NCT01427595

Who might be able to join this trial:

• Girls between the ages of 10 and 17
• Girls who have higher-than-normal levels of male hormones (specifically a hormone called free testosterone) for their stage of puberty
• Girls whose kidneys are working well, filtering blood at a healthy rate (confirm with trial site)
• Girls whose blood count (hemoglobin or hematocrit) is at a normal, healthy level
• Girls whose routine blood test results are mostly normal, apart from the hormone-related differences expected with high male hormone levels
• Girls who are sexually active must agree to either abstain from sex or use two forms of barrier contraception (such as condoms) during the study
• Girls must agree not to take any other medications during the study unless the study doctors give their approval

Who may not be able to join:

• Girls whose routine blood test results are abnormal (beyond the expected hormone-related differences)
• Girls whose kidneys are not filtering blood at a healthy enough rate (confirm with trial site)
• Girls whose blood count is below a healthy level
• Girls with abnormal liver function based on specific blood tests
• Girls who weigh less than 34 kg (approximately 75 pounds)
• Girls who have a history of kidney problems, liver problems, heart failure, blood clots in the veins, or breast, uterine, or cervical cancer
• Girls who are currently pregnant or breastfeeding
• Girls who have taken certain hormonal or related medications (such as birth control pills, metformin, or spironolactone) within the last 3 months before the study
• Girls who are currently in another research study or have participated in one within the last 30 days
• Girls who are taking certain restricted medications, unless their regular doctor approves stopping them (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.