Peripheral Arterial Disease

**Who might be able to join this trial:** - You have been newly diagnosed with a soft tissue sarcoma (a type of tumor in soft tissues like fat, muscle, or nerves) that is not a rhabdomyosarcoma, and this has been confirmed by a central review of your tissue sample - Your sarcoma may or may not have spread to other par...

**Who might be able to join this trial:** - People aged 16 or older who are able to give written consent to participate (those under 18 also need a parent or guardian to provide consent) - People diagnosed with NUT Midline Carcinoma (NMC), confirmed by specific laboratory testing — either new to treatment or having ha...

**Who might be able to join this trial:** - You are willing and able to take part in all parts of the study - You (or your legal representative) have read, understood, and signed the consent form - You are older than 18 years of age - You have leg artery disease that causes symptoms ranging from mild leg cramping when...

Who might be able to join this trial: - A patient, or their legal guardian or representative, must provide written consent or authorisation as required by the hospital or country where the trial is taking place - The patient has received, is currently receiving, or is planned to receive treatment with a qualifying Medt...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have had, or are planning to have, a medical procedure using one or more specific Abbott medical devices covered by this registry - People who are willing and able to attend follow-up appointments as outlined in the study p...

**Who might be able to join this trial:** - You have symptoms of blocked or narrowed arteries in your legs that cause pain or cramping during activity or at rest (a condition rated at a moderate level of severity) - Your doctor expects you to live for more than 36 months - If you are a woman who could become pregnant,...

Who might be able to join this trial: - Adults aged 18 years or older - People who are willing and able to sign a written consent form allowing their data to be used - People who have been treated with a specific Boston Scientific drug-coated medical device (one that releases medication to keep blood vessels open) that...

**Who might be able to join this trial:** - People aged over 18 years - People who have been diagnosed with peripheral artery disease (narrowing of the arteries in the legs) that is causing symptoms, AND who meet at least one of the following conditions: - People who experience leg pain when walking (called claudicati...

**Who might be able to join this trial:** - You are at least 18 years old (male or female) - You have been diagnosed with end-stage kidney disease and have been on regular dialysis for at least 12 weeks - A blood test shows your inflammation levels (called hs-CRP) are at or above a certain level — 2.0 mg/L (confirm wit...

Who might be able to join this trial: - People who (or whose legal representative) have given written consent before any study procedures begin, using the approved consent form. - People who agree not to take part in any other clinical drug or device trial for at least 12 months after the procedure (non-invasive questi...

Who might be able to join this trial: - Adults aged 18 or older who are legally able to give consent - People who have leg pain during activity or at rest that limits daily life, at a specific level of severity as measured by a standard scale (Rutherford-Becker scale 2–4), with reduced blood flow to the lower leg confi...

Who might be able to join this trial: - People who have peripheral artery disease (PAD) that causes leg pain or cramping when walking (known as intermittent claudication), at a specific stage of severity called Fontaine Stage II. - People whose ankle-brachial index (ABI) score — a simple test that compares blood pressu...

Who might be able to join this trial: - The patient must be a child or young person between 0 and 18 years old who is scheduled for a planned (non-emergency) same-day surgery or a procedure that requires anesthesia outside of an operating room - The patient must need a drip or IV line placed into a vein - A parent or l...

Who might be able to join this trial: - People who have been diagnosed with Neurofibromatosis Type 2 (NF2), either through established medical criteria or genetic testing. - People aged between 8 and 75 years old. - People who are able to have repeated MRI scans of the brain and spine without needing sedation through a...

Who might be able to join this trial: - You have had a minimally invasive procedure to treat a blocked or narrowed blood vessel (known as an endovascular intervention) - The blood vessel treated was located in your pelvis, thigh, knee, or lower leg area (specifically one of the following: iliac, common or superficial f...

**Who might be able to join this trial:** - People whose medical records include a past endovascular procedure (a minimally invasive blood vessel treatment) for symptomatic peripheral artery disease (reduced blood flow in the limbs causing symptoms), performed between January 2006 and the date the trial was approved —...

**Who might be able to join this trial:** - You have confirmed, lasting damage to your central or peripheral nervous system that is unlikely to get better with current standard treatments. - Your condition began at least 6 months ago. - If you are currently on medication or have had surgery for your condition, your hea...

Who might be able to join this trial: - People who have a long-term history of claudication (leg pain or cramping during walking caused by reduced blood flow). - People whose leg pain during walking has been confirmed by a vascular surgeon, both through discussion and by observing them during a walking test. - People w...

**Who might be able to join this trial:** - People who have been diagnosed with pre-diabetes, shown by specific blood sugar test results: a HbA1c (average blood sugar level) between 5.7% and 6.4%, or fasting blood sugar readings of 100–125 mg/dL on two separate days, or a blood sugar level of 140–199 mg/dL two hours a...

**Who might be able to join this trial:** - Adults aged 18 or older - People with multiple myeloma (a type of blood cancer) that has come back or stopped responding to treatment, and who have previously been treated with three specific types of therapy: an immunomodulatory drug, a proteasome inhibitor, and an alkylati...

Who might be able to join this trial: - People who were diagnosed with cancer before age 26 and have at least one blood relative (within three degrees of relation) who was diagnosed with cancer before age 51. - People who have had more than one cancer diagnosis, where at least one of those cancers was diagnosed before...

**Who might be able to join this trial:** - People who have been referred to the vascular unit because they have difficulty with exercise or physical activity **Who may not be able to join:** - People who are unable to walk on a treadmill - People who have a serious heart condition that makes stress testing (exercise...

Who might be able to join this trial: - Adults between the ages of 18 and 85 who have been diagnosed with peripheral artery disease (a condition affecting blood flow in the arteries, usually in the legs). - Both men and women of any ethnicity are welcome to participate. - Diagnosis of peripheral artery disease is confi...

Who might be able to join this trial: - People who have been diagnosed with Critical Limb Ischemia (a severe condition where not enough blood reaches the limbs, usually the legs or feet) Who may not be able to join: - Women who are currently pregnant or breastfeeding - People who have been diagnosed with advanced kidn...

Who might be able to join this trial: - People who have had a lower limb amputation due to a chronic wound, bone infection, poor blood supply, or tissue death - People who have been assessed by a specialist doctor as being medically suitable to receive hyperbaric oxygen therapy - People who are able to cooperate with t...

**Who might be able to join this trial:** *For people with peripheral artery disease (poor blood flow in the legs):* - People who are 18 years of age or older - People who have test results (such as blood pressure ankle measurements, imaging scans, or ultrasound) showing a significant blockage or narrowing in one or m...

**Who might be able to join this trial:** **Cohort 1 — Children, Adolescents and Young Adults:** - Written consent must be provided by the patient, parent, or legal guardian, and patients aged 16 or older who are developmentally able will also be asked to give their agreement - People aged 8 to 24 years old at the ti...

**Who might be able to join this trial:** - You are a woman who has gone through menopause and are not currently taking hormone replacement therapy - A test measuring blood flow from your heart to your ankles shows a result below 0.90 (this is called an ankle-brachial index test — confirm with trial site if unsure) - Y...

**Who might be able to join this trial:** - People aged 18 or older. - People who are considered legally able to make their own decisions, have been fully informed about the study, and have voluntarily signed a consent form. - People whose leg artery disease falls within a moderate-to-moderately-severe range of sympto...

Who might be able to join this trial: - People who have a history of claudication (leg pain or cramping that occurs during walking or physical activity due to reduced blood flow). - People who have been diagnosed with peripheral artery disease (PAD), confirmed by at least one of the following: a resting ankle-brachial...

**Who might be able to join this trial:** - You or a close family member has been diagnosed with the condition being studied in this trial. - You are an NHS patient at one of the participating clinics or hospitals, even if you do not have the condition being studied (you may be asked to take part as a comparison partic...

Who might be able to join this trial: - You have had one leg amputated below the knee (not due to an injury or accident) - You have diabetes and/or poor circulation in your legs (peripheral artery disease) - You are able to walk around in the community without using a cane, walker, or other walking aid - Your two steps...

Who might be able to join this trial: - People who are 18 years of age or older, of any gender - People who are having a procedure to treat varicose veins, OR - People who are having a lower limb (leg or foot) amputation, OR - People who are having bypass surgery on a lower limb (leg or foot) Who may not be able to jo...

Who might be able to join this trial: **Primary group:** - People attending the Leicester Vascular Institute with a condition called severe limb ischaemia (SLI), which is serious reduced blood flow to a limb **Frailty & Cognitive assessments (additional group):** - People already in the primary group who have been sc...

**Who might be able to join this trial:** - People who have been diagnosed with primary or idiopathic erythromelalgia (a condition causing burning pain and redness, not caused by another underlying disease) - People aged 18 or older whose chronic pain has not responded to medical treatments for at least 6 months - Peop...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have signs of severely reduced blood flow to their limbs (a condition called critical limb ischemia) and whose doctors have identified them as candidates for a procedure to restore that blood flow - Women of childbearing ag...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with a meningioma (a type of brain tumor) confirmed by a pathology report, and where scans suggest the tumor may have come back or some tumor may remain after treatment - People with certain other types...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have a medical need for a specific type of heart support device, such as a peripheral VA-ECMO (a machine that temporarily takes over the work of the heart and lungs), a microaxial flow pump called an IMPELLA (a small device that helps t...

**Who might be able to join this trial:** - People scheduled for planned (non-emergency) surgery for a popliteal artery aneurysm (a bulge in an artery behind the knee) that is not causing symptoms - People scheduled for planned surgery for peripheral artery disease (reduced blood flow in the arteries of the legs) - Peo...

**Who might be able to join this trial:** - People who have been diagnosed with peripheral artery disease (PAD), a condition affecting blood flow in the legs, confirmed through one of several recognised tests (confirm with trial site for which test applies) - People aged 18 or older - People with a Body Mass Index (BM...

Who might be able to join this trial: - People aged 18 years or older, of any gender. - People diagnosed with critical lower limb ischemia, meaning they have rest pain (pain in the leg or foot while lying down) or a wound such as a foot ulcer or gangrene that has been present for more than 2 weeks, along with specific...

Who might be able to join this trial: - You have been diagnosed with coronary artery disease (narrowed or blocked heart arteries), confirmed by a past heart attack, a procedure to open blocked arteries, or clear evidence seen on a heart scan or imaging test. Who may not be able to join: - You are not willing or able t...

Who might be able to join this trial: **General requirements (all participants):** - People who have a confirmed genetic change in the NF2 gene, or who meet recognised medical diagnostic criteria for a condition called NF2 (neurofibromatosis type 2), which can involve tumours on the hearing nerves, brain, or spinal co...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of giving consent. - People who have a significant narrowing (70% or more) or blockage in one or more arteries in the hip, thigh, knee, or lower leg area, in either a new or previously treated area, that a doctor determines...

**Who might be able to join this trial:** - People who have read, understood, and signed a consent form, and are willing to attend all study visits and follow all study procedures for the full duration of the trial. - People who are 18 years of age or older. - Women who could become pregnant must agree to use a highly...

**Who might be able to join this trial:** - You are 18 years of age or older - You have a significant blockage or narrowing in the artery running down your thigh to behind your knee, classified as a complex type (TASC-C or TASC-D), and it has not been treated before - The blockage starts in the main thigh artery and do...

**Who might be able to join this trial:** - People aged 21 years or older - People who have a serious limb condition rated as Rutherford class 4 to 6 — this means the affected leg has rest pain, non-healing wounds, or tissue loss (confirm with trial site) - People whose leg artery blockage or narrowing (greater than 5...

**Who might be able to join this trial:** - People aged 18 or older - People who are between 6 weeks and 6 months after a stroke, with remaining weakness on one side of the body that includes foot-drop (difficulty lifting the front part of the foot) - People who are more than 6 months after a stroke, with remaining wea...

**Who might be able to join this trial:** - People who have been diagnosed with biliary tract cancer (either cholangiocarcinoma or gallbladder cancer), confirmed through a tissue or cell sample from a biopsy or surgery. - People whose cancer cannot be surgically removed. - People who have already received a first roun...

Who might be able to join this trial: - People diagnosed with a brain tumor that has a generally favorable outlook, where the median survival is expected to be more than 10 years - People aged 18 years or older - People who are in good general health and able to carry out normal daily activities, as measured by standar...

**Who might be able to join this trial:** - People who have had Type 2 diabetes for more than 1 year - People whose diabetes is classified as stage 3 or lower (confirm with trial site) - People who are 18 years of age or older - People who have ongoing, hard-to-treat nerve pain in their legs or feet related to diabetes...

**Who might be able to join this trial:** - You have been diagnosed with a blood clot in a deep vein (DVT) along with a significant narrowing (more than 50%) in the vein in your hip/pelvis area on the same side, either caused by vein compression or leftover clot after a clot-removal procedure. - You have had a mechani...

**Who might be able to join this trial:** **As a patient participant:** - People who are older than 20 years of age at the time of screening. - People who have chronic kidney disease with a moderate reduction in kidney function (a specific kidney filtering measure called eGFR must be between 15 and 60), and whose kidn...

**Who might be able to join this trial:** *Group 1 — People with both chronic kidney disease and peripheral artery disease:* - People who are older than 20 years of age at the time of screening - People with chronic kidney disease where the kidneys are working at a reduced but stable level (a specific kidney function...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have a blockage or narrowing in the blood vessels below the knee (in the lower leg area) - People who have at least one blood vessel still open and carrying blood flow in the foot - People whose leg circulation problems fal...

**Who might be able to join this trial:** - People aged 55 or older - People diagnosed with peripheral artery disease (PAD), which the trial defines in one of three ways: a standard circulation test result (called an ABI) showing 0.90 or below; imaging or lab results showing a significant blockage or reduced blood flo...

**Who might be able to join this trial:** - People who have been diagnosed with peripheral arterial disease (reduced blood flow) in the lower limbs, with a specific test score below 0.90, narrowing of the arteries in the legs, and leg pain or cramping when walking - People who have no medical reason preventing them fro...

**Who might be able to join this trial:** - People aged 18 to 75 years old - People with a leg circulation problem rated at Rutherford category 3, 4, or 5 — meaning moderate to severe symptoms such as leg pain at rest or small wounds that won't heal (confirm with trial site) - People who have a significant narrowing (7...

**Who might be able to join this trial:** - You are older than 40 years of age - You are an eligible U.S. Veteran - You have been diagnosed with peripheral artery disease (PAD), confirmed by a vascular test or medical imaging - You have had leg pain or cramping when walking (a condition called intermittent claudicatio...

**Who might be able to join this trial:** - People who have been diagnosed with peripheral artery disease (a condition where the arteries supplying blood to the limbs become narrowed or blocked), confirmed in one or more of the following ways: - People who experience leg pain when walking (called intermittent claudica...

**Who might be able to join this trial:** - People aged 18 to 90 years old. - People who agree not to take part in any other trial involving an investigational drug or device for at least six months after the procedure (non-invasive studies or questionnaire-based studies are allowed). - People who provide written cons...

Who might be able to join this trial: - People who have signed and dated a consent form agreeing to take part (or where allowed, those who have not objected to taking part) Who may not be able to join: - People whose medical device was used to treat two or more different health conditions during the same procedure - P...

**Who might be able to join this trial:** - People who had a stroke at least 6 months ago - People who have enough mental clarity to follow simple instructions and understand the study — this is measured by a short memory and thinking test, with a score above 21 required - People who have mild to moderate weakness or...

**Who might be able to join this trial:** - People aged 18 or older (depending on local rules where the trial is being conducted) - People with a life expectancy of at least one year - People who have a serious, long-standing reduction in blood flow to a limb, classified as Rutherford category 4 (rest pain) or categor...

Who might be able to join this trial: - You are 20 years old or older - You have been diagnosed with peripheral artery disease (a condition where narrowed arteries reduce blood flow to the limbs), confirmed by a specialist test or a doctor's assessment - You experience claudication, which means you have pain, cramping,...

Who might be able to join this trial: - People who are 18 years of age or older - People who have moderate to severe Raynaud's phenomenon (a condition affecting blood flow to the fingers and toes) that has not been controlled after 3 months of standard treatment prescribed by a Rheumatologist, or people who have severe...

**Who might be able to join this trial:** - You are a male or female Veteran between the ages of 36 and 88 - You have symptoms of leg pain or cramping when walking (known as intermittent claudication) - You have been medically stable and receiving standard treatments for more than 3 months, such as cholesterol-lowerin...

**Who might be able to join this trial:** - You have leg pain when walking or more serious leg problems due to poor blood flow (classified at a certain level of severity by your doctor) - You are considered a suitable candidate for a procedure that uses X-ray imaging to look at your blood vessels and for a minimally in...

**Who might be able to join this trial:** - You are 18 years of age or older - You have swallowing difficulties caused by a neurological condition, which may include any of the following: - Stroke (either a blockage or bleed in the brain, in any part of the brain) - A nerve condition affecting multiple nerves throughou...

"Who might be able to join this trial: - People who have had a total hip replacement and have continued to limp, with a specific walking test (called Trendelenburg's sign) showing a positive result, for at least 12 months after the surgery - People whose gluteus medius tendon (a tendon in the hip/buttock area) has been...

Who might be able to join this trial: - People who have osteoarthritis in one hip (not both) and are scheduled to have a total hip replacement surgery. - People who are able to understand and write in Swedish. Who may not be able to join: - People who have problems with their other hip or either knee that cause them t...

**Who might be able to join this trial:** - People diagnosed with lymphoma who have received no more than 2 previous treatments, or people with multiple myeloma who have received exactly one previous treatment - People whose cancer responded at least partially to their previous treatment - People whose doctors conside...

"Who might be able to join this trial: - People who are able to understand and agree to participate in the trial by giving informed consent Who may not be able to join: - People who are currently pregnant - People whose results from a Barbeau test (a test that checks blood flow in the wrist area) come back negative (c...

**Who might be able to join this trial:** - You are a man between 51 and 79 years old - You identify as White or African American - You speak English - You have a specific measurement of blood flow in your legs that falls in a certain low range (called an ABI of 0.4 to below 0.60 — confirm with trial site what this mea...

**Who might be able to join this trial:** - You have been diagnosed with a level of limb blood flow problems rated between grades 3 and 6 on a standard medical scale (this covers moderate to severe symptoms — confirm with trial site) - You are able and willing to attend follow-up appointments as scheduled - You are bet...

**Who might be able to join this trial:** - You are a Veteran with enough blood flow in your leg (shown by a detectable pulse behind the knee or in the upper thigh with a signal behind the knee) to allow healing after a below-the-knee amputation - You are willing and expected to take part in rehabilitation and learn t...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been experiencing leg pain or cramping when walking (claudication) due to peripheral artery disease (PAD) for more than 3 months - People whose blood pressure measurement in the affected leg is below a certain level, indicating...

Who might be able to join this trial: - You are a man or woman aged 51 or older - You have a reduced blood flow to your legs, shown by a specific test called an ankle-brachial index (ABI) of 0.9 or less in at least one leg (confirm with trial site) - If your ABI is slightly above 0.9, you may still qualify if a heel-ri...

**Who might be able to join this trial:** - Adults who have been diagnosed with peripheral artery disease (PAD) — a condition where narrowed arteries reduce blood flow to the legs — and are experiencing symptoms such as leg pain when walking - People whose ankle-brachial index (a blood pressure measurement comparing th...

**Who might be able to join this trial:** - People who have been assessed as having a Rutherford grade 4, 5, or 6 — a medical rating that indicates serious reduced blood flow to the legs, causing rest pain, ulcers, or gangrene (confirm with trial site) - People who understand the study's purpose, are willing to take p...

**Who might be able to join this trial:** - People aged 50 years or older. - People who have been diagnosed with peripheral artery disease (PAD), a condition where blood flow to the legs is reduced, confirmed through specific circulation tests or imaging showing significant artery narrowing. - People whose circulation...

**Who might be able to join this trial:** - People aged 19 years or older - People who have severe heart failure (cardiogenic shock) that has not responded to treatment, and who are currently on a heart-lung bypass support machine called a VA-ECMO connected through the leg (peripheral VA-ECMO) - People who are able to...

Who might be able to join this trial: - People aged 18 or older - People currently being supported by a specific heart-lung bypass device used through the blood vessels (called peripheral VA-ECMO) - People who have this support in place because their heart is not pumping enough blood (a condition called cardiogenic sho...

**Who might be able to join this trial:** - Adults aged 18 or older - People who are willing to give written consent before the procedure on the target artery is carried out - People who are willing to attend the required follow-up appointments as scheduled by the trial - People with leg artery disease classified as R...

**Who might be able to join this trial:** - You have a history of leg pain while walking (called claudication), assessed using a standard walking questionnaire - You experience leg pain in one or both legs during walking, which is confirmed during a treadmill test - A blood pressure test of your ankles shows reduced bl...

Who might be able to join this trial: - People who have been diagnosed with peripheral artery disease (reduced blood flow in the arteries of the legs) in one or both legs, confirmed by a specific circulation test showing poor blood flow or hardened, non-compressible blood vessels. - People who have a severe form of thi...

Who might be able to join this trial: - People aged 16 years or older. - People who have been diagnosed with a neurological injury affecting the brain, spinal cord, and/or peripheral nerves during their current hospital stay. - People whose injury is complex enough to require admission to a specialist neurorehabilitati...

**Who might be able to join this trial:** - Adults between 18 and 80 years old, of any gender - People who have been diagnosed with peripheral artery disease (PAD) affecting the legs — a condition where blood flow to the legs is reduced due to narrowed arteries - People whose symptoms fall within a specific range of s...

Who might be able to join this trial: - You must be an adult aged 18 or older - You must be receiving a type of life support called peripheral venoarterial ECMO (a machine that helps the heart and lungs by pumping blood outside the body through tubes inserted into blood vessels) - You must be sedated (in a medically in...

**Who might be able to join this trial:** - People aged between 18 and 65 years old - People who have been diagnosed with a condition called atherosclerotic peripheral arterial disease (a narrowing or blockage of the arteries in the limbs due to fatty deposits) - People for whom surgery or a procedure to restore blood...

Who might be able to join this trial: - People who have had a procedure to treat a blocked blood vessel where a device called the Pounce Thrombectomy System was used or attempted - People who are willing and able to give their consent to have their data collected for the study, or where a formal consent waiver has been...

Who might be able to join this trial: - People aged 18 years or older. - People (or their legal representative) who understand what the procedure involves and are willing to sign a consent form before the study begins. - People with a disease of the aorta (the body's main artery) who need a type of minimally invasive s...

**Who might be able to join this trial:** - You have been rated between 2 and 5 on a scale doctors use to measure leg circulation problems (called the Rutherford classification) - You are willing to attend follow-up check-ups at the required times after the procedure - You are older than 18 years of age - You understan...

**Who might be able to join this trial:** - People who are over 18 years old. - People who understand what the procedure involves and are willing to sign a consent form before joining the study. - People whose affected blood vessel(s) are located in the kidney, hip/pelvic, or leg arteries. - People whose condition is s...

**Who might be able to join this trial:** - Adults aged 18 or older - People who are willing to participate and sign an approved consent form - People who are able to walk on their own or with a non-motorised walking aid (such as a cane or walker) - People who have been diagnosed with peripheral artery disease (PAD) —...

**Who might be able to join this trial:** - Adults aged 18 or over (men or women) who have been diagnosed with a blockage or narrowing of the arteries in their legs, confirmed by an ultrasound or imaging scan of the blood vessels. **Who may not be able to join:** - People under 18 years of age. - People who have had a...

**Who might be able to join this trial:** - People aged between 18 and 85 years old. - People who are able to understand the purpose of the trial, are willing to take part voluntarily, sign a consent form, and commit to follow-up appointments over 12 months. - People who have a serious condition called Critical Limb I...

**Who might be able to join this trial:** - People who are able to give written, informed consent - People who have a confirmed diagnosis of blocked or narrowed arteries in the lower limbs, based on blood pressure measurements taken at the ankle and arm, and/or medical imaging of the arteries - People who have a histor...

**Who might be able to join this trial:** - You had a procedure to restore blood flow in the aorta (the main large artery in your body) or other arteries in your limbs at the Peripheral Vascular Disease Center, Asan Medical Center, any time from 2011 onwards - You have been diagnosed with a disease of the aorta or peri...

**Who might be able to join this trial:** - You are 50 years of age or older. - You have been diagnosed with peripheral artery disease (PAD), which is reduced blood flow to the legs — confirmed by a specific blood pressure test in the ankle or toe, or by imaging that shows a significant blockage in a leg artery, or by...

**Who might be able to join this trial:** - You can be a man or a woman - You have been diagnosed with peripheral artery disease (PAD) in your legs caused by narrowed or blocked arteries - You experience leg pain or cramping when walking, at a mild to moderate level (your doctor can confirm where you fall on this scale...

**Who might be able to join this trial:** - You have been diagnosed with peripheral artery disease (PAD), a condition affecting blood flow in the legs - Your PAD symptoms have been stable for at least 3 months - You are between 40 and 85 years old - You are a man or a woman who is not currently pregnant or breastfeedin...

**Who might be able to join this trial:** **For people who have experienced cortical blindness (vision loss from brain injury):** - You live in the United States or Canada - You had a stroke or similar brain injury affecting the vision area of your brain, and it happened between the ages of 21 and 75 (confirmed by MRI...

Who might be able to join this trial: - People who have had an acute (sudden-onset) stroke caused by a blocked small blood vessel in the brain, confirmed by MRI, within the last 72 hours - People whose stroke symptoms have noticeably worsened — either a significant drop in overall neurological function or worsening of...

Who might be able to join this trial: - People with severe limb-threatening poor blood flow (called critical limb ischemia, or CLI) who are scheduled for surgery to explore or bypass blood vessels behind the knee. - People with severe limb-threatening poor blood flow where the tissue damage is permanent and/or gangrene...

Who might be able to join this trial: - People aged 18 or older - People who are scheduled for a planned leg artery surgery, either as a routine or urgent procedure — this includes certain types of bypass surgery or procedures to clear or repair a leg artery - People who have access to a telephone for follow-up calls a...

**Who might be able to join this trial:** - A person (or their legally authorised representative) has signed a consent form approved by the relevant ethics committee before any study procedures begin. - The person agrees not to take part in any other trial involving an investigational drug or device for at least 12 mo...

Who might be able to join this trial: - People who are 18 years of age or older - People who are willing and able to sign a consent form agreeing to take part in the trial - People who have significant leg pain when walking short distances (less than 200 metres) due to poor blood flow, or who have more severe condition...

**Who might be able to join this trial:** - People who have had ongoing, severe leg pain for at least 6 months, with a pain level of 5 or higher on a standard 0–10 pain scale - People who, or whose legal guardian, have fully understood the details of the trial and signed a consent form (where a signature was possible t...

**Who might be able to join this trial:** - People aged 18 or older - People who have been told about the study, agree to take part, and have signed an approved consent form - People who understand how long the study runs, are willing to attend follow-up visits, and agree to complete required tests - People with a Ruth...

**Who might be able to join this trial:** - You have been diagnosed with Peripheral Arterial Disease (PAD) — a condition affecting blood flow to the legs — and have symptoms such as leg pain when walking - A test measuring blood flow in your legs (called an ABPI test) shows reduced circulation in at least one leg - Yo...

Who might be able to join this trial: - People diagnosed with a serious condition where severely reduced blood flow to a limb is causing significant symptoms (classified as Rutherford Category 4 or higher) - People who have calcified (hardened) blockages in the arteries of the upper leg, behind the knee, or lower leg t...

Who might be able to join this trial: - People diagnosed with Guillain-Barré syndrome who have been on a breathing machine (mechanical ventilator) for at least 48 hours and are having difficulty being weaned off it (meaning they have failed at least one attempt to breathe on their own and may need up to three attempts...

Who might be able to join this trial: - You have had surgery involving nerve release and a fat tissue graft procedure to treat a returning case of a nerve compression condition affecting the shoulder, chest, and arm area (confirm with trial site) Who may not be able to join: - You are unable to express that you are ok...

**Who might be able to join this trial:** - People aged 21 years or older (minimum age may vary depending on the US state) - People who have a serious reduction in blood flow to a limb causing rest pain (a condition classified as Rutherford class 4), with a documented wound, ischaemia, and foot infection (WIfI) score,...

**Who might be able to join this trial:** *For patients with peripheral artery disease (PAD):* - Men and women between 40 and 85 years old. - People diagnosed with peripheral artery disease (reduced blood flow in the limbs) at certain severity levels, including some with minor wounds on the feet or legs. - People who...

Who might be able to join this trial: - Men and women between 40 and 90 years old who have an abdominal aortic aneurysm (a bulge in the main blood vessel in the abdomen) larger than 3cm, in various locations in the abdomen or pelvis - Men and women between 40 and 90 years old who have an infection-related aneurysm (som...

**Who might be able to join this trial:** *For the LEAD (leg artery disease) group:* - People who have been diagnosed with lower limb artery disease (a condition where reduced blood flow affects the legs) - People experiencing symptoms ranging from no pain at rest through to severe limb pain or wounds, as classified b...

**Who might be able to join this trial:** - You are a man or woman between 18 and 90 years old - You have been diagnosed with peripheral arterial disease (poor blood flow) in your legs or feet - You are willing and able to attend follow-up appointments at the required times - You understand what the study involves and...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender - People who have been diagnosed with primary aldosteronism (a hormonal condition affecting the adrenal glands) following proper testing, and whose specific type has been identified as either an aldosterone-producing growth or generalis...

**Who might be able to join this trial:** - People aged between 19 and 80 years old - People who have been diagnosed with hardening of the arteries affecting the blood vessels in the legs — this includes people whose ankle-to-arm blood pressure ratio is below 0.85 with leg pain when walking, people with more than 50% n...

Who might be able to join this trial: - You must be currently admitted as a patient at the hospital running this trial. - You must have a condition called chronic permanent ischemia (poor blood flow to the limbs that has been present for a long time), confirmed by a specific oxygen measurement taken while resting that...

Who might be able to join this trial: - People who were between 1 and 30 years old at the time of the biopsy that confirmed their diagnosis of non-rhabdomyosarcoma soft tissue sarcoma (NRSTS). - People who had surgery to remove the tumour before enrolling, provided treatment can begin within 28 days of that surgery. -...

**Who might be able to join this trial:** - You have agreed and given written consent to take part before any study activities begin - You are 50 years of age or older and have been diagnosed with leg artery disease causing significant leg pain when walking or serious problems with blood flow to your limbs, and you hav...

Who might be able to join this trial: - You must be 18 years of age or older with a history of a condition where fatty deposits have narrowed or blocked the arteries in your legs or feet (called peripheral arterial disease). - You must have received treatment for this condition between 1st January 2015 and 1st January...

Who might be able to join this trial: - People who are of legal adult age (male or female) - People who are scheduled to have a transfemoral amputation (removal of the leg above the knee) as part of their standard medical care at the Hôpitaux Universitaires de Strasbourg vascular surgery department - People who are alr...

Who might be able to join this trial: - People aged 60 or older who have a serious reduction in blood flow to a limb (called chronic limb threatening ischemia) and are scheduled to have surgery to restore that blood flow, either through a minimally invasive (endovascular) procedure or open bypass surgery. Who may not...

Who might be able to join this trial: - People who have peripheral artery disease (reduced blood flow in the legs) along with rest pain, gangrene, or a leg wound that has not healed for more than 2 weeks — a condition known as chronic limb-threatening ischemia. - People whose blocked or narrowed arteries are located be...

Who might be able to join this trial: - People who are currently admitted to the Heart-Lung Unit at Montpellier University Hospital, for any medical reason - People who either have lower limb artery disease (a condition affecting blood flow in the legs) at any stage, or who do not have this condition at all - People wh...

**Who might be able to join this trial:** - You must be 18 years of age or older - You must have signed an approved consent form agreeing to take part in the trial - You must have severe reduced blood flow to your lower limb(s) that cannot be treated by reopening the blood vessels, either because two previous attempts...

**Who might be able to join this trial:** - People aged 18 or older - People who have been referred to a vascular medicine department at one of the study centres for an arterial ultrasound of at least one leg, and who are also having a blood pressure measurement taken at the toe - People who have a confirmed arterial d...

Who might be able to join this trial: - People who experience leg pain while walking caused by narrowed arteries, where the pain goes away with rest (known as intermittent claudication). - People whose blood flow measurements meet certain minimum levels — specifically, an ankle-to-arm blood pressure ratio above 50 mmHg...

Who might be able to join this trial: - You are 18 years old or older - You are seen at a clinic for heart and blood vessel care, general/primary care, foot care, vascular surgery, or diabetes management - You have a diagnosis of PAD (peripheral artery disease, a condition affecting blood flow in the arteries) recorded...

Who might be able to join this trial: - People who are over 18 years of age - Both men and women are eligible - People who are expected to have a below-the-knee (transtibial) amputation - People who have peripheral arterial disease (a condition affecting blood flow in the arteries), and who may have had a specific oxyg...

Who might be able to join this trial: - People who are at least 18 years old - People who are willing and able to sign a written consent form agreeing to take part - People who have been diagnosed with critical limb ischemia caused by atherosclerosis (a condition where narrowed arteries severely reduce blood flow to th...

Who might be able to join this trial: **For people with peripheral artery disease (PAD) — reduced blood flow to the legs:** - People who are able to sign a written consent form agreeing to take part - People aged between 50 and 75 years - People diagnosed with PAD at a stage where walking causes leg pain (Fontaine sta...

**Who might be able to join this trial:** - You are 18 years of age or older - Your doctor has recommended a procedure to remove plaque buildup from a blood vessel in your lower leg or foot (called atherectomy) - Your doctor believes you are expected to live for more than 1 year - Tests show that blood flow to your lo...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of giving consent - People who are willing to attend all required follow-up visits and have signed an approved consent form - Women who could become pregnant must have a negative pregnancy test within 7 days before the proc...

**Who might be able to join this trial:** - People aged 18 or older at the time of enrolling in the trial. - People who have been diagnosed with a large bulge (aneurysm) in the major blood vessel of the chest and/or abdomen that requires a specific type of internal repair using a custom-fitted device delivered through...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with one of the medical conditions that this study is looking at (confirm with trial site) Who may not be able to join: - You are under 18 years of age - You have not been diagnosed with one of the medical conditions that t...

**Who might be able to join this trial:** **For people with Peripheral Arterial Disease (PAD):** - People who are able to give written consent to participate - People aged between 50 and 85 years old - People diagnosed with PAD at a stage where walking causes leg pain (known as Fontaine stage II or III) - Women who ha...

**Who might be able to join this trial:** - People who meet all of Johns Hopkins' internal requirements for a reduced-intensity stem cell transplant from a donor (using peripheral blood stem cells, not cord blood) — eligible donor types include matched related donors, half-matched (haploidentical) donors, matched unre...

**Who might be able to join this trial:** - You are 50 years of age or older - You have been diagnosed with peripheral artery disease (PAD), which is a condition where the arteries supplying blood to your legs are narrowed or blocked - Your PAD has been confirmed by a specific blood pressure measurement in your ankle...

**Who might be able to join this trial:** - People aged 50 and older - People who have been diagnosed with peripheral artery disease (PAD) — a condition where reduced blood flow affects the legs — confirmed by one of the following: a specific blood pressure test in the ankle showing reduced flow, imaging evidence of a...

Who might be able to join this trial: - People who have a long-term history of claudication (leg pain or cramping during walking caused by poor blood flow) - People whose claudication limits their ability to exercise, as confirmed by a vascular surgeon through observation during a walking test - People who have been di...

**Who might be able to join this trial:** - You have been diagnosed with peripheral artery disease (PAD) that is currently stable - A specific blood flow test (comparing blood pressure in your ankle to your arm) shows a reading between 0.41 and 0.90 in one or both legs - You have mild to moderate leg pain when walking...

Who might be able to join this trial: - You have a specific blood flow test result (called an ankle-brachial index) of 0.90 or lower, which can indicate reduced blood flow to the legs - Your condition has been stable for at least 3 months Who may not be able to join: - You have been regularly exercising or taking part...

Who might be able to join this trial: - People whose affected leg has been classified as Rutherford category 4, 5, or 6, which generally means serious limb problems such as rest pain, minor tissue loss, or major tissue loss (confirm with trial site) - People who are older than 18 years of age - People who have agreed t...

**Who might be able to join this trial:** - You must be 18 years of age or older - You must have been diagnosed with type 1 or type 2 diabetes - You must have a foot ulcer that measures between 1.0 cm² and 20.0 cm² in size after any wound cleaning has been done - Your foot ulcer must have been present for at least 4 w...

**Who might be able to join this trial:** - You experience calf pain when walking 300 metres or less on a treadmill - Your symptoms have been stable and consistent for at least 6 months - Your calf pain goes away within 5 minutes after you stop walking - Your ankle-brachial index (a blood pressure test comparing your a...

**Who might be able to join this trial:** - People between 40 and 80 years of age. - People who identify as White or African American. - People who can read and write in English. - People with a specific ankle-brachial index (a blood pressure measurement comparing the ankle and arm) result between 0.4 and 0.90, taken...

**Who might be able to join this trial:** - People between 19 and 89 years old - People who have been diagnosed with diabetes - People who have signs or symptoms of nerve damage (neuropathy), with a pain score of 5 or higher on a pain scale, and have been diagnosed with poor blood flow in the legs (peripheral arterial...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People who have been diagnosed with critical limb ischemia (a serious condition where blood flow to the legs is severely reduced), with a severity rating of Rutherford score 4–6 (confirm with trial site) - People who cannot have surgi...

**Who might be able to join this trial:** - You have signed and dated a consent form agreeing to take part. - You are between 18 and 85 years old (inclusive). - You have been assessed as having severe leg pain when walking or wounds/sores on your leg due to poor blood flow (confirm with trial site for exact classifica...

Who might be able to join this trial: - People who have symptoms of peripheral artery disease (reduced blood flow in the legs) that fall within a certain severity range, and whose doctor has recommended a procedure to reopen the blocked or narrowed artery from the inside - People who have a specific type of blockage or...

Who might be able to join this trial: - People who have a possible or probable diagnosis of mild cognitive impairment (MCI) or early dementia. - People aged between 30 and 95 years old. - People who have a study partner (such as a family member or close friend) who has some contact with them at least once a week. - Peo...

**Who might be able to join this trial:** - People aged 18 to 85 years old, of any sex - People whose blocked or narrowed artery is located in the upper leg artery (superficial femoral artery) or the upper part of the artery behind the knee (proximal popliteal artery) - People with leg artery narrowing or blockage tha...

**Who might be able to join this trial:** - Adults aged 18 or older who have been diagnosed with atherosclerotic cardiovascular disease (a condition where arteries are narrowed or blocked by fatty deposits) — confirmed by at least one of the conditions listed below - People with a history of a heart attack caused by a...

Who might be able to join this trial: - People who have poor blood flow in the arteries of the leg or foot, along with wounds or tissue damage that are considered severe (classified as Rutherford stage 5 or 6, meaning significant ulcers or gangrene) - People who are already scheduled to have a minimally invasive proced...

**Who might be able to join this trial:** - You have an arteriovenous fistula (AVF — a surgically created connection between an artery and vein used for dialysis) that is not working well, with at least one narrowing causing problems with blood flow or dialysis performance (both new and returning narrowings are accepte...

Who might be able to join this trial: - You are an adult (male or female) who has been diagnosed with peripheral artery disease (PAD), which is a condition affecting blood flow in the legs - You experience pain in your legs when you walk - You are already scheduled to have a stent procedure for your PAD (a stent is a s...

**Who might be able to join this trial:** - You are over 40 years old - You have been diagnosed with Type 2 Diabetes (whether or not you use insulin) for at least 5 years - You have been diagnosed with a heart or blood vessel disease (such as heart disease, stroke-related disease, or poor circulation in the legs) — OR...

Who might be able to join this trial: - People aged 18 or older - People with a specific type of aortoiliac artery blockage or narrowing (classified under a system called TASC-II as modified class A, B, C, or D — confirm with trial site) - People with a Rutherford score of 2 to 5, which is a scale used to measure how s...

Who might be able to join this trial: - People who have been diagnosed with Type 2 Diabetes. - People who have swelling in one foot (not both). - People who have an active condition called Charcot Neuroarthropathy, which is a serious condition affecting the bones and joints of the foot, often linked to diabetes-related...

Who might be able to join this trial: - People aged 18 to 80 years, of any sex - People who have been diagnosed with a build-up of fatty deposits (atherosclerosis) in the main or outer iliac arteries, which are located in the pelvis and upper leg area - People whose leg symptoms fall within a specific range of severity...

Who might be able to join this trial: - You were first diagnosed between the ages of 18 months and 18 years, and you are at least 3 years old at the time of joining the trial. - You have a solid tumour that has come back or stopped responding to treatment, and a recent scan (done within the last 3 months) showed that y...

Who might be able to join this trial: - You are 18 years of age or older - You have been referred for a heart MRI scan (called a cardiovascular magnetic resonance or CMR scan) at the Montefiore Health System Who may not be able to join: - Anyone who does not meet the requirements listed above Important: Always verify...

**Who might be able to join this trial:** - People who have recently had an acute subarachnoid hemorrhage (a type of bleeding around the brain) - People who are over 18 years old - People whose aneurysm (the weakened blood vessel that caused the bleed) has already been treated and closed off - People who are able to co...

Who might be able to join this trial: - Adults aged 18 to 80 years old who have been diagnosed with peripheral artery disease (PAD) — a condition causing leg pain during walking — with a specific test result confirming reduced blood flow to the legs. - Adults aged 18 to 80 years old who have never been diagnosed with p...

Who might be able to join this trial: - People who are having vascular (blood vessel) reconstruction surgery that involves a cut in the groin area Who may not be able to join: - People who have previously had surgery involving a cut in the groin area - People who are having surgery because of an injury, bleeding, or a...

Who might be able to join this trial: - People who have peripheral arterial disease (reduced blood flow in the legs) with either sudden or long-standing symptoms affecting their ability to walk or causing leg pain, wounds, or tissue damage - People who are scheduled to have a procedure to open up or treat blocked arter...

**Who might be able to join this trial:** - People who have a low ankle-brachial index (ABI) score of 0.90 or below — this is a simple test comparing blood pressure in the ankle and arm to check blood flow in the legs. - People who have laboratory or imaging evidence of peripheral artery disease (PAD), such as reduced...

Who might be able to join this trial: - People who are 18 years of age or older - People who are able to give written consent to participate - People who have been diagnosed with Systemic Sclerosis (SSc) according to a specific set of medical classification guidelines, and who also have a positive ANA (a type of blood...

**Who might be able to join this trial:** - People who have had a successful procedure to restore blood flow in a leg artery for a condition called peripheral artery disease (PAD) that was causing significant walking difficulties, where the procedure was done at least 30 days before initial testing and between 30 and 1...

**Who might be able to join this trial:** - You are planned to receive treatment with a device called the Serranator® for blockages or re-narrowing in arteries in your hip, groin, thigh, knee, lower leg, or foot — or for a poorly functioning dialysis access point in your arm (either natural or artificial). - You have l...

**Who might be able to join this trial:** - People who have been diagnosed with diabetes. - People who have a diabetic foot wound or ulcer rated as moderate to severe (Grade 2 to 4 on a standard medical scale) that has been present for more than 4 weeks. - People who are able to attend follow-up visits over a full year...

**Who might be able to join this trial:** - People aged 18 to 90 years old - People whose life expectancy is greater than 12 months - People with a diagnosis of primary varicose veins (a condition where leg veins become enlarged and twisted), with disease severity falling within a specific range (called CEAP classific...

**Who might be able to join this trial:** - People aged 18 to 90 years old - People who have been diagnosed with primary varicose veins in the lower legs, rated at a certain level of severity (a medical grading called C2–C6), where treatment of one or both of the main leg veins is needed - People experiencing at least...

**Who might be able to join this trial:** - People aged 18 or older - People whose leg artery symptoms fall within a specific range of severity, known as Rutherford Classification 2–5 (confirm with trial site for what this means for your situation) - People who have a significant narrowing (more than 70%) or complete...

Who might be able to join this trial: - Adults aged 18 or older - People who have given written agreement to take part in the study - People experiencing symptoms of reduced blood flow to the lower legs, rated at a moderate level of severity (Rutherford classification 2 to 4) (confirm with trial site) - People who have...

**Who might be able to join this trial:** - People who are 22 years of age or older. - People who have active bleeding in blood vessels outside the brain and heart, confirmed by imaging (such as a scan or camera procedure), and where a procedure to block the bleeding vessel is considered appropriate by the treating do...

**Who might be able to join this trial:** - People aged 18 or older - People who have given written consent to participate in the trial - People with a Rutherford classification (a scale used to measure leg blood flow problems) between 2 and 6 - People whose affected blood vessel measures between 2mm and 7mm in diamet...

Who might be able to join this trial: **Main (Randomised Controlled) Trial:** - People aged 18 or older. - People with a life expectancy of at least one year. - People who are able and willing to take part in all required study visits and assessments. - People who have been fully informed about the study and have sign...

**Who might be able to join this trial:** - You must be 18 years old or older with peripheral artery disease (PAD) that causes rest pain, minor tissue loss, or significant wounds/gangrene (this is called Rutherford Category 4, 5, or 6 — confirm with trial site if unsure which category applies to you) - You must have at...

**Who might be able to join this trial:** - You are over 18 years old - You have been diagnosed with a deep vein thrombosis (DVT – a blood clot in a deep vein) that either happened on its own, was caused by a specific event (such as surgery), or is related to cancer - Your blood clot is located in a vein in one or both...

**Who might be able to join this trial:** - People aged 8 years or older - People who have weakness or movement difficulties in their lower limbs caused by conditions such as cerebral palsy, stroke, spinal cord injury, spina bifida, or nerve injury - People whose situation requires a custom-made ankle-foot brace (AFO)...

**Who might be able to join this trial:** - People whose renal (kidney) artery is at least 4 mm wide and at least 20 mm long - People aged between 18 and 75 years, of any gender - People who are already scheduled for a keyhole (laparoscopic) surgery on their adrenal gland or kidney, such as for an adrenal tumour, earl...

**Who might be able to join this trial:** - People who are between 50 and 85 years of age - People who have had a single stroke more than 6 months ago but less than 15 years ago - People who have at least a small amount of active movement in their ankle (specifically, being able to lift the foot upward at least 5 degre...

**Who might be able to join this trial:** - You are between 18 and 65 years old - You have been assessed by a doctor as being in generally good or only mildly affected health before surgery (this is called ASA level I or II — confirm with trial site if unsure) - You are having surgery that requires continuous blood pre...

Who might be able to join this trial: - People diagnosed with Parkinson's Disease (a condition affecting movement and coordination) - People diagnosed with Multiple System Atrophy (a rare condition affecting the nervous system and movement) - People diagnosed with Dementia with Lewy Bodies (a type of dementia linked to...

**Who might be able to join this trial:** - You are between 18 and 75 years old (any gender) - You have been diagnosed with one of these specific types of soft tissue sarcoma, confirmed by a tissue sample test: undifferentiated sarcoma (except small round cell type), synovial sarcoma, angiosarcoma, fibrosarcoma, smoot...

Who might be able to join this trial: - Adults between 18 and 55 years old. - Healthy adults with no history of major mental health conditions, as confirmed by a licensed clinical psychologist. - Adults diagnosed with major depressive disorder (a condition involving persistent low mood and related symptoms) who are cur...

Who might be able to join this trial: - You must be an adult of any age and any gender - You must have a serious condition where blood flow to a limb is severely reduced, and your doctors are planning to treat it with either a procedure to open blocked vessels or bypass surgery at a specific hospital in Brazil (HC/EBSE...

**Who might be able to join this trial:** - People aged 20 years or older - People who have been diagnosed with moderate or severe reduced blood flow in the lower legs and also have a wound on a lower limb - People whose doctors have determined, after vascular examination and CT imaging, that no further procedures (su...

**Who might be able to join this trial:** - People who have a serious, long-term condition where blood flow to a limb is severely reduced, classified as "Rutherford 5" (this typically means there is tissue loss such as ulcers or gangrene — confirm with trial site) - People who have a blockage or narrowing of 10 centime...

**Who might be able to join this trial:** - You have been diagnosed with peripheral artery disease (poor blood flow in the legs) and have had a bypass surgery on a leg artery - You have had a bypass surgery involving the large artery in your abdomen (aorta) connecting to the leg arteries - You have had a procedure to...

**Who might be able to join this trial:** This trial has three groups. You may qualify for one of the following: - **Group 1:** You have no personal history of vein problems in your pelvis or hip area, and have never had symptoms related to those veins - **Group 2:** You have symptoms or scan results suggesting that...

Who might be able to join this trial: - People aged 18 or older, of any gender - People who are willing to sign and date a consent form agreeing to take part - People who are willing to follow all study procedures and are available for the full length of the study - People who are having an ABI test (a non-invasive tes...

**Who might be able to join this trial:** - You have a blocked femoral artery in your leg and need planned surgery to reroute blood flow above the knee (called a femoral popliteal bypass) - Your leg circulation problem has been rated at a specific level of severity (Rutherford grade 3, 4, or 5), and your blockage is c...

Who might be able to join this trial: **Patient volunteers:** - Adults aged 18 or older of any gender - People who have leg pain or cramping when walking (claudication) and are suspected of having Peripheral Artery Disease (PAD) - People who are already scheduled for vascular (blood vessel) testing **Healthy voluntee...

**Who might be able to join this trial:** *For the acute coronary syndrome (ACS) group — there are three types:* - **STEMI (a type of heart attack):** People who have elevated heart enzyme levels in their blood (indicating heart muscle damage), a specific abnormal pattern on their heart tracing (ECG), AND at least on...

**Who might be able to join this trial:** - People who have peripheral artery disease (PAD) in their legs that has progressed to a serious stage called chronic limb-threatening ischemia (CLTI) — meaning they have foot pain at rest, wounds that are not healing, or gangrene that has been present for at least two weeks,...

**Who might be able to join this trial:** - You are willing to take part in the study - You have been diagnosed with Thoracic Outlet Syndrome (TOS) by a chest/thoracic surgeon - You are between 18 and 65 years old - You have been experiencing pain for more than 6 months **Who may not be able to join:** - You have had...

**Who might be able to join this trial:** - People who are willing and able to give written consent before any study-related procedures take place. - People who are willing and able to follow the study procedures and attend all follow-up appointments. - People who have been diagnosed with Critical Limb Ischemia (a ser...

**Who might be able to join this trial:** - You have recently been diagnosed with leg pain or cramping when walking (called claudication), identified by answering a specific question about your symptoms - Your ankle-arm blood pressure reading (a test that checks blood flow to your legs) shows a result below 0.9, sugges...

**Who might be able to join this trial:** - The person joining (or their legal representative) must be willing and able to sign a consent form that has been approved by the relevant ethics review board. - People who are 22 years of age or older at the time of signing the consent form. - People who have a blockage or n...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been recently diagnosed with Multiple Myeloma (MM) based on standard international diagnostic guidelines - People who are currently being treated with a chemotherapy regimen called VRd, which includes a drug called bo...

Who might be able to join this trial: - You have been diagnosed with peripheral arterial disease (a condition affecting blood flow in the leg arteries) and are experiencing symptoms - You experience leg pain when walking (called claudication) or have more severe reduced blood flow to the limb that causes pain even at r...

Who might be able to join this trial: - People who are currently pregnant (at any stage of pregnancy) or who have given birth within the last 3 days - People who are 18 years of age or older - People who need to be admitted to an intensive care unit (ICU) for any medical reason - People whose ICU stay lasts at least 24...

**Who might be able to join this trial:** - You are 40 years old or older - You have leg artery disease that causes rest pain or small sores/wounds on your foot or toes (known as Rutherford category 4 or 5) - Imaging has shown that you have blocked or narrowed arteries in the lower part of your leg, below the knee **W...

**Who might be able to join this trial:** - You are 45 years old or older at the time of joining the trial - You are scheduled to have, or have had within the last 30 days, a procedure to open up a blocked blood vessel in your leg or pelvis (called a peripheral vascular intervention) - Your medical data is being shared...

Who might be able to join this trial: - You are 21 years old or older and have diabetes, and you are having a procedure to open up blocked arteries in your lower leg or foot (called an angioplasty) - You are willing to take part in the study and have your foot circulation measured using a special light-based scanning m...

**Who might be able to join this trial:** - Adults aged 18 or older at the time of giving consent - People receiving first-time treatment using the Cleaner Vac® Thrombectomy System (a device used to remove blood clots in leg or pelvic veins), where at least one part of the device is used inside the body - People who h...

**Who might be able to join this trial:** *For people with stroke, brain tumor, or traumatic brain injury:* - People who are 18 years of age or older. - People who are able to give informed consent and follow the study procedures. - People who have damage to one or both sides of the brain that has caused vision loss....

**Who might be able to join this trial:** - Adults aged 18 or older - People with active Raynaud's Phenomenon that has not responded well to treatment, with four or more Raynaud's attacks per week in the four weeks before joining the study - People with either primary Raynaud's Phenomenon, or Raynaud's Phenomenon caus...

**Who might be able to join this trial:** - You are between 18 and 80 years old (any gender). - You have ongoing leg pain, cramping, or non-healing wounds caused by poor blood flow to your lower limb (a condition that falls into certain severity categories known as Rutherford 2, 3, 4, or 5 — confirm with trial site if...

Who might be able to join this trial: - Adults aged 18 to 75, both men and women, who are willing to participate as volunteers - People who have been diagnosed with Complex Regional Pain Syndrome (a chronic pain condition) based on the 2012 international diagnostic guidelines - People whose pain level is rated above 4...

**Who might be able to join this trial:** - You have been diagnosed with peripheral artery disease (reduced blood flow in the arteries of the legs) - You have significant calcium buildup in your arteries (rated as severe, based on a specific medical scoring system) - The blocked or narrowed area being treated is locat...

**Who might be able to join this trial:** - You have been diagnosed with peripheral artery disease (poor blood flow in the legs) that causes symptoms such as leg cramping when walking or pain at rest, but does not yet involve tissue death or gangrene (a specific level called Rutherford 2–4) - The blocked or narrowed bl...

Who might be able to join this trial: - People who have been diagnosed with Type 1 diabetes based on the American Diabetes Association (ADA) guidelines - People who are either older than 11 years of age, or have had diabetes for more than 2 years - Cases where both the child or young person with diabetes and their pare...

**Who might be able to join this trial:** - You have had, or are scheduled to have, a blood vessel procedure on your legs (either open surgery or a less invasive procedure) because of poor blood flow, either sudden or long-term - You have been taking a type of medication called an SGLT2 inhibitor (also known as "flozin...

Who might be able to join this trial: - People who have been diagnosed with Waldenström's Macroglobulinemia (a rare type of blood cancer) and are also experiencing symptoms of nerve damage, such as numbness, tingling, or weakness in the hands or feet Who may not be able to join: - People who have been assessed and fou...

**Who might be able to join this trial:** - You are willing and able to sign a written consent form agreeing to take part in the study - You are a man or woman who has had a blood vessel in your leg or arm (peripheral artery) repaired or replaced using a specific type of graft called the Advanta VXT or Flixene vascular...

Who might be able to join this trial: - People who have been diagnosed with peripheral artery disease (a condition affecting blood flow in the legs) by a cardiovascular surgery department - People whose blood flow measurements in the legs meet certain thresholds, or who have been diagnosed with a calcified (hardened) b...

Who might be able to join this trial: - People aged 50 years or older - People with a body mass index (BMI) of 20 or above (a measure of body weight relative to height) - People who have a history of at least one of the following conditions: stroke, coronary artery disease, heart attack, peripheral artery disease (redu...

Who might be able to join this trial: - You (or a family member or support person on your behalf) have agreed to take part in the study - You are 18 years of age or older - You are currently admitted to an intensive care unit - You already have a central venous catheter (a thin tube inserted into a large vein, usually...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with peripheral arterial disease and have stable leg pain when walking (symptoms that have not changed for at least 6 months) - People whose ankle-brachial index (a blood pressure measurement comparing the a...

Who might be able to join this trial: - You must be able to read and sign a consent form agreeing to take part in the study. - You must be 19 years of age or older. - You may or may not have been diagnosed with peripheral artery disease (a condition affecting blood flow in the legs). Who may not be able to join: - You...

**Who might be able to join this trial:** - You are between 18 and 85 years old - You have lower back pain and/or leg pain caused by a narrowing of the spinal canal in your lower back (called lumbar spinal stenosis) - An MRI scan of your lower back has shown spinal canal narrowing in at least one area that matches your...

Who might be able to join this trial: - Adults aged 18 years or older - People who are having surgery on the lower leg, ankle, or foot (below the knee) - People who fall within certain health classification categories used by anaesthetists to assess overall health, ranging from healthy to having a severe systemic condi...

**Who might be able to join this trial:** - People who have at least 3 toes on each foot - People whose feet are otherwise in generally intact condition - People who do not have skin conditions such as eczema, thickened skin, hardened skin disorders, or excessive sweating on the areas of the foot where the study produc...

**Who might be able to join this trial:** - People aged 18 or older - People who are willing and able to sign a consent form agreeing to take part - People whose condition is suitable for treatment using the Reduced Profile GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis (BXB) device, as determined by the treating...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with peripheral artery disease (a condition affecting blood flow in the limbs) and are being seen either in hospital or at an outpatient vascular clinic, at any stage of the condition and regardless of whether you have had s...

**Who might be able to join this trial:** - Doctors, nurses, and other healthcare staff who order, carry out, or review heart ultrasound tests (called echocardiograms) and make care decisions based on the results, at a participating Mayo Clinic location - Clinicians caring for patients aged 18 or older who are having...

**Who might be able to join this trial:** *For participants with PAD (Cases – Part 1):* - People aged 18 or older - People who are willing and able to give informed consent to participate - People who have been officially diagnosed with peripheral artery disease (PAD) by a doctor - People who are able to follow the st...

Who might be able to join this trial: - People who are able to understand and willing to sign a consent form and follow the study rules. - People aged 18 to 75 years old (inclusive). - People with a body mass index (BMI) between 18.0 and 35.0 — a measure of body weight relative to height. - People with a history of lon...

**Who might be able to join this trial:** - You have recently had a procedure to restore blood flow in a leg artery (below a certain point in the pelvis) due to artery blockages caused by plaque build-up, and this procedure happened within the last 10 days - You meet at least one of the following risk factors: you rece...

Who might be able to join this trial: - People who are willing and able to sign a written consent form as required by the overseeing ethics or review board - People (male or female) who have had a surgery to bypass, replace, or repair blood vessels in the legs or arms, the main artery in the body (aorta), or the neck a...

**Who might be able to join this trial:** - People who are willing to take part and follow all study procedures - People who are able to do basic physical activity and complete leg circulation and movement assessments - People who have normal thinking and understanding abilities, enough to follow instructions and agre...

**Who might be able to join this trial:** - You have agreed to take part and signed a consent form - You are 18 years of age or older - You have been diagnosed with atherosclerotic vascular disease (a condition where arteries are narrowed or blocked by fatty deposits), which may include: a history of heart artery disea...

Who might be able to join this trial: - The patient is 22 years of age or older at the time of the procedure - The Liberant device is used according to its official labeling within 72 hours of the main procedure Who may not be able to join: - No specific exclusion criteria were listed in the official eligibility infor...

Who might be able to join this trial: - You have had a cardiac MRI (a special heart scan) since 2010 and doctors suspect you may have a rare heart muscle disease. Who may not be able to join: - You have a serious irregular heartbeat (severe arrhythmia). - You have a serious disease affecting the valves of your heart t...

Who might be able to join this trial: - People who are 18 years of age or older - People who are willing and able to attend follow-up appointments as required by the study schedule - People who are willing and able to sign a written consent form before any study-related information is collected - People who have a plan...

**Who might be able to join this trial:** *For trial parts A1, B1, and B2 (people with more severe artery disease):* - Men between 45 and 85 years old, or women up to 85 years old who have gone through menopause (no periods for 12 months without another medical reason) - People diagnosed with peripheral artery diseas...

Who might be able to join this trial: - Adults aged 18 years or older (up to 100 years old) - People who have been diagnosed with peripheral artery disease (PAD) — a condition where reduced blood flow affects the arteries in the legs — confirmed through symptoms, physical examination, a circulation test called an ankle...

Who might be able to join this trial: - People between 50 and 60 years of age, of any sex - People who have been diagnosed with high blood pressure for at least 5 years - People whose blood pressure remains high (systolic at or above 140 mmHg and/or diastolic at or above 90 mmHg) despite taking three or more different...

Who might be able to join this trial: - No inclusion criteria have been listed for this trial (confirm with trial site) Who may not be able to join: - No exclusion criteria have been listed for this trial (confirm with trial site) Important: Always verify eligibility with the trial site directly before applying.

**Who might be able to join this trial:** - People between 55 and 75 years of age - People who have been diagnosed with a stroke, confirmed by an MRI or CT scan, more than 6 months ago - People who have full voluntary control of their unaffected arm and at least some ability to lift their affected shoulder against grav...

Who might be able to join this trial: - Adults of any gender are eligible to participate. - People who have been diagnosed with a serious condition called critical limb-threatening ischemia (CLTI), which means poor blood flow in the leg causing non-healing wounds or ulcers (confirm with trial site for full classificati...

Who might be able to join this trial: - People aged between 45 and 75 years old - Both men and women are welcome to participate - People who have had a stroke less than 6 months ago (known as a subacute stroke) - People whose stroke severity has been rated above 6 on a standard medical stroke assessment scale (confirm...

Who might be able to join this trial: - People who have a confirmed diagnosis (proven by biopsy) of systemic AL amyloidosis, POEMS syndrome, or multiple myeloma - People who are already scheduled to have a blood sample taken from a vein, and possibly also a bone marrow sample, as part of their usual care - People who a...

**Who might be able to join this trial:** - People who are willing and able to give informed consent and can follow the study requirements, including all follow-up visits - People who, in the doctor's opinion, are expected to live for more than one year - People who are over 18 years of age - People who have serious s...

**Who might be able to join this trial:** - Adults aged 18 or older (male or female) - People who have been diagnosed with peripheral artery disease (a condition where narrowed arteries reduce blood flow to the limbs) and have symptoms, which may include one or more of the following: - People who experience leg pain o...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with type 1 or type 2 diabetes - People whose foot health has been assessed as moderate to high risk for foot problems (classified as IWGDF Risk 2 or 3 — confirm with trial site if unsure what this means) -...

**Who might be able to join this trial:** - People who have a brain lesion (an abnormal area in the brain) and are already scheduled to have it surgically removed as part of their normal medical care — this includes people who have previously had chemotherapy, radiation, or a biopsy to diagnose their condition. - Peopl...

**Who might be able to join this trial:** - People who are between 18 and 65 years old - People who have been diagnosed with peripheral artery disease at Fontaine stage I or II, confirmed by a scan of the blood vessels or an ultrasound of the arteries - People who are willing to take part in the study - People who have...

**Who might be able to join this trial:** - People aged 19 years or older - People who are able to give informed consent before any trial activities begin - People who have been diagnosed with peripheral artery disease (PAD) causing leg pain or cramping when walking, at a stage where they can walk more than 200 metres...

**Who might be able to join this trial:** - Adults aged 18 or older - People who are currently hospitalised with a serious limb circulation condition causing rest pain or a non-healing wound, ulcer, or limited area of tissue loss that has been present for more than 2 weeks, along with at least one abnormal blood flow...

**Who might be able to join this trial:** - People aged 18 to 75 years at the time of signing consent - People with a laboratory-confirmed blood cancer or related condition, including: B-cell acute lymphoblastic leukaemia (B-ALL); B-cell non-Hodgkin lymphoma, chronic lymphocytic leukaemia, or small lymphocytic lymphom...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed with chronic limb-threatening ischemia (a serious condition where reduced blood flow to a limb causes severe symptoms), confirmed by imaging such as a scan or ultrasound taken within the past 12 months - People whose b...

Who might be able to join this trial: - People who are scheduled to have a procedure to restore blood flow to the lower legs or feet - People who will have a special dye-based imaging test (using a substance called indocyanine green and a type of light called near-infrared) to measure blood flow before and after their...

Who might be able to join this trial: - People who are able to give written consent to participate in the study - People who have been diagnosed with amyloid cardiomyopathy (a heart condition caused by abnormal protein build-up) - People who have a history of atrial fibrillation or atrial flutter (irregular heart rhyth...

Who might be able to join this trial: - People who have chronic (long-term) coronary artery disease, which is a condition where the arteries supplying the heart are narrowed or blocked - People who have had a type of heart event called a non-ST elevation acute coronary syndrome, which is a form of chest pain or heart a...

Who might be able to join this trial: - You are showing signs of circulatory shock or your blood circulation is at serious risk of failing - Doctors are able to monitor your blood pressure, either through a standard cuff or through a more direct medical monitoring device - It is possible for medical staff to feel your...

**Who might be able to join this trial:** - You have an injury to a named artery in an arm or leg, or you need surgery to restore blood flow in a named blood vessel due to a condition called atherosclerosis (hardening/narrowing of the arteries), whether the procedure is open surgery or a less invasive procedure - You a...

Who might be able to join this trial: - People who are 18 years of age or older - People who are already scheduled to have a routine blood vessel procedure done through an artery in the wrist or forearm - People who are able to give their consent to participate Who may not be able to join: - People who are under 18 ye...

**Who might be able to join this trial:** - People who have been fully informed about the study and are willing to sign a consent form before any procedures begin. - Healthy men and women aged 18 to 55 years (inclusive) at the time of signing the consent form. - People with a body mass index (BMI) between 18 and 32, a...

Who might be able to join this trial: - People who are at least 18 years old. - People who are able to give informed consent and follow the study procedures. - People who have damage to one or both sides of the brain in a specific area, which has caused them to lose part of their vision. - People who are at least three...

Who might be able to join this trial: - Adults aged 18 or older, of any sex - People who have a significant narrowing or blockage in one or both of the large arteries in the pelvis (the common iliac artery and/or external iliac artery), confirmed by a CT scan, MRI scan, or angiogram - People with peripheral artery dise...

**Who might be able to join this trial:** - You are between 2 and 21 years old when joining the study - You are scheduled to receive chemotherapy for a newly diagnosed cancer, including certain soft tissue sarcomas, rhabdomyosarcoma, bone cancer (osteosarcoma), Ewing's sarcoma, neuroblastoma, Wilms' tumor (Stage III/IV...