Macular Degeneration

**Who might be able to join this trial:** - You are male or female, aged 50 or older - Your vision in the study eye is at least 20/320 (you can read some letters on a special eye chart, even if not perfectly) - You have been diagnosed with geographic atrophy (GA) of the macula caused by age-related macular degeneratio...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of wet age-related macular degeneration (AMD) in the eye being studied, and you have not yet received any treatment for it - You are able and willing to follow all the rules and requirements of the study, as judged by the study do...

**Who might be able to join this trial:** - You are willing to sign a consent form before taking part in the study - You are 50 years of age or older at the time of screening - You have never received any anti-VEGF treatment (a type of eye injection therapy) in either eye or anywhere else in your body - Your eye has b...

Who might be able to join this trial: - You must be aged 50 or older and have been diagnosed with geographic atrophy (a type of eye condition causing vision loss) that affects the centre and/or outer areas of the eye - You must have fully completed the previous related study called GATHER2 (ISEE2008), including attendi...

**Who might be able to join this trial:** - People who are 60 years of age or older at the time of screening. - People who have been diagnosed with dry (non-exudative) age-related macular degeneration (AMD) in both eyes, with signs such as drusen (small deposits under the retina). - People whose affected eye has an ar...

**Who might be able to join this trial:** - People who previously enrolled in and completed one of three related studies (called Ladder, Archway, or Velodrome) without stopping treatment or leaving the study early, or who were in the Velodrome study and either were not selected for randomisation at Week 24 or complete...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with age-related macular degeneration (AMD), which means having at least one medium-sized deposit (called a drusen) in your eye measuring more than 63 micrometres; OR you have normal age-related eye changes with only...

**Who might be able to join this trial:** - People who are able to give written consent, understand what the study involves, and are willing to complete all required study procedures - People aged 50 years or older - People who have a specific type of eye condition called wet age-related macular degeneration (wet AMD)...

Who might be able to join this trial: - People who are 60 years of age or older at the time of signing the consent form - People who are willing and able to understand the study and sign a written consent form - People who are able to attend scheduled treatment visits and follow-up appointments - People who are able to...

**Who might be able to join this trial:** - You must have already taken part in one of two specific earlier studies (called 81201887MDG2001 or 81201887MDG1003) and received either the treatment JNJ-81201887 or a sham (inactive) procedure as part of that study - You must be willing to sign a consent form showing you und...

**Who might be able to join this trial:** - People who have at least one large deposit (called a druse) in the eye that is larger than 125 microns in diameter, caused by age-related macular degeneration (AMD). - People whose vision in the affected eye falls within a specific range — roughly equivalent to seeing betwee...

**Who might be able to join this trial:** - People aged 18 to 85 years old at the time of agreeing to take part - People who are willing and able to give informed consent before any study procedures begin - People who are willing and able to follow all study instructions, attend all visits, and complete all assessment...

Who might be able to join this trial: - People who are 50 years of age or older at the time of signing the consent form - People who are willing to follow all study procedures and sign the required consent form - People who either have healthy eyes with no known eye conditions, or who have been diagnosed with any stage...

**Who might be able to join this trial:** - People who have been diagnosed with geographic atrophy (a type of vision loss affecting the central part of the eye) caused by age-related macular degeneration (AMD) - People whose affected area in the eye falls within a specific size range, as measured at the screening visi...

**Who might be able to join this trial:** - You are 50 years of age or older at the time you give consent - You have been diagnosed with a specific type of wet age-related macular degeneration (wet AMD) that has caused abnormal blood vessel growth in your eye, and you have either never received eye injections for this...

**Who might be able to join this trial:** - You are 60 years old or older - You have been diagnosed with geographic atrophy (GA) caused by age-related macular degeneration (AMD) - The vision in your study eye (the eye being treated) meets specific vision test score ranges depending on which part of the trial you are jo...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of joining the trial - People who have a confirmed diagnosis of an inherited condition causing the retina to break down, affecting the central part of the eye (macula) in both eyes - People whose vision in the eye being stu...

**Who might be able to join this trial:** - You are a man or woman between 18 and 55 years old (inclusive) at the time of screening - You weigh at least 50 kg (about 110 lbs) and your Body Mass Index (BMI) falls between 18.5 and 29.9 (a standard measure of body weight relative to height) - You are in good general healt...

**Who might be able to join this trial:** - People who have a specific type of eye condition called choroidal neovascularization (abnormal blood vessel growth at the back of the eye) caused by age-related macular degeneration, including certain related conditions affecting the retina, in at least one eye — and who have...

Who might be able to join this trial: - People aged 50 or older, of any gender. - People who have been diagnosed with geographic atrophy (a type of vision loss) caused by age-related macular degeneration (AMD) in at least one eye, where the affected area is within a specific size range — not too small and not too large...

Who might be able to join this trial: - Adults aged 50 or older who are able to give their agreement to participate and follow the study's requirements - People who have a specific type of vision loss called geographic atrophy (GA) caused by dry age-related macular degeneration (AMD), where the damaged area does not af...

**Who might be able to join this trial:** - You are 50 years of age or older (any gender) - You have been diagnosed with an abnormal growth of blood vessels under the central part of your retina (the back of your eye), caused by age-related macular degeneration (AMD) - A specific type of eye scan (called an SD-OCT) has...

**Who might be able to join this trial:** - You are willing and able to sign a consent form agreeing to take part - You are 55 years of age or older - You have been diagnosed with geographic atrophy (a form of advanced dry age-related macular degeneration, or AMD) in one eye, and have AMD in the other eye (unless you...

**Who might be able to join this trial:** - You must have received a vaccination against a bacterial infection called Neisseria meningitidis before joining. - You must be able to understand and sign a consent form agreeing to take part. - You must have a condition called geographic atrophy (a type of damage to the back...

**Who might be able to join this trial:** **All participants must meet these general criteria:** - Adults between 55 and 80 years old (inclusive) - Considered medically stable and able to understand and follow the study procedures, as determined by the trial investigator - Having sufficient hearing, vision, and langua...

**Who might be able to join this trial:** - People who are able to understand the study and agree to take part in it - Healthy people with no eye or other conditions - People who have been diagnosed with age-related macular degeneration (AMD), diabetic retinopathy, central serous chorioretinopathy (a condition affectin...

**Who might be able to join this trial:** - You are able to understand and agree to participate, or have a parent, guardian, or legal representative who can do so on your behalf. - You have been diagnosed with an eye condition such as a degenerative retinal disease, optic nerve damage, a very small or absent eye, or a...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have not had a chromovitrectomy (eye surgery using coloured dyes to help the surgeon see tissue) in the previous 6 months. - People whose surgery involves the use of only one of three specific dyes: Brilliant Blue G (BBG), Indocyanine G...

Who might be able to join this trial: - People aged 7 years or older, either male or female. - Children aged 7 to 17 years old must give their own agreement (assent) to take part, and a parent or guardian must also give their permission. - People who are willing and able to follow the imaging procedures as assessed by...

**Who might be able to join this trial:** - People aged 20 years or older - People who need eye treatments for a decrease in vision of any level - People who have been diagnosed with certain diseases affecting the back of the eye, including diabetic retinopathy, diseases affecting the blood vessels in the retina, age-r...

**Who might be able to join this trial:** *For people with wet AMD (age-related macular degeneration):* - Adults aged 50 or older who have been diagnosed with wet AMD with active abnormal blood vessel growth, and who have never received treatment for it before *For people with healthy eyes (comparison group):* - Peop...

**Who might be able to join this trial:** - You must be 5 years old or older - You (or your parent/legal guardian) must be willing and able to understand and sign a consent form for the study - You must be able to cooperate with the tests required during the study *If you have a retinal disease:* - You must have a ret...

**Who might be able to join this trial:** - People who are willing to take the medication tacrolimus and willing to stop any medications that are known to interact strongly with it. - People who are able and willing to attend all scheduled appointments up to the 52-week visit. - People currently taking an antidepressa...

**Who might be able to join this trial:** - People who have been newly diagnosed with a specific form of wet age-related macular degeneration (AMD) where abnormal blood vessel growth is located behind the central part of the retina, in one or both eyes (only one eye per patient will be studied) - People who are planned...

Who might be able to join this trial: **Community level:** - The community must be located within the service area of either Bharatpur Eye Hospital or Lumbini Eye Institute - The community must be accessible by a standard vehicle (not requiring a four-wheel drive) - The community must be in an urban or peri-urban (nea...

Who might be able to join this trial: - People who are 16 years of age or older. - People who have lost central vision in both eyes, where the area of vision loss is at least 5 degrees wide and includes the central focal point of vision. - People whose eyes hold a steady, consistent gaze within a very small range (with...

**Who might be able to join this trial:** - Adults aged 18 years or older (men and women) - People who have signed a consent form agreeing to participate - People whose vision prescription (short-sightedness, long-sightedness, or astigmatism) is below 3 diopters - People who are able and willing to follow the study in...

**Who might be able to join this trial:** - People aged 18 or older - People who have an eye condition, or healthy volunteers with no eye condition - People who have signed a consent form to participate - People who are covered by health insurance **Who may not be able to join:** - People who have a history of being s...

**Who might be able to join this trial:** - Adults between 18 and 85 years old who are willing to take part and agree to the study's terms. - For one part of the trial (Phase A): people whose eye condition is currently managed with anti-inflammatory eye drops, and who have not yet needed steroid injections into the ey...

**Who might be able to join this trial:** - People aged 55 to 85 years old at the time of joining the trial. - People who are able to understand and sign the trial's consent form. - People who have a specific type of eye condition called geographic atrophy (GA) — an area of damage to the back of the eye — in at least...

**Who might be able to join this trial:** - People who are 55 years of age or older. - People who have been diagnosed with dry age-related macular degeneration (AMD), meaning at least one medium or large deposit (called a drusen) has been found in the central part of the eye, and a condition called geographic atrophy...

**Who might be able to join this trial:** *Group 1 (people with a specific eye condition involving abnormal blood vessel growth):* - People who have a type of abnormal blood vessel growth under the retina (called type 1 choroidal neovascularization) related to either a condition called central serous chorioretinopathy...

**Who might be able to join this trial:** - People who have been diagnosed with wet age-related macular degeneration (a condition where abnormal blood vessels grow under the retina and leak fluid, damaging central vision) - People whose wet AMD has been treated only with anti-VEGF eye injections (a common type of medi...

**Who might be able to join this trial:** - People who are already enrolled in a related research study called NEPTUNE (either in the group that had a kidney biopsy or the group that did not). - People who meet the eligibility requirements for at least one of the partnering clinical trials linked to this study — note t...

Who might be able to join this trial: - People who are willing to follow all study procedures and are available for the full duration of the trial. - People who are at least 10 years old. - People who are able to complete the required vision and eye imaging tests. - People who have a mutation in the ELOVL4 gene and sho...

**Who might be able to join this trial:** - People who have been diagnosed with dry age-related macular degeneration (a condition affecting vision in the back of the eye) - People who are able to understand what the trial involves and agree to take part - Adults aged over 55 years - People who are medically well enough...

**Who might be able to join this trial:** - You are aged 50 years or older - You have bleeding under the retina in one eye (called a submacular haemorrhage) that is related to a wet/exudative form of age-related macular degeneration (AMD), whether or not you have had previous treatment for it - The bleed in your eye i...

**Who might be able to join this trial:** - You are male or female and older than 50 years of age - You are willing and able to sign a written consent form to participate - You are registered with the French social security system - Your blood sample amounts (for both care and research) can be managed safely based on y...

**Who might be able to join this trial:** - People who have been diagnosed with intermediate age-related macular degeneration (a mid-stage eye condition affecting the retina) in one or both eyes - People whose study eye has a specific higher-risk form of this condition, involving a large number of deposits under the r...

Who might be able to join this trial: - People who have been diagnosed with age-related macular degeneration (a condition affecting central vision) and are aged 60 or older, or people who have been diagnosed with juvenile macular degeneration and are currently aged 18 or older. - People whose vision in their better eye...

**Who might be able to join this trial:** - People who are 55 years of age or older. - People who have been found to have a specific type of advanced age-related macular degeneration (a condition affecting the centre of the retina) confirmed by eye imaging tests. - People who have a cataract (clouding of the eye's nat...

**Who might be able to join this trial:** - People aged 50 years or older - People who have reticular pseudodrusen (a type of deposit in the eye) caused by age-related macular degeneration (AMD) - People whose best vision (with glasses or contacts if needed) falls within a certain range — roughly from normal vision do...

**Who might be able to join this trial:** - People who have been diagnosed with a form of wet age-related macular degeneration (AMD) called neovascular AMD (nAMD), where abnormal blood vessels affect the central part of the retina (the macula) - People whose two eyes have a similar level of a specific cell count in th...

Who might be able to join this trial: - People aged 18 or older who have been diagnosed with a specific eye condition called neovascular age-related macular degeneration (nAMD), and whose treating doctor has prescribed a medication called Brolucizumab for them as per approved guidelines. - People who have been clearly...

**Who might be able to join this trial:** - You are 50 years of age or older - You have been diagnosed with active wet age-related macular degeneration (AMD) in one eye, confirmed by specific eye imaging tests - Your vision in the eye being studied is at least 20/200 (a basic level of vision, not complete blindness) -...

Who might be able to join this trial: - You have been diagnosed with a condition called NAION (non-arteritic ischemic optic neuropathy), which is a type of damage to the optic nerve caused by reduced blood flow - You are able to understand and are willing to sign a written consent form agreeing to take part Who may no...

Who might be able to join this trial: **Main Trial** - People aged 50 or older - People who have been diagnosed with a type of abnormal blood vessel growth in the eye (called CNV) caused by age-related macular degeneration (AMD), confirmed by a specialist reading centre - People whose unaffected eye has a certain mini...

Who might be able to join this trial: - People who are 21 years of age or older - People who are able to follow simple instructions during eye imaging (similar to what a standard eye exam involves) - People who are able to understand and sign a consent form (note: the trial does not enrol people whose primary language...

**Who might be able to join this trial:** - People aged between 50 and 89 years old - People whose vision in the study eye falls within a specific range on a standard eye chart test (confirm with trial site for exact letter score details) - People who have been diagnosed with a specific type of age-related macular deg...

**Who might be able to join this trial:** - People who are at least 65 years old at the pre-surgery visit - People whose vision in both eyes is severely reduced (roughly between 20/160 and 20/800 on an eye chart) due to blind spots in the centre of their vision caused by advanced age-related macular degeneration (AMD)...

**Who might be able to join this trial:** - You are between 50 and 75 years old - You have been diagnosed with late-stage dry age-related macular degeneration (AMD), with one or more areas of damage larger than a certain size in the central part of your eye (confirm with trial site) - You have been diagnosed with wet A...

**Who might be able to join this trial:** - People aged 18 to 89 years old - People who have severely reduced vision in both eyes (vision of 20/100 or worse) - People who have been diagnosed with Macular Degeneration by an eye specialist (Ophthalmologist) - People whose central retina (the macula) shows significantly...

**Who might be able to join this trial:** - You are an adult who has been diagnosed with early or intermediate stage dry age-related macular degeneration (AMD), confirmed by eye imaging photos. - You are willing to stop taking omega-3 fatty acid, choline, or astaxanthin supplements during the trial. - You are willing t...

Who might be able to join this trial: - A healthcare provider who knows about the study's protocol has agreed that the study team may contact the infant's parent or legal guardian - The infant's parent or legal guardian is willing and able to give consent for the infant to take part in the study - The infant meets the...

**Who might be able to join this trial:** - People who were first diagnosed with a type of wet age-related macular degeneration (wet AMD) within the 9 months before their screening appointment - People who have already received at least three injections into the eye (called anti-VEGF injections) as standard treatment...

**Who might be able to join this trial:** - People who are able to undergo an eye surgery procedure with monitored sedation (rather than full general anaesthesia) - People who have been diagnosed with geographic atrophy (a form of advanced age-related macular degeneration, or AMD) - People whose vision in the study ey...

**Who might be able to join this trial:** - People who received a kidney transplant from the year 2000 onwards - People who were diagnosed with a kidney condition called FSGS (focal segmental glomerulosclerosis) or MCD (minimal change disease) in their original kidney, before the transplant took place **Who may not be...

**Who might be able to join this trial:** - You are willing and able to sign a consent form agreeing to take part in the study - You are a man or woman between 50 and 85 years old and have been diagnosed with wet age-related macular degeneration (wet AMD) - You are currently receiving anti-VEGF injections for wet AMD a...

Who might be able to join this trial: - Adults aged between 50 and 80 who speak Chinese and live in the community (not in a care facility) - People who have been diagnosed with age-related macular degeneration in one or both eyes, of any type or cause Who may not be able to join: - People who are unable to understand...

**Who might be able to join this trial:** - You are 65 years of age or older - You have been diagnosed with dry age-related macular degeneration (AMD) affecting both eyes - Your vision (when measured with corrective lenses using a standard eye chart) falls within a specific range — roughly between being able to see 1/1...

Who might be able to join this trial: - You must be able to understand and agree to take part in the study by signing a consent form - You must have been diagnosed with a specific inherited eye condition called Best disease (also known as vitelliform macular dystrophy), confirmed by a specialist eye doctor at the unive...

Who might be able to join this trial: - People who have been diagnosed by a doctor with a disease affecting the macula (a part of the eye responsible for central vision) - People who have been diagnosed by a doctor with glaucoma (a condition that damages the optic nerve) - Older adults with normal vision who are the sa...

**Who might be able to join this trial:** - You are a Veteran who has been diagnosed with an intermediate stage of age-related macular degeneration (AMD) in at least one eye - You are between 65 and 89 years old - You are willing and able to take part in the study's activities and assessments - You have scored above 26...

**Who might be able to join this trial:** - You are male or female, aged 50 or older, of any ethnicity - Your eye being studied has at least one early area of damage to the light-sensitive layer at the back of the eye (called the retinal pigment epithelium), either partial or complete, as detected by a special eye scan...

**Who might be able to join this trial:** - You have been diagnosed with an inherited retinal disease (a genetic condition affecting the retina in the back of your eye) - You are between 18 and 80 years old - You have had genetic testing that clearly confirmed your inherited retinal disease - You are male or female - Y...

**Who might be able to join this trial:** - People who are willing to take part voluntarily and are able to sign and date a consent form before any study procedures begin, and who are able to complete the study as required - People who are 50 years of age or older at the time of screening - People who have been diagnos...

**Who might be able to join this trial:** - People aged 50 to 80 years old at the time of signing the consent form - People who have been diagnosed with abnormal blood vessel growth under the retina (called choroidal neovascularization) caused by age-related macular degeneration (AMD), in the eye being studied - People...

Who might be able to join this trial: - People whose vision meets a minimum level, measured by a standard eye chart test called ETDRS (a score above 40 letters when tested at 4 metres) - People who have been diagnosed with dry age-related macular degeneration (AMD) at a specific stage of the disease, known as AREDS gra...

Who might be able to join this trial: - People between the ages of 5 and 110 years old - People who are able to follow instructions during the imaging procedure - People who have provided written informed consent to participate Who may not be able to join: - People who have dementia - People who are unable to follow i...

**Who might be able to join this trial:** - People aged 50 or older, of any gender - People who are willing and able to sign a written consent form agreeing to take part - People who have been diagnosed with wet age-related macular degeneration (a condition where abnormal blood vessels grow under the retina) in the ey...

Who might be able to join this trial: - People who are willing and able to follow the study procedures throughout the trial. - People aged 50 years or older. - People who have been clinically diagnosed with a condition called choroidal neovascularisation (CNV) caused by wet age-related macular degeneration (wet AMD), w...

**Who might be able to join this trial:** - You have been diagnosed with dry age-related macular degeneration (AMD) with at least one large deposit (called a drusen) in your eye, larger than a specific size (125 microns) as defined by a major eye health study. - You are able to undergo certain eye imaging and vision te...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form before any study procedures begin, and who are able to complete all parts of the study as required - People who are 50 years of age or older at the time of screening - People who have been diagnosed with a specific type o...

**Who might be able to join this trial:** - People who have a family history of age-related macular degeneration (AMD), a condition affecting eyesight - People who have high cholesterol (hyperlipidemia) or diabetes that is being managed - People between the ages of 65 and 95 **Who may not be able to join:** - People w...

**Who might be able to join this trial:** - You are 18 years old or older, male or female, and have been diagnosed with the "wet" (exudative) form of age-related macular degeneration (AMD). - You have been receiving eye injections of either ranibizumab or aflibercept for more than 1 year to treat your condition. - Your...

**Who might be able to join this trial:** - People of any sex who are 18 years of age or older. - People who speak English and are able to understand and sign a consent form. - People who are willing to follow all study procedures and are available for the full duration of the study. - People who are in generally good...

Who might be able to join this trial: - You must have previously taken part in a related study called SKG0106 and received an injection of SKG0106 for a condition called neovascular age-related macular degeneration (a serious eye condition affecting vision) - You are willing to sign a consent form and agree to follow t...

Who might be able to join this trial: - People who have been diagnosed with dry age-related macular degeneration (dry AMD), confirmed by the trial doctor - People who are able to communicate clearly with the trial team and are willing and able to follow the study requirements - People who have been fully informed about...

**Who might be able to join this trial:** - People aged between 55 and 99 years old. - People who have a specific type of eye condition called complete RPE and outer retinal atrophy (cRORA) — this is a particular pattern of damage to a layer at the back of the eye, confirmed through detailed eye imaging (confirm with...

**Who might be able to join this trial:** - You are between 55 and 99 years old. - You have been diagnosed with early or intermediate age-related macular degeneration (AMD) in at least one eye, which may include certain deposits under the retina (drusen) and/or changes in pigmentation. - If both of your eyes are affect...

**Who might be able to join this trial:** - You have been diagnosed with a retinal condition such as retinitis pigmentosa (in both eyes), choroideremia, Stargardt macular dystrophy, geographic atrophy from age-related macular degeneration, X-linked retinoschisis, or another inherited retinal disease, confirmed by past...

**Who might be able to join this trial:** - People aged 50 or older at the time of screening. - People who have been diagnosed with Geographic Atrophy (a form of advanced age-related macular degeneration that causes areas of the retina to break down). - People whose vision in the study eye is 20/200 or worse on a stan...

**Who might be able to join this trial:** - You are willing and able to give written consent to participate - You are male or female, between 12 and 65 years old - You have been diagnosed with Stargardt disease (STGD1) caused by specific changes in the ABCA4 gene, confirmed by an approved genetic testing lab - Your St...

**Who might be able to join this trial:** - You have been found to have a change (mutation) in a gene called ABCA4 - You have been diagnosed with an eye condition linked to the ABCA4 gene, such as Stargardt disease type 1 or a condition called cone-rod dystrophy **Who may not be able to join:** - You have a gene chang...

**Who might be able to join this trial:** - You are willing and able to read and sign a consent form agreeing to take part in the study - You are a man or woman between 50 and 85 years old (inclusive) and have been diagnosed with wet age-related macular degeneration (wet AMD) - You have previously been treated for wet...

**Who might be able to join this trial:** - People who have a mutation (change) in a gene called ABCA4 - People diagnosed with an ABCA4-related eye condition, specifically Stargardt disease type 1 or cone-rod dystrophy - People who have an area of damaged or lost tissue (atrophy) in the central part of the eye being st...

**Who might be able to join this trial:** - Adults aged 50 years or older - People whose best vision (with glasses or contact lenses if needed) falls within a specific range — roughly equivalent to seeing between 20/40 and 20/320 on a standard eye chart — as measured during a screening appointment - People who have rea...

**Who might be able to join this trial:** - Your eye measurement called MPOD (a measure of a pigment in the eye) must be below 0.43 - You must report having vision of 20/40 or better in each eye, even with glasses or contact lenses - Your Body Mass Index (BMI) must be between 18.5 and 30 (a measure of body weight relat...

Who might be able to join this trial: - People who are willing and able to follow the study procedures throughout the trial - People who are between 50 and 80 years old at the time of signing the consent form - People who have been clinically diagnosed with neovascular age-related macular degeneration (a specific type...

**Who might be able to join this trial:** - People who are 65 years of age or older - People who have dry age-related macular degeneration (a condition affecting the central part of the retina) in both eyes - People whose vision, when tested with a standard eye chart using corrective lenses, falls within a specific ran...

Who might be able to join this trial: - People who have geographic atrophy (GA) of the central part of the eye (the macula) caused by age-related macular degeneration (AMD) - People whose GA affects an area of a specific size — not too small and not too large — as measured during screening (confirm with trial site) - P...

**Who might be able to join this trial:** - People aged 50 or older, of any gender - People diagnosed with intermediate age-related macular degeneration (AMD), specifically classified as AREDS Grade 3 - People where both eyes meet the study's requirements - People willing to sign a consent form, follow the study's proc...

Who might be able to join this trial: - You are between 55 and 90 years old (inclusive). - You have been diagnosed with advanced dry age-related macular degeneration (AMD) where the central part of your retina (the fovea) is affected by a condition called geographic atrophy. - The affected area in your eye is within a...

Who might be able to join this trial: - People who have been diagnosed with Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), or Glaucoma - People who are willing to allow their personal information (with identifying details removed) to be used to evaluate outcomes in this study Who may not be able to...

**Who might be able to join this trial:** - People of any age who have high short-sightedness (nearsightedness), meaning their prescription is -6 or stronger **Who may not be able to join:** - People who have a history of other eye diseases, or conditions affecting the rest of the body that may impact blood flow to th...

Who might be able to join this trial: - People who live in Scotland, are aged 60 or older, and have been diagnosed with advanced AMD (age-related macular degeneration). - People who have been receiving treatment at Princess Alexandra Eye Pavilion (PAEP) for at least 6 months and whose condition has been responding posi...

Who might be able to join this trial: - People who are willing and able to give their consent to participate - People who have been diagnosed with early or intermediate dry age-related macular degeneration, geographic atrophy, or who have healthy eyes (for the control group) - People who are at least 50 years of age W...

**Who might be able to join this trial:** - People who are 55 years of age or older at the time of screening. - People who are able and willing to give their consent to participate and attend all required study visits. - Women or intersex individuals who are either past menopause for at least 12 months, have had surge...

**Who might be able to join this trial:** - People aged 55 or older - People who are willing and able to sign a written consent form agreeing to take part - People who are willing and able to follow the study schedule and attend all required visits and assessments - People who are able to apply eye drops themselves, o...

**Who might be able to join this trial:** - You are willing and able to sign a consent form to take part in the study - You are between 45 and 80 years old (male or female) - Your eye being studied has been diagnosed with a condition called "wet" age-related macular degeneration (nAMD) - There is currently active abnor...

**Who might be able to join this trial:** - People who are over 18 years of age - People whose vision is fully corrected to 10/10 in each eye - People who have signs of early or intermediate age-related macular degeneration (AMD) in at least one eye — this includes the presence of small or large deposits under the reti...

Who might be able to join this trial: - You must have already been enrolled in the AL-001 study and received the AL-001 eye injection as part of that study. - You (or your legal guardian or representative) must agree to take part in this study and sign a written consent form. - You must be willing and able to attend al...

**Who might be able to join this trial:** - You are over 50 years old - You have been diagnosed with a type of age-related macular degeneration (AMD) that involves abnormal blood vessel growth (called neovascular AMD) affecting the central part of your retina - You may be either new to treatment or have had treatment b...

**Who might be able to join this trial:** **Group 1 – Generally Healthy People with Gum Disease:** - You are between 30 and 60 years old - You are male or female - You have been diagnosed with moderate to severe gum disease (called periodontitis stage II or III) - You do not have any other health conditions - You are...

Who might be able to join this trial: - People who are between 55 and 80 years old (inclusive) at the time of signing the consent form. - People with a body mass index (BMI) between 19 and 34 kg/m² (a standard measure of body weight relative to height). - People who agree to use reliable contraception for at least 12 m...

**Who might be able to join this trial:** - You have a condition called geographic atrophy (a type of damage to the center of the eye) caused by age-related macular degeneration (AMD), in one or both eyes - Your doctor has already decided that you should be treated with a medication called avacincaptad pegol (ACP), giv...

Who might be able to join this trial: - Adults between 18 and 65 years old who have been diagnosed with retinitis pigmentosa (RP), either through genetic testing or clinical assessment. - People whose vision in at least one eye meets a minimum level of 1/60 (a measure of very limited but present vision — confirm exact...

**Who might be able to join this trial:** - You are 18 years of age or older (male or female) - You are able to understand the study and agree to take part by signing a consent form - You are able to follow the study rules and complete all required tests - You fall into one of three groups: (1) you have normal vision...

Who might be able to join this trial: - People who have been taking hydroxychloroquine (a medication commonly used for conditions like lupus or rheumatoid arthritis) for more than 10 years. Who may not be able to join: - People who have existing eye conditions that could look similar to, or interfere with the detectio...

Who might be able to join this trial: - Adults aged 50 or older who are being seen at an eye clinic that is not a retinal specialist clinic, where the VeriSee AMD tool is being used. - Adults aged 20 or older who have diabetes and are being seen at an eye clinic that is not a retinal specialist clinic, where the VeriSe...

**Who might be able to join this trial:** - People who were first diagnosed with a condition called neovascular age-related macular degeneration (nAMD) — a type of wet macular degeneration — within the last 24 months before the screening visit - People who have already received at least 3 eye injections (called anti-V...

**Who might be able to join this trial:** - People who have been diagnosed with type 2 diabetes - People who have a type of eye condition called diabetic maculopathy (damage to the central part of the retina caused by diabetes), diagnosed using a standard set of criteria called the ETDRS guidelines - People whose visio...

Who might be able to join this trial: - People who previously received treatment with EXG102-031 in the related study (EXG102-031-111) - People who have given informed consent and are willing to follow the procedures set out in the study protocol Who may not be able to join: - People who are unwilling or unable to tak...

**Who might be able to join this trial:** - You have been newly diagnosed with a type of abnormal blood vessel growth (called CNV) in the central part of your eye (the macula), confirmed by specific eye scans, and have not yet received any treatment for it. - Your vision in the study eye is reduced — roughly between 20...

Who might be able to join this trial: - People who are 50 years of age or older. - People who have a confirmed diagnosis of age-related macular degeneration (AMD) in at least one eye. - People who have regular eye clinic follow-up appointments already planned as part of their normal care. Who may not be able to join:...

Who might be able to join this trial: - People aged 55 years or older - People with moderate to severe vision loss (able to see between 1/10 and 2/10 on a standard vision test) - People who have been diagnosed with advanced dry (non-exudative) age-related macular degeneration (AMD), a condition where the central part o...

**Who might be able to join this trial:** - You are a man or woman aged 55 or older - You are able to understand and sign a consent form agreeing to take part - You have been diagnosed with age-related macular degeneration (AMD) at category 3 (an intermediate stage) in one or both eyes, based on a standard eye disease...

**Who might be able to join this trial:** - You must be willing and able to sign a consent form agreeing to take part (younger participants will also need to give their own agreement). - In Part A of the trial, you must be between 18 and 65 years old; in Part B, you must be between 12 and 65 years old (people over 65...

"Who might be able to join this trial: - People who are already taking part in the VIEW II study and have been referred to the eye hospital at their eye screening visit. Who may not be able to join: - People who live in an area where mobile phone or internet connectivity is not reliable. Important: Always verify elig...

Who might be able to join this trial: - People who have been diagnosed with a condition called neovascular Age-related Macular Degeneration (a type of eye disease affecting central vision). - People aged 50 years or older. - People whose eye specialist has determined they need treatment with a type of medication called...

**Who might be able to join this trial:** - You have diabetes and have been referred to the hospital eye service to check for possible diabetic eye disease affecting the central part of your vision (maculopathy) or early changes to the blood vessels at the back of your eye (pre-proliferative retinopathy) at Hywel Dda U...

Who might be able to join this trial: - Adults between 18 and 50 years old, of any sex or racial background - People who are willing to follow the study instructions throughout the trial - People who have read (or had read to them), understood, and signed an informed consent form Who may not be able to join: - People...

**Who might be able to join this trial:** - You have swelling in the central part of your retina (the back of your eye) caused by inflammation, and a scan shows the swelling is above a certain thickness level. - A special eye scan shows there is fluid inside or underneath your retina in the eye being studied. - Your v...

Who might be able to join this trial: - People whose study eye has macular edema (swelling in the central part of the retina) caused by inflammation, with a specific level of retinal thickness (between 320 and 400 microns) measured by a special eye scan called SD-OCT. - People whose study eye has a certain level of vis...

Who might be able to join this trial: - People who are willing and able to provide written consent to participate in the study - People who are 6 years of age or older - People who have been clinically diagnosed with a macular condition that matches the pattern of a hereditary eye disease called Stargardt disease - Peo...

Who might be able to join this trial: - Adults over 18 years old (male or female) who have been diagnosed with wet (exudative) age-related macular degeneration (AMD), a condition where abnormal blood vessels grow under the retina - People whose treating doctor considers gene therapy to be a possible option for their ca...

**Who might be able to join this trial:** - You are between 50 and 85 years old at the time of signing up for the trial - You have been diagnosed with a type of age-related macular degeneration (AMD) that involves abnormal blood vessel growth, in one or both eyes - The vision in your study eye (the eye being treated)...

**Who might be able to join this trial:** - Your eye had cataract surgery at least 12 weeks before the first screening visit, and you now have an artificial lens in it. - You have been diagnosed with abnormal blood vessel growth (called choroidal neovascularization) in your eye caused by age-related macular degeneratio...

Who might be able to join this trial: - You are 70 years old or older - You have one or more long-term (chronic) health conditions - You are currently being seen by a GP (family doctor) because of a long-term health condition Who may not be able to join: - You have been diagnosed with dementia - You have a known eye c...

Who might be able to join this trial: - Adults aged 18 or older - People who have been diagnosed with an idiopathic epiretinal membrane (a type of scar tissue that forms on the surface of the retina) confirmed by eye examination and a special eye scan called OCT imaging - People whose eye has clear enough internal stru...

Who might be able to join this trial: - People who are willing to sign a consent form and attend follow-up appointments. - People aged 50 or older. - People who have been diagnosed with active wet age-related macular degeneration (AMD) causing abnormal blood vessel growth under the retina. - People whose vision in the...

Who might be able to join this trial: - You are between 6 and 17 years old (inclusive) and have been diagnosed with Stargardt disease - You have a specific gene change (at least one ABCA4 gene variant on each chromosome) linked to Stargardt disease - Both of your eyes have clearly visible areas of damage in the central...

Who might be able to join this trial: - Adults aged 50 or older who are having their eyes checked at a general eye clinic (not a specialist retinal clinic), where the VeriSee AMD tool is being used. - Adults aged 20 or older who have diabetes and are being seen at a general eye clinic (not a specialist retinal clinic),...

**Who might be able to join this trial:** - You are willing and able to attend clinic visits and follow the study procedures - You are able to read and sign a consent form agreeing to take part in the study **Who may not be able to join:** - You have already been diagnosed with age-related macular degeneration (AMD),...

**Who might be able to join this trial:** - People who are able to verbally identify or describe colors and can understand and follow instructions during color vision testing - People who have been formally diagnosed with an inherited retinal dystrophy (a genetic condition affecting the retina) — for the IRD participa...

Who might be able to join this trial: - People who are 35 years of age or older - People who are living in the Sub-District of Char Fasson in the Bhola District Who may not be able to join: - People who have already been diagnosed with a known eye disease Important: Always verify eligibility with the trial site direc...

**Who might be able to join this trial:** - You are 55 years of age or older at the time of signing the consent form - You have geographic atrophy (GA) in both eyes caused by age-related macular degeneration (AMD), confirmed by specialist imaging, and at least one eye has a GA area within a specific size range (confir...

**Who might be able to join this trial:** - People who have signed a consent form before the screening process begins - Men or women aged between 50 and 85 years old at the time of signing the consent form - People who have geographic atrophy (a form of damage to the central part of the retina) affecting the central a...

**Who might be able to join this trial:** **For both parts of the trial (Stage 1 and Stage 2):** - People who have been diagnosed with geographic atrophy (a condition where patches of cells in the back of the eye break down) caused by age-related macular degeneration, in the eye being studied. **For Stage 1 only:** -...

Who might be able to join this trial: - People who have been diagnosed with Stargardt disease caused by a change (mutation) in a gene called ABCA4, confirmed through genetic testing - People who are willing to follow all the study requirements and give their informed consent Who may not be able to join: - People who a...

**Who might be able to join this trial:** - People who are 55 years of age or older. - People who have been diagnosed with late-stage age-related macular degeneration (AMD), specifically with damage to the central part of the retina in both eyes. - People who have had cataract surgery with lens implants placed in both...

**Who might be able to join this trial:** - People who are able to give their agreement to participate and are willing to follow all study procedures for the full duration of the trial - People who are male, or if female, have had a surgical procedure to prevent pregnancy or have not had a menstrual period for at leas...

**Who might be able to join this trial:** - Adults aged 18 or older (male or female) who need cataract surgery with no other surgical procedures performed at the same time - People who agree not to have any other eye surgery in either eye within 15 days before the study treatment starts, or at any point during the stud...

Who might be able to join this trial: - You are willing and able to give your agreement to take part and follow all study requirements for the whole duration of the trial. - You are 18 years old or older. - Your vision in the eye being studied is at a certain level: if you are the first person in your group, it must be...

**Who might be able to join this trial:** - You are between 50 and 80 years old (for Phase I) or between 50 and 85 years old (for Phase II) at the time of signing the consent form, and you are male or female - You have been diagnosed with active abnormal blood vessel growth under the retina (called choroidal neovascul...

Who might be able to join this trial: - The eye being studied has been diagnosed with intermediate age-related macular degeneration (a condition affecting central vision) according to standard medical criteria - The eye being studied has at least one large deposit under the retina (called a drusen) measuring 125 microm...

**Who might be able to join this trial:** - People aged 60 years or older - People who have been diagnosed with geographic atrophy (GA) of the macula caused by age-related macular degeneration (AMD) in one or both eyes - People whose vision in the study eye measures 50 letters or better on a standard eye chart (roughl...

Who might be able to join this trial: - People who have been diagnosed with geographic atrophy (a form of damage to the central part of the retina) caused by dry age-related macular degeneration (AMD) in the eye being studied. - People whose area of retinal damage in the study eye is at least a certain minimum size (ro...

Who might be able to join this trial: - People who are between 45 and 90 years of age and have active wet age-related macular degeneration (a condition where abnormal blood vessels grow in the back of the eye) - People whose eye condition is currently showing signs of activity, as seen during a routine eye examination...

**Who might be able to join this trial:** - People aged 50 or older at the time of signing consent - People who are willing and able to give informed consent - People who are able and willing to attend all scheduled visits and follow all study procedures - Women who are either unable to become pregnant, or who have a...

**Who might be able to join this trial:** - You are between 50 and 99 years old - You are any gender - You are able to understand spoken instructions in English (British or American), Chinese, or Bahasa Melayu, and can show that you can use the device - You are able to turn on a computer and connect a webcam by yoursel...

**Who might be able to join this trial:** - People who have signed a consent form before taking part in the research - Men or women aged 50 or older at the time of signing the consent form - People who have abnormal blood vessel growth (called CNV) under or involving the central area of the retina (the macula), caused...

**Who might be able to join this trial:** - You are willing and able to sign a consent form agreeing to take part in this study - You are between 50 and 80 years old (inclusive) - You have been diagnosed with active abnormal blood vessel growth in your eye caused by wet age-related macular degeneration (AMD), confirmed...

**Who might be able to join this trial:** **For Parts A and B (healthy volunteer sections):** - People aged between 18 and 50 years who are in good health - People who are willing to provide written, signed consent before being selected - People whose weight and height fall within a healthy range — specifically a BMI...

Who might be able to join this trial: - People who are willing to take part voluntarily and are able to sign a written consent form - Adults aged 50 years or older at the time of joining the study - People who, in the opinion of the study doctor, are able to follow the study requirements - People whose vision in the st...

**Who might be able to join this trial:** - People who meet the trial's required age range (confirm with trial site for specific age details) - People who have geographic atrophy in both eyes caused by age-related macular degeneration (AMD), confirmed by a specialist reading centre - People whose affected area in the...

Who might be able to join this trial: - People aged 50 or older. - People who have been diagnosed with age-related macular degeneration (AMD) in one or both eyes. - People whose affected eye or eyes have a specific type of abnormal fluid layer under the retina (called SHRM) along with a certain type of abnormal blood v...

**Who might be able to join this trial:** - You are a healthy person between 18 and 55 years old (inclusive) - If you are male, you weigh at least 50 kg (about 110 lbs); if you are female, you weigh at least 45 kg (about 99 lbs); and your body mass index (BMI) is between 19.0 and 28.0 - If you could become pregnant, o...

Who might be able to join this trial: - You are between 8 and 45 years old (inclusive) at the time of screening - If you are a woman who could become pregnant, or a man whose partner could become pregnant, you must be willing to use approved contraception methods from consent until a set period after the last dose (con...

**Who might be able to join this trial:** - Adults aged 18 or older who have the "wet" (neovascular) form of age-related macular degeneration (a condition where abnormal blood vessels grow under the retina) - People who have been receiving injections into the eye (called anti-VEGF therapy) to treat this condition for m...

Who might be able to join this trial: - People who have been clinically diagnosed with a macular dystrophy that looks like Stargardt disease, confirmed by genetic testing showing specific changes in the ABCA4 gene or another gene known to cause macular dystrophy. - People whose eyes are clear enough and whose pupils ca...

Who might be able to join this trial: - People who are having a procedure called pneumatic displacement to treat a bleed under the central part of their retina (called a submacular hemorrhage), which was caused by abnormal blood vessel growth in the eye - People who are 50 years of age or older at the time their retina...

**Who might be able to join this trial:** - You have been diagnosed with a specific type of wet age-related macular degeneration (wet AMD) where abnormal blood vessels have grown under the central part of your retina, with no restriction on how large the affected area is. - Your wet AMD is considered active, meaning s...

**Who might be able to join this trial:** - People aged 16 years or older, of any gender - People who are able to attend all scheduled visits and complete all required study assessments - People who have been diagnosed with Stargardt Disease, confirmed through genetic testing - People whose vision (with best possible...

**Who might be able to join this trial:** *For people with AMD:* - Adults over 40 years of age who have been diagnosed with a specific type of age-related macular degeneration (AMD) - People who are able to understand and sign an ethics-approved consent form - People who have attended the clinic at least once before -...

Who might be able to join this trial: - People who have active polypoidal lesions in the central area of the retina, confirmed by specific eye imaging tests, along with fluid or bleeding affecting the central part of the retina. - People whose vision in the study eye falls within a specific range — not too strong and...

**Who might be able to join this trial:** - You are able and willing to give your consent to participate (or have a legal representative who can do this on your behalf), and you are able to follow the study schedule and requirements - You have been diagnosed with a specific type of abnormal blood vessel growth in the...

Who might be able to join this trial: - People who have a specific type of eye condition called choroidal neovascularization (abnormal blood vessel growth at the back of the eye) caused by age-related macular degeneration, which has not been treated before, in at least one eye (confirm with trial site for exact lesion...

Who might be able to join this trial: - People who are 18 years of age or older - People who are able to understand what the study involves and are willing to sign a written agreement to participate - People who are willing and able to attend study visits and follow study procedures For people joining as "case" partic...

Who might be able to join this trial: - People who have been diagnosed with a condition affecting both eyes called retinitis pigmentosa, or another inherited retinal condition that damages side (peripheral) vision, confirmed by past eye examination records - People whose best vision (with glasses or contact lenses if n...

**Who might be able to join this trial:** - People who are willing and able to provide written consent to participate - People of any biological sex or gender identity - People aged 18 or older (for the healthy volunteer group) or aged 55 or older (for the group with age-related macular degeneration, known as AMD) - P...

**Who might be able to join this trial:** - People who are willing and able to understand the study and sign a consent form - People aged 60 years or older - People who have been diagnosed with geographic atrophy caused by age-related macular degeneration, confirmed by eye imaging - People whose affected eye area falls...

Who might be able to join this trial: - People diagnosed with Neovascular Age-related Macular Degeneration (a type of eye condition where abnormal blood vessels grow under the retina). - People who are willing to sign a consent form agreeing to take part in the study. - People who have already tried at least two standa...

**Who might be able to join this trial:** - You must be 55 years of age or older - If joining the "Intermediate AMD Observation Arm," you must have an intermediate stage of age-related macular degeneration (AMD) in one eye - If joining one of the "GA" study arms, you must have geographic atrophy (GA) — a form of AMD —...

Who might be able to join this trial: - People who have blind spots in the centre of their vision in both eyes, confirmed by a specific vision field test - People whose vision in at least one eye falls within a certain range of impairment (not fully sighted but not completely blind — roughly able to read large print bu...

**Who might be able to join this trial:** - You are between 65 and 90 years old - You have been diagnosed with Geographic Atrophy (a type of advanced dry age-related macular degeneration, which causes vision loss) in at least one eye - The affected area in your eye is a specific size — not too small and not too large...

Who might be able to join this trial: - People aged 50 or older who have been diagnosed with the "wet" form of age-related macular degeneration (AMD), a condition where abnormal blood vessels grow in the eye - People who are able and willing to attend clinic visits and follow the study procedures - People who have give...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with a retinal disease that involves breakdown of a layer in the eye called the retinal pigment epithelium (for example, geographic atrophy or Stargardt disease) - Your level of vision falls within the specific range...

**Who might be able to join this trial:** - People aged 50 or older who are able to give written consent to participate - People who have a specific type of age-related macular degeneration (AMD) causing abnormal blood vessel growth beneath the central part of the retina, confirmed by specialist eye scans, and who hav...

**Who might be able to join this trial:** - You are 50 years old or older at the time of your first screening visit - You are willing to use an acceptable form of birth control during the trial - You have been diagnosed with abnormal blood vessel growth behind both eyes (a condition called bilateral CNV) caused by wet...

**Who might be able to join this trial:** - People aged 50 years or older - People who have been diagnosed with neovascular age-related macular degeneration (a type of eye condition affecting vision — confirm with trial site if unsure whether this applies) - People for whom a doctor has already decided, as part of norm...

Who might be able to join this trial: - Adults who are 55 years of age or older - People who do not have serious health conditions that would prevent them from taking part in the study - People who are willing and able to go through the required study procedures for both eyes - People who are willing and able to sign a...

Who might be able to join this trial: - People who are able and willing to attend all required study visits - People who are able and willing to sign a consent form and follow the study instructions - People who are able and willing to have eye imaging performed - Adults aged 18 years or older - People who have no abno...

**Who might be able to join this trial:** - People aged 50 years or older - People whose study eye has been confirmed, through specific eye imaging tests, to have an active abnormal blood vessel growth beneath the central part of the retina, caused by wet age-related macular degeneration (wet AMD) - People whose study...