NCT01253681

Who might be able to join this trial:

• You are a woman aged 18 or older who has been newly diagnosed with a specific type of ovarian, peritoneal, or fallopian tube cancer (certain aggressive or advanced stages) and are planned to receive 6 cycles of paclitaxel and carboplatin chemotherapy as your first treatment
• If you have early-stage or moderately advanced disease, you must have already had surgery to remove the tumor, completed between 4 and 12 weeks before joining, and have fully recovered from that surgery
• If you have the most advanced stage of disease and have not yet had tumor-removal surgery, there must be a plan for that surgery after your first 3 cycles of treatment
• You must be in good general health, able to carry out normal activities or light work (as measured by a standard scale called GOG Performance Status 0 or 1)
• Your doctors expect you to live for at least 3 months
• You are able to start the trial treatment within 7 days of enrolling
• Your blood, kidney, and liver function results must meet certain minimum levels shown through blood and urine tests
• If you could become pregnant and are sexually active, you must agree to use a non-hormonal double-barrier method of contraception (such as a condom plus diaphragm) from signing consent through 6 months after your last dose

Who may not be able to join:

• You have already received any cancer treatment or experimental therapy for ovarian, peritoneal, or fallopian tube cancer
• You have previously had external beam radiation therapy to your abdomen or pelvis
• You are considered at higher-than-average risk of a bowel perforation (a hole in the bowel), including if you currently have a bowel blockage, have had a bowel perforation or abnormal passageway (fistula) in the past 6 months, or require intravenous nutrition
• You have had a blood clot in an artery or vein within the past 12 months
• You have had a significant bleeding episode within the past 6 months
• Your cancer has spread to your brain or central nervous system
• You have an active infection (other than a simple urinary tract infection) within the 14 days before enrolling
• You have previously been treated with AMG 386 or similar drugs that target the same biological pathway
• You are currently taking or have taken immune-suppressing medications such as cyclosporine or tacrolimus within the past 30 days
• You have previously had high-dose chemotherapy requiring a stem cell or bone marrow transplant
• You have had a significant heart problem in the past 12 months, such as a heart attack, unstable chest pain, stroke, mini-stroke, heart failure, or uncontrolled heart rhythm problems
• Your blood pressure is not well controlled (specifically, lower reading above 90 or upper reading above 140), though blood pressure medications are allowed
• You have a history of another cancer, unless it was fully treated at least 3 years ago with no sign of return, or was a minor skin cancer or early cervical cell changes that were fully treated
• You have had major surgery within the past 28 days or have not yet fully recovered from a previous surgery
• You have had a minor surgical procedure, including placement of a central line (a tube for delivering medicines), within the past 3 days
• You have a known allergy to bacterially-produced proteins, or to paclitaxel or the substance used to deliver it (cremophor)
• You are pregnant, breastfeeding, or planning to become pregnant within 6 months of finishing treatment
• You have tested positive for HIV, hepatitis C, or active hepatitis B
• You have a wound, ulcer (including in the digestive tract), or bone fracture that is not healing
• You have previously enrolled in this same trial
• You will not be available for follow-up appointments after treatment
• You have a condition that affects your ability to understand and agree to take part in the study or to follow the study procedures
• Any other serious ongoing illness or medical condition that, in your doctor's opinion, makes participation unsafe or could affect the study results

Important: Always verify eligibility with the trial site directly before applying.