NCT01624493

Who might be able to join this trial:

For the early phase (Phase I) of the trial:

• You have been diagnosed with ovarian cancer, primary peritoneal cancer, or fallopian tube cancer that has been confirmed by a lab test, including all types and a type called carcinosarcoma.

For the later phase (Phase II) of the trial:

• You have been diagnosed with ovarian cancer, primary peritoneal cancer, or fallopian tube cancer confirmed by a lab test (not including carcinosarcoma or mucinous carcinoma types).
• Your cancer came back between 4 and 9 months after your first round of chemotherapy, or between 4 and 12 months after a second round of chemotherapy that included a platinum-based drug (cisplatin or carboplatin).
• Your cancer has gotten worse since your last platinum-based chemotherapy, as shown by blood tests or scans.
• Your response to treatment can be measured using blood tests or scans.
• If you have fluid build-up in your abdomen or around your lungs, your cancer must be measurable by scan.
• You are able to start the study treatment within 7 days of being assigned to a treatment group.

Who may not be able to join:

• Your ovarian cancer is a non-epithelial type, or your tumour is considered "borderline" (low risk of spreading).
• You have had more than two different chemotherapy treatments for ovarian cancer in the past (not counting hormone therapy or biological treatments).
• You have had chemotherapy for a different type of cancer in the past (though for Phase II, treatment more than 10 years ago may be acceptable — confirm with trial site), especially if it involved high-dose chemotherapy or a stem cell/bone marrow transplant.
• You had chemotherapy within the last 20 days.
• You had hormone therapy or biological therapy within the last 28 days.
• You are currently receiving another experimental treatment or any other cancer treatment.
• You are currently taking blood-thinning or antiplatelet medicines such as clopidogrel, ticlopidine, or persantin.
• You had radiotherapy within the last 21 days, or radiotherapy that covered more than 15% of your bone marrow.
• You still have side effects from previous chemotherapy that are more than mild in severity.
• You have cancer that has spread to your brain or the lining around your brain or spinal cord.
• You have had another type of cancer in the last 3 years, with some exceptions such as certain early-stage skin cancers, early cervical changes (carcinoma in situ), or a specific early-stage womb cancer (confirm with trial site).
• You have untreated or uncontrolled heart problems, or have had a heart attack, heart failure, or serious irregular heartbeat within the past year, or have a history of certain heart conduction problems.
• You have had a stroke or a mini-stroke (TIA) within the last 6 months.
• Your blood pressure is poorly controlled (above 150/100 mmHg), even after two separate readings — blood pressure medication is allowed if it brings your readings within the acceptable range.
• You have had a blood clot in a vein or lung within the last 6 months, or a blood clot in an artery within the last 12 months.
• You are taking full-dose blood-thinning medication such as warfarin, other oral anticoagulants, or heparin injections (low-dose preventative heparin and low-dose aspirin of 325 mg or less per day are acceptable).
• You have a serious active infection, including active hepatitis B, hepatitis C with abnormal liver results, or HIV.
• You have a serious medical or mental health condition that could make it difficult to follow the trial treatment plan.
• You have had a major operation, open biopsy, or serious injury within the last 28 days.
• You are pregnant, breastfeeding, or not using reliable contraception — if you could become pregnant, you must have a negative pregnancy test within 7 days before joining.
• Your doctors estimate that you have less than 12 weeks to live.

Important: Always verify eligibility with the trial site directly before applying.