Cardiomyopathy

**Who might be able to join this trial:** - You have been living with heart failure for at least 3 months, and your symptoms are classified as moderate to severe (NYHA class II, III, or IV — confirm with trial site if unsure of your class) - Your red blood cell levels (hemoglobin) are mildly low, falling between 9.0 an...

Who might be able to join this trial: - People aged 14 to 23 years old, either male or female - Athletes who have competed in endurance sports at a national or international level for at least 2 years, in sports such as triathlon, cycling, distance running (races of 1500 metres or longer), rowing, or swimming - People...

**Who might be able to join this trial:** - People who have been formally diagnosed with ATTR amyloidosis that has affected the heart (a condition where abnormal proteins build up in the heart muscle) - People who have a medical history of heart failure - People whose heart failure symptoms are well-controlled and who...

**Who might be able to join this trial:** - People who have a structural heart condition — such as a heart affected by blocked arteries, a weakened heart muscle, or a heart defect present from birth — where heart scans or tests show abnormal heart wall movement, thickened heart muscle, or scarring in the heart. - Peop...

**Who might be able to join this trial:** - You are between 18 and 75 years old (inclusive) - You have had a genetic test (for medical reasons) that confirmed you carry a gene change in the TTR gene that is known or likely to cause disease (for example, variants called V30M, V122I, T60A, or others) - Your age is within...

Who might be able to join this trial: - People who have a confirmed diagnosis of ATTR amyloidosis affecting the heart, either the inherited form (hATTR) or the age-related form (wATTR). - People who have a history of heart failure, with at least one previous hospital stay for heart failure, or who have heart failure sy...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been formally diagnosed with a condition called ATTR cardiomyopathy (a disease where a protein called TTR builds up in the heart), either the inherited type or the age-related type - Your diagnosis has been confirmed through a hear...

Who might be able to join this trial: - People who have had a heart attack at least 4 weeks ago - People who have had reduced heart pumping function (not caused by blocked arteries) for at least 9 months - People whose heart is pumping at 35% or less of its normal capacity - People who have had their ICD (implanted hea...

Who might be able to join this trial: - People whose heart is pumping at 35% or less of its normal capacity, and who have been referred by their doctor to have a defibrillator device (ICD) implanted to prevent a serious heart rhythm problem from happening in the future (not because one has already occurred) - People be...

Who might be able to join this trial: - You are 15 years old or older - You have been diagnosed with hypertrophic cardiomyopathy (HCM), which means the wall of your heart's main pumping chamber is thickened — at least 13mm thick if other family members have the condition, or at least 15mm thick if no family members are...

Who might be able to join this trial: - People who receive an ICD (implantable cardioverter-defibrillator) or CRT-D (a combined heart rhythm and resynchronisation device) for the first time or as a replacement device, for either preventative reasons or because they have already had a serious heart rhythm problem. - Peo...

Who might be able to join this trial: - Adults between 18 and 65 years old - People who have been diagnosed with dilated cardiomyopathy (a condition where the heart is enlarged and cannot pump blood properly) according to established European cardiology guidelines - People who have been on the best available standard m...

**Who might be able to join this trial:** - You are older than 18 years of age - You have been diagnosed with light chain (AL) amyloidosis confirmed through standard blood, urine, or tissue tests - If you are traveling from out of town and your biopsy results are still pending, you may be able to start the study befor...

**Who might be able to join this trial:** - You have been diagnosed with a heart condition called hypertrophic cardiomyopathy (HCM), meaning your heart wall is thicker than normal (at least 15mm) as seen on a heart scan (echocardiogram or MRI), with no other known cause for the thickening. - If a close family member ha...

"Who might be able to join this trial: - People aged 16 to 90 years old. Who may not be able to join: - No specific exclusion criteria have been listed for this trial beyond the age requirement above. Important: Always verify eligibility with the trial site directly before applying."

Who might be able to join this trial: - You must be between 18 and 90 years old. - You must have already been diagnosed with, or are suspected to have, one of these heart conditions: reduced blood flow to the heart or a heart attack, a thickened heart muscle (hypertrophic cardiomyopathy), a heart muscle affected by a b...

**Who might be able to join this trial:** - You have a weakened heart (reduced pumping ability of 40% or less) that was caused by chemotherapy drugs called anthracyclines, used to treat any type of cancer, at any dose and at any point in the past, with no other known cause for the heart weakness. - You are between 18...

Who might be able to join this trial: - You survived a sudden cardiac arrest (heart suddenly stopping) that was NOT caused by a heart attack - A family member died suddenly from cardiac arrest that was NOT caused by a heart attack, and you are involved in their case - You had a sudden cardiac arrest that happened along...

**Who might be able to join this trial:** - You are willing and able to give your consent to take part in the study - You are aged between 18 and 75 years old (inclusive) - You have been diagnosed with stable type 2 diabetes, confirmed by your GP's records along with either a glucose tolerance test or a specific blood...

**Who might be able to join this trial:** - People who have been diagnosed with Takotsubo cardiomyopathy (a temporary heart condition, sometimes called "broken heart syndrome," where the heart muscle suddenly weakens) **Who may not be able to join:** - No specific exclusion criteria have been listed for this trial (co...

**Who might be able to join this trial:** - People who are willing to take part in the study and are able to sign a consent form agreeing to participate - People who have had heart tests (an ECG, which records the heart's electrical activity, and an echocardiogram, which uses sound waves to create images of the heart)...

Who might be able to join this trial: - People who have been diagnosed with ischemic cardiomyopathy (heart muscle damage caused by reduced blood flow to the heart) - People who have been diagnosed with dilated cardiomyopathy (a condition where the heart becomes enlarged and cannot pump blood effectively) - People who h...

**Who might be able to join this trial:** **As a healthy volunteer:** - People aged 7 years or older who do not have a known heart or cardiovascular condition - People who are able to follow instructions and lie still inside an MRI scanner - People who are able to give written consent, or whose parent or guardian is a...

**Who might be able to join this trial:** - You have been receiving kidney dialysis (haemodialysis) for more than 3 months - You are on a supportive (palliative) care programme and doctors expect that you may pass away within the next 12 months - You are able to give your informed agreement to take part in the study -...

**Who might be able to join this trial:** - People who are older than 18 years of age - People who have been diagnosed with a heart condition called ARVD (a disease affecting the right side of the heart), confirmed using specific international diagnostic guidelines that require a combination of major and minor diagnost...

Who might be able to join this trial: - People who have been diagnosed with Takotsubo syndrome (a type of temporary heart condition, sometimes called "broken heart syndrome") by a doctor - People who are over 18 years of age Who may not be able to join: - People who are unable to understand and agree to participation...

Who might be able to join this trial: - You have been diagnosed with an irregular heartbeat (ventricular arrhythmia) that is caused by a structural problem with your heart, such as ischemic cardiomyopathy (heart damage from reduced blood flow), arrhythmogenic right ventricular cardiomyopathy (a condition where heart mu...

**Who might be able to join this trial:** - You have been diagnosed with a heart condition called hypertrophic cardiomyopathy (HCM), which means part of your heart wall is thicker than normal (confirm with trial site for exact measurements) - You are 16 years old or older - You either do not have an internal heart defi...

Who might be able to join this trial: - You have been diagnosed with Takotsubo (a type of heart condition, sometimes called "broken heart syndrome") by your doctor and agree to take part in the trial. - You are able to provide your full medical records needed for the trial team to confirm your diagnosis. Who may not b...

Who might be able to join this trial: - People aged 18 to 70 years old who have been diagnosed with hypertrophic cardiomyopathy (HCM), thoracic aortic disease (TAD), and/or radiation-induced heart disease (RIHD), and who are attending the Cleveland Clinic Main Campus for a full cardiac assessment to plan their care (co...

**Who might be able to join this trial:** - You have been told you may have had a heart attack with no blocked arteries (sometimes called MINOCA) or a condition called takotsubo syndrome (also known as "broken heart syndrome"), confirmed by a heart artery scan showing no major blockages - You are between 35 and 80 year...

**Who might be able to join this trial:** - People who have been diagnosed with a hereditary heart rhythm or heart muscle condition — such as arrhythmogenic, hypertrophic, or dilated cardiomyopathy, cardiac sarcoidosis, Long QT syndrome, Brugada syndrome, or catecholaminergic polymorphic ventricular tachycardia (CPVT)...

**Who might be able to join this trial:** - People aged 18 to 80 years old - People who are able to understand and sign a consent form - People diagnosed with a non-ischemic structural heart muscle disease (a heart muscle condition not caused by blocked arteries), specifically at least one of the following: - People wi...

Who might be able to join this trial: - People who come to the Houston Methodist CMR Laboratory who have been diagnosed with, or are suspected to have, a heart or blood vessel condition. Who may not be able to join: - People who are unable to give their own consent to take part in the study (for example, if they are u...

"Who might be able to join this trial: - You have been diagnosed with Takotsubo syndrome (a type of heart condition sometimes called "broken heart syndrome," where the heart muscle suddenly weakens, often triggered by stress) Who may not be able to join: - The exclusion criteria listed are unclear or incomplete (confi...

Who might be able to join this trial: - You are scheduled to receive a pacemaker or implantable defibrillator (ICD) device, with the goal of avoiding a specific type of irregular heart rhythm caused by the device itself, in line with current medical guidelines - You are 18 years old or older Who may not be able to joi...

**Who might be able to join this trial:** *For healthy volunteers:* - You are over 18 years old and able to give informed consent - You do not have any known significant medical conditions that affect your heart or breathing *For patients:* - You are over 18 years old and able to give informed consent - You have alre...

**Who might be able to join this trial:** - Adults between 18 and 80 years old (inclusive) at the time of signing the consent form - People who have been diagnosed with non-ischemic dilated cardiomyopathy (a type of weakened, enlarged heart not caused by blocked arteries) with a heart pumping function of 45% or less -...

**Who might be able to join this trial:** - You are between 21 and 80 years old (inclusive) - Your kidneys are working at a reduced but not completely failed level, based on a specific kidney function test result (eGFR between 15 and 75) - A urine test shows a certain level of protein leaking into your urine (albumin-...

**Who might be able to join this trial:** - You are a woman who has recently been diagnosed with a weakened heart (either caused by blocked arteries or another reason), and your heart's pumping ability is at or below 35% at the time you are given a wearable heart device (WCD). - You have been prescribed the wearable h...

Who might be able to join this trial: - People who have been diagnosed with Takotsubo cardiomyopathy (a type of heart condition sometimes called "broken heart syndrome") in Scotland at any point from 2010 to the present. - People anywhere in the world who have a family member also diagnosed with Takotsubo cardiomyopath...

Who might be able to join this trial: - People who have given their written agreement to take part in the trial. - People who are 18 years of age or older. - People who have been clinically suspected of having myocarditis (inflammation of the heart muscle). - People who are enrolled through one of the medical centres o...

**Who might be able to join this trial:** - People diagnosed with non-ischemic dilated cardiomyopathy (a type of heart muscle disease not caused by blocked arteries, either with no known cause or running in the family) - People whose heart pumping function is at or below 35%, and whose heart scan shows scarring in the...

Who might be able to join this trial: **People with heart failure (with or without type 2 diabetes):** - Adults aged 18 or over - People who have had a diagnosis of heart failure with symptoms and reduced pumping function for at least 2 months - People whose heart's pumping capacity (ejection fraction) is 40% or less...

Who might be able to join this trial: - You must be 18 years of age or older - Both men and women are welcome to apply - You must be able to understand and agree to take part in the study yourself - You have been diagnosed with a heart muscle condition called cardiomyopathy or an inflammation of the heart called myocar...

Who might be able to join this trial: - People who have been diagnosed with Takotsubo syndrome (a temporary heart condition, sometimes called "broken heart syndrome," where the heart muscle suddenly weakens) Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with tri...

**Who might be able to join this trial:** - People who have had a HeartMate 3 heart pump device implanted at the Medical University of Vienna - People who are able to understand and sign a consent form agreeing to take part in the study **Who may not be able to join:** - People who are under 18 or over 75 years of age...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been clinically diagnosed with Takotsubo Syndrome (TS), including having a heart pumping function (ejection fraction) below 50% at the start of the trial - People who are able and willing to provide written consent to participat...

**Who might be able to join this trial:** *For the main (randomised) part of the trial — patients arriving within 24 hours:* - You are 18 years old or older and are suspected to have had a serious type of heart attack (called a STEMI), shown by specific changes on a heart tracing (ECG). - Your heart attack symptoms be...

Who might be able to join this trial: - You are 18 years old or older. - You are already scheduled to have a heart ultrasound (echocardiogram) at Tulane Medical Center. Who may not be able to join: - You are under 18 years of age. - You have a condition that affects thinking, memory, or understanding (cognitive impair...

Who might be able to join this trial: - You have been diagnosed with acute myocarditis (inflammation of the heart muscle), confirmed either by a special heart scan called a cardiac MRI or by a small tissue sample taken from the heart - You are enrolled in the French national health insurance system ("Sécurité sociale")...

Who might be able to join this trial: - People who have been diagnosed with Fabry disease - People who are 18 years of age or older Who may not be able to join: - People who have previously had a heart attack - People for whom MRI scans are not safe or suitable (for example, those with certain metal implants or pacema...

**Who might be able to join this trial:** - You are between 18 and 90 years old (any gender) and have been diagnosed with AL cardiac amyloidosis (a condition where abnormal proteins build up in the heart) at the Second Affiliated Hospital of Zhejiang University School of Medicine. - You are able to understand what the...

Who might be able to join this trial: - People aged 18 to 90 years old who have been diagnosed with ATTR-CM (a heart condition caused by a protein called transthyretin building up in the heart), or who carry the gene associated with this condition, confirmed at the Second Affiliated Hospital of Zhejiang University Scho...

**Who might be able to join this trial:** - People who have been referred to a cardiology or genetics department because of symptoms that resemble heart failure, or for heart or genetic screening related to the heart. - People who are 16 years of age or older. **Who may not be able to join:** - People who do not wish...

**Who might be able to join this trial:** - People whose heart is not pumping blood as strongly as normal (the heart's pumping function is measured at less than 50%) - People whose heart's main pumping chamber is larger than the normal range for their body size and age **Who may not be able to join:** - People with an...

**Who might be able to join this trial:** - You are over 18 years old - You have been diagnosed with advanced heart muscle disease (of any severity level) and your heart failure medical team has decided you are a suitable candidate for a left ventricular assist device (LVAD), which is a mechanical pump to help your he...

**Who might be able to join this trial:** - People who were eligible to receive a COVID-19 vaccine. - People who experienced at least one heart-related symptom within 42 days of a COVID-19 vaccine, such as chest pain, chest pressure or discomfort, shortness of breath or pain when breathing, a pounding or irregular hea...

**Who might be able to join this trial:** - People who have been diagnosed with, or are suspected to have, coronary artery disease (a condition where the arteries supplying the heart become narrowed or blocked) - People who have hypertrophic cardiomyopathy (a condition where the heart muscle becomes abnormally thick) -...

Who might be able to join this trial: - Adults aged 18 or older at the time of signing the consent form to take part in the study - People who have been diagnosed with ATTR cardiomyopathy (a heart condition caused by a protein called amyloid building up in the heart), as defined by the trial's criteria - People who are...

**Who might be able to join this trial:** *Retrospective part (using existing records):* - Children under 18 years old at the time they were enrolled or at the time of death, for whom medical data is available. - People who have genetic test results showing at least one harmful or likely harmful change (mutation) in a...

**Who might be able to join this trial:** - You have been admitted to hospital with a suspected condition called myocarditis (inflammation of the heart muscle) - You are between 18 and 69 years old - You have signs of acute heart failure, confirmed by a blood test showing certain heart stress markers above a specific...

Who might be able to join this trial: - People who have recently been diagnosed with peripartum cardiomyopathy (a type of heart condition that develops around the time of childbirth) for the first time - People who have already given birth and are within the first 5 months after delivery - People whose heart pumping st...

Here is the eligibility information in plain English: **Who might be able to join this trial:** - (For the main study group) People who have been diagnosed with a specific heart condition called arrhythmogenic right ventricular dysplasia (a disease affecting the right side of the heart's pumping chambers) and are sch...

**Who might be able to join this trial:** - You received a COVID-19 vaccine and afterwards developed one of these conditions: Guillain-Barré Syndrome (a nerve disorder), a serious blood clotting and low platelet condition (sometimes called VITT or TTS), or inflammation of the heart or its surrounding lining (myocarditi...

Who might be able to join this trial: - You must be 18 years of age or older. - You must be willing to take part and able to sign a consent form agreeing to join the study. - You must have a heart that is pumping well enough (with a specific heart function measurement above 50%) and have been recommended by your doctor...

**Who might be able to join this trial:** - People aged 18 to 64 years (any sex) who carry a gene variant known or likely to cause dilated cardiomyopathy (a condition where the heart muscle weakens and enlarges), as confirmed using recognised genetic classification guidelines. - People whose heart pumping function is a...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been experiencing heart failure symptoms (such as shortness of breath or fatigue) rated as moderate to severe within the last month - Tests such as an ultrasound, MRI, or nuclear scan have shown that your heart's pumping strength i...

**Who might be able to join this trial:** - People who have a significant blockage of blood flow leaving the heart (either at rest or when triggered), along with a notably thickened heart wall, as measured by specific medical tests. - People whose heart function has been rated as moderately reduced or worse according t...

**Who might be able to join this trial:** - People who have given their written consent to participate before any study procedures begin (or whose legal representative has done so on their behalf, where permitted). - People aged 18 or older at the time of giving consent. - People who have recently received an FDA-appr...

**Who might be able to join this trial:** - You are over 18 years old - Your heart's pumping function is measured at 40% or less (called an "ejection fraction"), confirmed by a heart scan within the past 2 months - You have significant blockages in multiple heart arteries — specifically in three vessels, or in two ves...

**Who might be able to join this trial:** - You are male or female and are over 16 years old **Who may not be able to join:** - You or a close family member have a specific type of heart muscle disease affecting the left or both sides of the heart (called arrhythmogenic cardiomyopathy), AND carry a faulty gene variant...

Who might be able to join this trial: **Group 1 – Carriers of a changed TTR gene (or matched non-carriers) without heart failure:** - Men and women aged 30–80 who carry a disease-causing change in the TTR gene (or who are matched non-carriers), and who have no history of heart failure, meaning: no hospital stay for he...

**Who might be able to join this trial:** - You must be 18 years of age or older at the time you agree to take part. - You must be willing and able to sign a consent form before the study begins (or have a legal representative do so on your behalf if you are unable to). **If applying for the US part of the study:** -...

Who might be able to join this trial: - People aged 18 or older - People whose heart is pumping at less than 50% of its normal capacity (as measured by a heart function test called ejection fraction) - People whose ejection fraction is between 36–50% and who also have elevated levels of certain heart stress markers in...

**Who might be able to join this trial:** - People who are 18 years of age or older - People with breast cancer who are starting treatment with doxorubicin or another similar chemotherapy drug (called an anthracycline), or who are receiving a drug called trastuzumab without that type of chemotherapy, as part of treatm...

**Who might be able to join this trial:** - You are a man or woman between 18 and 85 years old who already has an implanted defibrillator (ICD) device in your chest - You have been diagnosed with heart damage caused by a previous heart attack, confirmed by heart tests or imaging - You have had one of the following in t...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form before any study procedures begin - People aged between 18 and 75 years old (any gender) - People who have had a confirmed positive test for Chagas disease within the last two years, shown by at least two different blood...

Who might be able to join this trial: - You have had a specific type of heart attack (called STEMI) and were treated quickly with a procedure to open the blocked artery (catheterization) - Your condition has been stable after the procedure - You are male or female and are 18 years of age or older Who may not be able t...

Who might be able to join this trial: - People who have a heart rhythm disorder (including one present from birth) that has already been diagnosed, or who have been identified as being at high risk of developing a heart rhythm disorder - People who are 18 years of age or older - People who are willing and able to give...

Who might be able to join this trial: - People who have been diagnosed with a structural cardiomyopathy (a condition where the heart muscle is abnormally structured or weakened) - First-degree relatives (such as parents, siblings, or children) of someone diagnosed with cardiomyopathy Who may not be able to join: - Peo...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of heart condition called non-ischemic cardiomyopathy (a weakened heart not caused by blocked arteries), confirmed by a special type of heart scan using a dye (contrast-enhanced MRI). - Your heart MRI shows areas of scarring in th...

**Who might be able to join this trial:** - Adults aged 18 or older - People whose heart wall has a maximum thickness of 15mm or more, where this thickening is not caused by high blood pressure, valve disease, or a storage disease, AND who also meet at least one of the following conditions: - Their heart failure symp...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed with hypertrophic cardiomyopathy (a condition where the heart muscle is thickened), confirmed by an imaging test such as an echocardiogram, MRI, or CT scan, meeting specific thickness measurements based on genetic test...

**Who might be able to join this trial:** - You have agreed to take part and given your written consent - A heart scan (echocardiogram) has shown that your heart's pumping strength is between 15% and 40% (lower than normal) - You have been diagnosed with heart failure with symptoms ranging from mild (noticeable during...

**Who might be able to join this trial:** - Adults aged 18 or older - People whose heart's pumping strength (measured as the left ventricle ejection fraction, or LVEF) has been recorded at 50% or below within the past 6 months - People who have had an electrical heart tracing (ECG) showing a delayed or widened electri...

**Who might be able to join this trial:** - You are attending a scheduled cardiology or diabetes/hormone specialist follow-up appointment - You are willing to fast before having a blood sample taken - You are between 40 and 85 years old (inclusive) - You do not object to taking part in this research - You agree to hav...

Who might be able to join this trial: - You must be 18 years old or older - You must be willing and able to sign a consent form agreeing to take part - If you are not a healthy volunteer, you must have been diagnosed with a heart or blood vessel (cardiovascular) disease Who may not be able to join: - People who are cu...

Who might be able to join this trial: - Children under 1 year of age who are admitted for heart surgery using a heart-lung bypass machine at the CHU of Lille hospital during the study period. - Children who have a congenital heart condition (a heart problem present from birth) that requires surgery before the age of 1....

**Who might be able to join this trial:** *For the forward-looking (prospective) part of the study:* - You have been diagnosed with, or are suspected to have, a heart condition caused by an irregular heartbeat (arrhythmia-induced cardiomyopathy), based on your medical records or a referral from a heart or internal med...

Who might be able to join this trial: - You previously took part in a clinical study run by Intellia and received all or part of a dose of the treatment called NTLA-2001 (whether you finished the study or left it early). - You have agreed to take part in this long-term follow-up study by signing a consent form. Who ma...

**Who might be able to join this trial:** **As a mentee (younger participant):** - People who have been diagnosed with a heart condition - People who received their diagnosis at least 4 months ago - People between the ages of 12 and 17 years old - People who can speak and read English - People willing to commit to 5–1...

Who might be able to join this trial: - People who are 18 years of age or older. - People who have been diagnosed with TTS (Takotsubo Syndrome, a type of heart condition — confirm with trial site). - People for whom data about short-term and/or long-term exposure to air pollution is available. - People who are willing...

Who might be able to join this trial: - Adults who are able to understand and agree to participate on their own behalf - Children whose parent or guardian is able to give consent on their behalf - People of any gender (male or female) - People who have been formally diagnosed with cardiomyopathy (a condition affecting...

**Who might be able to join this trial:** - You are willing to follow the study rules and have signed a consent form agreeing to take part - You are between 18 and 80 years old (male or female) - You have been diagnosed with a type of heart failure caused by blocked arteries (ischemic) or another cause (non-ischemic) -...

Who might be able to join this trial: - People who are older than 18 years of age - People whose heart is pumping at 40% or less of its normal capacity (a measurement called LVEF) - People who have a significant amount of blockages or narrowing in the arteries that supply blood to the heart, measured using a specific s...

**Who might be able to join this trial:** - You are willing to follow the study rules and have agreed in writing to take part - You are between 18 and 80 years old (male or female) - You have been diagnosed with heart failure caused by blocked arteries or another heart muscle problem - You have had heart failure sympt...

**Who might be able to join this trial:** **For people with Takotsubo Syndrome (TTS) — a temporary heart condition often triggered by stress:** - Written consent has been provided by the patient, or by a parent, guardian, or legal representative on their behalf. - A diagnosis of TTS has been confirmed by a doctor usin...

**Who might be able to join this trial:** - Adults between 18 and 80 years old who have been diagnosed with hypertrophic cardiomyopathy (a condition where the heart muscle is thicker than normal), confirmed by a specific heart ultrasound measurement or by other supporting signs such as a family history of the conditio...

**Who might be able to join this trial:** - People who are at least 19 years old - People who have been diagnosed with stage C heart failure and a weakened heart pump (where the heart is pumping less than 40% of its normal capacity) - People who have significant blockages in the arteries supplying the heart, confirmed...

**Who might be able to join this trial:** - You have had a documented episode of a fast, abnormal heart rhythm (ventricular arrhythmia) lasting more than 30 seconds, confirmed by a heart monitor, ECG, defibrillator, or implanted device recording - This is your first time being diagnosed with this type of abnormal heart...

Who might be able to join this trial: - You have a specific gene change (mutation) in a gene called MYBPC3 - You have been diagnosed with a heart condition called hypertrophic cardiomyopathy (where the heart muscle becomes abnormally thick), either the type that blocks blood flow or the type that does not - Your heart...

**Who might be able to join this trial:** - Symptoms began 28 days ago or less - The condition first appeared with chest pain, signs of heart failure, and/or palpitations - A blood test result called troponin was above the normal upper limit at any point between hospital admission and enrolment in the trial - A heart...

Who might be able to join this trial: - People who have been diagnosed with hypertrophic cardiomyopathy (a condition where the heart muscle becomes abnormally thick) and are willing to give their consent to take part in the registry. - Family members of people diagnosed with hypertrophic cardiomyopathy who are willing...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of signing the consent form - People who are able and willing to sign a consent form agreeing to take part - People who have been clinically diagnosed with ACM (arrhythmogenic cardiomyopathy) based on a specific set of recognised diagnosti...

**Who might be able to join this trial:** - Adults aged 18 years or older - People undergoing their first radiofrequency ablation procedure for a type of irregular heartbeat (ventricular tachycardia) caused by ischaemic heart disease (reduced blood flow to the heart) - People who have an implanted defibrillator (ICD) w...

**Who might be able to join this trial:** - People who have had abnormal heart rhythms or unusual heart electrical patterns (such as fast heartbeats, irregular rhythms, or the heart stopping) that were recorded on a short-term heart monitor (ECG) with at least one recording channel. - People who have a suspected or co...

Who might be able to join this trial: - You are a woman aged 18 or older - You can read and understand English - You have been diagnosed with breast cancer (Stage I, II, or III) and are planned to receive chemotherapy as part of your treatment Who may not be able to join: - You are not receiving chemotherapy with the...

"Who might be able to join this trial: - You must have taken at least one dose of a medication called mavacamten at any point during pregnancy (including up to 4 months before becoming pregnant) or while breastfeeding (up to 12 months after the baby is born, or until you stopped breastfeeding, whichever happened first)...

Who might be able to join this trial: - Adults who have had a heart ultrasound (echocardiography) that produced clear, good-quality images. Who may not be able to join: - People under 18 years of age. - People who are under legal protection measures, such as being under the care of a court-appointed guardian or curato...

**Who might be able to join this trial:** - You are 18 years of age or older - You can be enrolled and receive the first dose of the study medication within 24 hours of having a heart catheter procedure - Your heart scan (either during the catheter procedure or on ultrasound) showed an abnormal pattern of heart wall mo...

**Who might be able to join this trial:** - You are between 18 and 80 years old (male or female) - A heart scan (echocardiogram) done within the last 30 days showed that your heart's pumping function is below normal (less than 50%) - You have had heart failure for more than 6 months that has not improved with standard...

**Who might be able to join this trial:** - Your heart's pumping function (measured by a special heart scan called a cardiac MRI) shows that your heart is pumping at less than 55% of its normal capacity - You have a leaky mitral valve (a valve in your heart) that is at least moderately severe, confirmed by either a car...

Who might be able to join this trial: - You have been officially diagnosed with Takotsubo Syndrome (a type of heart condition sometimes called "broken heart syndrome") - You are over 18 years old Who may not be able to join: - You are already receiving psychotherapy (talk therapy) as part of your treatment for Takotsu...

**Who might be able to join this trial:** - People who have been diagnosed with myocarditis (inflammation of the heart muscle) according to established medical criteria - People who are regularly attending follow-up appointments at a cardiovascular (heart) centre that is part of this trial **Who may not be able to joi...

**Who might be able to join this trial:** - You are willing and able to sign a written consent form agreeing to take part in the study - You are willing and able to attend scheduled appointments and follow the study procedures - You are a male or female between 18 and 85 years old - You have been diagnosed with a type...

Who might be able to join this trial: - People who have had spinal decompression surgery (a procedure to relieve pressure on the spine or nerves) within the past 20 years before joining the study. - People who were aged 50 or older at the time of that spinal surgery. - People who are able to understand and sign a conse...

**Who might be able to join this trial:** - You have been formally diagnosed with a heart condition called ARVC (Arrhythmogenic Right Ventricular Cardiomyopathy) based on specific medical guidelines from 2010 - You carry a known or likely harmful change (variant) in one of three specific heart-related genes (PKP-2, DS...

Who might be able to join this trial: - People who already have a right-sided heart pacemaker, where the heart's pumping function (measured as a percentage called ejection fraction) is between 35% and 50%, and the pacemaker is being used heavily (more than 40% of the time) - People whose doctor has recommended upgradin...

Who might be able to join this trial: - People who are older than 18 years of age - People who have a specific small heart monitor implanted under the skin called a Medtronic LINQ II ILR - People who are willing and able to sign a written consent form Who may not be able to join: - People who have had a heart attack i...

**Who might be able to join this trial:** - The child is between 0 and 16 years old (under 17 years) - The child weighs between 3 and 80 kilograms - The child is using a specific type of heart-lung bypass machine called the Cardiohelp system, to support a failing heart (VA-ECMO) - This is the child's first time on this...

**Who might be able to join this trial:** - People aged 18 to 80 years old at the time of signing the consent form. - People diagnosed with transthyretin cardiac amyloidosis (a condition where a protein called transthyretin builds up in the heart), either the inherited form or the age-related form, according to recogn...

**Who might be able to join this trial:** - You have been diagnosed with dilated cardiomyopathy (a condition where the heart muscle is weakened and the heart becomes enlarged) - Your heart pumping function was previously measured as less than 40% (meaning the heart was not pumping well) - Your heart pumping function h...

**Who might be able to join this trial:** - People who have been confirmed to carry a harmful or likely harmful change (variant) in a gene called LAMP2 - People who are male - People who are 8 years of age or older - People whose heart shows abnormal thickening of the left ventricular wall (a part of the heart muscle)...

Who might be able to join this trial: - People who are between 18 and 65 years of age - People who have been diagnosed with cirrhosis (severe scarring of the liver), confirmed through clinical assessment, blood tests, tissue samples (when available), and ultrasound imaging - People with cirrhosis who are seriously ill...

Who might be able to join this trial: - You are 60 years old or older - You have a narrowing of the spinal canal in your lower back and are scheduled to have spine surgery - A tissue sample taken from a ligament in your spine (called the ligamentum flavum) during surgery shows a significant build-up of a protein deposi...

**Who might be able to join this trial:** - You have been newly diagnosed with heart failure (either as an outpatient or during a hospital stay) where the heart is not pumping as strongly as it should (the pumping function is 40% or less on an ultrasound of the heart) - You have moderate to severe heart failure symptom...

Who might be able to join this trial: - You are having a specific type of heart attack called an "ST-elevation myocardial infarction" (or a similar equivalent condition, such as a newly detected heart rhythm problem called LBBB) - Your symptoms started less than 12 hours ago - The blood flow in the affected heart arter...

Who might be able to join this trial: - You have been diagnosed with cardiac amyloidosis (a condition where abnormal proteins build up in the heart) confirmed by current medical standards Who may not be able to join: - You do not wish to take part in the trial Important: Always verify eligibility with the trial site...

**Who might be able to join this trial:** - You are 18 years of age or older. - You have a heart condition caused by reduced blood flow to the heart muscle (known as ischemic cardiomyopathy). - You have had a documented episode of a specific type of fast, abnormal heart rhythm (called sustained monomorphic ventricular...

Who might be able to join this trial: - People who have been diagnosed with Type 2 diabetes - People who have chronic kidney disease at a moderate stage, meaning their kidneys are working at a reduced but not severely low level (confirmed by a specific kidney function measurement called eGFR, falling between 25 and 90)...

**Who might be able to join this trial:** - People aged between 21 and 85 years old - People who have been diagnosed with coronary artery disease (a significant blockage in at least one of the heart's main arteries), along with evidence of heart muscle damage, reduced heart pumping ability, and symptoms of heart failu...

Who might be able to join this trial: - You must be 19 years of age or older - You must be taking the medication mavacamten as directed by its approved prescribing guidelines - You must be willing and able to sign a consent form agreeing to take part in the study Who may not be able to join: - You may not be eligible...

Who might be able to join this trial: - Men and women who have an inflammatory heart muscle disease linked to abnormal heart rhythms coming from the lower chambers, a weakened pumping function, or significantly raised levels of certain heart stress markers in the blood. - People aged 18 years or older. - People who hav...

**Who might be able to join this trial:** - You have been found to carry a specific genetic change (variant) in one of these genes: PKP2, DSG2, DSC2, DSP, or JUP (note: JUP carriers must have the variant on both copies of the gene), OR you carry a specific variant called TMEM43-p.S358L (confirm with trial site) - A he...

**Who might be able to join this trial:** - People who have been diagnosed with a type of heart condition involving an enlarged left atrial chamber (confirmed by a specific heart measurement) - People who have been confirmed through a heart tracing test (ECG) to have an irregular heart rhythm called atrial fibrillatio...

**Who might be able to join this trial:** - You have been diagnosed with heart failure - Your doctors are not planning to change your heart failure medications or devices during the study - You have not had an unplanned hospital stay in the last 2 months - Your fluid levels are considered stable and well-controlled by...

**Who might be able to join this trial:** **For people joining the prospective (forward-looking) group:** - A certified genetic testing laboratory has confirmed a harmful or likely harmful change in the LAMP2 gene - The patient, or their parent or legal guardian, is able and willing to sign a consent form - The person...

**Who might be able to join this trial:** - You have a specific gene change (mutation) in the PKP2 gene that is known or likely to cause disease - You have been diagnosed with a heart condition called Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), based on specific medical guidelines from 2010 - Your heart's p...

Who might be able to join this trial: - You are between 18 and 70 years old. - You have been diagnosed with dilated cardiomyopathy, meaning your heart is enlarged and does not pump blood as well as it should, confirmed by heart imaging tests, and without severe blockages in your heart arteries or major heart valve prob...

**Who might be able to join this trial:** - You are at least 19 years old. - You have symptoms of heart failure (such as shortness of breath during activity or at rest) and your heart's pumping function is reduced (confirmed by a heart scan or test). - You already need a procedure called a coronary angiography (an imag...

**Who might be able to join this trial:** - Women between the ages of 18 and 50 years old - People diagnosed with ischemic cardiomyopathy (heart muscle damage caused by reduced blood flow) or de novo dilated cardiomyopathy (a newly diagnosed condition where the heart muscle is weakened and enlarged) **Who may not be a...

Who might be able to join this trial: - People who have been diagnosed with wild-type ATTR amyloidosis (a specific type of protein build-up disease that is not inherited) - People who are 18 years of age or older - People who have signs that the heart is affected, as shown by an ultrasound of the heart or a cardiac MRI...

Who might be able to join this trial: - People who have been diagnosed with Takotsubo syndrome (a type of temporary heart condition, sometimes called "broken heart syndrome") according to specific European heart guidelines - People who are adults aged 18 or older - People who have had baseline clinical information reco...

**Who might be able to join this trial:** **Group 1 – People with a specific type of heart condition called wild-type ATTR cardiac amyloidosis (wtATTR-CM):** - Adults over 18 years old who have been diagnosed with wtATTR-CM, either through a small tissue sample taken from the heart (endomyocardial biopsy), or through...

Who might be able to join this trial: - People who are between 14 and 65 years old at the time of signing consent - People who have a confirmed harmful or likely harmful change (mutation) in the PKP2 gene - People who have been diagnosed with a heart condition called ARVC, meeting a specific set of diagnostic guideline...

**Who might be able to join this trial:** - People who have liver cirrhosis and are being considered for a liver transplant, with no medical reasons ruling out transplantation - Women who have gone through menopause at least 24 months ago, have had a surgical procedure that prevents pregnancy, or are using an effectiv...

**Who might be able to join this trial:** - You have been diagnosed with Takotsubo cardiomyopathy (sometimes called "broken heart syndrome") or have had a heart attack within the last 6 months - You are older than 18 years of age - You are willing and able to sign a consent form agreeing to take part **Who may not be...

Who might be able to join this trial: - You must have received CAR-T cell therapy (a type of cancer treatment) between 3 and 5 days before having a heart ultrasound (echocardiography) done as part of this study. - You must have already had a heart ultrasound and a heart tracing test (EKG/ECG) done before starting your...

Who might be able to join this trial: - You must be over 18 years old. - You must have been diagnosed with ACM (a heart condition called Arrhythmogenic Cardiomyopathy), confirmed through tests such as a heart ultrasound, electrocardiogram (ECG), heart scan (MRI), tissue examination, and genetic testing. - You (or a fam...

Who might be able to join this trial: - You must be over 18 years old. - You must have been diagnosed with a heart muscle disease (cardiomyopathy), confirmed through tests such as a heart ultrasound, ECG (heart tracing), MRI scan, tissue examination, or genetic testing. - You (or a family member on your behalf) must ag...

**Who might be able to join this trial:** - Adults (male or female) aged 18 or older - People who have recently been diagnosed for the first time with a type of heart condition called idiopathic dilated cardiomyopathy (a weakened, enlarged heart with no known cause), where the heart's pumping function is significantly...

Who might be able to join this trial: - People who attend the outpatient clinic for hypertrophic cardiomyopathy (a type of heart muscle thickening) at one of the participating medical centres that are part of the HCM Registry - People whose heart wall measurement (the wall between the two lower chambers of the heart) m...

Who might be able to join this trial: - Adults between 18 and 80 years of age - People who have been diagnosed with Cardiovascular Disease (a condition affecting the heart and blood vessels) - People who have been diagnosed with Cerebrovascular Disease (a condition affecting blood flow to the brain) - People who have b...

**Who might be able to join this trial:** - Your heart scan (echocardiogram or MRI) shows that certain walls of your heart are thickened — specifically, the wall between the two lower chambers or the back wall of the heart measures 13mm or more - The tip (apex) of your heart wall measures 15mm or more, OR the tip of th...

Who might be able to join this trial: - People who have given their signed agreement to take part in the trial - People who are scheduled to have open-heart surgery, including coronary artery bypass grafting (a procedure to improve blood flow to the heart), heart valve repair or replacement, surgery on the main artery...

Who might be able to join this trial: **General requirements (apply to all groups):** - People aged between 30 and 90 years old, male or female - People who are willing and able to give their signed agreement to participate before any study procedures begin **Heart failure with preserved pumping function (HFpEF) grou...

**Who might be able to join this trial:** - People who are aged 12 and under 18 years old at the time of screening and at the start of the trial. - People who weigh at least 45 kg (for the first group of participants), or at least 35 kg once the trial has confirmed safety data from at least 10 earlier participants. -...

**Who might be able to join this trial:** - People aged 18 years or older - People who have never received chemotherapy before and have a biopsy-confirmed diagnosis of breast cancer at stage I, II, or III - People whose treatment plan includes at least 4 cycles of a chemotherapy drug called doxorubicin - People who ar...

**Who might be able to join this trial:** - People between 18 and 65 years of age - People who have been diagnosed with compensated cirrhosis (a form of liver scarring where the liver is still managing to function), confirmed through a liver biopsy, blood tests, or ultrasound scan - People whose heart scans (a type of...

**Who might be able to join this trial:** - Adults aged 18 or older, of any sex - People who are willing and able to sign a consent form agreeing to take part in the study - People who are available for the full length of the study and willing to follow all study procedures - People who are able to swallow tablets and...

**Who might be able to join this trial:** - You are aged 10 years or older (male or female) - You are able to provide written agreement to take part (or a parent/guardian can do so on your behalf if you are younger) - You have a known or likely harmful change (variant) in one of five specific heart muscle genes (TTN, L...

Who might be able to join this trial: - People aged 16 years and older but under 40 years old (for Phase 1A of the trial). - People aged 4 years and older but under 16 years old (for Phase 1B of the trial). - People in Phase 1A must be able to sign their own consent form. - People who have been diagnosed with dilated c...

Who might be able to join this trial: - You are receiving your first ever pacemaker (either a single- or dual-chamber device) because your heart beats too slowly due to a serious electrical conduction problem between the upper and lower chambers of the heart, or because you have an irregular heart rhythm (atrial fibril...

**Who might be able to join this trial:** - People whose heart condition is significantly affecting their quality of life, based on a specific symptom score (called the KCCQ CSS) of less than 85 - People whose heart condition limits their physical activity to a moderate or slight degree (known as NYHA Class II or III)...

**Who might be able to join this trial:** - The wall of your heart's main pumping chamber is thickened (15mm or more), as shown on an ultrasound or MRI scan of the heart - You are in a stable condition with mild or no symptoms of heart failure (able to do light activity without major discomfort) - You are 18 years of a...

Who might be able to join this trial: - You are 18 years of age or older - You have been admitted to hospital because of chest pain and signs of heart muscle damage - Your doctor has recommended a cardiac MRI because you may have had a heart attack with no major blockages in your arteries, heart muscle inflammation, or...

**Who might be able to join this trial:** - People whose heart has a thickened wall of 13mm or more (measured by ultrasound of the heart at a specific point in the heart's pumping cycle) - People who have at least two or more "warning signs" linked to a condition called Fabry Disease (FD) — these warning signs can be...

**Who might be able to join this trial:** - People aged 18 to 80 years old (any gender) - People who weigh between 40 and 90 kg at the time of screening - People who have had a TTR gene mutation confirmed through genetic testing - People whose liver function blood test results (AST, ALT, and bilirubin) are within the...

Who might be able to join this trial: - People aged 18 or older, of any gender or ethnicity - People who have been diagnosed with stage 5 chronic kidney disease (the most advanced stage of kidney failure), based on established medical guidelines - People who are newly diagnosed with kidney failure and are planning to s...

Who might be able to join this trial: - People who have been clinically diagnosed with a hereditary cardiovascular disease, based on current medical guidelines - People who agree to receive genetic counseling as part of the trial - People who are willing to sign a consent form agreeing to take part - People who are abl...

Who might be able to join this trial: - You are 18 years of age or older. - You have been prescribed a medication called mavacamten for a heart condition called obstructive hypertrophic cardiomyopathy (a thickening of the heart muscle that blocks blood flow). - You are willing and able to give your consent to take part...

Who might be able to join this trial: - You (or your child) have been diagnosed with a RASopathy (a group of genetic conditions affecting growth and development) - You (or your child) have been diagnosed with hypertrophic cardiomyopathy (a condition where the heart muscle becomes thickened) - You (or your child's guard...

**Who might be able to join this trial:** - People who have heart failure caused by reduced blood flow to the heart, where the heart's pumping strength is 35% or less (measured within the 6 weeks before joining the trial) - People who have been assessed as eligible for a heart transplant due to severe heart failure - P...

**Who might be able to join this trial:** - You are a male or female between the ages of 18 and 75 years old - You have had a specific type of heart attack called a STEMI and are receiving a procedure to open the blocked artery (called PCI or coronary angioplasty) **Who may not be able to join:** - You have had a prev...

Who might be able to join this trial: - People who had their first-ever coronary artery bypass graft (heart bypass) surgery less than 10 days before joining the study. - People whose doctor prescribed a wearable defibrillator vest (a device worn on the body that can detect and treat dangerous heart rhythms) primarily b...

**Who might be able to join this trial:** - Adults aged 18 or older - People who were diagnosed with an irregular heart rhythm condition — either atrial fibrillation (AF), frequent extra heartbeats from the lower heart (PVCs), or a fast abnormal heart rhythm (VT) — before the age of 60 - People who are already schedule...

**Who might be able to join this trial:** - People who have read and understood the research protocol and have signed a consent form - Adults aged 20 to 79 years old - People who do not have diabetes, or people who have type 2 diabetes with a blood sugar control measure (HbA1c) between 6.5% and 10.5% - People diagnose...

Who might be able to join this trial: - You (or your child's guardian) must be willing to sign a written consent form to take part. - The patient must be under 18 years old (a child or young person). - The patient must be suspected by doctors of having myocarditis (inflammation of the heart muscle). - The patient must...

Who might be able to join this trial: - You are a primary care provider (such as a doctor or nurse practitioner) who sees patients with diabetes in your clinic Who may not be able to join: - You are a healthcare provider who does not see patients with diabetes in your practice Important: Always verify eligibility wit...

Who might be able to join this trial: - People who have given written agreement to take part (for children, a parent or guardian must provide this consent on their behalf, following the rules of the country where the trial takes place) - People who are suspected of having, have been diagnosed with, or have a genetic pr...

**Who might be able to join this trial:** - You are 18 years old or older and have a permanent irregular heart rhythm (called atrial fibrillation) along with a heart that pumps less efficiently than normal (less than 50% of its capacity) - You either need electrical pacing to keep your heart from beating too slowly (in...

**Who might be able to join this trial:** - People diagnosed with dilated cardiomyopathy (a condition where the heart is enlarged and weakened) whose heart is still not pumping well enough, even with treatment, as confirmed by specific heart scan measurements - People whose heart condition is classified as moderately...

**Who might be able to join this trial:** - People between 40 and 80 years old. - People who have heart failure with a weakened heart pump (where the heart is pumping less blood than normal), caused either by blocked arteries or other reasons, confirmed by a heart scan showing the pumping function is below 40%. - Peop...

**Who might be able to join this trial:** - You are 12 years old or older at the time of signing the consent form - You are able and willing to sign a consent form and follow the study's rules and requirements - You have been diagnosed with a heart condition called arrhythmogenic cardiomyopathy (ACM), a disease affecti...

**Who might be able to join this trial:** - You are over 18 years old - You live within approximately 20 km of Gap, Laragne-Montéglin, Veynes, or Clermont-Ferrand in France - You have been personally invited to take part by staff at a medical facility involved in the trial - You have been diagnosed with one of the foll...

**Who might be able to join this trial:** - People who are able to understand the study and are willing to sign a consent form and follow the study rules - People aged 18 to 80 years old - Women who are postmenopausal (no periods for at least 12 months), have had a hysterectomy, both ovaries or fallopian tubes removed...

Who might be able to join this trial: - People aged 18 or older - People with advanced heart failure that has not responded well to treatment, rated as Class II, III, or IV on a standard heart failure severity scale - People whose heart failure has been stable for the last 6 months and who are already on the maximum re...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with Takotsubo syndrome (a type of temporary heart condition, sometimes called "broken heart syndrome") - People who are willing to sign a consent form agreeing to take part in the study Who may not be able to join:...

**Who might be able to join this trial:** **For the main patient (called the "Proband"):** - You are 18 years of age or older - A doctor has confirmed you have a specific type of heart condition called non-ischemic dilated cardiomyopathy (a weakened, enlarged heart not caused by blocked arteries), where your heart's p...

Who might be able to join this trial: - Adults aged 18 years or older - People who are able and medically suitable to wear a Holter monitor (a small portable heart recording device) Who may not be able to join: - People who are using mechanical support for breathing, heart circulation, or kidney function at the time o...

**Who might be able to join this trial:** - People who have had a heart attack that caused scarring of the heart muscle (ischemic cardiomyopathy), or people with heart muscle scarring from a non-blockage-related cause confirmed by heart imaging (non-ischemic cardiomyopathy). - People who have had at least one episode...

Who might be able to join this trial: - People who are female - People who are over 18 years old - People who have been diagnosed with breast cancer - People whose treatment plan includes chemotherapy, with a planned total dose equivalent to 240 mg/m2 of doxorubicin (a specific chemotherapy drug) Who may not be able t...

**Who might be able to join this trial:** - You have been diagnosed with a non-ischemic heart condition affecting the left side of your heart, specifically dilated cardiomyopathy (an enlarged heart), non-dilated left ventricular cardiomyopathy (a heart muscle disease without enlargement), or cardiomyopathy that develop...

**Who might be able to join this trial:** - People who are older than 18 years of age - People who were diagnosed with myocarditis (inflammation of the heart muscle) more than 6 months before joining the study - People who have had a specific type of heart scan (called a CMR scan) performed more than 6 months after the...

**Who might be able to join this trial:** - People who have been diagnosed with cancer and have been receiving immune checkpoint inhibitor (ICI) treatment for at least 3 months, with at least 2 doses received, and who have not developed any new heart or muscle symptoms, abnormal heart test (ECG) results, abnormal hear...

**Who might be able to join this trial:** - People aged 18 to 75 years, of any gender - People who have been diagnosed with dilated cardiomyopathy - People (or their legal guardians) who are willing to participate voluntarily and sign a consent form after being fully informed about the study and its risks **Who may no...

**Who might be able to join this trial:** - You have been diagnosed with VMC (confirm with trial site for full diagnosis details) - Your symptoms started no more than 30 days ago - You are between 18 and 75 years old - You (or your legal guardian) are willing to be fully informed about the study, join voluntarily, and...

Who might be able to join this trial: - Adults aged 18 or older, of any sex. - People who have been diagnosed with heart failure caused by a condition called non-ischemic dilated cardiomyopathy (a type of weakened, enlarged heart not caused by blocked arteries), with or without a known genetic cause. - People whose hea...

**For patients with Fabry disease:** Who might be able to join this trial: - You have been diagnosed with Fabry disease confirmed by genetic testing - You are 18 years of age or older - You are able to understand and sign a consent form agreeing to take part Who may not be able to join: - You have a condition that ma...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with sepsis (a serious response to infection) based on specific medical scoring criteria, meaning they have a suspected or confirmed infection along with signs that their organs are under stress - People who...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with a type of heart disease called dilated cardiomyopathy, where the heart is enlarged and pumping very poorly (confirm with trial site for specific measurements) - Your doctor has decided you need temporary mechanic...

**Who might be able to join this trial:** - You are 18 years old or older - You have come in with sudden chest pain and your doctor has recommended a specific CT scan (either a "triple-rule-out" CT or a heart CT scan) because there is a low or moderate chance you may have an acute heart/coronary artery problem - Your E...

Who might be able to join this trial: **For people with ischemic heart disease (heart disease caused by blocked arteries):** - Adults between 18 and 80 years old (male or female) - People who have been scheduled for coronary artery bypass graft (CABG) heart surgery as part of their regular medical care - People who ha...

Who might be able to join this trial: - Adults aged 18 to 99 years old - People who have given written consent to participate - People who have been diagnosed with decompensated liver cirrhosis (a serious stage of liver scarring where the liver is no longer functioning well), confirmed through clinical assessment, imag...

**Who might be able to join this trial:** - You are between 18 and 85 years old (inclusive), either male or female - Your body mass index (a measure of body weight relative to height) is below 35 kg/m² - You understand what the study involves, are willing to take part, and can sign a consent form - If you are a woman w...

Who might be able to join this trial: - You are a woman who has been seen in a cardio-obstetrics clinic (a clinic that manages heart conditions during pregnancy) before, during, or after pregnancy - You have been diagnosed with a congenital heart disease (a heart condition you were born with) that falls into a moderate...

Who might be able to join this trial: - People who have been diagnosed with a heart condition called ATTR cardiomyopathy (a disease where a protein called transthyretin builds up in the heart muscle) - People who have had a detailed heart ultrasound (echocardiogram) done within 6 months before or after their diagnosis,...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of breast cancer called triple-negative breast cancer (TNBC), or a hormone receptor-low invasive breast cancer, at Stage II or Stage IIIA/B (meaning the cancer is locally advanced but has not spread to distant parts of the...

**Who might be able to join this trial:** - You are 18 years old or older and have been diagnosed with a heart muscle disease (cardiomyopathy), confirmed by tests such as an ultrasound of the heart or other imaging. - Your condition is stable and you are already taking standard medications for cardiomyopathy, such as A...

Who might be able to join this trial: - You have been diagnosed with a condition called amyloidosis (a disease where abnormal proteins build up in the body's organs and tissues) - You carry a gene change (mutation) in the transthyretin gene but do not yet have symptoms - You are at least 18 years old at the time of you...

Who might be able to join this trial: - People who have been diagnosed with sepsis (a serious infection-related illness affecting the whole body) - People who received care in the Intensive Care Unit (ICU) at the University Medical Center in Ho Chi Minh City during the study period Who may not be able to join: - Peopl...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with, or your doctor suspects you may have, amyloidosis (any type) - You are willing and able to sign a written consent form to take part in the study **Who may not be able to join:** - You are under 18 years of age...

Who might be able to join this trial: - You have been diagnosed with myocarditis (inflammation of the heart muscle), confirmed by a heart tissue biopsy and/or a special type of heart MRI scan - You are 10 years old or older - You are willing to have your heart rhythm monitored remotely using an ECG device - You have gi...

Who might be able to join this trial: - You have atrial fibrillation or atrial flutter that does not go away on its own. - You have had a heart imaging test (such as an echocardiogram, MRI, or CT scan) during your heart rhythm problem that showed your heart's pumping strength (called ejection fraction) is below 50%, an...

**Who might be able to join this trial:** - You have been diagnosed with septic shock (a life-threatening condition where an infection causes dangerously low blood pressure and organ problems), diagnosed using the "Sepsis 3.0" medical guidelines - You are 18 years old or older **Who may not be able to join:** - You ar...

Who might be able to join this trial: - People who have had chest pain that feels like it is coming from around the heart or that resembles a heart attack. - People who have had shortness of breath during activity or at rest for up to 3 months. - People who have had shortness of breath during activity or at rest lastin...

**Who might be able to join this trial:** - People aged between 18 and 75 years old who have been diagnosed with dilated cardiomyopathy (a condition where the heart muscle is weakened and enlarged). - People who are able to confirm they understand the risks, benefits, and treatment options involved, and who (or whose...

Who might be able to join this trial: - People who are at least 18 years old - People who are fluent in Italian - People who are a patient, a presymptomatic carrier, or a caregiver of someone with ATTRv (a hereditary form of amyloidosis), and who are under the care of the Amyloidosis Center at Fondazione IRCCS Policlin...

**Who might be able to join this trial:** - People diagnosed with idiopathic dilated cardiomyopathy (a type of heart disease where the heart muscle is weakened for no known reason) who still have significant symptoms despite receiving proper heart failure treatment, classified as NYHA class III or IV (meaning moderate...

**Who might be able to join this trial:** - People who have been diagnosed with dilated cardiomyopathy (a condition where the heart is enlarged and cannot pump blood well) - People who have a specific antibody in their blood called an anti-β1-adrenergic receptor antibody (confirm with trial site) - People between 18 an...

**Who might be able to join this trial:** - You are 18 years of age or older at the time of signing the consent form - You have been diagnosed with Arrhythmogenic Cardiomyopathy (a specific heart condition) based on established medical criteria **Who may not be able to join:** - You have a known allergy or sensitivity...

**Who might be able to join this trial:** - People aged 19 years or older - People who are able to verbally confirm they understand the risks, benefits, and alternatives of the procedures involved, and who (or whose legal representative) can provide written consent before any study procedures begin - People whose hear...

Who might be able to join this trial: - You must be a fully qualified or in-the-process-of-qualifying heart specialist doctor (cardiologist). Who may not be able to join: - You may not be able to join if you are not currently seeing and treating patients in a clinical setting. Important: Always verify eligibility wit...

**Who might be able to join this trial:** - You have frequent extra heartbeats (called PVCs) that happen on their own, with no known cause, making up more than 5% of your heartbeats on multiple 24-hour heart monitor recordings - Your heart's structure and function appear normal on an ultrasound of the heart (echocardi...

**Who might be able to join this trial:** - People who were admitted to hospital within 48 hours of their stroke symptoms starting, where a CT or MRI scan has confirmed they had a stroke (either a blocked blood vessel or a bleed in the brain) - People whose stroke has been rated as moderate to severe, based on a standa...

Who might be able to join this trial: - You are 18 years of age or older - You have an implanted defibrillator device (ICD) that was placed to prevent a first serious heart event, due to heart failure with reduced pumping ability, and your device can be monitored remotely - You are currently taking a heart medication c...

Who might be able to join this trial: - You have heart failure caused by reduced blood flow to the heart (ischemic cardiomyopathy) that is currently stable - Your heart's pumping ability is significantly reduced, meaning tests show your heart pumps out 35% or less of blood with each beat - You have had an implanted def...

Who might be able to join this trial: - Adults who have been diagnosed with a heart condition called arrhythmogenic cardiomyopathy (ACM), based on a specific set of recognised medical guidelines from 2010. - People who have a confirmed genetic change in a gene called PKP2 that is known or likely to cause disease. - Peo...

Who might be able to join this trial: - People between 20 and 79 years old whose heart is pumping less efficiently than normal (the heart pumps out 40% or less of its blood with each beat, as measured by an ultrasound of the heart), and who are able to give written agreement to take part in the study voluntarily. Who...

**Who might be able to join this trial:** - You are between 18 and 80 years old (any sex) - You have been diagnosed with obstructive hypertrophic cardiomyopathy (a condition where the heart muscle is thickened and blocks blood flow) - You have noticeable symptoms such as shortness of breath, chest pain, tiredness, hear...

Who might be able to join this trial: - People between 18 and 85 years of age - People who are currently admitted to a Cardiac Care Unit (a specialised hospital ward for serious heart conditions) due to an acute heart problem, such as a heart attack, heart failure, or dangerous irregular heartbeats - People who are abl...

Who might be able to join this trial: - You have a heart condition called hypertrophic cardiomyopathy (a thickened heart muscle) and have already taken part in a previous study related to a drug called HRS-1893. - If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before...

Who might be able to join this trial: - Adults between 18 and 85 years old, of any gender - People with a Body Mass Index (BMI) below 35 (a measure of body weight relative to height) - People who have been diagnosed with obstructive hypertrophic cardiomyopathy (a condition where the heart muscle is abnormally thick and...

Who might be able to join this trial: - People who have been clinically diagnosed with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle becomes abnormally thick, in line with recognised medical guidelines - People whose specific type of HCM (non-obstructive HCM) has been confirmed through ultrasoun...

Who might be able to join this trial: - People aged 18 to 85 years who have been diagnosed with a type of heart condition called Acute Coronary Syndrome (ACS) and are having a procedure to open blocked heart arteries (called PCI) in the cardiology department or cardiac intensive care unit. Who may not be able to join:...

**Who might be able to join this trial:** - You were part of the original HCMR study group - You are between 18 and 65 years old (male or female) - **If you have the obstructive type of HCM (thickened heart muscle that blocks blood flow):** Your body weight relative to height (BMI) is under 35, and tests show that blo...

**Who might be able to join this trial:** - People aged 18 or older - People who have been hospitalised or visited an emergency department due to acute (sudden or worsening) heart failure, diagnosed according to recognised international guidelines, based on typical symptoms and signs - People with blood test results sh...

Who might be able to join this trial: - You must be 18 years of age or older - You must have been diagnosed with a heart condition called hypertrophic obstructive cardiomyopathy (a thickening of the heart muscle that blocks blood flow) - You must have been taking the same dose of a medication called mavacamten for at l...

Who might be able to join this trial: - Adults aged 18 or older who have been diagnosed with sepsis and admitted to Jimma University Medical Center during the study period - People who are willing to take part in the study and agree to have their condition monitored for at least one year Who may not be able to join: -...

Who might be able to join this trial: - Children and teenagers under 18 years old who have been diagnosed with myocarditis (inflammation of the heart muscle) that is also causing irregular heartbeats or problems with how well the heart is pumping Who may not be able to join: - Children whose parents or legal guardians...

**Who might be able to join this trial:** - You are 18 years old or older at the time you arrive at the healthcare facility - You have had a resting heart tracing test (ECG) that was flagged by a computer system called Viz HCM as possibly showing a heart condition called HCM (hypertrophic cardiomyopathy) - You may qual...

**Who might be able to join this trial:** - Your heart's pumping function (measured as a percentage called LVEF) is below 50% - Your heart's pumping function is between 50–55%, AND scans show specific changes to your heart tissue or an enlarged heart chamber, AND you carry a gene change known to cause a type of heart...

**Who might be able to join this trial:** - You have been diagnosed with, and your doctor has recommended, a heart procedure called catheter ablation to treat an irregular heartbeat — specifically ventricular tachycardia, premature ventricular complexes, atrial tachycardia, or atrial fibrillation (having had a previou...

Who might be able to join this trial: - People aged 18 or older who have given written agreement to take part. - People who have been diagnosed with a heart condition called Hypertrophic Obstructive Cardiomyopathy (HOCM), where the heart muscle is abnormally thick (at least 15mm) and blood flow out of the heart is part...

Who might be able to join this trial: - People aged 18 to 65 years old at the time of signing the consent form - People who are willing and able to sign a consent form agreeing to take part - People diagnosed with dilated cardiomyopathy (a condition where the heart is enlarged and does not pump well), with a heart pump...

Who might be able to join this trial: - People who are at least 18 years old and are being treated at or visiting a UIH (University of Illinois Health) location. - People who are willing and able to sign a written consent form agreeing to take part in the trial. Who may not be able to join: - Adults who are not able t...

**Who might be able to join this trial:** - Adults aged 18 years or older - People diagnosed with obstructive hypertrophic cardiomyopathy (a condition where the heart muscle is thickened and blocks blood flow) according to specific 2023 medical guidelines - People who already have a cardiac MRI scan with a special type...

**Who might be able to join this trial:** - You are between 40 and 80 years old - You weigh between 50 and 120 kg (approximately 110 to 265 lbs) - Your heart is beating in a normal, regular rhythm (called "sinus rhythm") - You have previously been diagnosed with a specific heart condition called "primary" hypertrophic...

Who might be able to join this trial: - People who have been diagnosed with dilated cardiomyopathy (an enlarged, weakened heart) linked to specific genetic variants (in genes called MYH7, TTN, or similar), or where the condition runs in the family - People whose heart failure symptoms fall into a moderate-to-severe ran...

**Who might be able to join this trial:** **Criteria that apply to all three groups:** - People aged 60 years or older - People who are willing and able to sign a consent form and follow the study requirements **Criteria for people with heart failure (with a heart pumping function above 40%), with or without a condit...

Who might be able to join this trial: - You have a specific gene change (mutation) in a gene called BAG3 that is known or likely to cause health problems - You have been diagnosed with a type of heart condition called dilated cardiomyopathy (DCM), where the heart is enlarged and does not pump well - You are on a stable...

**Who might be able to join this trial:** - People aged 18 years or older - People whose heart is pumping at a normal or preserved rate (a measure called LVEF of 50% or higher) - People who have been diagnosed with a type of heart failure called HFpEF — meaning they were admitted to hospital for heart failure in the p...

**Who might be able to join this trial:** - Adults between the ages of 18 and 80 who had a full heart ultrasound (echocardiogram) at UPMC Presbyterian Echocardiography Lab, referred because of a suspected stroke - People who have been formally diagnosed with a stroke by a specialist stroke doctor - People whose heart...

**Who might be able to join this trial:** - You are 19 years of age or older - You have been diagnosed with amyloid cardiomyopathy (a heart condition caused by abnormal protein deposits), confirmed by a heart tissue sample or special imaging tests - You have heart failure symptoms that are moderate — meaning you feel...

Who might be able to join this trial: - You must be between 18 and 80 years old at the time of screening - You must have already tested positive for a specific genetic change called the R14 del PLN mutation - Your heart's pumping ability (measured by an ultrasound of the heart) must show the heart is pumping out 45% or...

Who might be able to join this trial: - People who are participants in the Childhood Cancer Survivor Study (CCSS) - People who are 26 years of age or older - People who were treated for childhood cancer with a certain level of heart-affecting chemotherapy drugs called anthracyclines (at a cumulative dose of 100 mg/m² o...

**Who might be able to join this trial:** - You are 18 years of age or older - You are scheduled to have a dual-chamber pacemaker implanted because of a permanent complete or significant partial blockage in the heart's electrical system (called complete heart block or second-degree AV block) - Your heart's pumping stre...

Who might be able to join this trial: - You must be an adult aged 18 or older. - For the main heart condition group: You have been diagnosed with a condition called hypertrophic cardiomyopathy (a thickened heart muscle) according to specific Chinese medical guidelines from 2023. - For the "similar condition" group: An...

**Who might be able to join this trial:** - People aged between 18 and 80 years, of any gender - People whose doctors have determined that coronary artery bypass graft (CABG) heart surgery is an appropriate treatment for long-term reduced blood flow to the heart - People whose heart pumping strength (measured by echoc...

**Who might be able to join this trial:** - You have cirrhosis (scarring of the liver), from any cause, and are seriously ill - Your blood pressure has dropped to a dangerously low level as a result of a serious infection (sepsis) - You are between 18 and 65 years old **Who may not be able to join:** - You are already...

Who might be able to join this trial: - People who have been diagnosed with dilated cardiomyopathy (an enlarged heart) confirmed by an ultrasound of the heart, where the heart's main pumping chamber measures more than 55 mm in men or more than 50 mm in women. - People who have signs and symptoms of heart failure, along...

**Who might be able to join this trial:** - People aged 18 to 90 years old at the time of signing the consent form - People who have been diagnosed with ATTR-CM (a type of heart disease caused by abnormal protein deposits), confirmed by a specific scan (SPECT or SPECT/CT) or tissue biopsy done within the past 24 month...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with transthyretin cardiac amyloidosis (a condition where a protein called transthyretin builds up in the heart), with or without reduced heart function - People who are willing to follow the study's procedu...

**Who might be able to join this trial:** - People who are between 18 and 65 years old - People who have been diagnosed with cirrhosis (scarring of the liver), confirmed by a tissue sample or by blood tests and an ultrasound scan - People whose heart scans show a specific type of heart function problem (where the heart...

**Who might be able to join this trial:** - You have been diagnosed through genetic testing with a RASopathy (a group of conditions caused by changes in a specific set of genes that affect how cells grow and communicate) - A heart scan (echocardiogram) has shown that the walls of your heart are thicker than normal, wi...

**Who might be able to join this trial:** - You are 16 years old or older - A specific measurement of your heart's size (taken during a heart MRI scan) is within a certain range — below a set limit based on your sex (confirm with trial site for exact values) - Your heart's pumping ability is below 50%, and/or a heart M...

Who might be able to join this trial: - People who have been diagnosed with a heart condition caused by abnormal protein buildup, known as ATTR cardiomyopathy (ATTR-CM) - People who are starting treatment with a medication called vutrisiran, or another approved medication for ATTR-CM Who may not be able to join: - Peo...

Who might be able to join this trial: - People who are 19 years of age or older - People who have been diagnosed with sick sinus syndrome (a condition where the heart's natural pacemaker doesn't work properly) and are planned to receive their first permanent pacemaker or heart device implant - People, or their legal re...

**Who might be able to join this trial:** - People aged 18 or older who have been diagnosed with obstructive hypertrophic cardiomyopathy (a condition where the heart muscle is abnormally thick and blocks blood flow out of the heart). - People who have already started taking a medication called mavacamten, or who are p...

Who might be able to join this trial: - People who have been diagnosed with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle becomes abnormally thick. - People who are 18 years of age or older at the time of the screening visit. - People whose heart is pumping at a normal or near-normal strength, a...

**Who might be able to join this trial:** - People aged 65 years or older - People who have severe aortic valve narrowing (a heart valve problem) combined with iron deficiency, and who have successfully undergone a TAVI procedure (a minimally invasive heart valve replacement) - People whose iron deficiency is confirmed...

Who might be able to join this trial: - You are a man or woman aged 18 years or older - You have a heart condition called HCM (hypertrophic cardiomyopathy) and have previously had a surgical procedure called a myectomy, after which you developed a specific type of abnormal heart electrical pattern (called LBBB) with a...

Who might be able to join this trial: - You have been diagnosed with a heart condition called Hypertrophic Cardiomyopathy (HCM), where the heart muscle becomes abnormally thick, and this diagnosis has been confirmed by a doctor through clinical assessment — not simply because of another condition like high blood pressu...

**Who might be able to join this trial:** - People who have been diagnosed with a type of heart muscle disease called hypertrophic cardiomyopathy (a condition where the heart muscle becomes thickened), according to current European cardiology guidelines; OR a close blood relative (parent, child, or sibling) of someone...

Who might be able to join this trial: - You have a heart condition called obstructive hypertrophic cardiomyopathy (a thickening of the heart muscle that blocks blood flow) and your doctor has started you on a medication called Mavacamten for this condition at a medical facility in Japan during the study enrollment peri...

**Who might be able to join this trial:** - Adults aged 18 or older who have had at least one ECG (a heart rhythm test) and one echocardiogram (a heart ultrasound) recorded within the Yale New Haven Health System - People who have been diagnosed with a type of heart failure known as HFpEF or HFmrEF (heart failure where...

**Who might be able to join this trial:** - You are 18 years of age or older - You are able to understand the study and agree to have your data collected - You are able to follow the study rules and schedule - You are able to understand and respond to instructions given in English - You have been diagnosed with a quali...

Who might be able to join this trial: - You are between 18 and 55 years old (male or female) - You have a specific type of genetic change (called a "truncating mutation") in a gene called BAG3 - You have a weakened, enlarged heart (called dilated cardiomyopathy) where your heart is pumping at less than 45% of its norma...

Who might be able to join this trial: - People aged 18 to 85 years, of any gender - People who have been diagnosed with ischemic cardiomyopathy (a type of heart disease caused by reduced blood flow to the heart) - People who have significant blockages in the arteries that supply the heart - People whose heart's pumping...

Who might be able to join this trial: - People who have given written consent to participate before any study activities begin. - People of any gender. - People aged 60 years or older at the time of signing the consent form. - People who have a confirmed diagnosis of Transthyretin Amyloid Cardiomyopathy (ATTR-CM), a co...

**Who might be able to join this trial:** - You are between 18 and 55 years old (inclusive), of any gender - Your Body Mass Index (BMI) is between 19 and 28, your weight is between 50 kg and under 90 kg (if male), or between 45 kg and under 90 kg (if female) - A full physical examination and lab tests show no significa...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with hypertrophic cardiomyopathy (a condition where the heart muscle becomes abnormally thick) through an ultrasound of the heart, whether or not there is a blockage affecting blood flow out of the heart - P...

Who might be able to join this trial: - You are male or female and over 18 years old - You have been diagnosed with a condition called takotsubo cardiomyopathy (sometimes called "broken heart syndrome") - You are able to understand and agree to take part by giving formal consent Who may not be able to join: - You are...

**Who might be able to join this trial:** - You are between 18 and 75 years old. - You have been diagnosed with heart failure caused by reduced blood flow to the heart (ischemic cardiomyopathy), your heart is pumping at less than 35% of its normal capacity, and you have moderate to severe heart failure symptoms (such a...

Who might be able to join this trial: - People who are aged 18 to 75 years old and have been diagnosed with dilated cardiomyopathy (a condition where the heart becomes enlarged and cannot pump blood properly) - People who previously received a single infusion of a specific immune-modifying cell therapy called iCDC, and...

"Who might be able to join this trial: - Your heart's left main pumping chamber is larger than normal for your age and gender, and it is not pumping as strongly as it should be (confirm with trial site) Who may not be able to join: - You have significant blockages (more than 50%) in the major arteries that supply bloo...

**Who might be able to join this trial:** - People who have signed a consent form approved by an ethics committee before any trial procedures begin (or whose legal representative has signed on their behalf) - People who have been diagnosed with obstructive hypertrophic cardiomyopathy (a condition where the heart muscl...

Who might be able to join this trial: - People who have been diagnosed with chronic heart failure, where the heart's pumping function is reduced, mildly reduced, or only slightly affected, and whose symptoms are moderate (able to do some daily activities but limited by breathlessness or fatigue). - People who were admi...

**Who might be able to join this trial:** - Adults aged 18 or older at the time the study begins looking at their records - People who have been formally diagnosed with obstructive hypertrophic cardiomyopathy (a condition where the heart muscle becomes abnormally thick, blocking blood flow) - People who were prescribe...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with a specific heart muscle condition called arrhythmogenic right ventricular cardiomyopathy (ARVC), confirmed using recognised medical diagnostic guidelines - People who are currently being monitored and followed up...

Who might be able to join this trial: - You must be 18 years of age or older. - Before your heart procedure, a heart scan (echocardiogram) showed that your heart's pumping strength was 40% or below. - You have successfully had surgery or a procedure to fix a treatable heart problem, such as heart valve surgery (mitral,...

Who might be able to join this trial: - Adults aged 18 or older who had ongoing (persistent) atrial fibrillation (an irregular heart rhythm) before undergoing a heart procedure to correct the rhythm (either catheter ablation or cardioversion) - **Group 1 (Cases):** People whose heart pumping function was weakened (mea...

Who might be able to join this trial: - You are being checked for a heart condition called HCM (hypertrophic cardiomyopathy) because a family member has it or because of a genetic test result - You are between 10 and 18 years old (including those ages) - You are already a patient at the inherited cardiac conditions cli...

Who might be able to join this trial: - People who have been diagnosed with obstructive hypertrophic cardiomyopathy (a condition where the heart muscle is thickened and blocks blood flow) with a documented blockage measurement of 50 mmHg or more, and who are currently taking the medication mavacamten through a standard...

Who might be able to join this trial: - You must be 18 years old or older - You have been diagnosed with Takotsubo Syndrome (a type of stress-related heart condition) based on recognised international diagnostic standards - You have agreed to take part and signed a consent form Who may not be able to join: - You are u...

**Who might be able to join this trial:** - People who are 18 years of age or older and are able to give their own consent to participate - People who have been clinically diagnosed with a type of heart muscle disease called dilated cardiomyopathy (DCM) caused by a change in the LMNA gene, where the left side of the h...

Who might be able to join this trial: - People aged 18 years or older, of any gender. - People who have a suspected or confirmed heart condition (such as blocked arteries in the heart, heart muscle disease, heart inflammation, or heart valve problems) where a cardiac MRI scan is needed to understand the cause or assess...

Who might be able to join this trial: - You are a cancer patient who has received at least one immunotherapy drug known as an immune checkpoint inhibitor - You have been recorded in an international registry as possibly, probably, or definitely having developed heart inflammation (myocarditis) linked to your immune che...

**Who might be able to join this trial:** - People who have cirrhosis (severe liver scarring) that has caused serious complications, such as internal bleeding related to liver pressure, episodes of confusion caused by liver disease, or fluid build-up in the abdomen - People whose liver disease is rated as moderately s...

Who might be able to join this trial: - People who have been diagnosed with systemic amyloidosis (a disease where abnormal proteins build up in organs and tissues) - People who are 18 years of age or older at the time of joining the trial - People whose treating doctor has given consent for their participation - People...

Who might be able to join this trial: - Children and young people aged 1 month to 18 years old. - People who have been diagnosed with heart failure, confirmed by heart ultrasound showing the heart is not pumping or filling properly, along with signs of fluid build-up or poor blood flow. - People whose heart failure is...