Phase 1 Obesity Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For healthy participants (certain study groups):

• People aged 18 to under 65, or aged 65 to 80 (depending on which group of the study)
• People with a body mass index (a measure of body weight relative to height) between 18.5 and 30, and a body weight of at least 50 kg for men or 45 kg for women
• People who have not smoked or used any tobacco or nicotine products in the month before screening
• People who are considered healthy based on the study's medical guidelines

For overweight participants with cardiovascular risk factors (a specific study group):

• People aged 18 to 65
• People with a body mass index between 30 and under 42
• People whose body weight has stayed roughly the same (less than 5% change) in the 3 months before screening
• People who have at least one risk factor for heart disease, such as high blood pressure or high cholesterol — if being treated for these, the treatment must have been stable for at least 3 months
• People with a blood inflammation marker (hsCRP) of 3 mg/L or higher (confirmed by a blood test at screening)

Who may not be able to join:

• People who score above a certain level on a standard scale used to assess thoughts of self-harm or suicide
• People who test positive at screening for hepatitis B, hepatitis C, HIV, syphilis, or tuberculosis
• People who are pregnant or currently breastfeeding
• People with a history of any brain or nervous system disorder, or any history of seizures
• People with clinically significant abnormal results on heart trace tests (ECG), physical examination, vital signs, or blood/lab tests at screening
• People who have had a significant heart or stroke-related event in the 6 months before screening
• People with a history of active or untreated cancer, or who have been in remission from a significant cancer for less than 5 years (skin cancers such as basal cell or squamous cell, or early-stage cervical cancer, may not apply — confirm with trial site)
• People who have taken part in another clinical trial involving a drug or device within the past 30 days (or longer, depending on the drug), or a biological medicine trial within the past 90 days (or longer, depending on the medicine), or who are currently in another study
• People for whom a lumbar puncture (a procedure involving the lower spine) would not be medically appropriate, as assessed by the study doctor

Important: Always verify eligibility with the trial site directly before applying.