NCT02039674

Who might be able to join this trial:

• You have been diagnosed with advanced non-small cell lung cancer (stage 3B or stage 4).
• Your cancer came back more than 1 year after finishing treatment for an earlier stage of lung cancer (stages 1–3A), and you have not received any other treatment for the cancer since it came back.
• Any side effects from your most recent cancer treatment have cleared up (hair loss is the exception — that does not need to have resolved).
• You have at least one tumor or area of cancer that can be measured on a scan.
• You are generally well enough to carry out daily activities with little or no limitation (confirm with trial site what this means for your situation).
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 72 hours (about 3 days) before starting the study.
• If you could father or become pregnant, you must agree to use reliable birth control throughout the study and for a set period after your last dose of study treatment.

Who may not be able to join:

• You have taken part in another clinical trial or used an experimental medical device within the last 4 weeks.
• You are expected to need any other cancer treatment while taking part in this study.
• You are currently taking long-term steroid medication or any other medication that suppresses your immune system.
• You have received a live-virus vaccine (such as certain flu or travel vaccines) within the last 30 days.
• You have active diverticulitis, an abscess in your abdomen, a bowel blockage, or cancer that has spread widely inside the abdomen (confirm with trial site).
• You have a history of a blood cancer, a brain tumor, a type of cancer called sarcoma, or any other type of cancer — unless you received treatment that may have cured it and there has been no sign of it for at least 5 years.
• Your lung cancer has actively spread to the brain or the lining around the brain and spine.
• You have had a severe allergic reaction to a similar type of medication (a monoclonal antibody) in the past.
• You have an autoimmune disease (where your immune system attacks your own body) that has needed treatment with medication in the last 2 years (hormone replacement for deficiencies is allowed).
• You have previously received a specific type of immunotherapy drug that targets certain immune pathways (known as anti-PD-1, PD-L1, PD-L2, or similar agents).
• You have had chemotherapy, biological cancer therapy, or major surgery within the last 3 weeks.
• You have had radiation therapy to the lung above a certain dose level within the last 6 months (confirm with trial site).
• You have received a certain type of targeted cancer pill (tyrosine kinase inhibitor) or palliative radiation within the last 7 days.
• You currently have an infection that requires treatment.
• You have a history of HIV.
• You currently have active Hepatitis B or Hepatitis C.
• You have a significant build-up of fluid in your abdomen or around your lungs that is causing symptoms.
• You have a lung condition involving inflammation or scarring of the lung tissue that requires steroid medication taken by mouth or through a drip.
• You are pregnant, breastfeeding, or planning to have a child during the study period.
• You have a psychiatric condition or a problem with drug or alcohol misuse.

Important: Always verify eligibility with the trial site directly before applying.