Phase 3 study for people with Heart Disease

Recruiting Phase 3

Sources: ClinicalTrials.gov Checked: 11 October 2026 Not medical advice

This trial at a glance

Status Recruiting

Phase Phase 3

Sponsor Eli Lilly and Company

Registry number NCT07157774

Started 2 September 2025 Today 16 October 2026 Estimated completion 1 March 2031

Where this trial is running

Trial sites and the status recorded for each
Site	City	State or country	Status at this site
Nightingale Research	Adelaide	SA	Recruiting
Box Hill Hospital	Box Hill	VIC	Recruiting
Royal Brisbane and Women's Hospital	Brisbane	QLD	Recruiting
Heart of Australia	Brisbane	QLD	Recruiting
Cholesterol Care	Brisbane	QLD	Recruiting
Advara HeartCare - Burwood	Burwood	NSW	Recruiting
Victorian Heart Hospital	Clayton	VIC	Recruiting
Nightingale Research - Frankston	Frankston	VIC	Recruiting
Barwon Health	Geelong	VIC	Recruiting
Clinitrials - Mandurah	Greenfields	WA	Recruiting
Royal Hobart Hospital	Hobart	TAS	Recruiting
Ipswich Hospital	Ipswich	QLD	Recruiting
Advara HeartCare Joondalup	Joondalup	WA	Recruiting
Advara HeartCare Leabrook	Leabrook	SA	Recruiting
Sydney Cardiometabolic Centre	Liverpool	NSW	Recruiting
Maroochy Private Hospital	Maroochydore	QLD	Recruiting
University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook	Meadowbrook	QLD	Recruiting
The AIM Centre / Hunter Diabetes Centre	Merewether	NSW	Recruiting
Advara HeartCare - Milton	Milton	QLD	Recruiting
USC Clinical Trials Moreton Bay	Morayfield	QLD	Recruiting
Fusion Clinical Research	Norwood	SA	Recruiting
Southern Adelaide Diabetes & Endocrine Services	Oaklands Park	SA	Recruiting
USC Clinical Trials Sunshine Coast	Sippy Downs	QLD	Recruiting
USC Clinical Trials Brisbane (South Bank)	South Brisbane	QLD	Recruiting
Regional Research Institute	Toowoomba	QLD	Recruiting
Latrobe Regional Health	Traralgon	VIC	Recruiting
Clinitrials	West Perth	WA	Recruiting

voxsanity.com.au · trial sites from public registries · registry record synced 11 October 2026 · not medical advice

Who can join

Age 18 Years and over

Sex Anyone, regardless of sex

Healthy volunteers Not accepted

Enrolment target 10450

The official eligibility criteria

Registry text, reproduced exactly. These are the words the trial's sponsor published on ClinicalTrials.gov. They have not been edited, shortened or rewritten, and they are written for researchers rather than for patients.

Inclusion Criteria:

* Have Lp(a) ≥175 nanomoles per liter (nmol/L)

* Meet one of the following criteria:

* Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening

* Are at risk for a first ASCVD event, defined as one or more of the following:

* Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event

* A high coronary artery calcium (CAC) score

* Reduced kidney function with diabetes

* Combination(s) of high risk factors

Exclusion Criteria:

* Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization

* Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study

* Have uncontrolled high blood pressure

* Have New York Heart Association (NYHA) class III or IV heart failure

* Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study

* Have severe kidney impairment

* Have had cancer within 5 years prior to screening

Dates on the record

Started 2 September 2025

Estimated completion 1 March 2031

Registry last updated 24 September 2026

Checked by Voxsanity 11 October 2026

Results, publications and the official record

No results are posted on the official record yet.
No publications are listed on the official record yet.
Official record and contacts on ClinicalTrials.gov – contact details for each site are kept there, and are not copied onto this page.

Sources and dates

ClinicalTrials.gov – the record this page reformats
ClinicalTrials.gov processing date: 24 September 2026.
This page last checked by Voxsanity: 11 October 2026.

Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.

Not medical advice.

Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.

Letter for your doctor

A one-page summary of this trial to print or email to your GP. It carries the registry's own record of the trial and its eligibility criteria, and nothing Voxsanity has written about whether it suits you.

Voxsanity

Clinical trials recruiting in Australia, from the public registries · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial, which may be relevant to my care:

Trial: NCT07157774

Sponsor: Eli Lilly and Company

Phase: Phase 3

Status: Recruiting

Condition: Heart Disease

More information: https://clinicaltrials.gov/study/NCT07157774

Eligibility criteria, as the registry published them

Reproduced exactly, unedited. Written for researchers rather than for patients.

Inclusion Criteria:

Have Lp(a) ≥175 nanomoles per liter (nmol/L)
Meet one of the following criteria:
- Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening
- Are at risk for a first ASCVD event, defined as one or more of the following:
  - Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event
  - A high coronary artery calcium (CAC) score
  - Reduced kidney function with diabetes
  - Combination(s) of high risk factors

Exclusion Criteria:

Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization
Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study
Have uncontrolled high blood pressure
Have New York Heart Association (NYHA) class III or IV heart failure
Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study
Have severe kidney impairment
Have had cancer within 5 years prior to screening

A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a registered health practitioner to access unapproved therapeutic goods for individual patients.

Not medical advice. Voxsanity reformats information published by public registries. It does not give medical advice and is not a substitute for talking to your doctor.