NCT02028117

Who might be able to join this trial:

• You are willing and able to give written consent and follow the study rules
• You are 18 years old or older
• You have been diagnosed with ovarian, fallopian tube, or primary peritoneal cancer (confirmed by tissue testing) that cannot be surgically removed
• Your cancer has come back and stopped responding to platinum-based chemotherapy (meaning it got worse within 6 months of receiving that treatment), shown either by scans or a rising CA-125 blood test
• Your cancer can be measured or detected on scans (the exact requirement depends on which part of the trial you join — confirm with trial site)
• If you are due to receive the treatment directly into the abdomen, you are able to have a small tube placed in your abdomen and tolerate the related procedures
• You have largely recovered from the side effects of any previous cancer treatments (hair loss aside) before starting this trial
• You have a good general level of fitness and daily functioning (rated 0 or 1 on a standard scale used by doctors)
• Your kidneys are working well, based on blood and urine tests
• Your urine protein levels are within acceptable limits (confirm with trial site)
• Your liver is functioning well, based on blood tests
• Your blood counts (white cells, platelets, and red cells) are at acceptable levels
• Your blood clotting ability is within a normal range
• If you could become pregnant, you have a negative pregnancy test before joining the trial
• If you are able to become pregnant and are not postmenopausal or surgically sterile, you agree to use two reliable forms of contraception (at least one that is more than 99% effective) during treatment and for at least 3 months after your last dose
• If you are in a specific part of the trial involving tumour samples, your tumour must be reachable for a needle biopsy guided by imaging
• Your blood complement levels (part of your immune system) are within the normal range

Who may not be able to join:

• Your cancer is of a specific less common type, such as malignant mixed mesodermal, mucinous, Brenner, sex-cord, or other non-epithelial ovarian tumours
• You are currently experiencing symptoms of a partial bowel blockage, such as regular bloating, nausea, vomiting, constipation, or diarrhoea
• You are pregnant or breastfeeding
• You have a significant problem with your immune system due to a condition such as HIV/AIDS, or you are taking high-dose steroid medicines or other immune-suppressing drugs
• You have had your spleen completely removed
• You have previously had a bone marrow or organ transplant from another person or from your own stored cells
• You currently have an active infection that requires antibiotics or medical monitoring, or you have recurring fevers above 38°C linked to an active infection
• You have an active viral illness, or your blood tests are positive for HIV, hepatitis B, or hepatitis C
• You have taken certain antiviral medicines (such as ribavirin, adefovir, lamivudine, cidofovir, or pegylated interferon) in the days before starting the trial (confirm exact timeframes with trial site)
• You have taken part in another clinical drug trial within the past 28 days
• You are currently receiving any other cancer treatment alongside this trial
• You have had major surgery within 2 weeks before your first dose
• Depending on which part of the trial you join, you have had another type of cancer in the past 3 years (some exceptions apply — confirm with trial site)
• You have cancer that has spread to your brain and is causing symptoms
• You have an inflammatory bowel disease (such as Crohn's disease or ulcerative colitis)
• You have heart failure or a significant heart condition
• You have any other condition that, in the doctor's judgement, could put you at risk or affect the trial results
• You have a known allergy to the study drug or any of its ingredients
• You have any other medical or mental health condition that would prevent you from safely taking part or giving informed consent
• You have a history of kidney disease, kidney injury, or most autoimmune diseases (some mild autoimmune conditions may still be acceptable — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.