Alzheimer's Disease

You (or someone who knows you well) have noticed your memory has been slowly and gradually getting worse over at least 6 months You scored between 20 and 28 (inclusive) on a standard memory and thinking test called the MMSE, taken at the start of the study Your results from a specific brain scan (called an 18F…

You have been found to have mild memory or thinking problems on formal tests, but do not have dementia or major difficulties with daily activities. You do not have any serious medical or neurological conditions that could be causing your memory or thinking problems, or that might stop you from being followed up over…

You are between 50 and 85 years old You have been diagnosed with early-stage (prodromal) Alzheimer's disease and are not currently taking medications called memantine or cholinesterase inhibitors You have a family member, friend, or carer who sees you regularly and can accurately report on how your memory and daily…

You have a caregiver who knows you well and can be relied upon to support you. You are living at home or in the community (not currently staying in a hospital). You have been diagnosed with Alzheimer's disease (AD). Your Alzheimer's disease is considered mild to moderate in severity. You are already taking a stable…

You are 50 years of age or older You have been diagnosed with mild Alzheimer's disease, with signs of getting worse in the 6 months before screening, as confirmed by your doctor using recognised medical guidelines Your memory and thinking test score (called MMSE) is between 20 and 26 out of 30 Your overall dementia…

You are between 55 and 85 years old You have been diagnosed with mild-to-moderate Alzheimer's disease dementia, based on recognised medical guidelines Your memory and thinking scores fall within a specific range, as measured by standard tests given at the screening visit You have a reliable family member, friend, or…

You are between 18 and 80 years old You either know you carry a gene mutation that causes Alzheimer's disease, or you are unsure of your genetic status but have a family history of inherited (dominantly inherited) Alzheimer's disease You are within 15 years before or 10 years after the age when memory or thinking…

You scored between 18 and 28 on a standard memory and thinking test (called the MMSE) at two separate early visits You have been diagnosed with either mild cognitive impairment (MCI) or mild Alzheimer's Disease You scored 4 or below on a scale that helps rule out memory problems caused by reduced blood flow to the…

People who have given voluntary written consent before any study-related activities begin. Men or women aged 18 to 55 years old at the time of giving consent. People who are able to become pregnant must agree to use two forms of contraception (a highly effective method plus a condom where appropriate) from the…

The person joining (or their legal representative) must be willing and able to give written consent, attend all study visits, and follow all study requirements. Adults between 50 and 90 years of age (inclusive) at the time of screening are eligible. People who have been diagnosed with dementia due to Alzheimer's…

People who are healthy and between 18 and 55 years old. People who score between 27 and 30 on a standard memory and thinking test (called the MMSE) at the screening visit. People who are able to give their own written agreement to take part. People who are in good general health with no conditions expected to…

You are 18 years old or older You are the child of someone who has (or had) a specific inherited form of early-onset Alzheimer's disease, and the family has a known genetic mutation linked to this condition Your thinking and memory are normal, only very mildly affected, or mildly affected (this is measured using a…

You have been diagnosed with a rare disease, a disease where the number of people affected is unknown, or you have not yet received a diagnosis for your condition You have been identified as a carrier of a rare or uncommon disease, meaning you carry the gene for a condition but may not have symptoms yourself

People who are older than 50 years of age

People who are willing and able to sign a consent form, along with a study partner or legal representative if needed. People who are at least 18 years old. People who could become pregnant must have a negative pregnancy blood test at the start of the study, agree not to try to become pregnant during the study and for…

People who come to Eastern Health services with concerns about their memory or thinking, or who may have a condition affecting brain function over time

People who are at least 18 years old. People who carry a mutation in one of three genes (APP, PSEN1, or PSEN2) linked to a hereditary form of Alzheimer's disease, or people who do not yet know their own mutation status but have a known mutation in their family that puts them at direct risk of inheriting it. People who…

You must be between 55 and 90 years old at the time of your first screening visit. You must have been diagnosed with Alzheimer's disease based on the most recent 2024 Alzheimer's Association guidelines. You must have had a brain scan (MRI or CT) within the past 5 years, taken after your dementia symptoms began, to…

People who have a confirmed diagnosis of Alzheimer's disease at the mild or moderate stage, confirmed using specific updated diagnostic guidelines from 2024. People who score between 12 and 22 (inclusive) on a standard memory and thinking test called the MMSE, taken at the screening appointment. People who have a…

People who have a confirmed diagnosis of Alzheimer's disease at the mild (stage 4) or moderate (stage 5) dementia stage, diagnosed according to the most recent official criteria from the National Institute on Aging and Alzheimer's Association (NIA-AA). People whose score on a standard memory and thinking test (called…

You have been diagnosed with mild memory or thinking problems (mild cognitive impairment) or mild dementia caused by Alzheimer's disease You have a trusted person (such as a family member or close friend) who is willing and able to support you and take part in the study alongside you If you are already taking an…

You are between 50 and 85 years old You have been diagnosed with either Mild Cognitive Impairment (early memory/thinking problems) or mild Alzheimer's disease Your doctor has rated your memory and thinking abilities using a standard scale, with a score showing mild impairment (CDR score of 0.5 or 1.0) Your Alzheimer's…

People who completed the full treatment period in the related parent study (NCT06079190) People who may have missed some doses or had a temporary pause in treatment during the parent study, as long as they were not permanently removed from the study intervention or fully withdrawn from the parent study People who are…

People who are willing and able to complete all parts of the study — including MRI scans, genetic testing, and brain imaging or spinal fluid tests — for the full duration of the trial, either independently or with help from a study partner People whose vision and hearing are good enough, in the study doctor's…

People who have noticed memory problems in themselves, or whose close contacts have noticed memory concerns in them, within the past year — this applies whether or not a doctor has previously diagnosed them with mild cognitive impairment (MCI) or dementia related to Alzheimer's disease.

You must be older than 30 years of age. You have been diagnosed with dementia or a brain-related condition such as Alzheimer's disease, Parkinson's disease, Lewy body dementia, Niemann-Pick type 2, or vascular dementia (people without these conditions who are of a similar age and sex may also be invited to take part…

People who have experienced a gradual and ongoing decline in memory that has been noticed by themselves or someone who knows them well, lasting 6 months or more, consistent with a diagnosis of Alzheimer's disease dementia People whose score on a standard memory and thinking test (called the Mini Mental State…

Adults aged 18 to 54 years old who are generally healthy, male or female, and able to give written consent before the trial begins. People with a body mass index (BMI) between 18 and 32, where male participants weigh at least 50 kg and female participants weigh at least 40 kg. People who agree not to try to conceive a…

You must have already completed a specific earlier study called "3133K1-3000" and had a brain scan (MRI) that confirmed a diagnosis of Alzheimer's disease You must score 10 or higher on a standard memory and thinking test called the Mini-Mental Status Examination (MMSE) at the screening appointment You must have a…

You have been diagnosed with Alzheimer's Disease based on specific recognised medical guidelines You have already completed 80 weeks of participation in one of two related previous studies (called Study LZAM or Study LZAN) You have a trusted person (such as a family member or carer) who is in regular contact with you…

People aged 50 to 89 years old at the time of screening People who are able to give written agreement to take part, or who have a legally authorised representative who can do so on their behalf People who have a capable and willing caregiver who agrees in writing to support their participation and follow the study…

The study doctor believes you can understand and follow the study requirements You have signed a written consent form before any study activities begin You are physically able to complete memory and thinking tests, and you speak the language in which the tests are given Your memory and thinking are considered normal…

You must have already completed participation in one of three specific earlier TauRx research studies (TRx-237-005, TRx-237-008, or TRx-237-015) for dementia or probable Alzheimer's disease, including a 4-week follow-up visit at the end of that study Alternatively, you must have already completed participation up to…

You weigh between 40 and 120 kilograms (about 88 to 265 pounds) You have someone in your life (like a family member or close friend) who sees you regularly, can accurately describe your memory and daily functioning, is willing to attend clinic visits and sign a consent form, and has good enough memory themselves to…

A qualified doctor has diagnosed you with mild Alzheimer's disease dementia based on recognised medical guidelines. You scored between 20 and 26 (inclusive) on a standard memory and thinking test called the Mini-Mental State Examination at your screening appointment. A special brain scan (called a florbetapir PET…

You must have already taken part in a previous clinical trial called AMARANTH (NCT02245737) and still meet the requirements to continue into this new phase of the study.

You have experienced a slow, gradually worsening change in memory that has been happening for more than 6 months. You have been diagnosed with mild cognitive impairment (MCI) or mild Alzheimer's disease, based on standard medical assessments. Your memory and thinking problems have been confirmed through specific tests…

You are willing and able to take part in all parts of the study, including memory and thinking tests, physical and brain exams, MRI scans, spinal fluid collection, genetic testing, and PET scans. Your thinking and memory are currently normal, based on specific screening tests used by the study team. Tests show that…

You must have confirmed evidence of amyloid beta (an Alzheimer's-related protein) in your brain, shown through a spinal fluid test or a special brain scan called an amyloid PET scan. You must have noticed your memory getting worse gradually over at least the 6 months before the study screening, and someone who knows…

You must have already completed one of two specific earlier studies called RETHINK-ALZ or REFOCUS-ALZ. You still show signs and symptoms that are consistent with Alzheimer's disease. You have a study partner (such as a family member or caregiver) who is available to take part alongside you.

The patient lives in the community (not in a care home or facility) and is able to get around. The patient has been diagnosed with Alzheimer's disease. The patient is between 50 and 95 years old. The caregiver is between 18 and 90 years old. The patient is currently receiving treatment for Alzheimer's disease. Both…

You can be a veteran or a non-veteran You must be between 50 and 89 years old You have either normal memory and thinking, mild memory problems (MCI), or early-stage Alzheimer's disease You speak English You are right-handed You have good enough vision and hearing to take part in tests You are willing and able to have…

People aged 18 to 55 who have been formally diagnosed with schizophrenia according to standard diagnostic criteria (DSM-5). People whose schizophrenia has been in a stable, non-acute phase for at least 8 weeks before joining the trial. People who have been taking a second-generation (atypical) antipsychotic medication…

People aged 18 years or older. People who are current or previous participants in the ADRC Clinical Core, the WRAP study, or other selected ADRC-affiliated studies (not including ADRC-affiliated industry-sponsored studies), or donors of special circumstance including healthy controls, if approved on a case-by-case…

People between the ages of 30 and 100. People who have already completed, or are planned to undergo, neurological assessments through the Mayo Clinic Study of Aging, the Mayo Alzheimer's Disease Research Center (ADRC), or the Mayo neurodegenerative disease clinics.

Participants must already be enrolled in the Dominantly Inherited Alzheimer's Network (DIAN) Performance Site study or the DIAN Extended Registry. Participants must be male or female and at least 18 years old. Participants must have either normal thinking and memory function, or only mild dementia, as determined by a…

People between the ages of 50 and 90 (inclusive). People who are able to provide basic information about themselves, including personal details, medical history, and contact information. People who agree to have a specific gene (APOE) tested as part of the study, with the understanding that the results will not be…

You have been diagnosed with one of the following conditions: a brain tumor, epilepsy, migraine, mild cognitive impairment (including concussion), mild traumatic brain injury, multiple sclerosis, neuropathy, Parkinson's disease, restless legs syndrome, or stroke. You are able to receive one of the three treatments…

People who are already enrolled in a study with the Alzheimer's Disease Research Center.

Adults aged 18 years or older. People who have a family history of Alzheimer's disease and either have no memory or thinking concerns, have noticed some changes in their memory or thinking (even if tests appear normal), have early signs of Alzheimer's disease before symptoms fully develop, or have mild memory and…

People who have a confirmed diagnosis of Alzheimer's disease dementia, based on established international medical guidelines (the NIA-AA criteria). People whose dementia symptoms began before the age of 65. People aged between 50 and 75 years old (this applies to both the patient group and the healthy comparison…

People who have already met all the requirements to be enrolled in the Dominantly Inherited Alzheimer's Network (DIAN) or DIAN Extended Registry (DIAN EXR) study. Men or women aged 18 years or older. People who are either cognitively normal or have mild dementia, as determined by a clinical assessment. People who are…

People who have been told by a doctor that they have subjective cognitive complaints (meaning they notice memory or thinking changes themselves) or Mild Cognitive Impairment (an early stage of noticeable memory or thinking difficulties). Adults who are 60 years of age or older, with no upper age limit. People who…

People who are male or female and over 45 years of age. People who are seen at a memory clinic or are taking part in an observational study. People who have a caregiver or family member available to assist and take part in the study. People who have been diagnosed as being on the Alzheimer's disease (AD) biological…

Adults between 50 and 90 years old, male or female, who are in good general health with no conditions expected to interfere with the study. People who are willing to take part in health and thinking/memory assessments, brain scans (MRI and PET), and to have blood and spinal fluid (CSF) collected for genetic and…

Primary care doctors, nurse practitioners, or physician assistants working at one of the three study locations within the VA health system who are able to complete goals of care conversation notes and orders. Clinicians who have at least 15 eligible patients without goals of care conversation notes at the start of the…

You self-identify as African American You are 50 years of age or older You live in the community (not in a nursing home or care facility) You are showing signs of mild to moderate dementia, based on a family caregiver's report and meeting standard medical criteria for probable Alzheimer's disease (confirm with trial…

People aged between 50 and 80 years old (inclusive). People who score 16 or above on a telephone-based memory and thinking test called the MoCA. People aged 50 to 64 who score 27 or above on a standard cognitive test called the MMSE, or people aged 65 to 80 who score 26 or above on the same test. People aged 50 to 60…

People who are cognitively healthy (no memory or thinking problems). Cognitively healthy people evaluated through the Northwestern Mesulam Center who have a Beck Anxiety Index (BAI) score greater than 8 (a measure suggesting at least a mild level of anxiety) (confirm with trial site).

People who may or may not have concerns about their memory, whether noticed by themselves, a family member, or a doctor People whose memory test scores fall within the normal range for their level of education, based on a standard memory test People who score between 24 and 30 on a standard thinking and memory…

People who took part in the original Diabetes Prevention Program study and are still living. For the Brain Imaging part of the study only: participants who are aged 55 or older and do not have any reasons that would prevent them from having an MRI scan (such as being unable to lie flat, having claustrophobia, or…

People who have been diagnosed with probable, early-stage Alzheimer's disease, including a condition called Mild Cognitive Impairment (MCI) affecting memory, based on specific 2018 diagnostic guidelines. People who score between 0.5 and 1.0 on a standard memory and thinking assessment called the Clinical Dementia…

People who are right-handed, as measured by a standard assessment called the Edinburgh Inventory. People who are able to attend the scheduled TMS (brain stimulation) sessions. People who have given their consent to take part in the trial. People who are independent in their day-to-day activities.

People who have been diagnosed with dementia. People who live in an assisted living community that is taking part in this trial. People who are not blind. People who are not currently in hospice care and in a declining condition. People who are not expected to pass away or move to another facility within the next 6…

You are between 50 and 90 years old (inclusive) You have been diagnosed with Mild Cognitive Impairment (MCI) or mild Alzheimer's dementia, confirmed by a spinal fluid test or a special brain scan that detects amyloid protein You have had recent cognitive (thinking and memory) tests within the past 3 months showing…

Men and women aged 50 or older who complete a cognitive assessment tool called the eSAGE as part of a routine appointment at the Center for Cognitive and Memory Disorders.

People aged 65 or older People whose medication doses have been stable for more than one month People who have gone through menopause People who have a Clinical Dementia Rating (CDR) score of 0, meaning no signs of memory or thinking problems on this particular scale (confirm with trial site) People who have a history…

A doctor or prior research has determined that the person is either cognitively normal or has mild cognitive impairment. The person has already had their Alzheimer's-related biomarker status tested — as of July 2023, this must have been done through either an amyloid PET brain scan or a cerebrospinal fluid (spinal…

People who are in good general health. People who have no active neurological or psychiatric conditions, or who had a past neurological or psychiatric condition but have fully returned to normal health. People who have no complaints about their memory or thinking ability (for the healthy comparison group). People…

Adults aged 70 to 80 years old who report that their thinking and memory are working well and that they can manage everyday tasks independently. People who score 26 or higher on a standard memory and thinking test called the MoCA (Montreal Cognitive Assessment). People who have an elevated level of a specific protein…

People who have successfully completed the ACP-204-006 study. People aged 55 to 95 years old; women must not be able to become pregnant, and men must use appropriate contraception if their partner could become pregnant. People who have a designated study partner or caregiver. People who are able to attend all required…

People who were randomly assigned to a group in the Hope Study (CA-0011) and completed the full 12 months of participation in that study. People who are not able to become pregnant, or who are using a reliable form of birth control. People who have a Study Partner (such as a family member or caregiver) who is…

People living with dementia who are eligible to receive Lecanemab infusions at the participating clinics. Care partners (such as a family member or carer) who provide care for a person living with dementia who is eligible to receive Lecanemab infusions at the participating clinics. People living with dementia and…

People who are experiencing possible mild memory or thinking problems that doctors need to investigate further, including those with mild memory concerns or very early-stage dementia. People who are 18 years of age or older. People who are fluent in English.

People who have been diagnosed with Alzheimer's Dementia. People who score above 14 on a standard memory and thinking test called the MMSE. People aged 65 or older. People who are not currently living in a care facility or institution. People who are able to walk at least 5 metres on their own, with walking aids such…

People who are able to read and write.

People aged between 50 and 90 years old. Both men and women are eligible. People who have been diagnosed with mild memory or thinking problems, or mild Alzheimer's disease. People who have tested positive for amyloid (a protein linked to Alzheimer's disease) through a spinal fluid test or a brain scan. People who meet…

People who belong to a family where Alzheimer's disease runs in the family (a known inherited form of the condition). People who are currently being assessed at a memory clinic and have been given a diagnosis of mild memory or thinking difficulties (mild cognitive impairment) or Alzheimer's disease. Older adults who…

People who are willing to sign and date a consent form agreeing to take part in the study. People who are willing to follow all study procedures and are available for the full duration of the study. People who are male or female, aged between 65 and 90 years old at the time of giving consent. People who have a…

People who have been diagnosed with Mild Cognitive Impairment (MCI) or mild Alzheimer's disease. People who have test results (such as a brain scan or fluid sample from around the spine) showing signs of amyloid protein buildup in the brain, which is associated with Alzheimer's disease. People who have already had a…

Participants must be right-handed. Participants must be monolingual native Italian speakers. Participants must be between 50 and 85 years old. Participants must have normal vision, or vision that is fully corrected with glasses or contact lenses. Participants must give written and verbal consent to take part in the…

People who have been diagnosed with Mild Cognitive Impairment (MCI), or who have not yet been diagnosed but are showing memory changes as measured by a test called the MoCA. People whose MoCA test score falls between 18 and 28 (inclusive). People aged between 55 and 80 years (inclusive). People who have a "study…

The trial is looking for former college or professional football players (around 225 people total), as well as people with no football background who will serve as a comparison group (around 75 people), and people with early-stage Alzheimer's disease (around 50 people). Former college football players must have played…

People aged between 60 and 85 years old. (For people with a diagnosed condition — "cases") People with a diagnosis of Alzheimer's disease dementia based on clinical assessment and supported by biological markers, such as results from a spinal fluid test or a specialised brain scan. (For people with a diagnosed…

People who have been diagnosed with Alzheimer's Disease based on biomarkers, brain imaging, and clinical symptoms. People aged between 50 and 85 years old (inclusive), male or female. People who have at least one caregiver who is able to live with them for an extended period of time. People who do not have severe…

People aged between 50 and 80 years old. People who have been diagnosed with Alzheimer's disease according to the 2024 diagnostic guidelines published by the National Institute on Aging and Alzheimer's Association (NIA-AA). People with moderate-to-severe memory and thinking problems, as measured by two standard…

People who score between 0.5 and 2 on a standard scale used to measure dementia severity (called the Clinical Dementia Rating scale). People who have been diagnosed with early Alzheimer's Disease, mild dementia, or mild cognitive impairment (MCI), or people who are a caregiver to someone with one of these diagnoses.…

People aged 50 years or older. People who have received a clinical diagnosis of early-stage Alzheimer's disease or mild cognitive impairment (a condition where memory or thinking skills are slightly reduced), based on recognised national research guidelines. People who are able to understand and agree to take part in…

People who have been diagnosed with a neurological disease that involves protein build-up in the brain, such as Alzheimer's disease and its variants, Parkinson's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis (ALS), Tauopathies, or other related neurological conditions. People who have a caregiver who…

This trial follows the same eligibility requirements as the Master Protocol (trial NCT06957418), and no extra joining requirements have been added beyond those.

Adults between 60 and 90 years old Men, or women who have gone through menopause Men who are able to father children may be eligible if they are willing to use the contraception methods described in the participant information sheet, during treatment and for 90 days after the last dose People who are able to give…

People aged between 50 and 90 years, whether currently staying in a hospital or attending as an outpatient. People who have been diagnosed with either mild memory-related cognitive impairment or mild dementia linked to Alzheimer's disease, based on specific 2018 diagnostic guidelines set by leading Alzheimer's…

People who have been diagnosed with either "Possible Alzheimer's Disease" or "Probable Alzheimer's Disease" according to the National Institute on Aging-Alzheimer's Association (NIA-AA) guidelines. People who have sleep problems, shown by either a score above five on a standard sleep quality questionnaire (called the…

People who are willing to give their informed consent to participate. People who are willing to follow all study procedures and are available for the full duration of the study. People who are at least 45 years old. People who are already enrolled in either the Wisconsin Registry for Alzheimer's Prevention (WRAP) or…

People who have been diagnosed with Alzheimer's disease. People who agree to have a brain scan, and for whom a MRI scan is considered safe. People who have at least 10 of their own teeth remaining. People whose memory and thinking test score (called an MMSE) is above 15, indicating some level of cognitive function is…

You are willing and able to give your agreement to take part in the study, or if you are unable to do so yourself, someone close to you (a consultee) can advise on your behalf You are male or female, aged 45 years or older You have been referred to a specialist, or could be referred, because of problems with memory…

Adults over 18 years old who are willing to give a blood sample. People who have completed a full clinical and psychological assessment. Brain imaging scans may be included if available and appropriate, but this is not required for everyone. Healthy volunteers who do not have a muscle or nerve disease diagnosis…

The person sees themselves as the main carer for an older adult (aged 65 or over) who has been admitted to Northwell's medicine service with Alzheimer's disease or a related dementia condition, and also has difficulty swallowing. The carer is aged 18 or older. The carer has been named as the patient's legal…

People who have mild cognitive impairment, shown by a score of 19 to 25 on a standard memory and thinking test called the MoCA. People who are still able to carry out everyday tasks on their own, such as managing finances, using the phone, or shopping. People whose doctor has assessed their mild cognitive impairment…

People who are Chinese, right-handed, and between 60 and 85 years of age. People who have been identified as having mild thinking and memory difficulties related to early Alzheimer's disease, based on a specific memory test called the MoCA, with a score between 22 and 26. People whose sleep is considered poor or…

Adults over 18 years old who are willing to give a blood sample. People who have completed a full clinical and psychological assessment. Brain imaging scans may also be used if available, though this is not required as it is not suitable for everyone. People without a muscle disease or neurological disease diagnosis…

People who have been diagnosed with mild cognitive impairment, early symptomatic Alzheimer's disease, Alzheimer's disease, or dementia where Alzheimer's disease is suspected. People who are at least 18 years old and have reached the legal age to consent to research procedures in the country or region where the study…

People who are able to give their informed consent to participate. People who have been diagnosed with mild cognitive impairment (MCI) or Alzheimer's disease dementia, confirmed using a specific classification system called A/T/N. Healthy controls (people without a cognitive diagnosis may also be eligible — confirm…

You are willing and able to sign a consent form agreeing to take part, or if you are not able to do this yourself, a trusted legal representative can sign on your behalf and you can show your agreement in another way. You have already completed the full double-blind treatment period of a specific earlier study…

People who have a confirmed diagnosis of a neurological condition, such as traumatic brain injury, cerebral palsy, brain injury caused by lack of oxygen, stroke, or another disorder affecting the brain or nervous system. People who have already received, or are planned to receive, a nose-delivered therapy using a…

People who have at least one positive Alzheimer's-related biomarker test result, such as a specific blood test (plasma p-tau217), a brain imaging scan (amyloid PET), or a spinal fluid test showing abnormal protein ratios — as defined by 2024 Alzheimer's Association diagnostic criteria. People aged between 50 and 75…

You are over 45 years old Czech is your native language You meet certain requirements based on a questionnaire about your history of brain injuries, mental health background, and any medications you take (confirm with trial site) Your answers on mood questionnaires fall within the normal range You have been diagnosed…

People aged 65 years or older People who are active participants in a related study called SHUTi MIND (UVA IRB-HSR 220077) People who live in the United States People who are able to read and speak English People who use a computer and the internet, including email, at least twice a week and are willing to continue…

People who have been referred by their doctor for a standard PET scan as part of their usual medical care, for one of the conditions covered by this trial.

People aged between 50 and 75 years old (inclusive). People whose native language is Spanish. People who have been diagnosed with a mild memory-related condition linked to early Alzheimer's disease, confirmed through a spinal fluid test or a special brain scan that detects amyloid (a protein associated with…

People who are right-handed and of Han ethnicity. People who have been diagnosed with Alzheimer's disease according to the standard DSM-5 diagnostic criteria. People who are aged 60 or older, have completed at least primary school education, and are able to cooperate during testing. People who score below 24 on the…

People who have been diagnosed with Alzheimer's disease according to standard psychiatric diagnostic guidelines, with a memory and thinking test score between 5 and 25 out of 30. People who are already receiving standard Alzheimer's disease treatment as recommended by German national medical guidelines. People who are…

A person must have been diagnosed with Alzheimer's disease using the official diagnostic guidelines set by the National Institute on Ageing and the Alzheimer's Association. A person must be between 60 and 75 years of age. A person must have scored between 20 and 26 on a standard memory and thinking test called the…

People who have been newly diagnosed with Alzheimer's disease (AD) and have been referred to a specialist memory centre. People who have a diagnosis of probable or possible Alzheimer's disease, based on recognised medical diagnostic guidelines. People whose Alzheimer's disease is at a mild to moderate stage, shown by…

People who are 18 years of age or older. People who are able to attend follow-up visits, or can at least participate by phone or email. People who are able to understand the study plan and agree to take part voluntarily. People living with one of the following conditions: Arthritis (including Degenerative, Rheumatoid…

People who speak Mandarin. People who do not have clinical dementia. People whose scores on two memory and thinking assessments (called the MMSE and CDR) meet the required levels for this trial. People who carry specific variations in four particular genes (rs3777215, rs234434, rs71352238, and rs4420638) — (confirm…

People who speak Mandarin. People who have not been diagnosed with dementia. People whose scores on two memory and thinking tests (called the MMSE and CDR) meet the specific levels required by the trial. People who have low levels of certain proteins in their blood that are linked to brain cell activity (specifically…

The person has completed at least primary school education. The person has been diagnosed with probable Alzheimer's disease dementia based on recognised medical guidelines (NIA-AA criteria). The person has had a brain MRI scan during the screening period that matches an Alzheimer's disease diagnosis (a CT scan may be…

People who have been clinically diagnosed with Alzheimer's disease using internationally recognised diagnostic guidelines (the IWG criteria), confirmed at the screening visit. People whose score on a daily living activities scale (called the ADCS-ADL) is below 73 at both the screening and baseline visits. People whose…

People who have been diagnosed with mild to moderate Alzheimer's disease using established diagnostic guidelines, and who have had a brain scan (amyloid PET) showing positive results for amyloid protein. People who are between 50 and 85 years of age, either male or female. People whose cognitive testing scores fall…

People of any gender or ethnic background who are aged 60 or older and permanently live in the Tianma area of SheMountain Town, Songjiang District (suburbs), Shanghai. People who agree to have information collected about them, including results from brain and behaviour assessments, biological samples (such as blood)…

Adults who have been diagnosed with Alzheimer's disease, related dementias, mild cognitive impairment, Parkinson's disease, or multiple sclerosis, as recorded in their electronic health record. Adults who are being diagnosed and treated for one of the conditions listed above and are invited to take part. People who…

You have scored between 14 and 24 on a standard memory and thinking test called the Mini Mental State Exam (MMSE) A doctor has diagnosed you with probable Alzheimer's disease using recognised medical guidelines You have had a brain MRI scan within the last 12 months that is consistent with an Alzheimer's disease…

People who meet recognised research criteria for mild cognitive impairment or Alzheimer's disease, with brain biomarkers that strongly suggest Alzheimer's-related changes. People aged 45 to 70 years old. People who show certain types of unusual electrical brain activity (epileptic activity and/or specific…

Participants must be English-speaking and between 60 and 85 years old. Participants must score 22 or higher on a telephone-based memory and thinking test (T-MMSE) at the screening stage; if this score drops below 18 during the study, participation would be stopped. Participants must show signs of a mild memory…

People aged 60 years or older. People who are patients within the Mass General Brigham healthcare system. People who have been diagnosed with mild cognitive impairment or dementia that is no more severe than mild-moderate. People whose discharge plan includes being referred to home care services after leaving…

Volunteers aged 55 or older who can hold a conversation in English and read English. Staff members who are at least 18 years old, work at a residential care facility taking part in the study, and can speak and read English.

People aged between 50 and 85 years old, either male or female. People who have completed at least primary school education, have normal hearing, vision, and speech, and use Mandarin Chinese as their everyday language. People who have been diagnosed with Alzheimer's disease (AD) or mild cognitive impairment (MCI)…

People who are outpatients (not currently staying in hospital) of either sex. People aged 50 to 89 years old at the time of screening. Women must have had a surgical procedure to prevent pregnancy (such as tubal ligation, removal of the ovaries, or removal of the uterus), or must have been through menopause for at…

People who have been diagnosed with anxiety, schizoaffective disorder, bipolar disorder, ADHD, dementia, or other psychological conditions, OR autoimmune conditions such as fibromyalgia, lupus, or thyroid disease, OR neuropathy or chronic fatigue syndrome People who are able to swallow tablets

People aged 18 or older, of any gender People who are covered by, or are a dependent under, a social security scheme People who have been fully informed about how the study works and have signed a consent form agreeing to take part People whose medical care already requires a lumbar puncture (a procedure to collect…

People aged 60 to 85 years old, of any gender, who live independently in the community in the Yuyuan area of Shanghai. People who have not been diagnosed with Alzheimer's disease. People who are able to complete memory and thinking tests, provide biological samples (such as blood), take part in speech tests, and…

Adults aged over 60 years old who have been diagnosed with Alzheimer's dementia People who score less than 24 on a memory and thinking test called the Korean Mini-Mental State Examination (K-MMSE) People who score 0.5 or higher on a scale used to measure dementia severity, called the Clinical Dementia Rating (CDR)…

People aged 55 to 85 years old (inclusive) at the time of signing the consent form. People who have noticed memory concerns themselves, or whose family member, carer, or doctor has noticed memory concerns on their behalf. People who score between 24 and 30 (inclusive) on a standard memory and thinking test called the…

People who are 65 years of age or older. People who have had an initial RAI-HC assessment completed (this is a type of care needs assessment — confirm with trial site if unsure whether one has been done). People who attend an adult day program (this applies to the first group in the trial). People who receive any…

People who are between 50 and 90 years of age at the time of screening. People of any gender (male or female). People of any racial or ethnic background. People who are willing and able to provide written consent to participate. People who are available for the full length of the study. People who can speak, read, and…

People aged between 50 and 85 years old. People who scored 23 or lower on a Korean-language memory and thinking test called the K-MMSE. People who had a positive brain scan (called an 18F-Florbetaben PET scan) showing signs of Alzheimer's-related changes. People who have been diagnosed with either mild memory and…

People who meet the 2023 Alzheimer's Association revised diagnostic criteria for Alzheimer's disease. People who meet the 2023 International Psychogeriatric Association (IPA) definition of agitated symptoms related to cognitive impairment. People who score 45 points or more on a standardised agitation assessment tool…

People who have been diagnosed with Alzheimer's disease according to the NIA-AA standard diagnostic guidelines. People whose dementia has been rated as mild to moderate or less, based on a standard clinical assessment scale called the Clinical Dementia Rating Scale (a score of 2 points or lower). People who are…

People who are over 50 years of age. People who have been diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD). People whose score on a standard memory and thinking test (called the MMSE) falls between 12 and 26. People whose score on a scale used to assess stroke-related thinking problems (the…

People who have been diagnosed with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI). People who had a spinal fluid sample (lumbar puncture) taken as part of their diagnosis process. People who are 80 years old or younger. People who scored 24 or above on a standard memory and thinking test called…

People between the ages of 55 and 70. People who have been diagnosed with major depressive disorder or bipolar disorder (type I or type II), either currently or at some point in the past, according to standard psychiatric diagnostic guidelines (DSM-5). People who have read and signed an informed consent form before…

People who have been diagnosed with Mild Cognitive Impairment (a mild level of memory or thinking problems), rated at a specific level on a standard medical scale (CDR 0.5) People who have been diagnosed with mild Alzheimer's Disease, rated at either of two specific levels on a standard medical scale (CDR 0.5 or 1)

People who have been clinically diagnosed with Alzheimer's Disease. People who are between 18 and 80 years old. People who have signed a form giving their informed consent to take part.

The person joining must sign an informed consent form agreeing to take part. People who are able to lie still inside an MRI scanner for at least one hour. People with no current or past history of drug or alcohol abuse. People who are not taking any medications that interfere with thinking or memory. People with…

The diagnosis of Alzheimer's dementia must have been confirmed by at least two senior physicians (at the level of deputy chief physician or above), using recognised diagnostic guidelines (DSM-5). Participants must be between 18 and 80 years old. The person must have been living with the condition for at least one…

People who are informally caring for someone with mild or moderate Alzheimer's disease People who are the main (primary) caregiver for that person People who have been providing care to that person for at least six months People who provide care for at least six hours each day People who are able to read and write…

People aged between 60 and 90 years old (male or female). People who have come to the Department of Psychiatry at St. Vincent's Hospital with memory or thinking problems as their main concern. People who are able to have brain imaging scans, including a brain MRI and an amyloid PET CT scan. People who are able to…

Adults aged 60 or older, both male and female. People who meet the National Institute of Aging and Alzheimer's Association (NIA-AA) criteria for Mild Cognitive Impairment (MCI) — a condition involving mild memory or thinking changes — and who have had a brain scan (amyloid PET) showing a positive result for amyloid…

Men and women between 21 and 80 years of age People with a body mass index (BMI) between 18.5 and 30 (a measure of body weight relative to height) People who have test results confirming the presence of Alzheimer's-related proteins in the brain (detected through brain scans, spinal fluid, or blood tests) People who…

People who have been diagnosed with dementia caused by Alzheimer's disease, according to the 2024 guidelines set by the National Institute on Aging and the Alzheimer's Disease Association. People who are male or post-menopausal female, aged between 50 and 90 years old (inclusive), and who have completed at least…

The person has given their informed consent by reading and signing the relevant forms. The person is older than 55 years of age. The person has been assessed as having Mild Cognitive Impairment (MCI), meaning they show changes in memory or thinking based on a video screening that includes a clinical interview and…

People aged 65 years or older. People who have been formally diagnosed with Alzheimer's disease or a related condition, at a mild to moderate stage (confirmed through a standard memory and thinking test score of 15 or more out of 30). People who regularly attend the day hospital at Charles Foix Hospital. People who…

People who have been diagnosed with mild Alzheimer's disease within the past year. People who are willing to give their consent to take part in the study, in line with internationally recognised ethical guidelines for research. People who are not currently taking part in another clinical trial that could affect the…

Adults aged between 18 and 75 years old, either male or female. People who have been receiving treatment for mild cognitive impairment at the Nancy CHRU CMRR memory centre for between 1 and 2 years. People who are covered by, or eligible as a beneficiary of, a social security scheme. People who have been fully…

You are 50 years old or older You have been diagnosed with probable Alzheimer's disease based on recognised medical guidelines You scored between 10 and 24 on a standard memory and thinking test called the Mini-Mental State Examination at the screening and baseline appointments You scored 7 or below on a standard mood…

People aged 50 to 90 years old, of any gender. People who have been diagnosed with Alzheimer's disease according to the 2011 NIA-AA clinical diagnostic criteria. People whose score on a standard memory and thinking test (called the MMSE) falls between 12 and 26. People who have completed at least primary school…

People aged between 55 and 85 years old. People who have been diagnosed with mild to moderate Alzheimer's disease, based on recognised international diagnostic guidelines. People whose score on a standard memory and thinking test (called the MMSE) falls between 10 and 24 out of 30. People who show signs of difficulty…

People aged between 50 and 85 years old, either male or female. People who have completed at least primary school education, have normal hearing, vision, and speech, speak Mandarin as their daily language, and are able to complete the information collection required by the study. People who have been diagnosed with…

Adults aged 55 to 85 years old at the time of signing the consent form. People who have been diagnosed with Mild Cognitive Impairment (MCI) or mild Alzheimer's disease, based on the NIA-AA 2024 diagnostic guidelines. People whose score on the CDR Global Scale (a standard measure of dementia severity) falls between 0.5…

A doctor has diagnosed the person with probable Alzheimer's disease of mild to moderate severity, based on recognised medical diagnostic guidelines. The person is aged 50 or older. The person has adequate vision, hearing, language, and physical ability to complete study assessments (hearing aids and glasses are…

People aged between 50 and 85 years. People who have recently received their first diagnosis of probable Alzheimer's disease dementia or Alzheimer's-related mild memory and thinking difficulties, based on recognised diagnostic guidelines. People who scored between 22 and 30 on a standard memory and thinking test…

People who feel their memory or thinking has gotten worse compared to before, but whose results on standard cognitive tests are still normal for their age, sex, and education — and where no medical condition, mental health issue, medication, or substance use explains the change, and daily life is not affected. People…

People who are 18 years of age or older. People with severe or profound hearing loss (a loss of 70 decibels or more). People whose main language is French Sign Language. People who are able to give written consent after receiving a clear explanation of the study. People who are covered by the French national health…

The person has given their documented agreement to take part in the study procedures. The person is between 35 and 50 years of age (inclusive). Blood test results at screening show a protein level (phosphorylated tau 217) consistent with what is required for amyloid brain scan eligibility. The person has a confirmed…

Older adults living in the care setting who are physically able to use a rehabilitation pedalling bike.

A relative, friend, or partner aged 18 or older who has a personal relationship with a Veteran and regularly helps them with care or organising their care Living in a rural area, based on official rural classification codes (Rural-Urban Continuum Codes) Must be enrolled in the VA's General Caregiver Support Services…

People aged 50 to 90 years old at the time of signing the consent form. The person joining the trial (or their legal representative) and their caregiver must both sign a consent form agreeing to take part. There must be a caregiver — an identified adult who knows the person well enough to report on their thinking…

People who are 18 years of age or older People who are willing to take part in the study People who are a member of the Denizli Alzheimer Association People who have completed at least primary school education People who are able to communicate effectively People who have been providing primary care to someone…

People aged between 50 and 80 years old. People who have been diagnosed with Alzheimer's disease, frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), or Parkinson's disease dementia (PDD), based on specific established diagnostic guidelines for each condition. People whose scores on standard memory and…

Adults between 55 and 85 years of age. People who have been diagnosed with stage 3 Alzheimer's disease (also called Alzheimer's-related mild cognitive impairment). People who have been diagnosed with stage 4 Alzheimer's disease (also called mild Alzheimer's disease). People who are able to give their own consent to…

The person is aged 60 years or older The person is currently living in a nursing home The person has been diagnosed with an advanced-stage neurocognitive disorder (such as advanced dementia) The person has scored below 10 on a standard memory and thinking test called the MMSE, indicating severe cognitive decline The…

People who are members of a family known to carry the PSEN1 E280A genetic mutation. People who agree to undergo genetic testing as part of the trial (including testing for genes such as APOE and PSEN1 E280A, as permitted by local rules). People aged 25 to 65 years (male or female). People whose thinking and memory are…

People who have been diagnosed with early Alzheimer's disease dementia at a specific stage (known as GDS stage 4), based on recognised medical diagnostic guidelines. People who score between 15 and 20 on a standard memory and thinking test called the Mini-Mental State Examination, which reflects a moderate level of…

People aged between 60 and 85 years. People who have been diagnosed with Mild Cognitive Impairment (MCI) — a condition involving mild memory or thinking changes — based on specific medical criteria, with a rating of 0.5 on a standard memory assessment scale called the CDR. People who have been diagnosed with mild…

People who have been fully informed about the study and have not objected to taking part or to their data being used (and, where a legal guardian is involved, that guardian has also been informed and has not objected). People aged between 25 and 65 years old. People who have a record of intellectual disability in…

People who speak French at a near-native level, as the memory and thinking tests are conducted in French. People who are compatible with MRI scanning, meaning they have no metal implants, vascular clips, certain orthopaedic hardware, pacemakers, other stimulators, cochlear implants, or any other electronic devices in…

Adults aged 18 or older, of any gender. People who have been diagnosed with Alzheimer's disease based on a specific set of recognised diagnostic guidelines (known as NIA-AA criteria). People who have already received a treatment called DC-LVA. People who have given their written agreement to take part, either…

The person has been clinically diagnosed with Alzheimer's disease and has a moderate to severe score on a cognitive function assessment. The person is between 30 and 80 years old. Both males and females are eligible. The person or their family member has agreed to take part in the trial and has signed a consent form.…

Older adults may be considered for this trial.

People aged 55 years or older. People who have not been diagnosed with Alzheimer's disease. People who are able to complete memory and thinking tests, provide body fluid or tissue samples, undergo brain scans, and take part in all parts of the study from start to finish. People who have signed a form agreeing to take…

People who are willing to volunteer for the trial, and who (or whose legal guardian) have signed a consent form agreeing to take part. People of any gender aged between 18 and 75 years old (inclusive). People who have been diagnosed with Alzheimer's disease and have had a positive amyloid PET scan (a type of brain…

Adults between 18 and 75 years old. Healthy male volunteers who weigh at least 50 kg, or healthy female volunteers who weigh at least 45 kg, with a body mass index (BMI) between 19.0 and 28.0 kg/m². People who have been clinically diagnosed with a cognitive disorder such as Alzheimer's disease or mild cognitive…

People who are a family member, friend, or neighbor who consider themselves the main carer for someone with memory loss People who are older than 21 years of age People who are able to use an internet-connected device such as a computer, tablet, or smartphone, and have reliable internet access People who have been…

People who have been formally diagnosed with Alzheimer's disease based on established 2018 or 2021 medical diagnostic guidelines. People who have had at least two memory/cognitive assessments taken at least 12 months apart. People who have been receiving ongoing care at the Memory Clinic of CH Gonesse.

People who are 55 years of age or older. People who are able to walk without using a walking aid such as a cane, walker, or crutches (this is assessed by completing a specific walking test without any assistive device). People who are able to understand and agree to take part in the study, or who have a legally…

People whose memory and thinking abilities score between 16 and 25 points on a standard cognitive test called the Mini Mental State Examination (MMSE). People whose spinal fluid (the fluid around the brain and spine) shows specific levels of two proteins linked to Alzheimer's disease: β-Amyloid1-42 at 1030 pg/ml or…

People who have been diagnosed with dementia. People who use a 4-wheeled walker. People who are 65 years old or older. People who are able to understand and speak Turkish. People who have completed at least middle school education. People who are able to follow instructions and act on them. People who are able to walk…

Men and women (who are not pregnant or breastfeeding) between 40 and 65 years old who are generally in good health People with a body mass index (a measure of body weight relative to height) between 18.0 and 32.0 People with no significant health problems found during a medical check-up, blood tests, heart tracing…

People who have been diagnosed with Mild Cognitive Impairment (MCI) or mild-to-moderate Alzheimer's Disease, confirmed by specific clinical assessment scores and a brain scan showing the presence of amyloid protein deposits. People of any gender (male or female). People aged between 50 and 85 years old (inclusive).…

People whose first (native) language is French. People who are unpaid carers (such as a family member or close friend) for someone living at home with a neurodegenerative condition affecting memory or thinking, who do not have memory complaints themselves, and whose results on all tests in the diagnostic battery are…

People who are aged 60 years or older People who have been diagnosed with mild-stage Alzheimer's disease, based on recognised medical diagnostic standards People whose score on a standard memory and thinking test (called the MoCA) falls between 10 and 25, which suggests enough thinking ability to take part in the…

People who are 60 years of age or older. People who have been diagnosed with mild or moderate Alzheimer's disease. People who have enough physical and mental ability to take part in art therapy sessions. People who are able to give informed consent to participate.

People aged 50 or older, male or female, who show signs of one of the following conditions: Lewy body disease (a brain condition affecting thinking and movement), diagnosed using recognised medical guidelines and supported by specific brain scans and other tests where needed. People diagnosed with Alzheimer's disease…

People who are able to understand and agree to take part in the study (give informed consent). People who have someone in their life who can act as a reliable study partner and stay in regular contact with them throughout the trial. People who have been clinically diagnosed with Mild Cognitive Impairment (MCI) or…

People aged 50 or older, reflecting the age group most likely to have Alzheimer's Disease as the cause of their dementia. People who score between 3 and 5 (inclusive) on the Global Deterioration Scale, a tool doctors use to measure the stage of memory and thinking decline. People who score between 1 and 2 on the…

People aged 50 years or older at the time of signing consent forms. People who have been diagnosed with Alzheimer's disease using recognised international diagnostic guidelines, confirmed by a specific blood test result (plasma ptau217 at or above 0.471 pg/mL). People whose memory and thinking abilities fall within a…

People who have been diagnosed with mild cognitive impairment (MCI), which is a noticeable but mild decline in memory or thinking skills. People between the ages of 18 and 85 years old. People who, or whose close contacts, have noticed and reported problems with memory or thinking. People whose cognitive testing…

People who are older than 65 years of age and no older than 85 years of age at the time of enrolment. People who have had at least one year of formal education. People whose memory and thinking are currently normal, based on a standard cognitive test score — the required score depends on education level (confirm with…

The person must be able to understand and agree to take part in the study (give informed consent). There must be someone in the person's life who can act as a reliable study partner and has regular contact with them. The person must have a diagnosis of Alzheimer's disease based on the revised NIA-AA guidelines. The…

People aged over 50 years People who are fluent in Danish People who have completed at least 7 years of schooling People who have been diagnosed with either mild cognitive impairment (MCI) or Alzheimer's disease (AD) at the SUH memory clinic within the 6 months before joining the trial People aged over 50 years People…

People aged 45 to 85 years old People who have been diagnosed with mild to moderate Alzheimer's disease People whose Alzheimer's disease has been assessed as stage 4 or 5 on the Functional Assessment Staging Test (FAST) — a scale used to measure how the disease is progressing (confirm with trial site) People who score…

People who have been diagnosed with Alzheimer's disease, with the diagnosis confirmed using an approved test that detects Alzheimer's-related changes in the brain. People who have already received the Alzheimer's treatment lecanemab (brand name Leqembi®) at the standard dose, and have completed at least 14 infusions…

People aged 18 to 30 years old, or 65 to 80 years old People with normal vision, or vision that is fully corrected (for example, with glasses or contact lenses) People who are fluent in English

People aged between 50 and 90 years, whether currently in hospital or attending as outpatients. People who have been diagnosed with early-stage Alzheimer's-related memory problems (either mild cognitive impairment or mild dementia) based on recognised 2018 diagnostic guidelines. People whose memory and thinking test…

People aged 60 to 89 years old who have been living in Reunion for more than 5 years, are able to understand test instructions, are available for a one-hour interview, are enrolled in a social security scheme, and have given their consent to take part. People aged 60 to 89 years old who have been living in Reunion for…

Family members of someone who was diagnosed with Alzheimer's disease by a specialist doctor, where that person has since passed away, and the family member lived with or cared for them until the end of their life, and has agreed in writing to take part. Family members of someone currently diagnosed with Alzheimer's…

People aged between 65 and 85 years old. People who have been diagnosed with mild or moderate Alzheimer's disease. People who are able to speak, read, and understand English. People who have a carer, partner, friend, or family member available to help remind them to take the trial shots twice a day.

Adults who are 50 years of age or older. People who have lived in the local community for at least one year and have existing medical records there. People who report no history of memory or thinking problems (such as mild cognitive impairment, dementia, or Alzheimer's disease) and have not used medications prescribed…

Men and women between 18 and 40 years old (inclusive) at the time of signing the consent form. People with a body weight of at least 50 kg (for men) or at least 45 kg (for women), and a body mass index (BMI — a measure based on height and weight) between 19.0 and 26.0. People who agree to use contraception as required…

People who consider themselves a caregiver for someone with Alzheimer's disease or a related form of dementia who lives at home People who live in the specific area targeted by this study People who have a cell phone and are willing to receive text messages from the study team People who have an email address where…

People who have been diagnosed with dementia according to internationally recognised diagnostic standards (such as DSM-5 or NINCDS-ADRDA guidelines) People whose diagnosis was made through clinical assessment, memory and thinking tests, and other relevant examinations People aged 50 years or older who currently live…

People aged between 50 and 75 years, of any gender. People who have been diagnosed with moderate-to-severe obstructive sleep apnea (a condition where breathing repeatedly stops during sleep) through an overnight sleep study, with a breathing disruption score of 15 or more events per hour. People whose memory and…

People who are already taking part in a specific related research study called 'Decision Making and Implementation of Aging-in-Place/Long Term Care Plans among Older Adults' (R01AG058777) People aged 65 years or older People who speak English People who pass a standard assessment that checks whether someone can…

The person must have already completed an earlier part of this research (a single-dose study called Protocol RB-ADSC-02). The person, or someone legally authorised to decide on their behalf, must have signed a form agreeing to take part in this extension study. The person must have a family member or carer who is able…

People who are between 55 and 75 years old at the time of screening. People who are fluent in German. People who are able and willing to sign a written consent form before any study activities begin. People who own a compatible Android smartphone, or who are willing and able to use a smartphone provided by the study…

People who are over 50 years of age. People who have been diagnosed with mild cognitive impairment (MCI) related to Alzheimer's disease, based on recognised international guidelines (NIA-AA, 2024). People who score between 22 and 30 on a standard memory and thinking test called the MMSE (exceptions may apply for…

People aged 65 years or older People where a doctor suspects they may have mild cognitive impairment (MCI) or early Alzheimer's disease People who are alert, aware of their surroundings, and able to answer questions People who are willing and able to wear a monitoring device for 30 days People who have signed the…

People who are 55 years of age or older. People who have noticed possible signs of memory or thinking changes themselves, or whose family members or partners have noticed such signs. People who are able to understand and agree to participate in the trial on their own. People who are fluent in English, can read and…

People diagnosed with Mild Cognitive Impairment (MCI), Alzheimer's disease, or who have no memory or thinking problems, and who were referred from a Wisconsin clinic in the Wisconsin Alzheimer's Institute network or recruited from the community. People who may have previously taken part in one of these studies: the…

People who are 18 years of age or older People who consider themselves to have moderate to good English fluency (self-rated) People who are willing to take part in activities involving people living with dementia

People who have been diagnosed with mild cognitive impairment (MCI) or early dementia, or who have noticeable memory changes shown on a standard memory test called the MoCA (even if not yet formally diagnosed). People whose score on the MoCA memory test falls between 10 and 28 (inclusive). People aged between 50 and…

People who were 50 years of age or older at the time their brain scans were taken. People who had a specific type of brain scan called an amyloid PET (using a tracer called Florbetaben or Flutemetamol) performed for a clinical reason between January 1, 2025 and December 31, 2025. People who also have a structural…

People aged 60 or older who live in one of the four participating communities in rural areas of Phu Tho province, where each community is at least 10 km apart from the others. People where either the person themselves, a caregiver, or a healthcare provider has expressed concern about mild memory or thinking problems…

People aged between 60 and 79 years old People who are able to walk on a treadmill at their own comfortable pace for at least 30 minutes, with short breaks if needed People who have at least one risk factor for blood vessel or heart-related conditions, such as high blood pressure or high cholesterol People who have a…

People who are willing and able to give their informed consent to take part in the study. People aged between 30 and 90 years old. People who have been diagnosed with early Alzheimer's disease, including mild memory and thinking problems (MCI) or mild dementia. People whose score on a standard memory and thinking…

People who have been formally diagnosed with Alzheimer's Disease by both a neurologist and a psychiatrist at the hospital. People whose brain scan (called an Amyloid-PET scan) has come back positive, showing a build-up of amyloid plaques in the brain. People who are willing to sign a consent form, or who have a legal…

A person must have a confirmed diagnosis of Alzheimer's disease, shown through brain imaging or body fluid tests that detect the abnormal proteins amyloid-beta and tau. The Alzheimer's disease must be at a mild stage, measured by standard rating scales (CDR score of 1 or lower, or QDRS score of 8 or lower). A person…

Adults aged 18 years or older. People who are admitted to the Medicine, Surgery, or Neurology Intensive Care Unit (ICU) wards at Al-Basrah Teaching Hospital or Al-Fayhaa General Hospital. People who have been in hospital for at least 48 hours, to allow for baseline nutrition and medication assessments. People with a…

People who have mild memory or thinking difficulties, self-reported memory concerns, or normal thinking and memory abilities. People who have evidence of Alzheimer's-related changes in the brain, shown through a brain scan (PET scan) or through testing of fluid from the spine or blood. People who score 24 or higher on…

People who are willing to take part and sign a consent form agreeing to participate. Men or women between 18 and 65 years old (inclusive). People who are in good health, confirmed by a medical check-up. People whose body mass index (BMI) falls between 19 and 28 kg/m² (a standard measure of body weight relative to…

People who have been diagnosed with mild cognitive impairment (MCI) or early Alzheimer's disease, confirmed by a specific brain scan showing signs of Alzheimer's-related changes in the brain. People of any gender (male or female). People aged between 50 and 85 years old. People who are not currently taking part in any…

People aged between 50 and 75 years old at the time of signing the consent form, who have no cognitive impairment. People who are interested in taking part, are able to follow the study procedures, and understand that all tests are being done for research purposes. People who are willing to take part in all study…

People who have not previously been diagnosed with mild cognitive impairment (MCI) or Alzheimer's disease. People who have a visit with their primary care doctor scheduled within the next 4 to 6 weeks. People who feel they have been experiencing problems with their memory or thinking. People who score 26 or higher on…

People who have been diagnosed with amnestic Mild Cognitive Impairment (a type of early memory difficulty) using recognised international guidelines, and who have a positive result on a specific blood test measuring a protein linked to Alzheimer's disease (called plasma p-tau217). People who have been diagnosed with…

People aged 65 or older who live in Italy People with no memory or thinking problems (considered cognitively healthy) People who feel they have memory problems but have no formal diagnosis (subjective memory complaints) People who have been diagnosed with mild cognitive impairment (MCI) — a condition where there are…

People who are 18 years of age or older People who currently work as a community health worker or in a role related to community health work People who are able to read and understand English People who have access to the internet and a device such as a computer, tablet, or smartphone to complete online training and…

Men or women who have gone through menopause, aged between 50 and 75 years. People who have been diagnosed with probable Alzheimer's disease dementia based on established 2011 diagnostic guidelines. People whose Alzheimer's symptoms began at age 65 or younger. People who score between 5 and 20 on a specific cognitive…

People aged 65 or older who live at home or in an assisted living facility and came to the emergency department after a fall that happened within the last seven days The fall was not caused by fainting, being hit by a car, an assault, or being intoxicated The fall was not caused by a serious medical event such as a…

People who have been diagnosed with Alzheimer's disease according to a standard international classification system (ICD-10) People who are able to understand what the study involves and agree in writing to take part People who have early-onset Alzheimer's disease People who are older than 50 years of age People who…

People who voluntarily agree to take part and sign a written consent form before any trial activities begin. Healthy men and women between 18 and 55 years of age (inclusive). People whose body mass index (BMI) falls between 18 and 32 (inclusive) and who weigh at least 50 kg. People whose heart tracing test (ECG) comes…

The trial is open to two types of participants: people living with a chronic condition or cognitive impairment (and their caregivers). A score of 10 or higher on a standard sleep problem questionnaire (called the Insomnia Severity Index) is required. Participants must have trouble falling asleep, staying asleep, or…

Adults aged 50 to 90 years (inclusive) People whose first language is French People covered by or entitled to a social security scheme People who have been informed about the trial and have not objected to taking part Adults aged 50 to 90 years (inclusive) People whose first language is French People receiving memory…

A doctor has confirmed the person is amyloid-positive, based on a brain scan (amyloid PET), a past spinal fluid test, or a blood test measuring a protein called pTau-217. The person is 18 years of age or older, of any gender, race, or ethnicity. Women under 60 will be asked about their menopause status and may need to…

People aged 20 years or older. People with a Clinical Dementia Rating (CDR) score of 0.5 — this is a scale used to measure mild memory and thinking changes, and a score of 0.5 indicates very mild impairment (confirm with trial site). People for whom a doctor has determined that treatment with Ginkgo biloba extract is…

People who are participating voluntarily and have signed a consent form agreeing to take part. People who have completed at least junior high school and are able to complete memory and thinking tests as required by the study. People who meet the official 2024 diagnostic criteria for mild cognitive impairment (MCI) set…

People aged between 50 and 85 years old. People who have been diagnosed with Alzheimer's disease by a qualified neurologist using 2024 diagnostic guidelines, confirmed by at least one abnormal biological marker (such as a brain scan or blood/fluid test showing signs of Alzheimer's). People whose score on a standard…

People aged 55 years or older. People who have had a brain MRI scan available from a previous appointment (if the scan is more than 6 months old or not suitable, a new scan will be arranged). People who are able to tolerate a PET scan and are willing and able to follow all the steps required by the study. People who…

Men, or women who have not had a menstrual period for at least 12 months in a row (not due to medication), aged 60 to 85 years at the time of signing the consent form. Men who are sexually active with a partner who could become pregnant must be willing to follow the trial's contraception requirements and agree not to…

Native French speakers. People who are able to move around independently at least within their neighbourhood (based on a mobility assessment called the LSA-F). People who are enrolled in, or covered by, a French social security system. Patients in Subgroup A1 and healthy volunteers in Group C: people who have been…

People who have been diagnosed with probable Alzheimer's disease that is classified as mild to moderate, based on a standard memory and thinking test score between 0 and 24. People whose Alzheimer's disease has been confirmed through blood or brain scan tests showing specific biological markers related to the disease…

People who are family caregivers of someone with Alzheimer's disease. Family caregivers who live in the same home as the person with Alzheimer's disease and are their main carer. The person with Alzheimer's disease must be enrolled in one of the adult day care centres where the study takes place. People who are able…

People who are current 23andMe Research participants and have tested positive for the APOE4 genetic variant People who are between 60 and 80 years old at the time of signing the consent form People who have access to an Android or Apple iPhone smartphone and are able to download study apps People who live in the…

People who have been diagnosed with Subjective Cognitive Decline (SCD) — a condition where a person feels their memory or thinking has gotten worse compared to before, based on recognised international diagnostic guidelines. People who have noticed a persistent decline in their own memory or thinking ability compared…

People aged between 50 and 80 years old, male or female. People who have been clinically diagnosed with moderate probable Alzheimer's disease based on recognised diagnostic guidelines (NIA-AA criteria). People whose score on a standard memory and thinking test (called the MMSE) falls between 10 and 20 out of 30 at the…

People who have been diagnosed with probable Alzheimer's disease based on recognised 2011 and 2018 medical diagnostic guidelines, including specific biological markers that confirm the condition. People aged 50 to 80 years old at the time of signing the consent forms. People with severe memory and thinking problems…

People aged between 50 and 85 years old who have Alzheimer's disease. People who have been diagnosed with mild to moderate stage Alzheimer's disease.

The patient or their legal guardian is willing and able to sign a consent form agreeing to take part People aged between 50 and 80 years old (inclusive), of any gender People who have been newly diagnosed with Alzheimer's disease with dementia People with a score of 24 or below on a standard memory and thinking test…

People aged between 18 and 40 years old. People whose score on a memory and thinking screening test (called the CASI) falls within the normal range for their age and level of education. People with no history of serious brain or mental health conditions — such as stroke, epilepsy, depression, or migraines — that could…

People who have been diagnosed with Alzheimer's disease using a standard set of medical guidelines (known as the 2011 NIA-AA criteria). People whose memory and thinking abilities fall within a specific range, as measured by a standard test called the Mini-Mental State Examination (MMSE), with a score between 10 and…

People aged 50 to 79 years old. People who have been diagnosed with highly probable or probable Alzheimer's disease, confirmed using recognised international criteria, along with a positive Alzheimer's biomarker test result. People who score 18 or higher on a standard memory and thinking test called the MMSE. People…

People who weigh 150 kg (approximately 330 lbs) or less People who are willing and able to take part in all parts of the study for its full duration People who have adequate vision and hearing, in the investigator's judgment, to complete memory and thinking tests (glasses and hearing aids are allowed) People who are…

People aged 65 years or older. People who are able to understand and agree to take part in the study on their own behalf. People who are willing to follow all study procedures and are available for the full duration of the study. People who fall into one of two groups: those with early-stage Alzheimer's disease (mild…

Adults aged 18 or older. People who are available to support the patient throughout the study. People who are able and willing to sign a written consent form.

People who have at least one recorded diagnosis code for Alzheimer's disease (AD) from a hospital stay, or at least two recorded diagnosis codes for AD from outpatient visits that were at least 7 days apart but less than 365 days apart, on or before a key reference date used in the study. People who have had…

A person must have an early-stage Alzheimer's disease (AD) diagnosis, specifically what is classified as Stage 3 (mild cognitive impairment) or Stage 4 (mild AD dementia) according to the FDA's 2024 definition. A person must have specific biological markers in their spinal fluid or brain scan that are consistent with…

People who score 0.5 on a standard memory and thinking assessment called the Clinical Dementia Rating (CDR), or who score between 18 and 25 on another standard thinking and memory test called the Montreal Cognitive Assessment (MoCA).

The person must be fluent in English. The person must have a previously documented clinical diagnosis of mild cognitive impairment due to Alzheimer's disease, or mild Alzheimer's disease. The person must have tested positive for amyloid (a protein linked to Alzheimer's disease) through a brain scan (PET) or spinal…

People who have previously taken part in an Alzheimer's clinical trial using the drug buntanetap. People who have a study partner who can give written consent to participate, spends at least 10 hours per week with the participant, and can attend study visits at required times. Female participants who could become…

Adults aged 18 to 60 years old, male or female, who are not able to become pregnant People with a body mass index (BMI) between 18 and 32, and a body weight of at least 50 kg Female participants who are not able to become pregnant (for example, due to menopause or surgery) Male participants who have had both testicles…

People who are able to give written agreement to take part, either themselves or through a legally authorised representative. People aged between 45 and 75 years (inclusive). People who have completed at least primary school education. People who have been diagnosed within the Alzheimer's disease spectrum according to…

People aged 55 to 80 years, or aged 30 to 80 years if there is a documented family history of a gene mutation known to cause Alzheimer's disease passed down through generations. People who have been clinically diagnosed with either early-stage memory and thinking problems due to Alzheimer's disease, or mild…

The family must have at least two living members who have been diagnosed with Alzheimer's disease or another form of dementia (diagnosis can be at any age) Biological samples must be available from family members, which can be fresh blood, specially preserved blood cells grown in a lab (called immortalized…

You must be willing and able to agree to the terms and conditions of the Alzheimer's Prevention Registry website

People aged 18 or older, of any gender. People who are cognitively normal or have been clinically assessed as having mild dementia. People who are able and willing to undergo brain scanning (MRI or CT), a PET scan, an injection of a radioactive tracer, and optionally a lumbar puncture (spinal fluid sample); a CT scan…

People aged 18 to 70 years (or 18 to 85 years for those with Alzheimer's disease or healthy volunteers taking part as controls). People with relapsing-remitting multiple sclerosis (RRMS) where the disease has been active — meaning at least one relapse in the past 12 months, at least one area of active inflammation…

People who are willing and able to sign the official consent form approved by the relevant authorities. People who are already enrolled in the ALFA project (Study 45-65 FPM/2012). People whose brain MRI scan does not show any findings that would otherwise rule them out of the trial. People whose memory and thinking…

People who are over the age of 21 People who have a family member, friend, or carer who can give an independent assessment of how they are functioning day-to-day People whose primary language is English People whose symptoms came on gradually, have been getting worse over time, and who have received a clinical…

You have confirmed, lasting damage to your central or peripheral nervous system that is unlikely to get better with current standard treatments. Your condition began at least 6 months ago. If you are currently on medication or have had surgery for your condition, your health has been stable on that treatment and the…

People who are over 55 years old People who are seen during a memory consultation in the geriatric unit at Lyon Sud University Hospital People (or their legal representative and/or trusted person) who have not expressed opposition to taking part in the clinical trial People who are registered with the general social…

You are between 40 and 85 years old. French is your first language. You are being seen at the Amiens Memory Resource and Research Centre and have been diagnosed with mild cognitive impairment (early memory or thinking difficulties) or mild dementia caused by Alzheimer's disease, Lewy body disease, or a condition…

People aged between 60 and 85 years old People who have not been diagnosed with dementia People who are able to walk 10 metres on their own without using any walking aid, such as a walker or cane

Men and women aged 50 to 80 years (inclusive) who are not very physically active, meaning they do less than 3 sessions per week of vigorous exercise lasting 20 minutes or more People who have noticed problems with their own memory or thinking, confirmed by a score of 25 or higher on a standard memory complaint…

You are 55 years of age or older You have been diagnosed by a doctor with Alzheimer's-type dementia, ranging from very mild to severe You show signs of agitation or restlessness at nighttime, based on a specific assessment tool used by the study team Your doctor agrees that medication to help with agitation would be…

People who have no concerns about their own memory or thinking ability People who show no signs of cognitive problems on formal testing, as reviewed by an expert panel People with a Clinical Dementia Rating (CDR) score of 0 or 0.5 (a standard measure of memory and thinking; confirm with trial site) People whose blood…

People who are older than 20 years old People who are willing to sign an informed consent form (a document agreeing to take part in the study) People who have been diagnosed with their condition themselves (confirm with trial site) People who hold a Taiwanese ID People who have atherosclerotic vascular disease (a…

People aged between 40 and 65 years old People who a specialist doctor has assessed as having no signs of cognitive (thinking or memory) symptoms People who score between 27 and 30 on a standard memory and thinking test (called the MMSE) at the screening visit People who do not meet the medical criteria for mild…

You are between 18 and 65 years old (male or female) You have been diagnosed with Multiple Sclerosis (MS) according to a specific set of medical guidelines called the McDonald 2010 criteria Your level of disability, measured on a standard MS scale (called the EDSS), falls between 0 and 5.5, meaning mild to moderate…

Adults who have been diagnosed with a neurodegenerative condition, such as mild cognitive impairment (MCI), Parkinson's disease, Alzheimer's disease, ALS, multiple sclerosis, Huntington's disease, traumatic brain injury, concussion, PTSD, Down Syndrome, or similar conditions Adults who do not have a neurodegenerative…

You have noticed memory or thinking problems yourself, or a doctor has identified some during testing You (or a family member/caregiver, where legally permitted) are willing and able to sign a consent form agreeing to take part You can speak and understand English or French well enough to complete questionnaires and…

You have been diagnosed with ALS (Lou Gehrig's disease) or a related condition, such as primary lateral sclerosis or progressive muscular atrophy. You receive your medical care at a clinic or hospital that uses a health records system called Epic. You are able and willing to give your consent to participate, or…

You must already be enrolled in a related study at UAB called the UAB-ADC study (under a specific approved research program). If you are a woman who could become pregnant, you must have a negative pregnancy test (urine or blood) within 2 days before receiving the study scan — women who have gone through menopause (at…

People who are 18 years of age or older. People who fit into one of three groups: the Red group (already diagnosed with one or more neurological and/or psychiatric conditions), the Yellow group (considered at high risk of developing one or more neurological and/or psychiatric conditions), or the Green group (not in…

You have had a lumbar puncture (a procedure where fluid is taken from your lower back) done as part of your normal medical care to help diagnose dementia

People who are at least 50 years old (male or female) People who do not have a diagnosis of dementia People who are willing to take part in regular cognitive (thinking and memory) tests done remotely, and who may be referred for biological marker assessments based on their risk level

You are aged 55 or older (male or female) and willing to give your consent to take part You have been diagnosed with MCI (a mild level of memory or thinking difficulties that does not yet meet the level of dementia) based on recognised medical criteria Your memory loss is noticeable and may affect other areas of…

You are willing and able to give written agreement to take part (or a legal guardian can do this on your behalf) At least two close relatives (like parents or siblings) in your family have been diagnosed with Alzheimer's disease, and at least 3 people across 2 generations in your family have the condition At least one…

People who have been diagnosed with Alzheimer's disease People who have cognitive impairment (problems with memory, thinking, or understanding)

You have been diagnosed with Alzheimer's disease with mild or major memory and thinking problems, with a certain level of severity confirmed by a rating scale (confirm with trial site) You have been diagnosed with major depression, and your current episode of depression has lasted more than 4 weeks but less than 5…

People between 50 and 85 years of age (male or female) People who have been diagnosed with probable Alzheimer's disease People who, if already taking Alzheimer's medication, have been on that medication for at least 2 months, with the same dose for at least 3 months People who are able to describe what they are…

You are 45 years of age or older. If you are between 45 and 50 years old, you must have a close blood relative (such as a parent, sibling, or child) who has been diagnosed with a brain-related degenerative disease (such as Alzheimer's or Parkinson's disease).

A doctor has confirmed a diagnosis of probable Alzheimer's disease The dementia is mild, based on results from standard memory and thinking tests (confirm with trial site for specific scores) The person is older than 55 years The person is able to follow the study procedures The person has vision of at least 20/400…

You have been diagnosed with Alzheimer's disease that is mild to moderate in severity (based on a standard medical rating scale). You are 60 years old or older. You have reduced or impaired function in both of your inner ears (the parts that help control balance). You are able to take part in study activities…

People who are already enrolled in the UAB Alzheimer's Disease Center (UAB-ADC) study through a separately approved research program. People who are already enrolled in the UAB-ADC amyloid brain scan (amyloid-PET) sub-study through a separately approved research program. The amyloid brain scan does not need to be…

You are between 50 and 85 years old You have been diagnosed with Alzheimer's disease using a standard set of recognised medical diagnostic guidelines You have mild to moderate Alzheimer's disease, confirmed by a memory and thinking test (called the MMSE), with your score falling within a specific range depending on…

Women who previously took part in this study People who are currently aged 60 years or older People who completed chemotherapy or major surgery requiring general anaesthesia more than six months ago People who are willing and able to sign a consent form agreeing to take part Women who identify as African American…

People who are aged 65 or older at the time of signing consent People who can speak and understand English or Spanish People who have enough physical ability to use a computer for exercises (such as touching a screen or using a mouse) People who can read from a computer screen at a normal viewing distance People who…

Men and women who are between 45 and 74 years old and previously took part in a study called "45-65/FPM2012," or anyone over 45 years old who did not take part in that earlier study. People who are either experiencing normal memory concerns, have mild memory or thinking difficulties (mild cognitive impairment), or…

People aged 60 or older People who speak fluent English or Spanish People with vision and hearing good enough to complete computer-based and cognitive tests People who are in generally good health, with no conditions expected to interfere with the study People who are willing and able to participate for the full…

People who identify as African American People aged 60 years or older People who are willing to be randomly assigned to a study group People who are willing to attend group sessions as part of the study People who do not have plans to move away from the area during the study period People who do not have health…

You must be able to speak and understand Cantonese well enough to complete a thinking and memory test. You must have been officially diagnosed with Alzheimer's disease by a doctor. Your Alzheimer's disease must be at a certain stage — specifically stage 3, 4, or 5 on a scale used by doctors to measure how the…

People between the ages of 56 and 85 years old People who score 18 or above on a memory and thinking test called the Montreal Cognitive Assessment (MoCA) People whose level of daily functioning is not significantly affected by memory problems, as measured by a standard rating scale called the Clinical Dementia Rating…

You or a close family member has been diagnosed with the condition being studied in this trial. You are an NHS patient at one of the participating clinics or hospitals, even if you do not have the condition being studied (you may be asked to take part as a comparison participant). You are willing to donate a saliva…

You are a healthy person without any medical condition that affects brain function, and you do not have problems with concentration, memory, balance, or coordination. You have been referred by your doctor because you may have a condition affecting the flow of fluid around your brain (such as normal pressure…

People who are 50 years of age or older

People who have been diagnosed with mild cognitive impairment or early-stage Alzheimer's disease, or who have noticeable memory problems compared to how they used to function, confirmed by a standard memory assessment People whose score on the Mini-Mental State Examination (a standard memory and thinking test) is…

People who have normal color vision and can see clearly (vision of 20/30 or better) People who are able to put in genuine effort during memory testing (as measured by a specific effort test called the TOMM) People who have the ability to make their own decisions about participating People who are medically suitable…

You can be male or female, of any race You must be 18 years of age or older You must currently be an active participant enrolled in the Knight Alzheimer's Disease Research Center (ADRC) at Washington University

People aged 40 to 80 years. People who are covered by social security insurance or are a named beneficiary of such coverage. People who have signed an informed consent form, either personally or through a legal representative. People who have had cerebrospinal fluid (a fluid around the brain and spine) tested, with…

You have been diagnosed with Down syndrome (including trisomy 21, mosaic trisomy 21, Robertsonian translocation trisomy 21, or partial trisomy 21), confirmed by genetic testing or medical records You (or your legal representative on your behalf) are able to sign and date a consent form agreeing to take part You are…

People whose first language is English People with normal vision, or vision that is corrected to normal with glasses or contact lenses (20/40 binocular vision or better, as measured by a standard eye chart) People with a specific type and degree of hearing loss — sensorineural hearing loss — measured at a moderate…

Women who have gone through menopause (their periods have permanently stopped) Women between 40 and 65 years of age

You have shown signs of memory or thinking problems, based on a score from one of three recognised memory tests (confirm with trial site for specific score ranges) You have been diagnosed with mild memory problems or dementia possibly related to Alzheimer's disease, reduced blood flow to the brain, Parkinson's…

People who are over 50 years old. People who are willing to sign an informed consent form agreeing to take part in the study. People who do not meet the full diagnostic criteria for dementia according to a standard classification system called DSM-IV. People whose memory or thinking difficulties have been rated as…

People who are attending a memory clinic appointment due to memory concerns, or people who are accompanying someone to a memory clinic appointment for memory concerns

You have been diagnosed with trisomy 21 (Down syndrome) You are able to speak and communicate well enough to take part in the study procedures You agree to use non-hormonal contraception for the whole time you are in the study (for women: a copper coil/IUD, having had a tubal ligation, or your partner using condoms…

Adults aged 18 or older People who are able to understand the study and agree to sign a consent form (or have a legally authorised representative do so on their behalf) People who have been diagnosed by a neurologist or psychiatrist with mild cognitive impairment (MCI), ALS (motor neurone disease), Parkinson's…

People aged 51 or older People who have been diagnosed with Alzheimer's disease dementia, or a mixed dementia that includes Alzheimer's disease People whose score on a standard memory and thinking test (called the MMSE) falls between 4 and 28 People who show signs of agitation or aggression, as measured above a…

People aged between 50 and 85 years old (inclusive), either male or female. People who are able to think clearly enough to complete study tasks, can see and hear well enough to participate, and can read and speak the language used in the study (for example, having completed at least six years of schooling, or having…

People aged 55 or older (both men and women are eligible, but women must be post-menopausal) People who have been diagnosed with major dementia caused by Alzheimer's disease, including those whose dementia is thought to be caused by both Alzheimer's disease and problems with blood flow to the brain People who score 24…

People who have been diagnosed with Alzheimer's Disease or another form of dementia (for example, Primary Progressive Aphasia)

People aged 50 or older at the time of screening People who have been diagnosed with probable Alzheimer's disease using recognised medical guidelines, supported by brain scans (CT or MRI) and blood tests done as part of routine care People whose score on a standard memory and thinking test (called the MMSE) is 16 or…

You are willing and able to give written consent to take part, or a legal guardian can do this on your behalf. You are 18 years old or older. You have been diagnosed with Alzheimer's disease, mild cognitive impairment (early memory/thinking difficulties), pre-mild cognitive impairment (very early signs or risk factors…

You must be 50 years of age or older at the time of screening At screening, you either have no memory or thinking problems, or you have been diagnosed with a specific type of Alzheimer's disease (amnestic Alzheimer's disease, posterior cortical atrophy, or logopenic variant primary progressive aphasia) Your level of…

You can be male or female, of any race You must be over 18 years old You must already be taking part in a related research project connected to the Knight Alzheimer's Disease Research Center at Washington University, and be referred by their team and a Washington University doctor You must have either normal thinking…

People who have been diagnosed with mild cognitive impairment related to Alzheimer's disease, following recognised medical guidelines People whose thinking and memory are currently normal but who have at least one of the following risk factors for Alzheimer's disease: carrying a specific gene variant called APOE ε4…

People who are male or female, of any race or ethnicity. People who are aged 65 years or older and able to give written consent to participate. People whose memory and thinking is rated as normal on a standard assessment called the Global Clinical Dementia Rating (CDR score of 0). People who are willing and able to…

A person must have a diagnosis of Alzheimer's disease based on a specific set of medical criteria known as IWG-2. The person must be 50 years of age or older. The person must not be under any form of legal protection, such as guardianship or curatorship. The person must have a score of 10 or higher on a memory and…

People who have been diagnosed with a brain or nervous system condition such as Alzheimer's disease, Parkinson's disease, ALS (Lou Gehrig's disease), or a related condition People who have a family history of certain inherited brain or nervous system diseases (such as familial FTD or familial ALS), whether or not they…

People aged between 55 and 85 years old People who have had gradual, worsening memory loss for more than 1 year, with a memory and thinking test score (called the Montreal Cognitive Assessment) between 10 and 20 People whose brain scan (a PET scan) shows the presence of a substance called amyloid, which is linked to…

People who are able to use a computer mouse and a touch screen People whose primary language is English People whose primary language is Spanish (for those completing the Spanish-language version of the study)

People between the ages of 55 and 85 People who are fluent in English or Spanish People who are willing to be randomly assigned to either the study drug (10 mg Senicapoc) or a placebo, with a higher chance of receiving the active drug People who have a Clinical Dementia Rating (CDR) score of 0.5 or 1, which reflects…