NCT01606748

Who might be able to join this trial:

• You have an advanced or spreading solid tumor cancer (not colorectal cancer with a KRAS mutation) that has stopped responding to standard treatments, or no standard treatment is available for your cancer.
• Your cancer may or may not have measurable tumors on scans.
• Any serious side effects from previous cancer treatments (such as chemotherapy, surgery, radiation, or hormone therapy) have mostly or fully cleared up, except for hair loss.
• You are generally well enough to carry out light activity and care for yourself (confirm with trial site what this level of fitness means for you).
• Your liver, kidneys, and blood counts are at healthy enough levels.
• If you are a woman who could become pregnant, you agree to use highly effective birth control during the trial and for 6 months after, or you have had surgery to prevent pregnancy, or you are past menopause.
• If you are a man, you have had surgery to prevent fathering a child, or you agree to use highly effective birth control during and for 6 months after the trial.
• If you are a woman who could become pregnant, you have had a negative blood pregnancy test within 7 days before starting the trial treatment.

Who may not be able to join:

• You have received any systemic cancer treatment (including certain targeted therapy pills) or a medical device for cancer within the past 28 days.
• Your most recent cancer treatment included the chemotherapy drugs gemcitabine or cisplatin (or both).
• You have had radiation therapy within the past 14 days.
• You have had chemotherapy within the past 21 days.
• You are currently receiving any other cancer treatment, such as chemotherapy, immunotherapy, hormone therapy, radiation, or targeted therapy.
• Your cancer could potentially be removed by surgery.
• You have cancer that has spread to the brain and is causing symptoms, or requires steroids or seizure medication to manage.
• You have a blockage or narrowing in a major vein in your body.
• You have coronary artery disease or heart failure that is not well controlled.
• You have uncontrolled chest pain (angina), or you had a heart attack within the past 6 months.
• You have an active infection that requires treatment, including active tuberculosis or HIV.
• You have a significant history of neurological or psychiatric conditions such as dementia, seizures, or bipolar disorder.
• You have a known problem with drug or alcohol abuse.
• You are pregnant or currently breastfeeding.
• You have had major surgery within the past 28 days, or a port/venous access device placed under the skin within the past 7 days.
• You are currently in another clinical trial, or left one within the past 30 days, or are involved in other medical research that may conflict with this study.

Important: Always verify eligibility with the trial site directly before applying.