Phase 3 Peripheral Arterial Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged over 18 years
- People who have been diagnosed with peripheral artery disease (narrowing of the arteries in the legs) that is causing symptoms, AND who meet at least one of the following conditions:
- People who experience leg pain when walking (called claudication), where blood flow measurements in the ankle show reduced circulation OR where an artery is narrowed by 50% or more, AND who also have at least one of: atherosclerosis (artery hardening) affecting more than one area of the body, diabetes, heart failure, or reduced kidney function (confirm with trial site for specific kidney function levels)
- People who have pain in their foot while resting, or tissue death or gangrene in a limb, with reduced blood flow measurements in the ankle OR an artery narrowed by 50% or more
- People who have had surgery or a procedure to restore blood flow to a leg (such as bypass surgery or a procedure to open a blocked artery)
- People who have had an amputation of a leg or foot due to poor blood supply to the limb
- People who have given their consent to participate, either in writing or verbally
Who may not be able to join:
- People who have a medical reason they cannot take the drug colchicine
- People who already need to take colchicine long-term for another health condition
- People who are currently experiencing ongoing diarrhoea
- People whose kidneys are functioning at a significantly reduced level (confirm specific threshold with trial site)
- People who have cirrhosis or severe long-term liver disease
- Women who are pregnant, breastfeeding, planning to become pregnant during the study, or of childbearing age who are not using reliable contraception
- People who currently use or plan to use long-term certain medications, including cyclosporine, verapamil, some HIV medications, some antifungal medications, or most macrolide antibiotics (with the exception of azithromycin) — confirm with trial site if a specific medication is relevant
- People who are considered unlikely to attend follow-up appointments
- People whose life expectancy is less than one year
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Noel C Chan, MD, Population Health Research Institute, Hamilton, Ontario, Canada
Phone: 905-521-2100
Australian sites
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
1 site(s) in Australia. Confirm current status and contact details directly with the trial site.
Primary endpoints
Major adverse cardiovascular and limb events (MACE or MALE)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.