Heart Disease

**Who might be able to join this trial:** - People who are at least 18 years old - People (or their legal guardian) who understand what the study involves and have given written consent before any study-related tests begin - People under 20 years old enrolling at a site in Japan, where both the patient and their legal...

**Who might be able to join this trial:** - People who are at least 18 years old - People (or their legal guardian) who understand what the study involves and agree in writing before any study tests begin - People being enrolled at a Japanese site who are under 20 years old must have both their own written consent and...

**Who might be able to join this trial:** - You were hospitalised in the last 52 weeks (about one year) for a serious heart condition called Acute Coronary Syndrome (ACS), which includes events like a heart attack or severe chest pain caused by blocked arteries. **Who may not be able to join:** - You are younger than...

Who might be able to join this trial: - Adults aged 18 or older who have had a specific type of heart attack (called a STEMI) and arrived for treatment within 6 hours of symptoms starting, with at least 20 minutes of chest pain or shortness of breath and a confirmed abnormal heart tracing (ECG) matching Australian Nati...

**Who might be able to join this trial:** - Women aged 18 or older - People having coronary artery bypass grafting (a type of heart surgery to improve blood flow) as the only procedure being performed - People having this type of heart surgery for the first time - People with significant blockage or disease in specifi...

Who might be able to join this trial: - People who have previously had a COVID-19 infection - People who live close enough to the trial site to attend follow-up appointments Who may not be able to join: - People who have a moderate or severe problem with one or more heart valves (either narrowing or leaking) - People...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been admitted to hospital for a specific type of heart attack (called a Type I myocardial infarction) Who may not be able to join: - People whose LDL cholesterol level (a type of "bad" cholesterol measured by a blood test...

Who might be able to join this trial: - People who had cancer more than 5 years ago and received chemotherapy and/or radiation treatment that may have affected the heart (this mainly includes survivors of breast cancer, Hodgkin's lymphoma, and prostate cancer) Who may not be able to join: - People who are unable to gi...

**Who might be able to join this trial:** - People who have a blood marker of inflammation called hs-CRP at a level of 2 mg/L or higher, measured at the first screening visit. - People who meet at least one of the following heart-related blood marker conditions: a heart stress marker called NT-proBNP at 300 pg/mL or h...

**Who might be able to join this trial:** - People who have been diagnosed with a long-term low white blood cell condition (called chronic neutropenia) that is congenital (present from birth) or has developed over time due to an autoimmune or unknown cause, and where the condition has been present for at least 6 month...

**Who might be able to join this trial:** - You are 18 years old or older - You have been admitted to hospital with a heart attack confirmed by a procedure that looked inside your arteries (a type of X-ray of the heart's blood vessels) - You had a specific type of heart attack (called STEMI) where symptoms started wit...

**Who might be able to join this trial:** - People who have been diagnosed with heterozygous familial hypercholesterolemia (an inherited condition that causes high cholesterol) or with early-onset coronary artery disease (heart disease that developed at a younger age than typical) **Who may not be able to join:** - Pe...

Who might be able to join this trial: - People who fully understand the study's purpose and methods, and are willing to sign a consent form before any assessments begin. - Australian patients aged between 18 and 75 years (male or female). - People who have been diagnosed with coronary artery disease (fatty buildup in t...

Who might be able to join this trial: **For all participants:** - The person is able to understand what the study involves and agrees to take part in writing. - The person is able to follow the study schedule and complete all required assessments. **For healthy participants (certain parts of the trial):** - Adults (m...

**Who might be able to join this trial:** - People who are at least 18 years old. - People (or their legal guardian) who understand what the trial involves and have given written consent before any trial procedures begin. - People whose heart condition makes them suitable for a procedure called percutaneous coronary i...

Who might be able to join this trial: - People aged 50 years or older - People whose Lp(a) (a type of cholesterol-like particle in the blood) was measured at 200 nmol/L or higher during the screening process - People who have multiple risk factors for heart and blood vessel disease, and/or signs that fatty deposits hav...

**Who might be able to join this trial:** - People aged between 35 and 80 years old - People whose Lp(a) level (a type of cholesterol-related protein in the blood) was measured at 200 nmol/L or higher during the screening process - People whose heart scan (a specialised CT scan of the heart's arteries) shows a blockage...

Who might be able to join this trial: - People who are older than 18 years of age - Healthy volunteers: people with no history of heart disease - People with dilated cardiomyopathy: a history of heart failure and a weakened heart that pumps less than 40% of its blood with each beat - People with left ventricular hypert...

Who might be able to join this trial: - People who have coronary (heart) artery disease that can be treated with a procedure called PCI, where a small tube (stent) is used to open blocked arteries - People without specific medical or heart condition limitations that would prevent participation (confirm with trial site)...

Who might be able to join this trial: - You are scheduled to have heart surgery - You are willing to give your consent to take part in the trial Who may not be able to join: - You are already taking part in another clinical trial for a drug or medical device that does not allow you to join other trials at the same tim...

Who might be able to join this trial: - Adults aged 18 years or older - People who have given written consent to participate - People diagnosed with a type of heart attack or severe chest pain (called Acute Coronary Syndrome without ST-segment elevation, including NSTEMI or unstable angina) that requires urgent investi...

**Who might be able to join this trial:** - People who have been treated at Mayo Clinic and have been diagnosed with a spontaneous coronary artery dissection (SCAD) — a type of tear in a heart artery - Women who were pregnant or had given birth within the past 12 months at the time of their SCAD event - People who ide...

Who might be able to join this trial: - You must be older than 18 years old - You must have heart disease that causes frequent chest pain (angina) that is severe — rated as Class 3 or 4, meaning it happens with minimal activity or even at rest — and has not improved after at least 30 days of the best available medicati...

Who might be able to join this trial: - Adults aged 18 years or older who are safe to have an MRI scan Who may not be able to join: - People who have any metal in their body that has not been approved as MRI-safe - People who are pregnant or who may possibly become pregnant - People who experience claustrophobia (fear...

Who might be able to join this trial: - People who have coronary artery (heart) disease that can be treated with a procedure called PCI, where a small tube (stent) is placed in a blocked artery to open it up - People who do not have any specific medical or heart condition factors that would prevent them from participat...

Who might be able to join this trial: - People who were 18 years of age or older at the time of their surgery - People who had cardiovascular (heart or blood vessel) surgery at UC Davis Medical Center between January 1, 2001 and July 15, 2013 - People whose surgery was performed either with or without the use of a hear...

Who might be able to join this trial: - People who have been clinically diagnosed with Familial Hypercholesterolaemia (FH), a condition that causes very high cholesterol and runs in families - People with a personal or family history of high cholesterol levels - People with a personal or family history of heart disease...

**Who might be able to join this trial:** - You are older than 19 years of age - You are able to talk through and understand the risks, benefits, and other treatment options, and you (or your legal representative) are willing to sign a consent form before any study procedures begin - You have a significant blockage (mo...

Who might be able to join this trial: - People who have symptoms that suggest they may be having a heart attack - People who are able to give written consent to take part, following standard research guidelines and local laws - People who are at least 18 years old Who may not be able to join: - People who do not have...

Who might be able to join this trial: - You have been referred by a heart specialist (cardiologist) for a routine CT scan of the heart's arteries (called a CCTA). Who may not be able to join: - You are pregnant or may be pregnant - You have severe kidney problems - You have had a serious allergic reaction to the contr...

Who might be able to join this trial: - People who have been diagnosed with cardiomyopathy (a condition affecting the heart muscle) - Family members of someone who has been diagnosed with cardiomyopathy Who may not be able to join: - People who have not been diagnosed with cardiomyopathy - Family members of people who...

Who might be able to join this trial: - People who have been diagnosed with a narrowing of the aortic valve (a condition called aortic stenosis), confirmed by an ultrasound of the heart or through an invasive heart procedure. Who may not be able to join: - People who are currently experiencing an acute coronary syndro...

Who might be able to join this trial: - People who are currently in hospital being treated for congestive heart failure (a condition where the heart does not pump blood as well as it should). Who may not be able to join: - People who do not have congestive heart failure. - People who are under 18 years of age. - Peopl...

**Who might be able to join this trial:** - People who weigh at least 20 kg (44 lbs) - People who have a failing or poorly functioning conduit or previously implanted valve in the pulmonary (right side of the heart) position that needs treatment, and whose anatomy falls within the size range required by the device - Pe...

Who might be able to join this trial: - People who have coronary artery disease (a condition where the arteries supplying the heart become narrowed or blocked) - People who have already had antiplatelet medication testing done as part of their regular medical care, and/or have had genetic testing related to how their b...

Who might be able to join this trial: - Adults aged 18 years or older at the time of enrollment - People who have previously had a coronary angiogram (a procedure that takes X-ray images of the heart's blood vessels) or an angioplasty (a procedure to open blocked or narrowed blood vessels in the heart) Who may not be...

Who might be able to join this trial: - People who are over 18 years old and able to give their own consent to participate - People who have a specific pattern called a "Q wave" showing on their heart tracing (ECG) - People who have had a heart attack that has affected at least 50% of the thickness of a section of hear...

Who might be able to join this trial: - People who have been clinically diagnosed with severe coronary artery disease and are scheduled to have coronary artery bypass surgery (a heart operation to improve blood flow). Who may not be able to join: - People who are under 18 years of age. - People who are unwilling or un...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who have survived a cardiac arrest that was successfully treated, where the cause was a documented dangerous heart rhythm (ventricular fibrillation or a very fast ventricular heartbeat) - People who have been diagnosed with variant angi...

Who might be able to join this trial: - People aged 18 or older - People who are currently admitted to hospital with one of the following conditions: heart failure causing fluid build-up in the lungs or legs, a state where the heart is too weak to pump enough blood to the body (cardiogenic shock), or a condition where...

**Who might be able to join this trial:** **Heart Failure Group:** - People who have been medically recommended to receive a pacemaker, cardiac resynchronization device (a device that helps the heart beat in a more coordinated way), or a similar heart device, including a newer type called His-bundle or left bundle bra...

**Who might be able to join this trial:** - People who have been admitted to hospital with a main diagnosis of acute decompensated heart failure (a sudden worsening of heart failure symptoms), confirmed using a standard set of medical criteria called the modified Framingham criteria **Who may not be able to join:** -...

Who might be able to join this trial: - You must be 18 years old or older. - You must be a patient who has been seen or assessed at the Heart Failure unit or clinic at the facility running this trial. - You must have given your agreement to take part by signing a consent form. Who may not be able to join: - You may no...

**Who might be able to join this trial:** - People who have been diagnosed with heart failure and experience typical symptoms and signs of the condition, with a functional severity rating of Class II or above (meaning symptoms appear during ordinary activity or less) - People whose heart failure blood marker (NT-proBN...

Who might be able to join this trial: - You are a patient at the IHVI (Inova Heart and Vascular Institute) who has been treated by the Cardiogenic Shock team for either a sudden, severe worsening of heart failure or a heart attack that caused your heart to stop pumping blood effectively. Who may not be able to join: -...

Who might be able to join this trial: - People who have long-term heart failure where the heart's main pumping chamber is not squeezing properly (known as systolic heart failure) - People whose heart's pumping strength (called ejection fraction) is 35% or lower - People whose doctors have recommended a specific heart d...

Who might be able to join this trial: - People who have been diagnosed with a heart attack, confirmed through a procedure that takes X-ray images of the heart's blood vessels (called a coronary angiogram) Who may not be able to join: - No specific exclusion criteria were listed in the official trial information (confi...

Who might be able to join this trial: - People who are 19 years of age or older - People who have received a procedure called rotational atherectomy (a procedure used to treat blocked arteries) - People who, or whose legal guardian, have agreed to the study procedures and follow-up schedule and have signed a written co...

Who might be able to join this trial: - People who are older than 18 years of age - People who are willing to take part and are able to understand, read, and sign a consent form before any procedure takes place - People for whom a doctor has determined coronary angiography (an X-ray of the heart's arteries) and/or a pr...

Who might be able to join this trial: - People aged 19 years or older - People who are having a DeSyne X2 drug-eluting coronary stent procedure - People who have agreed to and signed a written informed consent form Who may not be able to join: - People who are having a DeSyne X2 drug-eluting coronary stent and another...

**Who might be able to join this trial:** - People who have had one or more episodes of a specific type of sustained abnormal heart rhythm called monomorphic ventricular tachycardia (VT) - People who have been referred for a heart procedure called catheter ablation (a procedure to correct abnormal heart rhythms) - Peop...

"Who might be able to join this trial: - People who are 18 years of age or older. - Adults experiencing severe heart and breathing failure that requires a life support machine called ECMO (a machine that pumps and oxygenates blood outside the body). - Adults for whom both a personal representative (such as a family mem...

"Who might be able to join this trial: - People with heart failure symptoms that fall into Class II, III, or IV on a standard medical scale — meaning those who experience symptoms ranging from slight limitations during physical activity up to severe limitations even at rest (confirm with trial site) Who may not be abl...

**Who might be able to join this trial:** - People who have been diagnosed with an ischemic stroke (a stroke caused by a blocked blood vessel) or a transient ischemic attack (TIA, sometimes called a "mini-stroke"). - People whose stroke or TIA symptoms started less than 30 days ago. - People who have been found to hav...

Who might be able to join this trial: - People who are having coronary artery bypass graft (CABG) surgery, with or without a heart-lung bypass machine, and with or without other heart procedures such as valve replacement. - People whose heart surgery will not fully restore blood flow to all areas of the heart, based on...

Who might be able to join this trial: - People who are admitted to the Emergency Department (ED) in Monastir, where their main diagnosis upon discharge is recorded as heart failure (HF). Who may not be able to join: - Women who are pregnant or currently breastfeeding. - People who are not fully alert or conscious, spe...

**Who might be able to join this trial:** - People who have been diagnosed with Acute Coronary Syndrome (ACS) — a term that covers serious heart conditions such as a heart attack or unstable chest pain caused by reduced blood flow to the heart - People who are 18 years of age or older **Who may not be able to join:**...

Who might be able to join this trial: - People aged 18 years or older - People who have blood test results showing signs of inflammation in the body (specific markers include CRP, IL-6, or a white blood cell ratio — the trial site can confirm what these mean for a specific case) - People who are currently hospitalised...

**Who might be able to join this trial:** This trial has four different groups. You may qualify for one of them: **Group 1 – Sarcoidosis patients without heart inflammation:** - You have been diagnosed with sarcoidosis according to recognised medical guidelines (ATS/ERS criteria) (confirm with trial site) - You have...

**Who might be able to join this trial:** - People who are 14 years of age or older - People who have typical heart failure symptoms as measured by a standard medical checklist called the Framingham criteria - People whose heart pumps less efficiently than normal (specifically, where the heart's pumping function is bel...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been hospitalised for at least a second acute episode of heart failure (either involving the upper or lower blood pressure reading) - People who were living at home before being hospitalised for this episode - People who are cov...

**Who might be able to join this trial:** - People who are having a type of heart attack called a STEMI (where a specific pattern is seen on a heart tracing), with symptoms that started less than 24 hours ago or that are still ongoing. - People who have read and signed a consent form agreeing to take part. **Who may n...

**Who might be able to join this trial:** - You are 18 years of age or older and are willing and able to give your consent to participate - You are being treated for acute heart failure, whether your heart pumps with reduced or normal strength - You are receiving treatment for fluid build-up in the lungs (pulmonary ede...

Who might be able to join this trial: - People who are admitted to hospital with a main diagnosis of Acute Coronary Syndrome (ACS), which is a condition where blood flow to the heart is suddenly reduced or blocked, such as a heart attack - People who are admitted to hospital where Acute Heart Failure (AHF) — a sudden w...

**Who might be able to join this trial:** - Adults aged 18 or older who are experiencing cardiogenic shock (a serious condition where the heart cannot pump enough blood to meet the body's needs) - People whose blood volume levels are considered adequate by their medical team - People who have been receiving a medicati...

**Who might be able to join this trial:** - People who have been admitted to hospital for a heart attack and are already enrolled in the Frenchie registry - People who score 5 or higher on a screening questionnaire used to check for gum disease - People who have at least six teeth, not counting wisdom teeth - People wh...

Who might be able to join this trial: - Adults aged 18 and over, of any sex, who are admitted to the intensive care unit directly after heart surgery and require blood pressure monitoring through an arterial line (a thin tube placed in the wrist or groin artery) or a Swan-Ganz catheter (a tube placed in the heart to mo...

**Who might be able to join this trial:** - People who have had a type of heart attack called a STEMI and arrive at the hospital within 48 hours of their symptoms starting. **Who may not be able to join:** - No specific exclusion criteria have been listed for this trial (confirm with trial site). **Important: Always...

Who might be able to join this trial: - People who have had their first-ever heart attack of a specific type (called an ST-elevation myocardial infarction, or STEMI), diagnosed using standard international medical guidelines - People who received an emergency procedure to open a blocked heart artery (called a primary P...

"Who might be able to join this trial: - People who are currently receiving ECMO (a machine that supports the heart and/or lungs by pumping and oxygenating blood outside the body) Who may not be able to join: - People who do not give their consent to participate in the trial Important: Always verify eligibility with...

Who might be able to join this trial: - People who have had a procedure to open blocked heart arteries (called a percutaneous coronary intervention, or PCI) at the trial institution - People who are willing to take part and are able to give their formal agreement to participate Who may not be able to join: - People wh...

Who might be able to join this trial: - You are having a procedure done to look at the blood vessels of your heart (called a coronary angiography) at the West German Heart and Vascular Center. Who may not be able to join: - There are no stated reasons that would stop someone from joining this trial. Important: Always...

Who might be able to join this trial: - People who have heart failure that has been confirmed through clinical assessment, heart ultrasound (echocardiogram), and hormone-level testing - People who have a cardiac pacemaker fitted - People who are physically able to complete a peak exercise test (an exercise test that me...

Who might be able to join this trial: - You receive your healthcare within the Yale New Haven Health System - You have been diagnosed with heart failure Who may not be able to join: - You are under 18 years of age Important: Always verify eligibility with the trial site directly before applying.

**Who might be able to join this trial:** - People who have had a serious heart event (called acute coronary syndrome) and are considered at high risk of future heart problems, and who have had a successful procedure to open blocked arteries (PCI) with at least one drug-coated stent placed - People who are willing and...

Who might be able to join this trial: - People who are admitted to hospital with a serious heart condition called cardiogenic shock (where the heart cannot pump enough blood to meet the body's needs) at one of the participating hospitals, between January 2020 and December 2030. - People whose blood pressure is dangerou...

Who might be able to join this trial: - People who have undergone cardiac (heart) surgery Who may not be able to join: - People under 18 years of age Important: Always verify eligibility with the trial site directly before applying.

**Who might be able to join this trial:** - People who have been admitted to hospital with acute (sudden or severe) heart failure - People whose doctor considers them ready to be discharged from hospital after being treated for acute heart failure - People aged 18 or older - People who have been fully informed about ho...

**Who might be able to join this trial:** - People who have been admitted to hospital with acute (sudden or severe) heart failure - People whose heart is pumping with a normal or near-normal squeezing strength (called "preserved ejection fraction," meaning the heart pumps out at least 50% of its blood with each beat) -...

**Who might be able to join this trial:** - People who are currently in hospital being treated for sudden (acute) worsening heart failure - People whose heart is not pumping as strongly as it should be (the heart's pumping strength is measured as less than 50%) - People who are considered medically ready to be discharg...

**Who might be able to join this trial:** - People who have signed a consent form agreeing to take part in the study. - People who have been diagnosed with a heart attack (either a STEMI or NSTEMI type), confirmed through heart tracing tests (ECG), blood tests (troponin I and CPK-MB), and a procedure that takes images...

**Who might be able to join this trial:** - You have heart failure with symptoms (such as shortness of breath or fatigue) and your heart's pumping strength is significantly reduced, confirmed by an ultrasound of the heart - You are already taking the standard recommended medications for heart failure - A blood test sh...

**Who might be able to join this trial:** - People aged 18 or older who have given written consent to participate - People living with long-term heart failure that causes symptoms, rated at a certain level of severity (NYHA Class 2 or above) - People whose left side of the heart shows higher pressure than the right si...

**Who might be able to join this trial:** - People aged 19 or older who have a known heart or blood vessel condition and are currently taking long-term blood-thinning medicines (such as blood clot prevention tablets or blood thinners taken by mouth). Qualifying conditions may include coronary artery disease, a history...

**Who might be able to join this trial:** - The patient (or their legal representative) has signed a consent form, and the investigator considers the patient able to participate and complete study questionnaires. - Adults aged 18 years or older. - People diagnosed with a moderate-to-severe level of heart failure (call...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People with heart failure who have had at least one hospital admission for heart failure in the past 12 months, with moderate symptoms (confirm with trial site for exact symptom classification) - People with heart failure who have had...

Who might be able to join this trial: - People who have had a specific type of heart attack (called a STEMI or Takotsubo syndrome) and are scheduled to have a procedure to look at the heart's blood vessels within 12 hours of symptoms starting - People who are able to give written agreement to take part in the trial Wh...

**Who might be able to join this trial:** - People who are willing and able to give their agreement to take part in the study - Healthy volunteers who are willing to give their agreement to take part in the study - People who have previously been diagnosed with a heart attack **Who may not be able to join:** - People...

"Who might be able to join this trial: - A blood sample containing a substance called Troponin T (a protein related to heart function) must have been collected from the patient being considered for the trial. Who may not be able to join: - People under 18 years of age are not eligible. Important: Always verify eligib...

**Who might be able to join this trial:** - You must be an adult (18 years or older) - You must have had heart surgery using a heart-lung bypass machine more than 24 hours ago, and have had your breathing tube removed for at least 6 hours - You must have had a weak heart (with the heart pumping less than 40% of its cap...

Who might be able to join this trial: - People aged between 30 and 65 years old - People who feel they have higher than normal levels of stress, or who score above 5 on a standard stress measurement questionnaire (called the Perceived Stress Scale), and who want to take part Who may not be able to join: - People who s...

**Who might be able to join this trial:** - People who report feeling stressed, or who score above 13 on a standard stress measurement scale (indicating moderate stress) - People who are willing to complete a stress reduction course and attend imaging sessions, with fewer than 3 missed appointments in the past year -...

Who might be able to join this trial: - People aged 18 years or older - People who are able to use the CamliGo device for 12 weeks - People who are willing to complete study questionnaires, blood tests, and EndoPat testing (a test of blood vessel function) at the start and end of the study - People who have recently ha...

Who might be able to join this trial: - People who have coronary artery disease (narrowed heart arteries) and experienced a cardiac arrest caused by a dangerous abnormal heart rhythm, and who had a procedure to open or bypass the blocked arteries before having a defibrillator device (ICD) implanted. - People aged 18 or...

"Who might be able to join this trial: - You must be an adult (18 years or older). - You must be able to understand the information given about the trial and be able to agree or disagree to take part. - You must have been diagnosed with type 2 diabetes and must NOT have heart failure at stage B or above. - You must be...

**Who might be able to join this trial:** - People who have chronic heart failure and have been taking water pills (diuretics) — either regularly or occasionally — for more than 30 days to manage their symptoms. - People whose heart failure symptoms fall into a moderate-to-severe category (known as NYHA Class II with...

**Who might be able to join this trial:** - People whose heart is pumping out blood at a normal or near-normal rate (a measure called ejection fraction of 50% or above) - People with elevated levels of certain proteins in the blood (NT-proBNP or BNP) that indicate the heart is under stress - People who have symptoms an...

**Who might be able to join this trial:** - The patient is an adolescent aged 12 to under 18 years (Cohort A), a child aged 2 to under 12 years (Cohort B), or an infant aged 1 to under 24 months (Cohort C) - The patient weighs at least 3 kg - The patient has been assessed by the investigator as needing, and being medi...

**Who might be able to join this trial:** - People aged between 18 and 85 years old - People who have a long-term heart condition causing chest pain or similar symptoms (called chronic coronary syndrome) that remains severe (classified as CCS class III or IV) despite already receiving the recommended medications - Peop...

**Who might be able to join this trial:** - People who have given written consent to take part in the study, including agreeing to two heart tissue biopsies and two heart MRI scans. - People who have been clinically suspected of having, or already diagnosed with, myocarditis (inflammation of the heart muscle) or infla...

Who might be able to join this trial: - People who have recently had a specific type of heart device (called a CRT-D or CRT-P) successfully implanted, where the device includes a special programming feature called SyncAV® - People whose heart device is compatible with a cardiac MRI scan (a detailed imaging scan of the...

**Who might be able to join this trial:** - You have been diagnosed with a type of heart attack (called ACS) and had a procedure to open blocked arteries (called PCI/stenting), and have been taking two blood-thinning medications together for at least 6 months afterward - You have tested positive for a stomach bacteria...

**Who might be able to join this trial:** - You are 18 years of age or older (male or female) - You have been diagnosed with heart failure (any type) - Your heart failure diagnosis was made more than 3 months ago - You do not currently have significant signs of fluid build-up in your body, such as crackling sounds in t...

**Who might be able to join this trial:** - Adults aged 18 or older - People with end-stage heart failure, as assessed by a local heart specialist team, where the heart's pumping ability (measured by a scan) is at or below 35%, confirmed within one week before joining the trial - People whose heart is not pumping enou...

Who might be able to join this trial: - People who are at least 19 years of age. - People who have been taking beta-blocker medication continuously for at least 1 year following a heart attack, regardless of when the heart attack was diagnosed. - People who are able to verbally confirm they understand the risks and ben...

Who might be able to join this trial: - People who have previously had coronary artery bypass graft (heart bypass) surgery - People who had one or more vein grafts taken from the leg used during that bypass surgery - People who are experiencing chest pain or discomfort (angina) that has come back after their bypass sur...

**Who might be able to join this trial:** - People who have three blocked heart arteries and have been scheduled for coronary artery bypass graft (CABG) heart surgery **Who may not be able to join:** - People whose bodies cannot tolerate the remote ischemic preconditioning (RIPC) procedure used in this trial (confirm...

**Who might be able to join this trial:** - Adults aged 18 or older who are able to provide written consent to participate - People who meet at least one "major" or two "minor" bleeding risk factors, as defined by an international research standard called the Academic Research Consortium (ARC) **Major bleeding risk f...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have already had, or are scheduled to have, a medically necessary procedure to take detailed pictures of the heart's arteries (called a coronary angiography). - People who have already had, or are scheduled to have, a medically necessar...

Who might be able to join this trial: - Adults who have been diagnosed with heart failure classified as mild to moderate in severity (known as NYHA Class I, II, or III). - People whose adherence to recommended health behaviours — such as following a healthy diet, exercising, and taking medications as directed — has bee...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with stable angina pectoris (chest pain or discomfort caused by reduced blood flow to the heart that occurs in a predictable pattern) - You have blockages in 2 or 3 coronary arteries (the blood vessels that supply your heart...

**Who might be able to join this trial:** - Adults aged 18 or older (both men and women) - People who are currently in hospital with a main diagnosis of acute worsening heart failure or a heart attack - People whose heart failure has been confirmed through symptoms, physical signs, fluid build-up in the lungs, abnormal...

"Who might be able to join this trial: - People who have been admitted to hospital with a type of heart attack or severe chest pain condition (known as ACS — this includes STEMI, NSTEMI, or unstable angina). - People who have a confirmed diagnosis of a specific type of artery tear called SCAD (spontaneous coronary arte...

**Who might be able to join this trial:** **Group A (people with a medical reason for a heart MRI):** - People aged 18 or older, of any gender, who are willing and able to sign a consent form and take part for the full length of the study - People who are already scheduled for a medically necessary heart MRI — for exa...

**Who might be able to join this trial:** - People aged 50 years or older - People who have been diagnosed with chronic heart failure and whose condition has been stable for at least 2 months, with heart medications adjusted to the highest tolerated dose during that time - People whose heart failure symptoms range from...

**Who might be able to join this trial:** - People who are 18 years of age or older - People whose heart is pumping at more than 35% of its normal capacity (a measure called ejection fraction) - People who need a heart pacemaker due to a significant electrical conduction problem between the upper and lower chambers of...

**Who might be able to join this trial:** - People who were diagnosed with cancer at age 39 or younger, and who are between 18 and 45 years old at the time of joining the trial - People who received cancer treatments known to carry risks to the heart, such as certain chemotherapy drugs (for example, anthracyclines, tr...

**Who might be able to join this trial:** - You are 18 years of age or older. - You have been diagnosed with acute coronary syndrome (a condition including heart attacks or serious chest pain caused by reduced blood flow to the heart). - You have one or more coronary artery blockages that are considered "intermediate"...

Who might be able to join this trial: - People who were at least 18 years old at the time of enrolment - People who had a blood clot in the left ventricle (a chamber of the heart) identified by an echocardiogram, MRI, or CT scan between January 1st, 2013 and July 31st, 2020 - People who received treatment at least once...

**Who might be able to join this trial:** - People who have been diagnosed with Type 2 Diabetes - People who have been diagnosed with heart failure with a reduced pumping function (the heart pumps out less than 50% of the blood it holds), rated as Class II or III severity by their doctor - People aged between 18 and 8...

**Who might be able to join this trial:** - People aged 21 or older but under 80 years of age. - People who are willing and able to provide written consent to participate. - People who have been diagnosed with long-term heart muscle weakness caused by a previous heart attack, confirmed by an imaging study showing bloc...

Who might be able to join this trial: - You are 18 years of age or older - You have had a heart attack (either a STEMI or NSTEMI type) - You are willing to sign a consent form agreeing to take part in the study - You are expected to be discharged from hospital within 7 days of your heart attack - You are willing to hav...

Who might be able to join this trial: - People who have been referred to an outpatient cardiac rehabilitation program for coronary artery disease or peripheral vascular disease, and who meet the program's eligibility requirements - People who are willing to be randomly assigned to a study group and complete all study a...

**Who might be able to join this trial:** - People who have been diagnosed with chronic heart failure where the heart's pumping function is still within normal range (a measurement of 50% or higher) - People who are admitted to hospital for a planned day visit or outpatient consultation related to their heart condition...

"Who might be able to join this trial: - People who are over 18 years of age - People who are having a procedure to open a blocked or narrowed artery at a point where the artery splits into two branches (a procedure known as bifurcation percutaneous coronary intervention) Who may not be able to join: - No exclusion cr...

Who might be able to join this trial: - People who have moderate heart failure symptoms that limit activity somewhat, but who are still able to do some physical activity (known as NYHA Class II or III). - People whose heart is pumping with at least 50% of its normal pumping strength (measured by an echocardiogram). - P...

Who might be able to join this trial: - People who began the relevant assessment or treatment period between January 1, 2019 and March 1, 2022 - People aged 18 years or older - People who had both an exercise test and either a cardiac CT scan or a coronary angiography performed within 3 months of each other - People wh...

**Who might be able to join this trial:** - Men aged 50 or older, or women aged 55 or older - People with an LDL ("bad") cholesterol level of 70 mg/dL or higher - People with stable coronary artery disease (meaning no surgery to open blocked arteries is planned before the study begins), confirmed by one or more of the...

Who might be able to join this trial: - People who have had a heart attack (either a STEMI or NSTEMI type) - People who have had a procedure to reopen the blocked heart artery (called PCI) done early after their heart attack - People whose blood pressure has dropped very low (90 mmHg or below) for more than 30 minutes,...

**Who might be able to join this trial:** - People aged between 50 and 80 years old - People who have been diagnosed with a stable form of heart failure where the heart's pumping function is preserved (known as HFpEF), with symptoms classified as moderate (NYHA Class II–III) or a specific elevated blood marker related...

**Who might be able to join this trial:** - Your condition has been stable and you have been on the same medication for it for more than 4 weeks. - You are willing and able to sign a consent form agreeing to take part. - You have been diagnosed with a left-heart disease (a condition affecting the left side of the heart...

Who might be able to join this trial: - People aged 18 or older (women must be either postmenopausal for more than 2 years with appropriate signs such as being over 55 with a history of hot flushes, or have had a hysterectomy and/or removal of both ovaries) - People who are having a specific type of heart attack called...

Who might be able to join this trial: - People who have coronary artery disease (a condition where the heart's blood vessels are narrowed or blocked) and need a procedure called PCI (a treatment that opens up blocked heart arteries, often using a small balloon or stent) - People who are 18 years of age or older - Peopl...

Who might be able to join this trial: - People aged 20 years or older - People who have already had a successful FFR measurement and pullback tracing performed (this is a heart artery pressure test used to check for blockages) Who may not be able to join: - People with severe chronic kidney disease (where kidney filte...

**Who might be able to join this trial:** - Adults and young people aged 16 or older are included in the study. - Both male and female patients are included. - People who have had a procedure to look at the blood vessels of the heart (called an angiogram) at Blackpool Heart Centre are included. - People who have had a...

**Who might be able to join this trial:** - People who are currently in hospital, being discharged, or are outpatients who have had a recent heart attack or unstable chest pain (angina) meeting specific medical criteria, OR outpatients who have a diagnosis related to heart and blood vessel disease, kidney disease, str...

**Who might be able to join this trial:** - People who have had a specific type of heart attack (called a Type 1 MI) caused by a blood clot blocking a coronary artery, where blood test results showed elevated heart damage markers along with at least one other sign such as chest symptoms, abnormal heart tracing (ECG),...

Who might be able to join this trial: - People aged 18 or older who have been admitted to an intensive care unit - People who have been diagnosed with cardiogenic shock at a moderate or severe level (known as SCAI class C or D), meaning the heart is not pumping enough blood to meet the body's needs Who may not be able...

**Who might be able to join this trial:** - People aged 19 years or older who have had a heart attack, confirmed by specific blood test results (called cardiac troponin) combined with symptoms of reduced blood flow to the heart - People whose heart arteries are found to be not significantly blocked — meaning less than...

**Who might be able to join this trial:** - People who have stable chest pain (angina) or have had a recent heart attack with at least one other stable, narrowed heart artery that was not the direct cause of the heart attack - People who have one or more significantly narrowed coronary arteries (the blood vessels suppl...

**Who might be able to join this trial:** - You are between 18 and 90 years old - You have a significant leaking mitral heart valve (a specific type called "secondary mitral regurgitation"), confirmed by heart scan at the end of the screening period - You are already receiving the best available medicines for your hea...

Who might be able to join this trial: - People who have been assessed as suitable candidates for a heart transplant - People who are willing to take part in the study and are able to understand and sign a written consent form Who may not be able to join: - People who are under 18 years of age Important: Always verify...

Who might be able to join this trial: - People aged 19 years or older - People who have been assessed as suitable candidates for treatment with a drug-coated or drug-eluting stent (a small mesh tube placed in an artery) due to a condition called acute coronary syndrome (a sudden, serious heart condition such as a heart...

**Who might be able to join this trial:** - People who are older than 18 years of age - People who are willing and able to give written consent to participate - People who have symptoms or signs that suggest possible coronary artery (heart) disease - People who are being considered for a procedure to open blocked heart...

**Who might be able to join this trial:** - People who are able to give signed and dated consent to take part in the trial - People who are 18 years of age or older at the time of giving consent - People whose heart condition meets the guidelines for a treatment called cardiac resynchronisation therapy (CRT), based on...

**Who might be able to join this trial:** - People who live in the Detroit area (defined as those who attended a Detroit-area community event) - People who are 18 years of age or older - People whose blood pressure at screening was measured at 140/90 mmHg or higher (without blood pressure medication) - People whose bl...

Who might be able to join this trial: - People with stable coronary artery disease (a long-term narrowing of the heart's arteries) who are scheduled for a planned, non-emergency procedure to open those arteries (called PCI) - Adults aged 18 or older, of any gender - People whose troponin blood test (a marker of heart m...

Who might be able to join this trial: - People who have given their signed agreement to take part in the study - People who have been diagnosed with a type 1 heart attack that has been recorded in a Swedish heart disease registry called SWEDEHEART - People who were between 18 and 79 years old when they left the hospita...

Who might be able to join this trial: - People who are older than 18 years of age Who may not be able to join: - People who are currently experiencing a heart attack or unstable chest pain (acute coronary syndrome) - People who have had a heart attack or unstable chest pain episode within the last 3 months - People wh...

**Who might be able to join this trial:** - People who have been diagnosed with chronic (long-term, stable) coronary artery disease, where one or more of the major blood vessels supplying the heart has at least 50% blockage, confirmed by a CT scan or angiogram (an X-ray of the heart's arteries) - People whose doctors h...

Who might be able to join this trial: - Adults older than 18 years old who have had a type of heart attack called a STEMI and were given clot-dissolving medication before arriving at the hospital. Who may not be able to join: - No exclusion criteria have been listed for this trial (confirm with trial site). Important...

Who might be able to join this trial: - People aged between 18 and 80 years old - People who experienced an acute coronary syndrome (a serious heart event such as a heart attack) within the last 24 hours - People diagnosed with cardiogenic shock, meaning the heart is not pumping enough blood — shown by low blood pressu...

Who might be able to join this trial: - Adults aged 18 years or older - People who identify as South Asian, with both biological parents having ancestry from India, Pakistan, Sri Lanka, Nepal, or Bangladesh - Adults from other ethnic backgrounds may also be eligible to join as a comparison group Who may not be able to...

**Who might be able to join this trial:** - People over 18 years old who have had a procedure to open blocked heart arteries (called PCI) AND who meet at least one "major" risk factor for serious bleeding, or at least two "minor" risk factors for bleeding, as listed below. **Major bleeding risk factors (one of these...

**Who might be able to join this trial:** - People who are 70 years of age or older - People whose heart pumps less efficiently than normal (the heart is pumping out 35% or less of its blood with each beat), confirmed by a heart scan done at the time of joining or within the 6 weeks before joining - People with moderat...

Who might be able to join this trial: - People who have a medical reason to undergo a coronary CT angiography (a special heart scan that looks at the arteries of the heart) - People who have read and signed a written consent form agreeing to take part Who may not be able to join: - People whose heart pumps at less tha...

**Who might be able to join this trial:** - People aged 20 or older (people aged 90 or older may need to complete a short memory/thinking check to confirm a minimum score) - People who have been admitted to hospital with acute heart failure and are being treated with diuretic medication given through a vein (IV), and...

**Who might be able to join this trial:** - People aged 18 to 75 years who weigh at least 45 kg - People who have been diagnosed with a specific type of heart attack (STEMI), where chest pain caused by reduced blood flow to the heart has lasted at least 30 minutes - People whose heart attack diagnosis is confirmed by...

**Who might be able to join this trial:** - Adult women who have recently been diagnosed with heart failure after being seen at the RVI Heart Failure Diagnostic Clinic - People who are able to walk and carry out everyday tasks (such as dressing and cooking) on their own - People whose heart failure symptoms fall withi...

Who might be able to join this trial: - Adults (18 years or older) may be considered for this trial. - People who are currently in hospital for heart failure, or for another condition where heart failure is playing a significant or worsening role (such as a co-infection), as recognised by their treating doctor, may be...

**Who might be able to join this trial:** - Adults aged 19 years or older - People experiencing typical chest pain, or who have test results showing reduced blood flow to the heart, where a procedure to open blocked arteries (called PCI) is considered appropriate - People who have new blockages in their heart arteries...

**Who might be able to join this trial:** - People aged between 18 and 75 years old - People who have a severe form of cardiogenic shock (when the heart cannot pump enough blood) that requires a specific heart-lung support machine called VA-ECMO, as determined by their treating medical team - People whose blood pressur...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who are already scheduled to have heart surgery for a medical reason, such as bypass surgery (CABG), heart valve replacement (aortic valve), replacement of part of the main artery from the heart (ascending aorta), or a combinat...

**Who might be able to join this trial:** - You are at least 18 years old and younger than 85 years old. - You are scheduled for a planned (non-emergency) heart procedure to open blocked arteries (called PCI). - You have either stable chest pain (stable angina) or a recent heart event (such as a heart attack), with spe...

**Who might be able to join this trial:** - Adults aged 18 or older. - People who have hardened (calcified) blockages in their heart arteries that need to be treated with a procedure to open the artery and place a stent, specifically using a device called a Shockwave catheter. - People whose calcium deposits in the ar...

Who might be able to join this trial: - People who have a failing surgically implanted heart valve (a type called a bioprosthetic valve) with severe narrowing and/or leaking of the aortic valve, where the heart team has approved a "valve-in-valve" procedure (placing a new valve inside the existing one) - People whose s...

**Who might be able to join this trial:** - People who have been diagnosed with coronary artery disease (a condition where the arteries supplying the heart become narrowed or blocked) and have had a heart attack and/or a procedure to open blocked heart arteries and/or heart bypass surgery, and who are currently taking...

**Who might be able to join this trial:** - Adults aged 18 or older - People who are currently admitted to the Clinical Hospital of the Catholic University with a heart condition involving chest pain and elevated blood markers of heart damage (with or without changes on a heart tracing test) - People who are scheduled...

**Who might be able to join this trial:** - Adults aged 18 or older - People with chronic left-sided heart failure who are still experiencing symptoms despite being on stable, guideline-recommended heart failure medications for at least 1 month - People who have been hospitalised for heart failure in the past 12 month...

**Who might be able to join this trial:** - People who have had a heart attack (specifically a type called STEMI) and are planned to have a procedure to open a blocked artery (called PCI or stent placement) - People whose heart attack is confirmed by at least 20 minutes of chest discomfort at rest, along with specific...

**Who might be able to join this trial:** - People who are over 18 years of age - People who have had ongoing chest pain (angina) symptoms rated as moderate to severe for at least 3 months, even while taking at least two anti-anginal (chest pain) medicines at the highest doses they can tolerate - People who are willing...

Who might be able to join this trial: - People who are taking part in an outpatient cardiac rehabilitation program (this is open to all age groups) - People who are able and willing to sign a written agreement to participate in the study Who may not be able to join: - People who are unable to continue attending the ou...

**Who might be able to join this trial:** - People aged 18 or older. - People who have heart failure caused by reduced blood flow to the heart (ischemic origin), with symptoms classified as moderate to severe (NYHA Class II to IV). - People whose heart's pumping strength (left ventricular ejection fraction) was measur...

Who might be able to join this trial: - Adults aged 18 years or older - People who are currently admitted to hospital for any medical reason - People who have had a cardiac arrest while in hospital (meaning their heart stopped and they needed at least 2 minutes of chest compressions) - People who need help with their b...

**Who might be able to join this trial:** - You have chest pain or other symptoms suggesting reduced blood flow to the heart, or tests have shown your heart is not getting enough blood - A previously placed drug-coated stent in one of your heart's own arteries has narrowed again by 50% or more - An imaging scan called...

**Who might be able to join this trial:** **For patients with heart failure:** - People who have a confirmed diagnosis of heart failure (either the pumping or relaxing type) - People who have had trouble taking their heart failure medications as prescribed - People who have a care partner (such as a spouse, child, par...

**Who might be able to join this trial:** - You are between 18 and 85 years old. - You have been diagnosed with a type of irregular heartbeat called paroxysmal atrial fibrillation, confirmed by a heart tracing (ECG), and your symptoms started less than 48 hours before arriving at the Emergency Department. - Alternativ...

**Who might be able to join this trial:** - People diagnosed with chronic heart failure (a long-term condition where the heart does not pump blood as well as it should) that is classified as moderate to severe, where the heart's pumping function is significantly reduced, and where a specific heart-related protein in th...

**Who might be able to join this trial:** - You are over 18 years old - Your heart's electrical signal takes longer than usual to travel through the heart (a measurement called QRS of 150 milliseconds or more), measured before your device was put in - Your heart failure is caused by a condition where the heart muscle i...

**Who might be able to join this trial:** - A patient (or their legal representative, family member, or close relative) is able to provide consent for the patient to take part - The patient is covered by French social security (excluding AME) - The patient is experiencing one of the following types of circulatory fail...

**Who might be able to join this trial:** - People aged between 18 and 79 years - People who have had a specific type of heart attack called an anterior wall STEMI (a blockage affecting the front wall of the heart) - People who have undergone an emergency procedure to open a blocked heart artery (known as a primary PCI...

**Who might be able to join this trial:** - People (men and women) who have previously had a procedure to open or bypass blocked heart arteries, OR who have been found on heart imaging to have significant blockages in major heart arteries. - People who are scheduled for a type of surgery considered to carry an interme...

**Who might be able to join this trial:** - People who have already had, or are planned to have, a procedure to check the blood vessels of the heart (called a coronary angiography) along with a procedure to open blocked heart arteries (called a percutaneous coronary intervention, or PCI — sometimes referred to as a ste...

Who might be able to join this trial: - People who are 18 years of age or older - People who are scheduled for coronary artery bypass grafting (heart bypass surgery) and/or aortic valve replacement, regardless of whether other valve surgery is also being performed at the same time Who may not be able to join: - People...

Who might be able to join this trial: - People who are over 18 years old - People who are able and willing to provide written consent to participate - For the bariatric (weight loss) surgery group: people with obesity (a body mass index of 30 or above) or, for the control group, people without obesity (a body mass inde...

Who might be able to join this trial: - People aged between 18 and 85 years old. - People who have had at least three episodes of a dangerous fast heart rhythm called ventricular tachycardia (VT) in the past six months, where their implanted heart device (ICD) had to deliver treatment to stop it. - People whose VT has...

**Who might be able to join this trial:** - People who are at least 18 years old - People for whom a procedure to open blocked heart arteries (called PCI) is recommended according to current European cardiology guidelines, or for whom this procedure has already been planned as part of their regular treatment - People w...

Who might be able to join this trial: - People who have been diagnosed with coronary heart disease, or who have unexplained chest pain and are scheduled to have a coronary angiography procedure (an imaging test to look at the heart's blood vessels). - Healthy people attending a routine health check-up who are willing t...

Who might be able to join this trial: - The heart's pumping function (left ventricle) is measured at 40% or less of normal capacity. - The person has been referred for a right heart catheterisation (a procedure to measure blood pressure and flow inside the heart) for one of the following reasons: to be assessed for adv...

Who might be able to join this trial: - People who are scheduled to have heart bypass surgery (coronary artery bypass grafting) - People who are older than 19 years - People whose bypass surgery will use a specific artery from the chest wall (left internal thoracic artery) and a vein taken from the leg (saphenous vein...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with INOCA (a condition where the heart does not get enough blood flow, but no blockages are found in the main heart arteries) - People who are currently taking low-dose aspirin (100 mg daily by mouth for more than 3 da...

Who might be able to join this trial: - You are between 18 and 80 years old (any gender) and are having a heart tissue sample (biopsy) taken at the Second Affiliated Hospital of Zhejiang University School of Medicine - You have been diagnosed with, or are suspected to have, myocarditis (heart inflammation), cardiomyopa...

**Who might be able to join this trial:** - People who have been diagnosed with acute coronary syndrome (a sudden reduction in blood flow to the heart, such as a heart attack or unstable chest pain) and need to have a procedure called percutaneous coronary intervention (a procedure to open blocked heart arteries). - Pe...

**Who might be able to join this trial:** - Adults aged 18 or older who are being discharged from hospital after being admitted or seen urgently, where heart failure was either the main reason for the visit or a significant complication that made the stay longer - Adults aged 18 or older who have been referred to a ca...

Who might be able to join this trial: - People who have had a coronary angiography (a special X-ray of the heart's blood vessels) performed at the Department of Cardiology, Peking University First Hospital - People whose medical records and background health information are complete - People whose coronary angiography...

Who might be able to join this trial: - People who have been admitted to hospital because of acute (sudden or severe) heart failure - People who are older than 18 years of age Who may not be able to join: - People who are unable to give their informed consent to take part in the registry (for example, if they are unab...

**Who might be able to join this trial:** - People who are admitted to an intensive care unit (ICU) due to cardiogenic shock (a condition where the heart suddenly cannot pump enough blood to meet the body's needs) - People whose cardiogenic shock meets the specific definition used by the FRENSCHOCK2 study (confirm with...

**Who might be able to join this trial:** - People who have been clinically diagnosed with heart failure - People whose doctors have no plans to change or adjust their heart failure medications or devices during the study period - People who have not had an unplanned hospital stay in the past 2 weeks - People whose fl...

**Who might be able to join this trial:** *Group 1 – Aortic Stenosis (a narrowing of a heart valve):* - You are male or female and aged 50 or older - You have been diagnosed with severe, moderate, or mild aortic stenosis (a narrowing of the main heart valve), or a thickened but not blocked aortic valve - You are willi...

Who might be able to join this trial: - People with severe, end-stage heart failure who have been assessed by doctors at the hospital and approved for a heart transplant on medical and ethical grounds - People who are organ donors providing a heart for transplant Who may not be able to join: - People who do not wish t...

**Who might be able to join this trial:** - People aged between 19 and 85 years - People who have had a heart artery-opening procedure (coronary revascularization) using a newer type of small mesh tube (drug-eluting stent) to keep the artery open **Who may not be able to join:** - People who have an allergy or sensiti...

Who might be able to join this trial: - People who have been diagnosed with a genetic condition called heterozygous familial hypercholesterolemia (an inherited form of high cholesterol) - Adults aged between 18 and 50 years old - People whose LDL ("bad") cholesterol level is above 100 mg/dL (or above 2.6 mmol/L) at the...

**Who might be able to join this trial:** - People aged 18 or older. - People who were given a combination of two blood-thinning medicines — aspirin and one of three specific medicines (ticagrelor, prasugrel, or clopidogrel) — either when their heart attack was diagnosed or at the latest during their emergency stenting...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who have been diagnosed with a specific type of heart attack (called STEMI), confirmed by a particular pattern seen on a heart tracing (ECG) test - People whose heart attack is being treated with a primary procedure to open the blocked a...

Who might be able to join this trial: - People who are at least 19 years of age - People who have no symptoms but have a high level of calcium buildup in the arteries of the heart, shown by a special scan score of 400 or higher (called an Agatston Score) Who may not be able to join: - People who have had test results...

**Who might be able to join this trial:** - People who have silent ischemia (reduced blood flow to the heart with no symptoms), stable or unstable chest pain (angina), or have had a certain type of heart attack — either a non-ST-segment elevation heart attack more than 48 hours ago, or an ST-segment elevation heart att...

Who might be able to join this trial: - People who are 19 years of age or older - People who have type 2 diabetes with no symptoms and who previously had a heart CT scan (called a CCTA) at the Diabetes Center of Asan Medical Center between February 2008 and June 2012 - People who are willing and able to give written co...

**Who might be able to join this trial:** - People aged 19 years or older - People who have chest pain (angina) with confirmed reduced blood flow to the heart muscle - People who have at least one major heart artery that needs a stent placed in it - People who have signed a consent form agreeing to take part in the stu...

Who might be able to join this trial: - People who have been diagnosed with heart failure where the heart's pumping function is relatively preserved (the left side of the heart squeezes out at least 55% of its blood with each beat), confirmed by a test done within the last year. - People whose heart failure symptoms fa...

Who might be able to join this trial: - Adults older than 18 years old - People who have been diagnosed with either stable coronary artery disease, unstable angina (chest pain that is unpredictable or occurs at rest), or a heart attack - People whose blocked or narrowed heart arteries have been assessed by a doctor as...

**Who might be able to join this trial:** - People aged 40 years or older, of any gender - People who have been found to have early-stage plaque buildup in the arteries of the heart (detected by a heart imaging scan called a coronary CT angiogram or coronary angiogram) within the past 2 years, without having had a hear...

**Who might be able to join this trial:** - People aged 50 years or older - People who help care for a household member aged 50 or older who has been diagnosed with a heart failure condition (New York Heart Association Class II, III, or IV) - People who provide at least 8 hours per week of unpaid care for that househo...

**Who might be able to join this trial:** - People aged 18 years or older - People who have coronary artery disease (a condition where the arteries supplying the heart become narrowed or blocked) and have a medical reason to undergo a procedure to open those arteries (called PCI or percutaneous coronary intervention) -...

Who might be able to join this trial: - People who previously took part in a specific research project called "Construction and key technology research of the whole myocardial protection system for acute myocardial infarction" and have already completed their one-year follow-up visit as part of that project - People (o...

**Who might be able to join this trial:** - People who are scheduled for routine PMI screening (a type of heart monitoring after surgery — confirm with trial site). - People who will need to stay in hospital for at least 2 nights after their surgery. - People aged between 40 and 85 years old who also have a history of...

Who might be able to join this trial: - You have been referred to Oslo University Hospital for a specific type of heart device implant (called CRT) or for a follow-up check after having one fitted - Your heart is beating in a normal, regular rhythm (called sinus rhythm) - You have been diagnosed with moderate heart fai...

Who might be able to join this trial: - People aged 18 to 75 years old. - People who have signed a consent form agreeing to take part in the study. - People with a body surface area (a measure of body size based on height and weight) of at least 1.2 m². - People with the most severe class of heart failure symptoms, kno...

Who might be able to join this trial: - People who have a condition where their coronary arteries (the blood vessels supplying the heart) are abnormally enlarged or widened, but without significant narrowing in those arteries. - People with this enlarged coronary artery condition, whether or not they have recently had...

Who might be able to join this trial: - People aged 21 years or older - People experiencing chest pain or other symptoms that could suggest a possible heart attack - People whose risk score for a heart attack (called a HEART score) falls between 4 and 6, indicating a moderate level of risk - People whose heart tracing...

**Who might be able to join this trial:** - People who are at least 18 years old - People (or their legal guardian) who understand what the trial involves and agree to take part in writing before any trial-related tests or treatment begin - People who need a procedure to open a blocked coronary artery (called PCI) bec...

Who might be able to join this trial: - People who have moderately to severely calcified (hardened) blockages in a coronary artery (a blood vessel supplying the heart). - People whose previously implanted stent (a small mesh tube used to keep an artery open) has not expanded properly, meaning it is more than 20% narrow...

**Who might be able to join this trial:** - People between 40 and 75 years of age - People who identify as Black or African American - People who live in the Cleveland Metro Area - People who were identified at a University Hospitals (UH) health fair screening as having at least two of the following health risk factor...

**Who might be able to join this trial:** - People who have a specific genetic background and have been hospitalised for a serious heart event called an acute coronary syndrome (ACS) within the past 3 months - People aged 45 years or older at the screening visit, both male and female - People whose genetic test (calle...

**Who might be able to join this trial:** - You have had a heart-related event in the past 6 months, such as a heart attack, heart failure, a procedure to open blocked arteries (with or without a stent), heart bypass surgery, or heart valve surgery. - You currently live in, or plan to live in, the Springfield, MA or gr...

Who might be able to join this trial: - People who have been diagnosed with left-sided heart failure where the heart muscle is weakened (specifically the types known as HFrEF or HFmEF). - People who are physically able, mentally able, and able to communicate in the study language well enough to take part in all parts o...

**Who might be able to join this trial:** - People who have been diagnosed with COPD, meaning they have a smoking history of more than 10 pack-years (a measure of how much someone has smoked over time) and either a specific breathing test result showing reduced airflow, or a chest CT scan showing signs of emphysema (l...

**Who might be able to join this trial:** - People who have signed a written consent form agreeing to take part in the study - People aged 50 or older - People who have been diagnosed with two or more of the following conditions: type 2 diabetes, chronic obstructive pulmonary disease (a lung condition), ischaemic heart...

**Who might be able to join this trial:** - People aged 18 years or older - People who have signed a consent form agreeing to take part in the study - People who have been admitted to hospital where the main reason for admission is a sudden worsening of heart failure, and where the treating doctor has prescribed a hear...

**Who might be able to join this trial:** - People who have been admitted to an intensive care unit after their heart stopped outside of a hospital and was successfully restarted - People where no clear cause for the cardiac arrest has been found after reviewing their medical history, a brain scan, and a lung blood ves...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have had a specific type of heart attack (called STEMI) and have blockages in multiple heart arteries, where the main blocked artery causing the heart attack has already been successfully treated with a procedure to open it up (including p...

Who might be able to join this trial: - People diagnosed with heart failure where the heart's pumping ability is reduced (specifically, where the pumping function is measured at 40% or below), who are over 20 years old and have a Biotronik brand heart device (such as an ICD or CRT) that is capable of wireless monitorin...

Who might be able to join this trial: - People who are 18 years of age or older. - People who have been referred for a catheter ablation procedure (not including AV-junction ablation) for atrial fibrillation — either the type that comes and goes (paroxysmal) or the longer-lasting type (persistent) — at the Department o...

Who might be able to join this trial: - People who have been diagnosed with a type of heart attack called a STEMI, confirmed by clinical assessment and a heart tracing (ECG) - People who have had a successful procedure to open the blocked heart artery (called PCI), with a modern type of stent placed, as determined by t...

**Who might be able to join this trial:** - You are 18 years of age or older - You are scheduled for your first heart bypass surgery (CABG) that is planned in advance (not an emergency), and at least one vein from your leg will be used during the surgery - You are able to give your consent to participate and are willin...

Who might be able to join this trial: - People aged 19 years or older. - People who have a specific type of blocked artery at a branching point in the heart, where the branch vessel measures between 2.25 and 2.75 mm wide, the main vessel is at least 2.5 mm wide, and the blockage meets a specific pattern called a "true...

**Who might be able to join this trial:** - You are between 18 and 65 years old - You have previously had a heart attack or a serious heart-related emergency (known as acute coronary syndrome) - Your health is currently stable - You typically spread your eating across at least 12 hours of the day (for example, eating f...

Who might be able to join this trial: - People who attended RuiJin Hospital for an ultrasound heart scan (called an echocardiogram) - People who have signed and dated a consent form agreeing to take part - People who are willing to follow all the study steps and take part in the full process - People who have already c...

Who might be able to join this trial: - Adults over 18 years of age - People who are able to give written consent to participate - People who are scheduled to have heart surgery using a heart-lung bypass machine - People whose heart failure symptoms fall into a mild-to-moderate category (rated as Class I, II, or III on...

**Who might be able to join this trial:** - People aged 18 or older - People living with chronic heart failure, where the heart's pumping function (measured as LVEF) is 50% or below - People whose heart failure has been stable for more than one month, with no recent hospital admission for heart failure in the past mon...

**Who might be able to join this trial:** - People who are willing and able to give consent (either personally or through an authorised representative, as allowed by local rules) - People aged 18 or older (or the legal age of adulthood in their country) - People who are currently in hospital, or who have recently been...

**Who might be able to join this trial:** - People who have been diagnosed with chronic (long-term) heart failure and whose condition is currently stable with the best available medical treatment - People whose heart is still pumping at least 30% of its normal capacity (a measurement called ejection fraction) - People...

Who might be able to join this trial: - Adults over 18 years of age, of any gender - People who have been diagnosed with heart failure (either with reduced or preserved pumping function), confirmed by a heart ultrasound (echocardiogram) - People whose heart failure causes symptoms such as breathlessness or fatigue duri...

**Who might be able to join this trial:** - You are 18 years of age or older at the time of screening. - You have already been diagnosed with a type of heart condition called non-ischemic dilated cardiomyopathy (a weakened, enlarged heart not caused by blocked arteries). - You have been on the best possible heart medic...

Who might be able to join this trial: - Adults over 18 years of age. - People who have been diagnosed with their first episode of Acute Coronary Syndrome (ACS — a term for conditions where blood flow to the heart is suddenly reduced or blocked), as defined by European heart disease guidelines from 2017. - People whose...

Who might be able to join this trial: - Adults aged 18 or older who have received a kidney transplant (from either a living or deceased donor) between 1 and 10 years ago - People whose transplanted kidney is working at a stable and consistent level, as determined by their doctor - People whose transplanted kidney is fu...

**Who might be able to join this trial:** - You have been recommended for surgery on either your aortic valve or mitral valve (one valve only, not combined with other heart procedures) - You are 18 years of age or older - You are willing and able to give written consent to take part **Who may not be able to join:** -...

**Who might be able to join this trial:** - You are scheduled for a planned (non-emergency) open heart bypass surgery (CABG) - You have been given a general health rating between I and IV by your anesthesia team (this covers a wide range of health conditions) - You are able to speak and read both English and Spanish *...

**Who might be able to join this trial:** - People who are already taking part in the 'CMR versus CT-FFR in CAD' study - People aged 18 or older - People who have been referred for an invasive coronary angiography (a procedure to look at the heart's arteries) to investigate chest pain - People who are willing and able...

Who might be able to join this trial: - People who are over 18 years of age - People who understand what the trial involves and agree to take part by signing a consent form - People for whom a doctor has recommended a heart procedure (called PCI) that involves placing a stent, and who would receive at least one specifi...

**Who might be able to join this trial:** - People who have a moderate blockage in a coronary artery (estimated at 50–90% narrowing) and whose doctor has decided that a procedure guided by a specific heart pressure measurement (called RFR) is clinically needed - People who have chosen to take part in the study on their...

Who might be able to join this trial: - People aged 19 or older - People who have coronary artery disease and have been treated with a GENOSS SES (a type of heart stent) - People who are willing to take part, agree to follow the study plan including scheduled check-ups, and sign a written consent form Who may not be a...

Who might be able to join this trial: - People who experience typical or atypical chest pain, or symptoms that may suggest reduced blood flow to the heart, including shortness of breath - People whose coronary angiogram or CT scan has shown no significant blockages in the heart's arteries (less than 50% narrowing) Who...

**Who might be able to join this trial:** - Adults (18 years of age or older) - People who have given written consent to participate in the study - People with chronic (long-term, stable) coronary artery disease — meaning heart artery problems that are not caused by a recent or emergency heart event - People who have n...

Who might be able to join this trial: - People who have been diagnosed with an abnormal origin of a coronary artery from the opposite side of the heart (known as AAOCA), whether they have been referred for surgery or are being monitored without surgery. Who may not be able to join: - People whose coronary artery conne...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with heart failure (any type — where the heart pumps weakly, moderately weakly, or with a stiff heart muscle), diagnosed using recognised European heart failure guidelines - People who are currently experiencing an epis...

Who might be able to join this trial: - People who have a heart device (either a CRT-D or ICD) implanted that has a feature called HeartLogic, and where that feature can be turned on or off as part of the trial - People who are 18 years of age or older - People who regularly use remote heart monitoring and are actively...

Who might be able to join this trial: - People who have been admitted to hospital with a type of heart condition called a non-ST-elevation heart attack or unstable angina, and who have been recommended for a non-urgent heart artery imaging procedure. - People who have a blood test result showing elevated troponin (a ma...

**Who might be able to join this trial:** - People who are willing to participate and have signed a consent form agreeing to take part in the study. - People who are 18 years of age or older. - People who have a specific heart electrical conduction problem called left bundle branch block, with certain measurements of...

"Who might be able to join this trial: - People who have been diagnosed with coronary heart disease, have undergone a procedure called PCI (a minimally invasive procedure to open blocked heart arteries), and attend follow-up appointments at University of California Davis Health. Who may not be able to join: - No speci...

**Who might be able to join this trial:** - Adults who have been diagnosed with stable heart failure with preserved ejection fraction (HFpEF) — a type of heart failure where the heart still pumps a normal amount of blood but does not relax properly — and who are experiencing symptoms from this condition **Who may not...

Who might be able to join this trial: - People who have had both blood pressure and blood flow measured inside at least one of their own (non-bypassed) heart arteries, tested using two different types of medications that cause the arteries to widen. Who may not be able to join: - People whose blood pressure or circula...

**Who might be able to join this trial:** - People aged 50 years or older at the time of signing the consent form - People who have a blood marker of inflammation (called hs-CRP) measured at 2 mg/L or above at the start of the study - People who have been diagnosed with a long-term heart condition called HFpEF (heart...

Who might be able to join this trial: - Adults aged 18 years or older - People who are scheduled to have heart surgery using a heart-lung bypass machine, where the bypass is expected to last more than 60 minutes - People who have been informed about the study and have not objected to taking part, at least the day befor...

**Who might be able to join this trial:** - You have been diagnosed with coronary artery disease (a condition affecting the blood vessels of the heart), but your heart's pumping function is still within a normal range - You were recently admitted to hospital and treated for a heart attack, and have since been discharge...

Who might be able to join this trial: - People who have previously been diagnosed with a type of heart failure where the heart is not pumping as well as it should, confirmed by a heart ultrasound scan showing the heart's pumping strength is below 50% - People who have been assessed as needing a pacemaker or a device th...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have been newly diagnosed with a specific type of heart attack (called an anterior wall STEMI) where symptoms started within the last 6 hours, and who are being treated with an emergency procedure to open the blocked artery (called prim...

Who might be able to join this trial: - People aged 50 or older - People who have had a confirmed diagnosis of heart failure recorded in their medical records for at least 6 months - People whose grip strength is below a certain level (under 28kg for men, under 18kg for women), who score 9 or below on a physical functi...

Who might be able to join this trial: - Adults aged 18 or older - People admitted to hospital with a diagnosis of acute heart failure where the body is retaining excess fluid - People showing signs that their water tablets (diuretics) may not be working well enough, which means either having taken daily diuretics by mo...

**Who might be able to join this trial:** *For people with stable chronic heart failure (CHF):* - People who are at least 18 years old - People who have been diagnosed with any type of chronic heart failure, are in a stable condition, and have specific blood marker levels (called NT-proBNP) that fall within ranges det...

Who might be able to join this trial: - Adults aged 18 or older who are admitted to an emergency department - People who have a build-up of fluid around the lungs, detected by an ultrasound, chest X-ray, or CT scan - People for whom a doctor has determined that draining the fluid is medically necessary — either to reli...

Who might be able to join this trial: - People who are older than 19 years of age - People who are having a coronary stent procedure to treat stable angina or an acute coronary syndrome (a serious heart condition including heart attacks) - People who have given their informed consent to take part Who may not be able t...

Who might be able to join this trial: - People with advanced kidney disease, meaning their kidneys are working at less than 20% of normal capacity and they are not yet on dialysis, OR people who started dialysis (either hemodialysis or peritoneal dialysis) within the last 6 months. (Note: for people who started dialysi...

Who might be able to join this trial: - People who are over 18 years old - People who have been referred to a rapid-access chest pain clinic and, after review, have been identified as needing further heart imaging — either a stress echocardiogram (a type of ultrasound of the heart during exercise) or a CT scan of the h...

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with coronary artery disease (a condition affecting the blood vessels of the heart), confirmed by a specific imaging test called a coronary angiography Who may not be able to join: - You have been diagnosed with any of t...

Who might be able to join this trial: - People who are older than 60 years - People who have high blood pressure (either a top number of 140 or more, a bottom number of 90 or more, or who take 2 or more blood pressure medications) - People who have Type 1 or Type 2 diabetes - People who have a heart rhythm condition ca...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been definitively diagnosed with Acute Coronary Syndrome (ACS — a condition such as a heart attack or unstable chest pain caused by reduced blood flow to the heart) - You are able and willing to sign a written consent form agreeing...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been admitted to hospital with confirmed or suspected coronary heart disease (a condition affecting the blood vessels of the heart), and who also have at least one of the following: a history of a procedure to open bl...

Who might be able to join this trial: - People who are 20 years of age or older - People who have end-stage kidney disease and have been on regular, ongoing dialysis with a stable fluid removal target (dry weight) for the past 6 months - People who have previously been diagnosed with a specific type of heart failure ca...

"Who might be able to join this trial: - People who receive both a carotid ultrasound (a scan of the blood vessels in the neck) and a coronary angiography (an imaging test that looks at the blood vessels of the heart). Who may not be able to join: - There are no listed exclusion criteria for this trial. Important: Al...

**Who might be able to join this trial:** - People aged 18 years or older - People who have chest pain or other symptoms suggesting reduced blood flow to the heart, and whose coronary artery imaging (either a catheter-based test or a CT scan) has shown that any narrowing in the arteries is less than 70% (not severely b...

**Who might be able to join this trial:** - People for whom the local heart team has determined that a procedure to open a completely blocked coronary artery (called a CTO PCI) is medically appropriate, based on symptoms such as chest pain or proven reduced blood flow or living heart tissue in the affected area. - Peop...

**Who might be able to join this trial:** - People who have moderate to severe or severe mitral regurgitation (a leaky heart valve) that is causing symptoms, which developed after a heart attack - People who are older than 18 years - People whose condition falls into a specific category (Type 2, 3, or 4) based on a pub...

**Who might be able to join this trial:** - People who are able to give written consent to participate in the study - People who have been diagnosed with heart failure (classified as NYHA class II, III, or IV — meaning symptoms ranging from mild to severe) for more than 3 months, regardless of the type of heart failure...

**Who might be able to join this trial:** - People who were admitted to hospital primarily because of a sudden worsening of heart failure, confirmed by symptoms plus at least one of: fluid buildup in the lungs seen on exam or chest X-ray, specific measurements on a heart ultrasound, pressure readings from a heart proc...

**Who might be able to join this trial:** - Adults aged 18 or older (women who could become pregnant must have a negative pregnancy test result) - People already taking two blood-thinning medications together — aspirin plus a second type called an ADP receptor antagonist — as part of their usual care - People diagnosed...

**Who might be able to join this trial:** - People who are having a pre-procedure imaging scan called optical coherence tomography (a type of detailed scan used to look inside blood vessels or tissue before a medical procedure is carried out) **Who may not be able to join:** - No specific exclusion criteria have been...

**Who might be able to join this trial:** - People who are older than 18 and younger than 80 years of age. - People who have been diagnosed with invasive breast cancer (stage I, II, or III) and who are planned to start a type of chemotherapy called anthracycline within 60 days. - People who have signed a consent form a...

Who might be able to join this trial: - You are currently in intensive care or are planned to receive intensive care with a device called an Impella (a small heart pump) to support your heart. - You already have, or are planned to have, a way of measuring how well your heart is pumping blood (called cardiac output), su...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who have been approved by their hospital to receive a left ventricular assist device (LVAD), which is a mechanical pump that helps the heart work. - People whose body surface area (a measure based on height and weight) is at...

Who might be able to join this trial: - People who have been diagnosed with stable angina or a chest pain condition for at least 1 month (this includes pain, pressure, or discomfort in the chest or other parts of the upper body). - People who have been receiving medical treatment for this condition for at least 1 month...

Who might be able to join this trial: - Adults aged 18 or older - People who have had an intra-aortic balloon pump (a device placed in the aorta to help the heart pump blood) in place for more than 48 hours - People receiving a heart-stimulating medication called dobutamine at a low dose (no more than 20 mcg/kg/min) -...

**Who might be able to join this trial:** - People who have been diagnosed with a type of heart attack called a non-ST-segment elevation myocardial infarction (a specific kind of heart attack — confirm with trial site if unsure which type applies) - People who have completed a heart procedure called coronary PCI (a pr...

**Who might be able to join this trial:** - Adults who are scheduled to have robotic surgery that requires lying in a head-down (tilted) position during the procedure **Who may not be able to join:** - People under 18 years of age - People who have dementia - People who are not able to provide written consent to parti...

**Who might be able to join this trial:** - You are between 18 and 80 years old - A heart artery scan (coronary angiography) showed a partial blockage of 20–70% in a main heart artery, and further detailed imaging confirmed at least one unstable or "at-risk" fatty plaque in that artery, but the artery does not need a s...

**Who might be able to join this trial:** - You must be older than 18 years of age. - You must have been diagnosed with a condition called ATTR cardiomyopathy (a disease where a protein called transthyretin builds up in the heart), whether or not you currently have symptoms. - Your heart must show signs of involvement...

Who might be able to join this trial: - Adults aged 18 years or older - People who have heart failure with reduced pumping ability and received a type of heart rhythm device called cardiac resynchronisation therapy (CRT) using a standard vein-based lead placement - People who had a lead (the wire connecting the device...

Who might be able to join this trial: - Adults over 18 years of age. - People who have had their first heart attack of a specific type (called an ST-segment elevation myocardial infarction) while already in hospital. - People who have had a procedure to examine their heart's arteries (called a coronary angiography) wit...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been admitted to hospital for acute heart failure at least once in the past 12 months - People who are able to attend medical appointments conducted by video or phone (telemedicine) - People who have access to a smartphone or other...

**Who might be able to join this trial:** - People who are having a specific type of serious heart attack (called a STEMI) and who need an emergency procedure to open a blocked artery (called a primary PCI, which uses a small tube and balloon to restore blood flow) **Who may not be able to join:** - People who are exp...

Who might be able to join this trial: - Adults aged 22 years or older who are scheduled to have coronary artery bypass graft (CABG) surgery — a type of open-heart surgery to improve blood flow to the heart — using a heart-lung bypass machine - People who have been diagnosed with heart failure where the heart's pumping...

**Who might be able to join this trial:** - People aged 19 to 80 years, either male or female - People who have been clinically diagnosed with a heart attack within the past 4 weeks before being enrolled in the trial - People who have had a successful procedure to open a blocked heart artery (resulting in good blood fl...

**Who might be able to join this trial:** - People between 18 and 80 years of age - People who have had a heart attack or severe chest pain (unstable angina) and are planned to have a procedure to open blocked arteries (called PCI, or percutaneous coronary intervention) - People who have had stents successfully placed...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with stable chest pain (chronic stable angina) or a recent heart event that has since been stabilised, with heart enzyme blood test results back within normal range - People who have at least one new (previously untrea...

Who might be able to join this trial: - People who had open heart surgery using a heart-lung bypass machine (a machine that temporarily takes over the work of the heart and lungs) between 15 December 2023 and 15 December 2024 - People who have signed a consent form agreeing to take part in the study Who may not be abl...

Who might be able to join this trial: - People who are willing and able to sign a consent form agreeing to take part in the study - People aged between 18 and 85 years old - People who have been diagnosed with heart failure for at least 3 months before joining, and whose heart failure symptoms fall into a moderate-to-s...

**Who might be able to join this trial:** - People aged 65 years or older - People scheduled for a planned (non-emergency) non-heart surgery that carries an intermediate or high level of risk, performed under general anaesthesia or a combination of general and regional anaesthesia - People with an ASA health classifica...

**Who might be able to join this trial:** - You are a man or woman aged 18 or older - You have been diagnosed with a type of heart failure called "heart failure with preserved ejection fraction" (HFpEF), meaning your heart pumps normally but doesn't relax properly, confirmed by a heart ultrasound and/or other heart mea...

Who might be able to join this trial: - Adults aged 18 years or older - People who are currently admitted to a Cardiac Care Unit due to a heart attack (either a type called NSTEMI or STEMI) - People who had a blood test to check cholesterol and fat levels done on the first day of their hospital admission - People who a...

**Who might be able to join this trial:** - People who have given written consent to participate - People who have been diagnosed with early atherosclerosis (fatty buildup in the heart's arteries), defined as men under 55 years old or women under 65 years old with this condition - People whose heart arteries have been...

Who might be able to join this trial: - The person must be female. - The person must be at least 18 years old. - The person must have coronary artery disease affecting multiple blood vessels or the main artery of the heart, where the medical team has determined that either open-heart bypass surgery or a stenting proced...

**Who might be able to join this trial:** - You identify as a member of a minority group - You are 18 years old or older - You have been found to have blockages in multiple heart arteries or in the main heart artery (left main), and your heart care team has decided that either open-heart bypass surgery (CABG) or a sten...

**Who might be able to join this trial:** - Adults aged 18 or older who have known or suspected coronary artery disease (a condition affecting the heart's blood vessels) and have been referred by their doctor for diagnostic testing - People whose heart scan (called a CCTA — a specialised CT scan of the heart) is perfor...

Who might be able to join this trial: - Adults aged 18 or older - People who have had a procedure attempted to open a completely blocked heart artery (called a CTO procedure) within the last 5 years - People who have had a special type of heart CT scan (called a CTCA, or coronary CT angiogram) either before or after th...

**Who might be able to join this trial:** - People aged 18 or older - People who are able to sign a consent form agreeing to take part - Men, or women who are not pregnant (women of childbearing age will be asked verbally about pregnancy status) - People who have presented with a heart condition involving blocked or na...

**Who might be able to join this trial:** - People who are 18 years of age or older and are willing to follow the study requirements - People who have a medical reason to receive a dual-chamber pacemaker or cardiac resynchronization therapy device, and are scheduled to have an Abbott pacing device implanted - People w...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed with stable coronary artery disease, a type of heart attack called non-ST-elevation myocardial infarction, or unstable angina (chest pain caused by reduced blood flow to the heart) - People whose left main coronary art...

Who might be able to join this trial: - Emergency Medical Technicians (EMTs), Advanced EMTs, and Paramedics who respond directly to emergency scenes may be eligible to participate. - Specialist emergency doctors (in either Pediatric Emergency Medicine or general Emergency Medicine) whose work includes providing remote...

**Who might be able to join this trial:** - Women aged 18 or older who have been diagnosed with a type of heart condition called Acute Coronary Syndrome (ACS), which includes heart attacks (STEMI or NSTEMI) or a serious type of chest pain called Unstable Angina **Who may not be able to join:** - People under 18 years...

**Who might be able to join this trial:** - People who are over 18 years old - People who have been admitted to hospital with heart failure that has gotten worse, with symptoms such as shortness of breath, fluid build-up (such as swelling), or signs of congestion in the lungs, along with elevated levels of a specific h...

Who might be able to join this trial: - People who live in a nursing home and are expected to live for more than one year - People who are able to take part in the study and have given their spoken agreement to do so Who may not be able to join: - People for whom an echocardiogram (a heart ultrasound scan) cannot be p...

**Who might be able to join this trial:** - People aged 18 to 90 years old at the time of screening - People whose heart's pumping strength (left ventricular ejection fraction) is below 50%, measured within the 90 days before the procedure - People who are considered high-risk due to one or more of the following heart...

**Who might be able to join this trial:** - People who are over 65 years old - People who have been diagnosed with a type of heart condition called acute coronary syndrome (this includes unstable angina, or a heart attack with or without a specific pattern on a heart tracing test) - People who have been treated with at...

Who might be able to join this trial: - You are 18 years of age or older - You were admitted to the hospital with a specific type of heart attack (called NSTEMI Type 1 or STEMI) and/or had a procedure to open blocked heart arteries (such as a stent) - Your LDL ("bad") cholesterol level was 70 mg/dL or higher during you...

**Who might be able to join this trial:** - People aged 18 to 75 years old - People who are conscious and able to sign and date a consent form agreeing to take part and to their personal data being used - People who are unconscious, where a legal representative, proxy, or relative has signed and dated a consent form o...

**Who might be able to join this trial:** - People diagnosed with Stage C heart failure with symptoms ranging from mild to moderate (NYHA Class I–III), who have recently been discharged from a hospital stay due to heart failure, OR have an upcoming cardiology appointment and have been hospitalised for heart failure in...

**Who might be able to join this trial:** - Women (people who were assigned female sex at birth) who have been diagnosed with coronary heart disease — for example, those who have had heart bypass surgery, a stent procedure, a heart attack, or certain types of reduced blood flow to the heart — at least 4 weeks after th...

**Who might be able to join this trial:** - People who have been diagnosed with coronary artery disease (a condition where the arteries supplying the heart become narrowed or blocked), confirmed through a heart imaging procedure, blood tests, and a heart tracing test (ECG) **Who may not be able to join:** - People who...

**Who might be able to join this trial:** - People who have heart failure (caused either by blocked arteries or by other heart conditions) where the heart's pumping strength is below 40% - People who have a heart condition called ATTR cardiomyopathy (a disease where abnormal proteins build up in the heart), regardless...

Who might be able to join this trial: - People who have stable chest pain (angina) symptoms, have a medical reason to undergo an invasive heart artery imaging procedure, and whose results show no significant blockages in the main heart arteries (measured using a test called FFR, with a result above 0.80) Who may not b...

Who might be able to join this trial: - This trial does not list any specific requirements that participants must meet in order to join (confirm with trial site) Who may not be able to join: - This trial does not list any specific conditions that would prevent someone from joining (confirm with trial site) Important:...

**Who might be able to join this trial:** - People over 21 years of age who have been admitted to the Coronary Unit of the Hospital de Clínicas with a diagnosis of Acute Coronary Syndrome (a serious heart condition caused by reduced blood flow to the heart). - People who agree to take part and sign a consent form confi...