NCT01155258

Who might be able to join this trial:

• You have a confirmed cancer that has spread or cannot be removed by surgery, and standard treatments no longer exist or are no longer working — specifically cancers of the lung, breast, ovary, cervix, prostate, uterus, kidney, bladder, or neuroendocrine tumors
• You are reasonably active and able to care for yourself most of the time (based on a standard activity scale scored 0–2)
• Your doctor expects you to live for at least 3 more months
• You are willing and able to give your informed consent before any study procedures begin
• If you are a woman who could become pregnant, you have a negative pregnancy test taken within 7 days before starting treatment
• You are willing to use a reliable form of contraception throughout the study (this applies to both women who could become pregnant and sexually active men); post-menopausal women must have had no periods for at least 12 months
• You have fully recovered from any serious side effects of previous surgery, chemotherapy, or radiation
• Your blood counts and organ function meet specific healthy thresholds, including: white blood cell count, platelet count, hemoglobin (red blood cells), kidney function, liver function, and bilirubin levels (confirm with trial site)
• You have little to no nerve damage (numbness, tingling, or weakness) in your hands or feet
• You are not currently receiving any other cancer treatments

Who may not be able to join:

• You have previously been treated with vinorelbine (a chemotherapy drug) or any mTOR inhibitor (a type of targeted therapy)
• You have taken part in another clinical trial or received an experimental treatment within the last 30 days
• Your last chemotherapy treatment ended less than 4 weeks before starting this study
• You received radiation therapy within the last 4 weeks, unless it was short-term radiotherapy purely for pain relief
• You still have side effects from a previous cancer treatment that are above a mild level (except for hair loss)
• You have any nerve damage (affecting movement or sensation) at the time of joining the study
• Your blood counts are too low — specifically white blood cells or platelets below required levels
• Your liver function tests are above acceptable limits
• You are currently taking certain strong medications that affect how the body processes drugs, including: ketoconazole, itraconazole, ritonavir, amprenavir, indinavir, nelfinavir, delavirdine, or voriconazole
• You are currently taking certain other medications that may interfere with the study drugs, including rifabutin, rifampicin, rifapentine, carbamazepine, phenobarbital, phenytoin, or St. John's Wort (confirm with trial site)
• You are on long-term steroid medication for an ongoing condition

Important: Always verify eligibility with the trial site directly before applying.