Phase 1 Parkinson's Disease Trial, Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- You are willing and able to give written consent and follow the study's rules and requirements
- You are between 30 and 85 years old (any sex)
- You have been diagnosed with Parkinson's disease (PD) according to recognised medical guidelines
- Your Parkinson's diagnosis was made within the last 7 years
- Your body weight is between 45 kg and 120 kg, and your body mass index (BMI) is between 18 and 40
- You are willing to give a blood sample for genetic testing related to Parkinson's disease
- Your Parkinson's symptoms are in a mild-to-moderate range based on a standard rating scale called Hoehn & Yahr (stages 1–3)
- You do not have severe movement problems or uncontrolled involuntary movements, as judged by the study doctor
- You are either not currently taking any medication for Parkinson's, or you have been on a stable Parkinson's medication dose for at least 3 months before the study starts
- You are not pregnant or breastfeeding
- If you could become pregnant or could father a child, you agree to use two forms of contraception during the study, as specified in the study rules
- You agree not to take part in any other clinical trial while in this study
- If you have a known change (mutation) in a gene called GBA1, it must be the type that has been linked to an increased risk of Parkinson's disease
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- You have another neurological condition such as Alzheimer's disease, multiple sclerosis, epilepsy, or certain other brain or nerve disorders
- You have a history of a condition called Gaucher disease, or your genetic results suggest a high risk of it
- You have a known genetic mutation linked to Parkinson's in a gene called LRRK2, or any other Parkinson's-related gene change other than GBA1
- You have dementia or significant memory and thinking difficulties (based on a standard cognitive test score)
- You have had an allergic reaction to the study drug (GT-02287) or any of its ingredients
- You are taking certain other medications that could interact with the study drug, including some that are broken down by the liver in a specific way — (confirm with trial site)
- You are currently taking dopamine-blocking medications (such as some antipsychotics) or certain medications that affect nerve signals (anticholinergics)
- You have certain other health conditions, including serious heart conditions, diabetes, autoimmune disease, cancer, active infections, psychotic symptoms, significant depression, or problems with alcohol or drug misuse — (confirm with trial site for full list)
- You have a condition that affects how your body absorbs food or medication through the gut
- Your routine blood or lab test results show significant abnormalities
- You have a medical reason that makes a lumbar puncture (a procedure to collect fluid from your spine) unsafe for you
- You have donated more than 500 mL of blood in the last 3 months
- You are unable to follow the study's rules about certain foods, smoking, or alcohol
- You have taken part in another clinical trial within the last 3 months (or longer, depending on the previous trial's medication)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Kids Helpline — 24/7, free and private for anyone aged 5 to 25: 1800 55 1800
- headspace — mental health support for 12 to 25 year olds: headspace.org.au
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Principal Investigator: Chief Medical Officer, Gain Therapeutics, Inc.
Phone: +41919211131
Australian sites
+61 408455183
+ 61 28890 6793
+61 436447386
1800 150 433
+61 3 9903 9402
+ 61 3 9342 8182
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.
Where this trial is recruiting
7 site(s) in Australia. Confirm current status and contact details directly with the trial site.
Primary endpoints
Incidence, nature, relationship to investigational product (IP), and severity of adverse events (AEs); Incidence of clinically significant findings for clinical laboratory evaluations, physical and neurological examinations, body weight , vital signs measurements, 12-lead o 12-lead electrocardiograms (ECGs), Columbia Suicide Severity Rating Scale (C-SSRS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 31 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.