NCT01767701

Who might be able to join this trial:

• You are between 18 and 55 years old.
• You have been diagnosed with Multiple Sclerosis (MS) according to specific 2010 diagnostic guidelines.
• Your MS disability level falls within a certain range, as measured by a standard MS scoring scale (confirm with trial site).
• You have had at least one MS relapse (flare-up) in the past 12 months, or a specific type of active lesion was found on a brain scan within the last 3 months.
• An active lesion was visible on your screening brain scan, if a brain scan was used to check your eligibility.
• If you are a woman who could become pregnant, you must agree to use an effective form of contraception from the time you consent until 6 weeks after finishing treatment.
• If you are a woman who could become pregnant, you must have a negative pregnancy test before each brain scan or within 7 days before starting the study.
• You are willing and able to sign a consent form agreeing to take part and allow your health information to be used.
• You are willing and able to provide blood, saliva, and urine samples at regular points throughout the study.
• You are willing and able to have contrast-enhanced brain scans (MRI scans using a special dye) at regular points throughout the study.
• You are able to follow all the requirements of the study.

Who may not be able to join:

• You are currently pregnant, breastfeeding, or are not willing to use contraception.
• You have taken immune-suppressing, immune-modifying, or experimental medications in the last 6 months (short-course steroids for MS relapses may be an exception — confirm with trial site).
• You have taken steroid treatment (by mouth or injection) in the 30 days before your initial study assessment.
• You have a serious or unstable medical condition, such as poorly controlled diabetes, high blood pressure, heart problems, abnormal liver tests, or certain abnormal blood count results (confirm with trial site).
• You have tested positive for HIV.
• You are currently taking a type of medication called a proton pump inhibitor, such as omeprazole or esomeprazole (used for acid reflux or stomach ulcers).
• You have active hepatitis B or C with abnormal liver test results above a certain level.
• You have taken part in another clinical drug trial within the last 30 days.
• You have a history of cancer, unless a special exception is approved by the lead researcher.
• You have had a problem with uncontrolled drug or alcohol use within the 6 months before joining the study.
• You have been treated with a medication called Rifampicin (an antibiotic) in the last 4 weeks.

Important: Always verify eligibility with the trial site directly before applying.