NCT02108821

Who might be able to join this trial:

• You have been diagnosed with Inflammatory Bowel Disease (IBD) — either Ulcerative Colitis (UC) or Crohn's Disease (CD)
• If you have Ulcerative Colitis, your current treatment is not working well enough and your doctor needs to perform a scope of your stomach and colon to reassess and adjust your treatment
• If you have Crohn's Disease affecting the large intestine or the area where the small and large intestines meet, your doctor needs to perform a scope of your stomach and colon because your disease is flaring or poorly controlled
• You are healthy enough to safely undergo a colonoscopy procedure
• Your Ulcerative Colitis activity score (PUCAI) is below 65, meaning your symptoms are not at the most severe level (confirm with trial site)
• Your Crohn's Disease activity score (PCDAI) is below 40, meaning your symptoms are not at the most severe level (confirm with trial site)

Who may not be able to join:

• You have Crohn's Disease with serious complications such as an abscess, blockage, perforation, abnormal connections between organs, or an active infection causing your flare-up
• You are taking a high level of immune-suppressing medications — specifically, a biologic medication combined with steroid doses above 30mg per day
• You have a central line (a tube inserted into a large vein for medical treatment)
• You require machines to support your blood pressure or breathing
• You are currently taking antibiotics
• You are not willing to give consent or follow the study guidelines for the full duration of the trial
• Your lab results, or those of the stool donor, show that the stool transplant procedure would not be safe or appropriate
• Your doctor decides participation is not appropriate for you
• You decide you no longer wish to take part

Regarding stool donors — donors cannot participate if they:

• Have taken antibiotics in the last 3 months before donating
• Have a personal history of any gut or digestive diseases
• Have a history of autoimmune conditions, severe allergies, or take medications that affect the immune system
• Have a history of chronic pain, neurological conditions, or developmental disorders
• Have metabolic syndrome, are malnourished, or are obese
• Have been exposed to infectious diseases
• Have had diarrhea or signs of a gut infection within two weeks before, or on the day of, donation
• Have a history of cancer or are currently receiving cancer treatment
• Weigh less than 15 kg (approximately 33 pounds)

Important: Always verify eligibility with the trial site directly before applying.