuscarinic medication (a type of bladder control…

People who have been diagnosed with idiopathic Parkinson's disease (the most common type, with no known cause) using a standard set of diagnostic guidelines called the UK Parkinson's Disease Society Brain Bank criteria. People who have no history of impulse control problems (such as compulsive gambling, shopping, or…

People who have been diagnosed with idiopathic Parkinson's disease (a specific form of Parkinson's not caused by another condition). People whose Parkinson's disease falls within a mild to moderate range of severity, based on a standard rating scale called the Hoehn and Yahr scale (stages 1 to 3). People who score 21…

People who are 18 years of age or older People who have been diagnosed with Parkinson's Disease People who have been diagnosed with hallucinations, impulse control disorder, or panic disorder (also called episodic anxiety) People who have already had a specific type of deep brain stimulation device (a Medtronic…

Adults diagnosed with Parkinson's disease who are being cared for at Grenoble University Hospital and for whom doctors have determined that brain stimulation surgery (placing electrodes deep in a specific area of the brain) is the right treatment option. People who have agreed to be fitted with a specific type of…

People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's disease without a known external cause). People who are between 50 and 80 years of age. People who score 21 or higher on a standard memory and thinking test called the Montreal Cognitive Assessment (MoCA). People whose Parkinson's disease…

People aged 40 to 75 years old (any gender) at the first study visit. People who have been diagnosed with idiopathic Parkinson's disease (the most common form, with no known cause) for at least 2 years, based on recognised medical diagnostic guidelines. People whose Parkinson's disease is rated at a moderate stage…

People who have been diagnosed with Parkinson's disease that has no known cause (called idiopathic Parkinson's disease). People who are between 40 and 80 years old. People whose Parkinson's medications have remained unchanged for more than 3 months. People whose Parkinson's symptoms fall within a mild-to-moderate…

People who have been diagnosed with idiopathic (naturally occurring, not caused by another condition) Parkinson's disease, confirmed by two neurologists using recognised Chinese diagnostic guidelines based on international Parkinson's diagnostic criteria. People whose Parkinson's symptoms, when their medication is…

A person must have a formal diagnosis of idiopathic Parkinson's disease (Parkinson's disease with no known external cause). The disease must be at a relatively early to moderate stage, rated below Stage III on a standard Parkinson's severity scale called the Hoehn & Yahr scale (confirm with trial site). The person…

People aged 21 to 80 years old. People who have been clinically diagnosed with Parkinson's disease, as defined by the Movement Disorder Society criteria. People who have adequate vision, hearing, thinking ability, and physical capability to participate.

People who have been formally diagnosed with Parkinson's disease using recognised international diagnostic guidelines. People who have been living with Parkinson's disease for at least 4 years. People who a medical team has determined are suitable candidates for a type of brain surgery called deep brain stimulation…

People aged between 60 and 90 years old (inclusive) People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's that develops on its own, not caused by another condition), confirmed by a neurologist or doctor, and verified through medical records and an in-clinic assessment People who are able to…

People who are right-handed People who have been diagnosed with idiopathic Parkinson's disease (a specific form of Parkinson's where no outside cause has been identified), based on recognised medical diagnostic standards People who have also been diagnosed with depression according to standard psychiatric guidelines…

People aged between 30 and 80 years old. People who have been diagnosed with Parkinson's disease (PD) based on recognised international diagnostic guidelines (Movement Disorders Society criteria). People whose Parkinson's disease is at a mild to moderate stage, rated between 1 and 3 on a standard scale used to measure…

People aged 30 to 70 years (inclusive), of any gender. People who fully understand the study's purpose, procedures, and possible side effects, and who are willing to sign a consent form to take part voluntarily. People who have been clinically diagnosed with idiopathic Parkinson's disease (Parkinson's disease with no…

People who are 18 years of age or older. People who speak French. People who have been diagnosed with Parkinson's disease by a neurologist.

A neurologist has diagnosed the person with Parkinson's disease using a recognised set of international diagnostic guidelines. The person is between 45 and 65 years old. The person was first diagnosed with Parkinson's disease at least 2 years ago but no more than 10 years ago. The person has a disability level of 3 or…

People who have been diagnosed with idiopathic Parkinson's disease (self-reported, with verification from a treating doctor or neurologist requested where possible). People whose Parkinson's disease is at a mild to moderate stage — able to move around with or without some assistance (Hoehn and Yahr stages I–IV).…

People aged 50 years or older. People who have at least one of the following signs that may indicate a higher risk of Parkinson's disease: a sleep condition called REM sleep behaviour disorder (where a person acts out their dreams), confirmed by an overnight sleep study; a significant drop in blood pressure when…

People who are willing and able to give written consent to participate after fully understanding the study. People aged 18 or older, of any gender. People who have been diagnosed with Parkinson's disease according to the 2016 Chinese Diagnostic Criteria for Parkinson's Disease, and whose disease stage is rated at 3 or…

People between 30 and 80 years of age. People who have already decided to have deep brain stimulation (DBS) surgery as part of their normal medical care. People who have been approved for DBS surgery by a specialist movement disorders committee as part of their routine care. People with persistent movement problems —…

Adults between 18 and 65 years of age. People who have had genetic testing that found a change in the PRKAG2 gene, classified as disease-causing, likely disease-causing, or of uncertain significance. People who have symptoms or signs consistent with a condition called PRKAG2 Syndrome. People who are able and willing…

People who are 18 years of age or older People who are part of a family where at least two living family members have been diagnosed with Parkinson's disease

People who are 18 years of age or older People who are able to understand and agree to participate in the research (give informed consent) People who have been diagnosed with Parkinson's disease (a movement disorder) that is not well controlled by medication, as confirmed by a specialist team People who have been…

This trial has four different groups of participants. Depending on which group applies, the relevant criteria are listed below. A confirmed diagnosis of idiopathic (no known cause) Parkinson's disease, based on a specific set of standard diagnostic guidelines Aged between 18 and 70 years old Experiencing movement…

A neurologist (brain and nervous system doctor) must have confirmed that you have essential tremor or Parkinson's-related tremor that is not well controlled by medication. You must prefer to receive radiation treatment for your tremor, rather than having surgery to implant a device (DBS) or surgery to remove part of…

People of any gender are eligible to participate People who are 18 years of age or older People who have been referred to one of the participating trial sites with symptoms of dizziness or lightheadedness when standing up, which go away when lying down

You have been diagnosed with Parkinson's disease using a specific set of recognised UK diagnostic guidelines Your Parkinson's disease is at an early stage

You meet the requirements set out in the official guidelines for the Vercise System device used in your country (confirm with trial site) You are at least 18 years old

You are 18 years of age or older. You are able to follow the study procedures and agree to take part by signing a consent form. You have been diagnosed with Parkinson's disease (PD), a form of dystonia (a movement disorder causing involuntary muscle contractions), or essential tremor (ET — a condition causing…

People who have been clinically diagnosed with Parkinson's disease or a similar movement condition (called "parkinsonism"), AND who either have a close family member (parent, sibling, child, grandparent, aunt, uncle, or first cousin) also affected by Parkinson's or parkinsonism, OR who first developed symptoms before…

You have been diagnosed with Parkinson's disease and show at least three of these symptoms: tremor at rest, muscle stiffness, slowness of movement, or problems with balance — or at least two of these symptoms where one side of your body is more affected than the other.

You have confirmed, lasting damage to your central or peripheral nervous system that is unlikely to get better with current standard treatments. Your condition began at least 6 months ago. If you are currently on medication or have had surgery for your condition, your health has been stable on that treatment and the…

Adults between the ages of 40 and 80 (men or women) who have been diagnosed with possible or probable Multiple System Atrophy, Pure Autonomic Failure, or Parkinson's disease, based on recognized medical guidelines. People who experience a significant drop in blood pressure when standing up (a condition called…

You must meet the standard medical criteria for the specific condition being studied in this trial (confirm with trial site). You must have enough thinking and memory ability to take part in the study activities, based on a short cognitive test where you score 10 or higher out of 30. You must have been on a stable…

You have been diagnosed with Parkinson's disease, meaning you have two or more of the main recognized symptoms and no other known cause for those symptoms. You are able to read and sign a consent form agreeing to take part. You are over 40 years old. You are fluent in English. You are willing to have your thinking and…

People aged between 40 and 65 years old People who a specialist doctor has assessed as having no signs of cognitive (thinking or memory) symptoms People who score between 27 and 30 on a standard memory and thinking test (called the MMSE) at the screening visit People who do not meet the medical criteria for mild…

You are between 18 and 65 years old (male or female) You have been diagnosed with Multiple Sclerosis (MS) according to a specific set of medical guidelines called the McDonald 2010 criteria Your level of disability, measured on a standard MS scale (called the EDSS), falls between 0 and 5.5, meaning mild to moderate…

Adults who have been diagnosed with a neurodegenerative condition, such as mild cognitive impairment (MCI), Parkinson's disease, Alzheimer's disease, ALS, multiple sclerosis, Huntington's disease, traumatic brain injury, concussion, PTSD, Down Syndrome, or similar conditions Adults who do not have a neurodegenerative…

Adults aged 18 years or older People who are right-handed, as assessed using a standard handedness questionnaire called the Modified Edinburgh Handedness Inventory People who have been diagnosed with Parkinson's disease according to a specific set of medical criteria called the Gibb criteria People who have had…

You have noticed memory or thinking problems yourself, or a doctor has identified some during testing You (or a family member/caregiver, where legally permitted) are willing and able to sign a consent form agreeing to take part You can speak and understand English or French well enough to complete questionnaires and…

You must already be enrolled in one of two specific UAB Parkinson's disease research studies (ask the trial site which ones apply to you). If you are a woman who could become pregnant, you must have a negative pregnancy test (urine or blood) within 2 days before the imaging scan. Women who have gone through menopause…

People who have been diagnosed with Parkinson's disease according to UK Brain Bank (UKBB) and other standard diagnostic guidelines, with symptoms first appearing at age 50 or younger.

People who have been clinically diagnosed with Parkinson's disease, and either have a close family member (such as a parent, sibling, or grandparent) who also has Parkinson's disease, or whose parents are closely related to someone who has been diagnosed with Parkinson's disease (whether or not that relative has…

You have been diagnosed with Parkinson's disease using recognised medical diagnostic guidelines (such as the UK Parkinson's Disease Society Brain Bank criteria or similar standards) You have been tested and found to have a change (variant) in a gene called SNCA, which is linked to Parkinson's disease

You have been diagnosed with Parkinson's disease using recognised medical diagnostic guidelines (such as the UK Parkinson's Disease Society Brain Bank criteria or similar standards) You have been found to carry a change (variant) in a gene called GBA, which has been linked to Parkinson's disease

People who have already received a deep brain stimulation (DBS) implant, or who have been assessed as suitable candidates for one by their medical team.

You must be a Veteran who receives care at Hines VA Hospital or Jesse Brown VA Medical Center You must have been diagnosed with Parkinson's disease or a related movement disorder by a neurologist You must have been found to have mild cognitive impairment (some memory or thinking difficulties, but not dementia) You…

You have been diagnosed with Parkinson's disease using recognised standard diagnostic guidelines (known as the UK Brain Bank Diagnostic Criteria)

People who are having surgery on organs in the abdomen. People who have been assessed as ASA physical status class 1, 2, or 3 (a standard medical rating of overall health before surgery — confirm with trial site).

You are willing and able to give your agreement to take part in the study You are male or female, aged 18 years or older You are already scheduled to have Deep Brain Stimulation (DBS) surgery (a type of brain surgery involving implanted electrodes) You are fluent in English For the experimental group only: you have…

People with Parkinson's disease at a mild to moderate stage (Hoen and Yahr scale stages 1 to 3) People who have some ability to walk, with a walking ability score of 2 or below on the FAC scale (confirm with trial site) People with a disability level score of 3 or below on the Ranking scale (confirm with trial site)…

You carry a specific genetic variation in a gene called GBA (for example, the p.L444P or p.N370S variant), meaning you have one changed copy of this gene You are between 18 and 80 years old

People who are 50 years of age or older

People who are between 40 and 80 years old People who have been experiencing Parkinson's symptoms for between 7 and 20 years People who have severe insomnia, based on a specific insomnia questionnaire score (called the ISI)

Adults (men and women) who have been diagnosed with Parkinson's disease, at any stage of the condition People who do not have a severe long-term neurological, mental, or psychiatric condition People who do not have significant memory or thinking difficulties that affect their daily independence (assessed using…

A doctor has diagnosed Parkinson's disease based on established UK Brain Bank criteria, and the person has at least two of these three symptoms: resting tremor (shaking at rest), muscle stiffness, or slowness of movement — and those symptoms respond to Parkinson's medication Age 55 or older at the time of joining the…

People who have been diagnosed with pure autonomic failure (a condition where the nervous system doesn't properly control automatic body functions like blood pressure) People who have autonomic failure along with a possible diagnosis of Parkinson's disease (PD), Multiple System Atrophy (MSA), or Dementia with Lewy…

People who have been scheduled for deep brain stimulation (DBS) surgery, as decided by a specialist medical team, and who have a confirmed diagnosis of Parkinson's disease, essential tremor, or dystonia. People who are able to give their consent to participate and follow the instructions involved in the study tasks.…

You have shown signs of memory or thinking problems, based on a score from one of three recognised memory tests (confirm with trial site for specific score ranges) You have been diagnosed with mild memory problems or dementia possibly related to Alzheimer's disease, reduced blood flow to the brain, Parkinson's…

You are willing and able to give written consent to take part in the trial. You have been diagnosed with Parkinson's disease, based on a specific set of medical guidelines called the MDS criteria. You are between 31 and 74 years old. You are fluent in the language used for the tests and questionnaires in the trial.

The person with Parkinson's disease must be a veteran aged 40 or older. The person must have a confirmed diagnosis of Parkinson's disease based on a specific set of recognised diagnostic guidelines (UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria). The person must be experiencing psychosis…

Adults between 18 and 90 years of age (men or women) People who have a long-term health condition that affects their ability to move around People who have given their written agreement to take part in the trial People who are part of the French healthcare system (for sites based in France)

People who have been diagnosed with Gaucher disease (type 1, 2, or 3, including subtypes 3a, 3b, and 3c). People who have Parkinson's disease that is linked to a change in the GBA gene (a gene connected to Gaucher disease).

People who are attending a memory clinic appointment due to memory concerns, or people who are accompanying someone to a memory clinic appointment for memory concerns

Adults aged 18 or older People who are able to understand the study and agree to sign a consent form (or have a legally authorised representative do so on their behalf) People who have been diagnosed by a neurologist or psychiatrist with mild cognitive impairment (MCI), ALS (motor neurone disease), Parkinson's…

People diagnosed with idiopathic (standard) Parkinson's disease, including those with a family history of the condition, based on a recognised set of diagnostic guidelines (UK Brain Bank criteria) People with mild to moderate Parkinson's symptoms, rated at stages 1 to 3 on a standard scale (Hoehn & Yahr) People who…

People aged 57 or older at the time of their screening visit People taking certain medications (alpha methyldopa, methylphenidate, amphetamine-based medicines, or modafinil) who are willing and medically able to stop taking them for a set period before a brain scan People whose screening brain scan (called a SPECT…

People who are 21 years of age or older People who have been clinically diagnosed with Parkinson's disease People who are interested in taking part in one or more research studies led by investigators at the University of Delaware

You are between 18 and 70 years old You are able to read and sign a consent form agreeing to take part You are able to understand instructions and perform a specific knee movement task Your knee can bend and straighten through a range of at least 70 degrees on your own Your knee cannot fully straighten, with a limited…

You are between 18 and 70 years old You are able to walk at least 20 meters (about 65 feet) without any walking aid or support You are able to read, understand, and willingly sign a consent form agreeing to take part You are able to understand simple instructions and complete a basic movement task You have at least…

People aged 18 years or older People who have been diagnosed with idiopathic Parkinson's Disease (Parkinson's with no known external cause) People who have previously had a specific brand of deep brain stimulation (DBS) device implanted — the Boston Scientific Vercise™ system People who have had this DBS device…

People who are 22 years of age or older People who speak English People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's disease with no known cause) at any stage of the disease, as confirmed by a neurologist People who have mild to moderate drooling or difficulty managing saliva, based on a…

People aged between 40 and 80 years old (male or female) People who have been diagnosed with "Clinically Probable Parkinson's Disease" using standard medical diagnostic criteria, with symptoms that started within three years before the study screening visit People whose brain scan (called a DAT-scan or DaT-SPECT)…

Children under 18 years old who have been diagnosed with congenital hyperinsulinism (a condition where the body produces too much insulin). Children under 18 years old who have been diagnosed with neuroblastoma (a type of cancer that develops from nerve cells). Children under 18 years old, or adults aged 18 and over…

People who have been diagnosed with a brain or nervous system condition such as Alzheimer's disease, Parkinson's disease, ALS (Lou Gehrig's disease), or a related condition People who have a family history of certain inherited brain or nervous system diseases (such as familial FTD or familial ALS), whether or not they…

You are scheduled to have deep brain stimulation (DBS) surgery at Vanderbilt University Medical Center while awake under local anesthesia The planned path for the brain electrode is expected to pass through a specific area of the brain called the caudate You are 40 years old or older You have been diagnosed with…

You have been diagnosed with idiopathic Parkinson's disease (a specific type of Parkinson's confirmed using standard medical guidelines) You are 18 years of age or older You have walking and/or balance problems that have not improved with levodopa (a common Parkinson's medication), as measured by a standard assessment…

People who are between 50 and 99 years of age

You can be male or female You have been clinically diagnosed with idiopathic Parkinson's Disease (Parkinson's that does not have a known external cause) You have had a brain MRI scan done as part of your normal care within the last 12 months You have had a specific brain scan (DaTSCAN or F-DOPA PET) done at any point…

People diagnosed with idiopathic (no known cause) Parkinson's disease, confirmed using a specific set of recognised diagnostic guidelines known as the UKPDSBB criteria People whose Parkinson's disease is at an early stage (Stage I or II on the Hoehn and Yahr scale, which measures how advanced the condition is) People…

People who have been approved for surgery following review by a team of medical specialists People who have been diagnosed with Parkinson's disease or Essential Tremor People whose movement disorder (Parkinson's disease, Essential Tremor, or dystonia) has not been adequately controlled by medication People who are…

You have been officially diagnosed with Parkinson's disease based on recognised medical guidelines You are able to give your written agreement to take part in the study, in English or Spanish You have mild, moderate, or severe Parkinson's disease and are still able to walk You are currently taking a fast-acting…

People diagnosed with idiopathic Parkinson's disease (Parkinson's that has no known cause) who were assessed by their doctors as suitable candidates for a specific type of brain stimulation surgery called Deep Brain Stimulation (DBS) targeting an area of the brain called the subthalamic nucleus (STN). People who have…

People who have been diagnosed with Parkinson's disease People whose Parkinson's disease falls within a mid-range of severity, known as Hoehn and Yahr stages II–III (confirm with trial site) People between the ages of 45 and 75 People who are physically able to ride a stationary upright bicycle People who are able to…

You have had a lumbar puncture (a procedure where a needle is used to collect fluid from your lower back) You have a clear and confirmed medical diagnosis

People who have been diagnosed with idiopathic Parkinson's disease (Parkinson's that develops on its own, without a known cause) People whose Parkinson's symptoms fall within a mild to moderate range, rated as stage 1 to 3 on a standard scale called Hoehn and Yahr People who are able to understand the Dutch language…

People who have been diagnosed with Parkinson's disease according to a specific set of medical diagnostic standards known as the UK PD Brain Bank criteria. People who have been diagnosed with a related condition called a "parkinsonian syndrome," which includes multiple system atrophy, progressive supranuclear palsy…

You have been diagnosed with Parkinson's disease You are willing to take part in the study voluntarily You have a breathing muscle weakness score above 2, as measured by a standard medical scale called the Modified Medical Research Council scale (confirm with trial site)

People who have been diagnosed with Parkinson's disease and whose doctors have recommended deep brain stimulation surgery to help manage their movement symptoms People whose pre-surgery MRI scan shows no signs of certain abnormalities, such as adhesions on the brain surface or unusual blood vessel changes People who…

People who are 30 years of age or older, of any gender People who are already scheduled to receive an Exablate procedure as part of their standard planned treatment for their condition at their local medical facility People who are willing to follow the registry's requirements, including attending all required study…

People who have been diagnosed with Parkinson's disease based on specific international diagnostic guidelines (called the MDS criteria), with a "probable" level of diagnosis. People who are willing to have genetic testing done and are happy to be told the results for several genes linked to Parkinson's disease (GBA…

People who receive medical care for a diagnosis of Parkinson's disease with mild cognitive impairment or dementia may be eligible to participate in the research database. People of any age, at any stage of the disease, and with any level of cognitive impairment may be considered, as long as the person is able to…

People who have been diagnosed with Parkinson's disease by a neurologist, or healthy individuals who have not been diagnosed with any neurological illness

Adults aged 18 or older who have been diagnosed with Parkinson's disease Adults aged 18 or older who have not been diagnosed with Parkinson's disease

People who have been diagnosed with Parkinson's Disease or Dystonia People who have a specific Medtronic brand brain stimulation device (either the Percept or RC+S model) already implanted in one of two specific brain regions (either the GPI or STN) People whose brain stimulation device was implanted on one side or…