NCT00948259

Who might be able to join this trial:

• You have been diagnosed with probable Alzheimer's disease based on recognised medical guidelines
• You are between 60 and 85 years old (those over 85 may still be considered after review by the study doctor)
• You have had a brain scan (MRI or CT) within the last 12 months that supports your Alzheimer's diagnosis and rules out other causes of memory problems
• Your Alzheimer's disease is at a mild to moderate stage, based on a standard memory and thinking test score between 16 and 26
• Your score on a test used to measure stroke-related thinking problems is 4 or below (confirm with trial site)
• Your score on a depression screening tool is 7 or below (confirm with trial site)
• If you are a woman, you must have gone through menopause (at least 1 year ago, confirmed by a blood test if not surgically sterilised) or have been surgically sterilised
• A caregiver or nurse is available who lives with you or sees you regularly, and can help make sure you take the study medicine correctly
• You live at home or in a care home
• Your general health is good enough to take part in a 6-month clinical trial
• You are able to swallow 100–150 ml of a liquid (water-based) medicine
• You are not regularly taking most medicines that affect the brain, immune system, steroids, or anti-inflammatory drugs — though certain specific medicines at stable, low doses may be allowed (confirm with trial site)
• You have not been treated with Warfarin, Digitoxin, or Coumarin-based blood thinners in the last month (some other blood thinners and heart medicines may be allowed — confirm with trial site)
• Any other medicines you take regularly have been at a stable dose for at least one month before the study starts
• You have been taking one of the standard approved Alzheimer's medicines (Donepezil, Galantamine, or Rivastigmine) at a stable dose for at least 2 months before the study starts
• You have not taken a medicine called Memantine in the last 3 months, and are not currently taking it
• You are able and willing to give signed consent to take part in the study

Who may not be able to join:

• You were unable to complete the required screening or initial assessments
• You have been hospitalised or had a change in your regular medicines within the month before screening
• You have been found to have another type of dementia, brain disease, nerve condition, significant stroke-related damage, seizures, or certain infections or metabolic conditions affecting the brain
• You currently have a diagnosis of severe depression, schizophrenia, or bipolar disorder
• You have a serious, unstable, or advanced illness that could affect the study results or put you at risk, such as significant liver, kidney, heart, or breathing problems, uncontrolled blood pressure or diabetes, certain heart rhythm problems, or a cancer diagnosis within the last 5 years (some exceptions may apply — confirm with trial site)
• You have a disability that would prevent you from completing all parts of the study, such as severe vision or hearing loss, or significant difficulty with language
• You are a woman who could become pregnant
• You are receiving blood-thinning treatment through an intravenous (IV) drip of heparin
• You regularly take certain medicines including specific antidepressants, sedatives, anti-epileptics, proton pump inhibitors (stomach acid medicines), anti-cholinergic drugs, certain blood pressure medicines, opioid painkillers, anti-inflammatory medicines (taken regularly), steroids, immune-suppressing drugs, Memantine, Lithium, or certain other drugs not covered by the allowed medicines list (confirm with trial site)
• You are suspected of or known to have a problem with drug or alcohol misuse
• You are known or thought to be allergic to any part of the study treatment
• You have taken part in another clinical trial or taken an experimental medicine within the last 3 months
• The study doctor believes for any other reason that it would not be suitable for you to join

Important: Always verify eligibility with the trial site directly before applying.